Environmental Health Perspectives, Journal Year: 2023, Volume and Issue: 131(12)
Published: Dec. 1, 2023
Language: Английский
Journal of Neurodevelopmental Disorders, Journal Year: 2025, Volume and Issue: 17(1)
Published: Feb. 19, 2025
Abstract Epigenetic mechanisms, including DNA methylation, act at the interface of genes and environment by allowing a static genome to respond adapt dynamic during lifespan an individual. Genome-wide methylation analyses on wide range human biospecimens are beginning identify epigenetic biomarkers that can predict risk intellectual/developmental disabilities (IDD). methylation-based signatures becoming clinically useful in categorizing benign from pathogenic genetic variants following exome sequencing. While marks differ tissue source, recent studies have shown accessible perinatal tissues, such as placenta, cord blood, newborn blood spots, cell free may serve surrogate tissues for testing relevant understanding genetic, environmental, gene interactions developing brain. These also provide important information about biological pathways become dysregulated prior disease progression could be used develop early pharmacological interventions. Future applications involve preventative screenings using pregnancy or period IDDs other neurodevelopmental disorders. adolescence adulthood likely tracking aging co-occurring health conditions across lifespan. In conclusion, expected more common clinical diagnoses IDD, improve complex IDD etiologies, endpoints trials, monitor potential concerns individuals with they age.
Language: Английский
Citations
1
The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 970, P. 178999 - 178999
Published: March 1, 2025
Air pollution exposure is linked to various adverse health effects including cardiopulmonary, neurological and reproductive outcomes. Susceptible populations such as pregnant women infants can be affected a greater extent compared healthy individuals. Thus, understanding air pollutant exposure-related toxicity pathways in pregnancy provide information on developmental origin of diseases both mothers infants. The objective this literature review was explore maternal mechanisms underlying the association between exposures maternal/infant effects. A total 209 articles published from 1996 until November 2024 were retrieved using PubMed, Scopus Web Science relevant search terms (e.g. "Air Pollution" AND "Maternal" "Infant" "Health" "Biomarker"). After screening removal based exclusion criteria, 36 observational studies included for final analysis. There relatively fewer air-pollution-related infant Of these selected review, 32 particulate matter (PM), PM2.5, few other (gaseous) pollutants one study mixtures pollutants. Adverse hypertensive disorders, gestational diabetes mellitus (GDM) clinically recognized early loss, while ranged low birth weight, preterm birth, changes fetal heart rate, crown rump length hyperinsulinism. Moreover, oxidative stress, inflammatory responses, endothelial metabolic dysfunction some implicated These findings warrant further validation work identification mechanism(s) constituting causal pathway.
Language: Английский
Citations
1
Brain Sciences, Journal Year: 2024, Volume and Issue: 14(5), P. 471 - 471
Published: May 7, 2024
Plastic production, which exceeds one million tons per year, is of global concern. The constituent low-density polymers enable spread over large distances and micro/nano particles (MNPLs) induce organ toxicity via digestion, inhalation, skin contact. Particles have been documented in all human tissues including breast milk. MNPLs, especially weathered particles, can breach the blood–brain barrier, inducing neurotoxicity. This has non-human species, human-induced pluripotent stem cell lines. Within brain, MNPLs initiate an inflammatory response with pro-inflammatory cytokine oxidative stress generation reactive oxygen mitochondrial dysfunction. Glutamate GABA neurotransmitter dysfunction also ensues alteration excitatory/inhibitory balance favor reduced inhibition resultant neuro-excitation. Inflammation cortical hyperexcitability are key abnormalities involved pathogenic cascade amyotrophic lateral sclerosis (ALS) intricately related to mislocalization aggregation TDP-43, a hallmark ALS. Water many foods contain humans, ingestion main form exposure. Digestion plastics within gut alter their properties, rendering them more toxic, they cause microbiome dysbiosis dysfunctional gut–brain axis. recognized as trigger and/or aggravating factor for ALS associated long (years or decades) preclinical period neonates infants exposed through milk, milk substitutes, toys. endangers time intense neurogenesis establishment neuronal circuitry, setting stage development neurodegeneration later life. MNPL neurotoxicity should be considered yet unrecognized risk diseases.
Language: Английский
Citations
6
Clinical Epigenetics, Journal Year: 2024, Volume and Issue: 16(1)
Published: Oct. 17, 2024
Epigenetic modifications control gene expression and are essential for turning genes on off to regulate maintain differentiated cell types. Epigenetics also modified by a multitude of environmental exposures, including diet pollutants, allowing an individual's environment influence resultant phenotypes clinical outcomes. These epigenetic due gene-environment interactions can be transmitted across generations, raising the possibility that influences occurred in one generation may beyond second generation, exerting long-lasting effect. In this review, we cover known mechanisms modification acquisition, reprogramming persistence, animal models human studies used understand multigenerational transmission, examples environmentally induced change its transmission generations. We highlight importance health not only current population but future generations will experience outcomes through inheritance.
Language: Английский
Citations
6
Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(6)
Published: June 1, 2024
Maternal exposure to environmental chemicals can cause adverse health effects in offspring. Mounting evidence supports that these are influenced, at least part, by epigenetic modifications. It is unknown whether changes surrogate tissues such as the blood reflective of similar target cortex or liver.
Language: Английский
Citations
4
Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 22, 2025
Language: Английский
Citations
0
Journal of Dairy Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
International Journal of Pediatric Otorhinolaryngology, Journal Year: 2025, Volume and Issue: 193, P. 112354 - 112354
Published: April 16, 2025
Language: Английский
Citations
0
The Lancet Rheumatology, Journal Year: 2024, Volume and Issue: 6(8), P. e573 - e586
Published: June 13, 2024
Language: Английский
Citations
1
médecine/sciences, Journal Year: 2024, Volume and Issue: 40(12), P. 947 - 954
Published: Dec. 1, 2024
Les expositions environnementales précoces peuvent influencer le développement et la santé de l’enfant à long terme. Des modifications épigénétiques pourraient partiellement expliquer ces effets, leur identification conduire des progrès significatifs dans compréhension mécanismes impliqués. Dans cette revue, nous présentons les données récentes en épidémiologie épigénétique environnementale pendant période 1 000 premiers jours vie concernant plusieurs très courantes, dont tabac, phénols phtalates, polluants l’air, température ambiante végétation.
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1