Stimulatory responses in α‐ and β‐cells by near‐infrared (810 nm) photobiomodulation DOI

Caleb Liebman,

Sheccid Alejandra Loya,

Michael C. Lawrence

et al.

Journal of Biophotonics, Journal Year: 2021, Volume and Issue: 15(3)

Published: Nov. 27, 2021

Significant efforts have been committed to better understand and regulate insulin secretion as it has direct implications on diabetes. The first phase of biphasic in response glucose lasts about 10 minutes, followed by a more sustained release persisting several hours. Attenuated the is typically associated with abnormal β-cells. While near-infrared photobiomodulation (PBM) demonstrates potential for multiple therapeutic applications, photostimulatory effects α- β-cells remain be further elucidated. Herein, we demonstrate that 810 nm PBM exposure at fluence 9 J/cm2 can elevate intracellular reactive oxygen species within 15 minutes following photostimulation. In addition, calcium spiking showed an approximately 3-fold increase both ATC1 (α-cells) BTC6 (β-cells) correlates hormone stimulation. Our findings could lay foundation development non-biologic therapeutics augment islet transplantation.

Language: Английский

Transcranial photobiomodulation enhances visual working memory capacity in humans DOI Creative Commons
Chenguang Zhao, Dongwei Li,

Yuanjun Kong

et al.

Science Advances, Journal Year: 2022, Volume and Issue: 8(48)

Published: Dec. 2, 2022

Transcranial photobiomodulation (tPBM) is a safe and noninvasive intervention that has shown promise for improving cognitive performance. Whether tPBM can modulate brain activity thereby enhance working memory (WM) capacity in humans remains unclear. In this study, we found 1064-nm applied to the right prefrontal cortex (PFC) improves visual increases occipitoparietal contralateral delay (CDA). The CDA set-size effect during retention mediated between subsequent WM capacity. behavioral benefits corresponding changes were absent with at wavelength of 852 nm or stimulation left PFC. Our findings provide converging evidence PFC improve

Language: Английский

Citations

49
Inflammation in obsessive–compulsive disorder: A literature review and hypothesis‐based potential of transcranial photobiomodulation DOI
David Richer Araujo Coelho, Joshua D. Salvi, Willians Fernando Vieira

et al.

Journal of Neuroscience Research, Journal Year: 2024, Volume and Issue: 102(3)

Published: March 1, 2024

Abstract Obsessive–compulsive disorder (OCD) is a disabling neuropsychiatric that affects about 2%–3% of the global population. Despite availability several treatments, many patients with OCD do not respond adequately, highlighting need for new therapeutic approaches. Recent studies have associated various inflammatory processes pathogenesis OCD, including alterations in peripheral immune cells, cytokine levels, and neuroinflammation. These findings suggest inflammation could be promising target intervention. Transcranial photobiomodulation (t‐PBM) near‐infrared light noninvasive neuromodulation technique has shown potential disorders. However, its efficacy remains to fully explored. This study aimed review literature on detailing associations T‐cell populations, monocytes, NLRP3 inflammasome components, microglial activation, elevated proinflammatory cytokines such as TNF‐α, CRP, IL‐1β, IL‐6. We also examined hypothesis‐based t‐PBM targeting these pathways focusing mechanisms modulation oxidative stress, regulation cell function, reduction deactivation neurotoxic microglia, upregulation BDNF gene expression. Our suggests promising, intervention modulate underlying processes. Future research should focus randomized clinical trials assess t‐PBM's optimal treatment parameters OCD. Biomarker analyses neuroimaging will important understanding relationship between symptom improvement following sessions.

Language: Английский

Citations

12
Unlocking the potential of photobiomodulation therapy for brain neurovascular coupling: The biological effects and medical applications DOI
Bingzi Yan, Jie Zhou, F. Yan

et al.

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Photobiomodulation (PBM) therapy stands as an innovative neurostimulation modality that has demonstrated both efficacy and safety in improving brain function. This exerts multifaceted influences on neurons, blood vessels, their intricate interplay known neurovascular coupling (NVC). Growing evidence indicates NVC may present a promising target for PBM intervention. However, the detailed mechanisms underlying its therapeutic benefits remain to be fully understood. review aims elucidate potential metabolic pathways signaling cascades involved modulatory effects of PBM, while also exploring extensive repertoire applications neurologic psychiatric conditions. The prospects within realm investigation are intensively considered, providing deeper insights into powerful capabilities revolutionize treatments.

