International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 9986 - 9986
Published: Sept. 16, 2024
Diabetes
mellitus
(DM)
severely
impairs
skin
wound
healing
capacity,
yet
few
treatment
options
exist
to
enhance
this
process.
N-acetylcysteine
(NAC)
is
an
antioxidant
that
improves
cellular
proliferation
and
enhances
in
healthy
animals,
its
use
the
context
of
type
II
DM
has
not
been
studied.
The
aim
our
research
was
investigate
effect
topically
applied
NAC-enriched
hydrogels
on
a
leptin-deficient
murine
model.
Four
excisional
wounds
were
created
backs
20
db/db
mice
subsequently
treated
with
containing
NAC
at
concentrations
5%,
10%
20%
or
placebo
(control).
Healing
monitored
for
28
days;
photographs
taken
every
third
day.
Wound
tissues
harvested
days
3,
7,
14
undergo
histological
examinations.
Wounds
5%
showed
improved
closure
speed
accompanied
by
increased
dermal
area
microscopic
assessment
compared
other
groups.
Higher
failed
show
beneficial
healing.
early
stages
model
increasing
speed,
likely
mediated
proliferation.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
25, P. 101014 - 101014
Published: Feb. 29, 2024
Traditional
hydrogel
design
and
optimization
methods
usually
rely
on
repeated
experiments,
which
is
time-consuming
expensive,
resulting
in
a
slow-moving
of
advanced
development.
With
the
rapid
development
artificial
intelligence
(AI)
technology
increasing
material
data,
AI-energized
hydrogels
for
biomedical
applications
has
emerged
as
revolutionary
breakthrough
materials
science.
This
review
begins
by
outlining
history
AI
potential
advantages
using
hydrogels,
such
prediction
properties,
multi-attribute
optimization,
high-throughput
screening,
automated
discovery,
optimizing
experimental
design,
etc.
Then,
we
focus
various
supported
biomedicine,
including
drug
delivery,
bio-inks
manufacturing,
tissue
repair,
biosensors,
so
to
provide
clear
comprehensive
understanding
researchers
this
field.
Finally,
discuss
future
directions
prospects,
new
perspective
research
novel
applications.
Journal of Orthopaedic Translation,
Journal Year:
2025,
Volume and Issue:
50, P. 111 - 128
Published: Jan. 1, 2025
The
treatment
of
orthopaedic
diseases,
such
as
fractures
and
osteoarthritis,
remains
a
significant
challenge
due
to
the
complex
requirements
for
mechanical
strength
tissue
repair.
Hydrogels
based
on
hyaluronic
acid
methacrylate
(HAMA)
show
promise
engineering
materials
these
conditions.
Hyaluronic
(HA)
is
natural
component
extracellular
matrix,
known
its
good
compatibility.
HAMA-based
hydrogels
can
be
adjusted
through
crosslinking
by
combining
them
with
other
materials.
This
review
provides
an
overview
recent
research
applications
in
diseases.
First,
we
summarize
techniques
preparation
characterization
HAMA
hydrogels.
Next,
offer
detailed
use
treating
conditions
cartilage
injuries,
bone
defects,
meniscus
injuries.
Additionally,
discuss
diseases
related
orthopaedics.
Finally,
point
out
challenges
propose
future
directions
clinical
translation
strong
translational
potential
orthopaedics
their
biocompatibility,
adjustable
properties,
regenerative
capabilities.
With
ongoing
research,
are
well-positioned
applications,
particularly
repair,
osteoarthritis
treatment.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4198 - 4217
Published: Jan. 1, 2024
The
utilization
of
extracellular
vesicles
(EVs)
in
wound
healing
has
been
well-documented.However,
the
direct
administration
free
EVs
via
subcutaneous
injection
at
sites
may
result
rapid
dissipation
bioactive
components
and
diminished
therapeutic
efficacy.Functionalized
hydrogels
provide
effective
protection,
as
well
ensure
sustained
release
bioactivity
during
process,
making
them
an
ideal
candidate
material
for
delivering
EVs.In
this
review,
we
introduce
mechanisms
by
which
accelerate
healing,
then
elaborate
on
construction
strategies
engineered
EVs.Subsequently,
discuss
synthesis
application
delivery
systems
to
enhance
complicated
healing.Furthermore,
face
wounds,
functionalized
with
specific
microenvironment
regulation
capabilities,
such
antimicrobial,
anti-inflammatory,
immune
regulation,
used
loading
EVs,
potential
approaches
addressing
these
challenges.Ultimately,
deliberate
future
trajectories
outlooks,
offering
a
fresh
viewpoint
advancement
artificial
intelligence
(AI)-energized
materials
3D
bio-printed
multifunctional
hydrogel-based
dressings
biomedical
applications.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(13), P. 1937 - 1937
Published: July 6, 2024
Over
millions
of
years
evolution,
nature
has
developed
a
myriad
unique
features
that
have
inspired
the
design
adhesives
for
wound
healing.
Bionic
hydrogel
adhesives,
capable
adapting
to
dynamic
movements
tissues,
possess
superior
biocompatibility
and
effectively
promote
healing
both
external
internal
wounds.
This
paper
provides
systematic
review
principles
these
focusing
on
treatment
skin
wounds,
explores
feasibility
incorporating
nature-inspired
properties
into
their
design.
The
adhesion
mechanisms
bionic
are
analyzed
from
chemical
physical
perspectives.
Materials
natural
synthetic
polymers
commonly
used
as
detailed
regarding
degradability.
multifunctional
elements
trauma
treatment,
such
self-healing,
drug
release,
responsive
design,
optimization
mechanical
properties,
further
explored.
aim
is
overcome
limitations
conventional
treatments
offer
safer,
more
effective
solution
application
dressings.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 5, 2025
Purslane
(Portulaca
oleracea
L.)
with
heat-clearing
and
detoxicating,
anti-inflammatory
resolving
swelling,
relieving
itching
astringing
function,
has
remarkable
efficacy
for
acute
eczema.
However,
most
of
the
clinical
applications
purslane
are
freshly
prepared
decoction,
not
as
easy
to
apply
cream,
because
decoction
is
breed
bacteria
oxidize.
Here,
based
on
theory
Chinese
medicines
compatibility,
we
made
a
purslane-tannic
acid
hydrogel
(PL-HATA)
by
simple
methods
under
mild
conditions
solve
drawbacks
oxidation
inconvenience
use
Purslane.
The
antimicrobial
activity
PL-HATA
can
exert
an
excellent
effect,
reducing
flora
skin
eczema
further
symptoms
At
same
time,
it
creates
normal
reactive
oxygen
species
(ROS)
microenvironment
promotes
recovery
from
It
also
improves
promoting
cell
proliferation
migration.
Importantly,
resulted
in
improved
lesion
scores,
scratching
behavior,
eosinophil
infiltration,
swelling
inflammation
levels,
immune
homeostasis,
histopathological
changes
rats
Besides,
HATA
only
suitable
Purslane's
decocted
metabolites
but
squeezed
metabolites.
This
application
protocol
solved
its
storage
stability
convenience
use,
which
key
issue
promote
application.
