Stimulatory responses in α‐ and β‐cells by near‐infrared (810 nm) photobiomodulation DOI

Caleb Liebman,

Sheccid Alejandra Loya,

Michael C. Lawrence

et al.

Journal of Biophotonics, Journal Year: 2021, Volume and Issue: 15(3)

Published: Nov. 27, 2021

Significant efforts have been committed to better understand and regulate insulin secretion as it has direct implications on diabetes. The first phase of biphasic in response glucose lasts about 10 minutes, followed by a more sustained release persisting several hours. Attenuated the is typically associated with abnormal β-cells. While near-infrared photobiomodulation (PBM) demonstrates potential for multiple therapeutic applications, photostimulatory effects α- β-cells remain be further elucidated. Herein, we demonstrate that 810 nm PBM exposure at fluence 9 J/cm2 can elevate intracellular reactive oxygen species within 15 minutes following photostimulation. In addition, calcium spiking showed an approximately 3-fold increase both ATC1 (α-cells) BTC6 (β-cells) correlates hormone stimulation. Our findings could lay foundation development non-biologic therapeutics augment islet transplantation.

Language: Английский

Singular and combined effects of transcranial infrared laser stimulation and exposure therapy on pathological fear: a randomized clinical trial DOI Creative Commons
Eric D. Zaizar, Santiago Papini, F. Gonzalez‐Lima

et al.

Psychological Medicine, Journal Year: 2021, Volume and Issue: 53(3), P. 908 - 917

Published: July 21, 2021

Abstract Background Preclinical findings suggest that transcranial infrared laser stimulation (TILS) improves fear extinction learning and cognitive function by enhancing prefrontal cortex (PFC) oxygen metabolism. These prompted our investigation of treating pathological using this non-invasive approach either alone to the dorsolateral PFC (dlPFC), or ventromedial (vmPFC) in combination with exposure therapy. Methods Volunteers enclosed spaces, contamination, public speaking, anxiety-related bodily sensations were recruited for randomized, single-blind, sham-controlled trial four arms: (a) Exposure + TILS_vmPFC ( n = 29), (b) sham (c) TILS_dlPFC 26), (d) Sham TILS _dlPFC 28). Post-treatment assessments occurred immediately following treatment. Follow-up 2 weeks after Results A total 112 participants randomized [age range: 18–63 years; 96 females (85.71%)]. Significant interactions Group × Time Context indicated differential treatment effects on retention (i.e. between time-points, averaged across contexts) generalization contexts, time-points), respectively. Among monotherapies, outperformed SHAM_dlPFC initial context, b −13.44, 95% CI (−25.73 −1.15), p 0.03. combined treatments, differences EX SHAM_vmPFC non-significant all contrasts. Conclusions dlPFC, one regions implicated emotion regulation, resulted a context-specific benefit as monotherapy reducing fear. Contrary prediction, vmPFC, region memory consolidation, did not enhance therapy outcome.

Language: Английский

Citations

15
Efficacy of transcranial photobiomodulation in the treatment for major depressive disorder: A TMS‐EEG and pilot study DOI

Wensi Hao,

Xiaona Dai,

Min Wei

et al.

Photodermatology Photoimmunology & Photomedicine, Journal Year: 2024, Volume and Issue: 40(2)

Published: March 1, 2024

Abstract Background Major depressive disorder (MDD) was a prevalent mental condition that may be accompanied by decreased excitability of left frontal pole (FP) and abnormal brain connections. An 820 nm tPBM can induce an increase in stimulated cortical excitability. The purpose our study to establish how clinical symptoms time‐varying network connectivity MDD were affected transcranial photobiomodulation (tPBM). Methods A total 11 patients with received targeting the FP for 14 consecutive days. severity evaluated neuropsychological assessments at baseline, after treatment, 4‐week 8‐week follow‐up; 8‐min magnetic stimulation combined electroencephalography (TMS‐EEG) performed five healthy controls before EEG analyzed using adaptive‐directed transfer function. Results All scales scores significantly 14‐day ( p < .01) remained follow‐up. analysis suggested regions enhanced connection information outflow became gradually more similar treatment. Conclusions This showed could improve normalize

Language: Английский

Citations

2
An Effective and Safe Novel Treatment of Opioid Use Disorder: Unilateral Transcranial Photobiomodulation DOI Creative Commons
Fredric Schiffer, Anzalee Khan,

Elizabeth Bolger

et al.

