Early life sleep in free-living fallow deer, Dama dama: the role of ontogeny, environment and individual differences

Animal Behaviour, Journal Year: 2024, Volume and Issue: 211, P. 163 - 180

Published: April 11, 2024

An individual's future behaviour and fitness are strongly influenced by early life experience. Within the suite of factors that underpin juvenile development, sleep plays a particularly important role, fulfilling vital physiological cognitive functions. Sleep ontogeny is process which time becomes shorter more consolidated into fewer bouts from in utero development to adulthood; however, how quantity, fragmentation quality develop neonates wild unknown. We investigated this question 19 free-ranging fallow deer fawns, Dama dama, during first 5 weeks life. Specifically, we examined developed, it differed between within individuals, was affected environmental conditions, using accelerometer-derived estimates Bayesian hierarchical modelling approach. showed duration rapidly decreased became consolidated, quickly approaching an adult-like condition. Moreover, fawns exhibited consistent individual differences quality, as well rate at developed. Finally, conditions affecting thermoregulation mediated behaviour; reduced lower on warmer days, further compromised humid but higher with greater rainfall. While partially shaped environment, our study reveals previously unknown present birth, development. suggest such may represent pace-of-life syndromes have consequences for later

Language: Английский

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Mechanism, autonomy and biological explanation

Biology & Philosophy, Journal Year: 2021, Volume and Issue: 36(6)

Published: Nov. 23, 2021

Abstract The new mechanists and the autonomy approach both aim to account for how biological phenomena are explained. One identifies appeals components of a mechanism organized so that their activities produce phenomenon. other directs attention towards whole organism focuses on it achieves self-maintenance. This paper discusses challenges each confronts could benefit from collaboration with other: mechanistic framework can gain by taking into what happens outside individual mechanisms, while ground itself in research actual constituting an autonomous system interact contribute different ways realize maintain system. To press case these two traditions should be constructively integrated we describe three recent developments tradition together provide bridge between traditions: (1) work constraints, (2) conception function grounded organization system, (3) focus control.

Language: Английский

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Mutation of the Drosophila melanogaster serotonin transporter dSERT impacts sleep, courtship, and feeding behaviors

PLoS Genetics, Journal Year: 2022, Volume and Issue: 18(11), P. e1010289 - e1010289

Published: Nov. 21, 2022

The Serotonin Transporter (SERT) regulates extracellular serotonin levels and is the target of most current drugs used to treat depression. mechanisms by which inhibition SERT activity influences behavior are poorly understood. To address this question in model organism Drosophila melanogaster , we developed new loss function mutations ( dSERT) . Previous studies both flies mammals have implicated as an important neuromodulator sleep, our newly generated dSERT mutants show increase total sleep altered architecture that mimicked feeding SSRI citalopram. Differences daytime versus nighttime well genetic rescue experiments unexpectedly suggest distinct serotonergic circuits may modulate sleep. also defects copulation food intake, akin clinical side effects SSRIs consistent with pleomorphic influence on D Starvation did not overcome drive male mutants, mate failed drive. be further explore its interplay other complex behaviors.

Language: Английский

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Sleep–Wake Disorders in Alzheimer’s Disease: A Review

ACS Chemical Neuroscience, Journal Year: 2022, Volume and Issue: 13(10), P. 1467 - 1478

Published: May 4, 2022

Alzheimer's disease (AD) is a multifactorial disease, and it has become serious health problem in the world. Senile plaques (SPs) neurofibrillary tangles (NFTs) are two main pathological characters of AD. SP mainly consists aggregated β-amyloid (Aβ), NFT formed by hyperphosphorylated tau protein. Sleep–wake disorders prevalent AD patients; however, links mechanisms sleep–wake on pathogenesis remain to be investigated. Here, we referred reviewed some evidence demonstrate relationship between On one hand, may lead increase Aβ production decrease clearance, spreading pathology, as well oxidative stress inflammation. other ApoE4 allele, risk gene for AD, was reported participate disorders. Furthermore, neurotransmitters, such acetylcholine, glutamate, serotonin, melatonin, orexins, their receptors were suggested involved development We discussed possible therapeutic strategies treatment based view sleep regulation. In general, this review explored different views find novel targets diagnosis therapy

Language: Английский

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Divergent evolution of sleep functions

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 28, 2023

Abstract Most living organisms have evolved to synchronize their biological activities with the earth’s rotation, a daily regulation of biology and behaviour controlled by an evolutionary conserved molecular machinery known as circadian clock. For most animals, mechanisms are meant maximize exposure positive ( e.g.: social interactions, mating, feeding – generally during day) minimize peril predation, weather, darkness night 1 ). On top regulation, some behaviours also feature second layer homeostatic control acting fail-safe ensure important not ignored. Sleep is one these behaviours: largely clock for its baseline appearance, it at same time modulated poorly understood regulator ensuring animals obey species-specific amount sleep 2 . An often considered main evidence core function beyond trivial (that is: keeping us out trouble limiting our energy expenditure danger 3,4 ) hypothesized that around this mysterious basic function. Here we characterize in group seven species Drosophila genus key distances representing variety ecological niche adaptations. We show spontaneous circadian-driven aspects among all but unexpectedly, not. uncover differences behavioural, cell-biological neuro-pharmacological suggest that, Drosophilids, primarily satisfy role, immobile dangerous hours day. The functions independently, fashion, conserved.

Language: Английский

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