Standardization of Optical Coherence Tomography Angiography Imaging Biomarkers in Diabetic Retinal Disease DOI Creative Commons
Stela Vujosevic, José Cunha‐Vaz, João Figueira

et al.

Ophthalmic Research, Journal Year: 2021, Volume and Issue: 64(6), P. 871 - 887

Published: Jan. 1, 2021

Optical coherence tomography Angiography (OCT-A) represents a revolution in the noninvasive evaluation of retinal and choroidal circulation especially detecting early clinical signs diabetic disease (DRD). With appropriate use, OCT-A characteristics measurements have potential to become new imaging biomarkers managing treating DRD. Major challenges include (a) provision standardized outputs from different instruments providing terminology correctly interpret data; (b) presence artifacts; (c) absence grading or interpretation method DRD, similar that already established fundus photography; (d) establishing how might be able provide surrogate markers demonstrate blood barrier breakdown vascular leakage, commonly associated with In fact, guidelines for DRD are still evolving. The quantitative data offer unique opportunity develop tools based on artificial intelligence assist clinicians diagnosing, monitoring, patients diabetes. addition, has useful tool cardiovascular diseases neurological including cognitive impairment. This article written by members Diabetic Retinopathy expert committee European Vision Clinical Research network will review available evidence use as an biomarker discuss limits current application well future developments its both practice research trials

Language: Английский

Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions DOI

Ágnes Lipécz,

Lauren R. Miller, Illés Kovács

et al.

GeroScience, Journal Year: 2019, Volume and Issue: 41(6), P. 813 - 845

Published: Dec. 1, 2019

Language: Английский

Citations

69
Use of optical coherence tomography angiography for assessment of microvascular changes in the macula and optic nerve head in hypertensive patients without hypertensive retinopathy DOI Creative Commons
Dihao Hua, Yishuang Xu,

Xiangbing Zeng

et al.

Microvascular Research, Journal Year: 2019, Volume and Issue: 129, P. 103969 - 103969

Published: Dec. 23, 2019

To compare optical coherence tomography angiography (OCTA) screening parameters of the macula and optic nerve head (ONH) between healthy volunteers chronic hypertensive patients without retinopathy.This was an observational, cross-sectional study. Fifty-seven retinopathy (22 men 35 women) 40 (17 23 women), ranging in age from 60 to 70 years, were included this Patients divided into three groups one eye selected randomly each participant. Group A comprised who had a history hypertension for >10 years (n = 35); B 5-10 22); C no hypertension. 3 × 3-mm scan 4.5 4.5-mm ONH performed group by OCTA using prototype AngioVue software within device. Vessel density (VD), foveal avascular zone (FAZ) area, choriocapillaris flow capillary density, retinal fiber layer (RNFL) thickness, demographic information compared among groups.Macula scans showed that superficial plexus VD significantly lower than (P < 0.05). In addition, FAZ area larger Inner thickness thinner scans, RNFL 0.05); it Inside disc peripapillary 0.05) greater 0.05), respectively, C.Superficial VD, inner changed retinopathy. However, only hypertension, provided method prospectively assess changes microvasculature thereby avoiding further long-term damage patients.

Language: Английский

Citations

67
Choroidal thickness in patients with cardiovascular disease: A review DOI
Shanna C. Yeung,

Yuyi You,

Kathryn L. Howe

et al.

Survey of Ophthalmology, Journal Year: 2020, Volume and Issue: 65(4), P. 473 - 486

Published: Jan. 8, 2020

Language: Английский

Citations

56
Using Artificial Intelligence to Analyse the Retinal Vascular Network: The Future of Cardiovascular Risk Assessment Based on Oculomics? A Narrative Review DOI Creative Commons
Louis Arnould, Fabrice Mériaudeau, Charles Guénancia

et al.

Ophthalmology and Therapy, Journal Year: 2022, Volume and Issue: 12(2), P. 657 - 674

Published: Dec. 23, 2022

The healthcare burden of cardiovascular diseases remains a major issue worldwide. Understanding the underlying mechanisms and improving identification people with higher risk profile systemic vascular disease through noninvasive examinations is crucial. In ophthalmology, retinal network imaging simple can provide in vivo information microstructure health. For more than 10 years, different research teams have been working on developing software to enable automatic analysis from techniques (retinal fundus photographs, OCT angiography, adaptive optics, etc.) description geometric characteristics its arterial venous components. Thus, structure vessels could be considered witness status. A new approach called "oculomics" using image datasets artificial intelligence algorithms recently increased interest microvascular biomarkers. Despite large volume associated research, role biomarkers screening, monitoring, or prediction uncertain. PubMed search was conducted until August 2022 yielded relevant peer-reviewed articles based set inclusion criteria. This literature review intended summarize state art oculomics research.

Language: Английский

Citations

32
Internal Carotid Artery Stenosis and Ipsilateral Subretinal Drusenoid Deposits DOI Creative Commons

Emanuel Mordechaev,

Jason J. Jo,

Samuel Mordechaev

et al.