Frontiers in Psychiatry, Journal Year: 2021, Volume and Issue: 12

Published: Aug. 10, 2021

Background: The opioid epidemic is a global tragedy even with current treatments, and novel, safe, effective treatment would be welcomed. We report here our findings from second randomized controlled trial to evaluate unilateral transcranial photobiomodulation as for use disorder. Methods: enrolled 39 participants active cravings at 2 sites, 19 received the which consisted of 4-min twice weekly (every 3 or 4 days) application light-emitting diode 810 nm an irradiance 250 mW/cm2 fluence 60 J/cm2 forehead over either left right dorsolateral prefrontal cortex brain 2.1 J/cm2. Twenty sham same device foil bulb. side was based on Dual-Brain Psychology, posits that one hemisphere more affected by past maltreatments prone anxiety drug other hemisphere. treated positive hemispheric emotional valence (HEV) tests HEV. Results: Our primary outcome changes in pre-treatment craving scale (OCS) minus baseline, we found using mixed model group had highly significant * time benefit group, p < 0.0001, effect size last follow-up 1.5. benefited those not buprenorphine well it. TimeLine Follow Back measure significantly better actively = 0.45. observed no adverse effects. Conclusion: Active HEV than reduction very degree RCT independent sites. In it both improvements study. No responses were reported group. ClinicalTrials.gov Identifier: NCT04340622.

Language: Английский

Citations

11
Brain Photobiomodulation Improves Sleep Quality in Subjective Cognitive Decline: A Randomized, Sham-Controlled Study DOI

Xing Zhao,

Wenying Du, Jiehui Jiang

et al.

Journal of Alzheimer s Disease, Journal Year: 2022, Volume and Issue: 87(4), P. 1581 - 1589

Published: April 29, 2022

Background: Sleep appears to be a sensitive biomarker that facilitates early detection and effective intervention for Alzheimer’s disease, while subjective cognitive decline (SCD) is risk factor disease. Prefrontal cortex atrophy associated with both sleep disruption decline. Transcranial brain photobiomodulation (PBM) therapy can enhance frontal oxygen consumption, increasing mediated memory function. Objective: This study aimed test whether PBM targeting the could improve function in SCD. Methods: Fifty-eight SCDs were divided into group (N = 32) which real light was administered sham 26). All participants received either or 6 days consecutively, data recorded. The n-back task employed measure each participant’s working memory. Results: We found no differences efficiency change (F 211, p 0.279), REM stage percent 420, 0.91), wake-up time 212, 0.277) between two groups. improved within true on fifth day. perform better than control test, accuracy higher 2-back (88.6% versus 79.6%, 0.001), reaction 1-back shorter (544.80±202.00 592.87±222.05, 0.003). Conclusion: After five of prefrontal cortex, N-back performance

Language: Английский

Citations

8
Stimulatory responses in α‐ and β‐cells by near‐infrared (810 nm) photobiomodulation DOI

Caleb Liebman,

Sheccid Alejandra Loya,

Michael C. Lawrence

et al.

Journal of Biophotonics, Journal Year: 2021, Volume and Issue: 15(3)

Published: Nov. 27, 2021

Significant efforts have been committed to better understand and regulate insulin secretion as it has direct implications on diabetes. The first phase of biphasic in response glucose lasts about 10 minutes, followed by a more sustained release persisting several hours. Attenuated the is typically associated with abnormal β-cells. While near-infrared photobiomodulation (PBM) demonstrates potential for multiple therapeutic applications, photostimulatory effects α- β-cells remain be further elucidated. Herein, we demonstrate that 810 nm PBM exposure at fluence 9 J/cm2 can elevate intracellular reactive oxygen species within 15 minutes following photostimulation. In addition, calcium spiking showed an approximately 3-fold increase both ATC1 (α-cells) BTC6 (β-cells) correlates hormone stimulation. Our findings could lay foundation development non-biologic therapeutics augment islet transplantation.

Language: Английский

Citations

8