Language: Английский

Citations

1
Photobiomodulation Enhances Memory Processing in Older Adults with Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy Study DOI
Agnes S. Chan, Tsz‐lok Lee, Michael R. Hamblin

et al.

Journal of Alzheimer s Disease, Journal Year: 2021, Volume and Issue: 83(4), P. 1471 - 1480

Published: May 11, 2021

Recent studies of photobiomodulation (PBM) in patients with cognitive or psychological disorders (including traumatic brain injury, stroke, and dementia) have yielded some encouraging results.In this study, we aimed to investigate the effect a single stimulation on memory older adults mild impairment (MCI).After PBM, hemodynamic changes, as measure functional activity, were evaluated using near-infrared spectroscopy (fNIRS). Eighteen subjects who met criteria MCI randomly assigned control experimental groups. A real sham PBM session was administered forehead each patient groups, respectively. All performed visual span test before after stimulation, their responses during tasks measured fNIRS.The results showed that among subjects, only those received but not demonstrated significant improvement performance reduction response tasks.These findings suggest may reduce efforts needed complete require high loads, thus improve individuals MCI.

Language: Английский

Citations

54
Photobiomodulation of Cytochrome c Oxidase by Chronic Transcranial Laser in Young and Aged Brains DOI Creative Commons
Fabrízio dos Santos Cardoso,

Douglas W. Barrett,

Zachary S. Wade

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: March 18, 2022

In cellular bioenergetics, cytochrome c oxidase (CCO) is the enzyme responsible for oxygen consumption in mitochondrial electron transport chain, which drives oxidative phosphorylation adenosine triphosphate (ATP) production. CCO also major intracellular acceptor of photons light wavelengths used photobiomodulation (PBM). Brain function critically dependent on by ATP Therefore, our objectives were (1) to conduct first detailed brain mapping study effects PBM regional activity, and (2) compare chronic young aged brains. Specifically, we quantitative histochemistry map differences activity regions healthy (4 months old) (20 rats from control groups with sham stimulation treated 58 consecutive days transcranial laser (810 nm wavelength 100 mW power). We found that aging predominantly decreased systems-level functional connectivity, while reversed these age-related effects. concluded modified causing laser-treated reach levels similar those rats. Given crucial role may be augment behavioral functions older individuals improving energy metabolism.

Language: Английский

Citations

32
Devices used for photobiomodulation of the brain—a comprehensive and systematic review DOI Creative Commons
Filipa Fernandes, Sofia Oliveira, Francisca Monteiro

et al.

Journal of NeuroEngineering and Rehabilitation, Journal Year: 2024, Volume and Issue: 21(1)

Published: April 10, 2024

Abstract A systematic review was conducted to determine the trends in devices and parameters used for brain photobiomodulation (PBM). The revised studies included clinical cadaveric approaches, which light stimuli were applied head and/or neck. PubMed, Scopus, Web of Science Google Scholar databases search. total 2133 records screened, from 97 this review. that extracted analysed each article device design, actuation area, site, wavelength, mode operation, power density, energy output, per session treatment time. To organize information, 11 categories defined, according their characteristics. most category laser handpieces, relate 21% all devices, while 28% not described. Studies cognitive function physiological characterisation are well defined ones with more tangible results. There is a lack consistency when reporting PBM studies, several articles under defining stimulation protocol, wide variety same health conditions (e.g., Alzheimer’s or Parkinson’s disease) resulting positive outcomes. Standardization report these warranted, as sham-controlled comparative have greatest effect on treatments different neurological conditions.

Language: Английский

Citations

8
Photobiomodulation in the aging brain: a systematic review from animal models to humans DOI Creative Commons

Lucia Rodríguez-Fernández,

Candela Zorzo,

Jorge L. Arias

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: June 11, 2024

Abstract Aging is a multifactorial biological process that may be associated with cognitive decline. Photobiomodulation (PBM) non-pharmacological therapy shows promising results in the treatment or prevention of age-related impairments. The aim this review to compile preclinical and clinical evidence effect PBM during aging healthy pathological conditions, including behavioral analysis neuropsychological assessment, as well brain-related modifications. 37 studies were identified by searching PubMed, Scopus, PsycInfo databases. Most use wavelengths 800, 810, 1064 nm but intensity days application highly variable. In animal studies, it has been shown improvements spatial memory, episodic-like social while different have found recognition memory. Locomotor activity improved Parkinson disease models. aged humans, outlined working inhibition, lexical/semantic access, general cognition was mainly enhanced on Alzheimer mild impairment. Anxiety assessment scarce mixed results. As for brain activity, outline effects reversing metabolic alterations enhancing mitochondrial function, evidenced restored CCO ATP levels. Additionally, demonstrated neuroprotective, anti-inflammatory, immunomodulatory hemodynamic effects. findings suggest holds promise non-invasive intervention modulation functional reorganization. It necessary develop standardized protocols correct, beneficial, homogeneous PBM.