Investigative Ophthalmology & Visual Science, Journal Year: 2024, Volume and Issue: 65(2), P. 37 - 37

Published: Feb. 26, 2024

Purpose: Subretinal drusenoid deposits (SDDs) in age-related macular degeneration (AMD) are strongly associated with vasculopathies such as myocardial infarction and ischemic stroke. This study evaluates stroke subjects for SDDs to determine whether ocular hypoperfusion from internal carotid artery (ICA) stenosis is ipsilateral SDDs. Methods: A cross-sectional at Mount Sinai Hospital recruited 39 (aged 52–90; 18 women, 21 men); 28 completed all procedures. Computed tomography (CT) of the head neck evaluated 54/56 ICAs criteria: none (n = 33), mild 12), moderate 3), severe complete 3). Spectral-domain optical coherence (SD-OCT) scans were read consensus by two masked graders soft drusen, choroidal thickness (CTh; thinning CTh < 250 µm). Univariate testing was done Fisher's exact test. Multivariate logistic regression models tested age, gender, ICA covariates. Results: Moderate or more (≥50%–69%) significantly (P 0.021) 0.005); latter present distal six nine stenosed versus five 33 normal ICAs. Mild (≥1%–49%) not found that older age 0.015) 0.011) remained significant independent risks Conclusions: At least thinning, supporting downstream ophthalmic mechanism SDD formation. may thus serve sensitive biomarkers other vascular diseases.

Language: Английский

Citations

7
Optical Coherence Tomography Angiography Evaluation of Retinal Microvasculature Before and After Carotid Angioplasty and Stenting DOI Creative Commons
Chia‐Wei Lee, Hui‐Chen Cheng, Feng‐Chi Chang

et al.

Scientific Reports, Journal Year: 2019, Volume and Issue: 9(1)

Published: Oct. 14, 2019

Abstract The aim of the study was to evaluate influence carotid angioplasty and stenting (CAS) on retinal microvasculature using optical coherence tomography angiography (OCTA) in patients with severe stenosis. 20 stenosis underwent comprehensive ophthalmic examinations OCTA before one month after CAS. Automated algorithms were used quantify vessel density macular superficial vascular complex (SVC), deep (DVC), radial peripapillary capillary (RPC) around optic disc. Eyes operated side constituted ipsilateral eye group, other fellow group. In DVC increased significantly stent implantation ( P = 0.010), but change SVC not statistically different 0.999). 0.028) 0.034) implantation. RPC did 0.363) or 0.878) groups. This shows that unilateral CAS for increases densities both eyes.

Language: Английский

Citations

44
Retinal Microvascular Signs as Screening and Prognostic Factors for Cardiac Disease: A Systematic Review of Current Evidence DOI
Raviv Allon, Michael Aronov,

Michael Belkin

et al.

The American Journal of Medicine, Journal Year: 2020, Volume and Issue: 134(1), P. 36 - 47.e7

Published: Aug. 27, 2020

Language: Английский

Citations

44
Retinal blood flow in critical illness and systemic disease: a review DOI Creative Commons

Ella Courtie,

Tonny Veenith, Ann Logan

et al.

Annals of Intensive Care, Journal Year: 2020, Volume and Issue: 10(1)

Published: Nov. 12, 2020

Assessment and maintenance of end-organ perfusion are key to resuscitation in critical illness, although there limited direct methods or proxy measures assess cerebral perfusion. Novel non-invasive monitoring microcirculation critically ill patients offer the potential for real-time updates improve patient outcomes. Parallel mechanisms autoregulate retinal maintain blood flow meet metabolic demands across a range pressures. Cerebral (CBF) is reduced autoregulation impaired sepsis, but current image CBF do not reproducibly microcirculation. Peripheral microcirculatory may be imaged sublingual conjunctival mucosa sepsis. Retinal can directly by optical coherence tomography angiography (OCTA) during perfusion-deficit states such as other systemic haemodynamic disturbances acute coronary syndrome, inflammatory conditions bowel disease. Monitoring offers enhance care patients, imaging illness biomarker

Language: Английский

Citations

42
Impaired retinal microcirculation in patients with non-obstructive coronary artery disease DOI
Yun Ren, Yijun Hu, Cong Li

et al.

Microvascular Research, Journal Year: 2023, Volume and Issue: 148, P. 104533 - 104533

Published: March 31, 2023

Language: Английский

Citations

14
Correlation Between Coronary and Retinal Microangiopathy in Patients With STEMI DOI Creative Commons

Anna-Maria Sideri,

Menelaos Kanakis, Andreas Katsimpris

et al.

Translational Vision Science & Technology, Journal Year: 2023, Volume and Issue: 12(5), P. 8 - 8

Published: May 5, 2023

To investigate the morphological and functional correlation between microvascular retinal changes in optical coherence tomography angiography (OCTA) coronary circulation patients with ST elevation myocardial infarction (STEMI) heart disease (CHD).A total of 330 eyes from 165 participants (88 cases 77 controls) were enrolled imaged. Superficial capillary plexus (SCP) deep (DCP) vascular density was measured central (1 mm) perifoveal (1-3 areas superficial foveal avascular zone (FAZ) choriocapillaris (3 mm). These parameters then correlated to left ventricular ejection fraction (LVEF), number affected arteries.Decreased vessel densities SCP DCP positively LVEF values (P = 0.006, P 0.026, 0.002, respectively). No statistically significant area or FAZ found. Regarding vessels, negative correlations revealed for < 0.001 0.001, respectively) 0.009).OCTA indices are significantly STEMI CHD. especially seems be a promising biomarker extent both macrovascular damage (number arteries) damage, as mirrored decreased at admission.OCTA offer valuable insight into status circulation.

Language: Английский

Citations

14