Language: Английский

Citations

7
A systematic review of the effects of transcranial photobiomodulation on brain activity in humans DOI
Marjorie Dole, Vincent Auboiroux,

Lilia Langar

et al.

Reviews in the Neurosciences, Journal Year: 2023, Volume and Issue: 34(6), P. 671 - 693

Published: March 17, 2023

Abstract In recent years, transcranial photobiomodulation (tPBM) has been developing as a promising method to protect and repair brain tissues against damages. The aim of our systematic review is examine the results available in literature concerning efficacy tPBM changing activity humans, either healthy individuals, or patients with neurological diseases. Four databases were screened for references containing terms encompassing photobiomodulation, activity, imaging, human. We also analysed quality included studies using validated tools. Results subjects showed that even after single session, can be effective influencing activity. particular, different approaches – focal stimulation helmet global seemed act at both vascular level by increasing regional cerebral blood flow (rCBF) neural neurons. addition, was sufficient induce change functional connectivity across networks. disease sparser; nevertheless, they indicated could improve rCBF several regions. Our highlighted heterogeneity methods generated, together need more randomised controlled trials summary, on function, but consistency needed order appreciate fully underlying mechanisms precise outcomes.

Language: Английский

Citations

15
Transcranial photobiomodulation for brain diseases: review of animal and human studies including mechanisms and emerging trends DOI Creative Commons
Hao Lin, Dongyu Li, Jingtan Zhu

et al.

Neurophotonics, Journal Year: 2024, Volume and Issue: 11(01)

Published: Feb. 5, 2024

The brain diseases account for 30% of all known diseases. Pharmacological treatment is hampered by the blood–brain barrier, limiting drug delivery to central nervous system (CNS). Transcranial photobiomodulation (tPBM) a promising technology treating diseases, due its effectiveness, non-invasiveness, and affordability. tPBM has been widely used in pre-clinical experiments clinical trials such as stroke Alzheimer's disease. This review provides comprehensive overview tPBM. We summarize emerging trends new discoveries based on over one hundred references published past 20 years. discuss advantages disadvantages highlight successful experimental protocols various A better understanding mechanisms, development guidelines practice, study dose-dependent personal effects hold great promise progress

Language: Английский

Citations

6
Directed physiological networks in the human prefrontal cortex at rest and post transcranial photobiomodulation DOI Creative Commons
Sadra Shahdadian, Xinlong Wang, Hanli Liu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 3, 2024

Cerebral infra-slow oscillation (ISO) is a source of vasomotion in endogenic (E; 0.005-0.02 Hz), neurogenic (N; 0.02-0.04 and myogenic (M; 0.04-0.2 Hz) frequency bands. In this study, we quantified changes prefrontal concentrations oxygenated hemoglobin (Δ[HbO]) redox-state cytochrome c oxidase (Δ[CCO]) as hemodynamic metabolic activity metrics, electroencephalogram (EEG) powers electrophysiological activity, using concurrent measurements 2-channel broadband near-infrared spectroscopy EEG on the forehead 22 healthy participants at rest. After preprocessing, multi-modality signals were analyzed generalized partial directed coherence to construct unilateral neurophysiological networks among three metrics (with simplified symbols HbO, CCO, EEG) each E/N/M band. The links these represent neurovascular, neurometabolic, metabolicvascular coupling (NVC, NMC, MVC). results illustrate that demand for oxygen by neuronal metabolism (EEG CCO) drives supply (HbO) all bands resting cortex. Furthermore, investigate effect transcranial photobiomodulation (tPBM), performed sham-controlled study delivering an 800-nm laser beam left right cortex same participants. performing data processing statistical analysis, obtained novel important findings: tPBM delivered either side triggered alteration or reversal network couplings entities (i.e., frequency-specific powers) physiological E N bands, demonstrating during post-tPBM period, both drive (PFC). Overall, revealed facilitates significant modulation directionality electrophysiological, metabolic, activities.

Language: Английский

Citations

5