Quercetin: Synergistic Interaction with Antibiotics against Colistin-Resistant Acinetobacter baumannii DOI Creative Commons
Elif Odabaş Köse, Özlem Koyuncu Özyurt,

Süreyya Bilmen

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(4), P. 739 - 739

Published: April 12, 2023

Infections caused by resistant strains of Acinetobacter baumannii are now a global problem that requires the immediate development new antimicrobial drugs. Combination therapy is one strategies used to solve this problem. Based on information, purpose study was determine whether quercetin (QUE), in combination with three antibiotics, effective against colistin-resistant A. (ColR-Ab). The effects QUE colistin (COL), amikacin (AMK), and meropenem (MEM) were evaluated according checkerboard synergy test. combinations + COL AMK showed synergistic activity ColR-Ab FICI values range 0.1875-0.5 0.1875-0.2825, respectively. A 4- 16-fold decrease MIC 16- 64-fold detected. Synergistic confirmed time-kill test, these found be bactericidal at end 24 h. According spectrophotometric measurements, induced membrane damage, leading leakage nucleic acids. Cell lysis cell death SEM observations. detected offers an opportunity for future treatment potential infections strains.

Language: Английский

Review on the Antibacterial Mechanism of Plant-Derived Compounds against Multidrug-Resistant Bacteria (MDR) DOI Open Access
Najwan Jubair,

Mogana Rajagopal,

Sasikala Chinnappan

et al.

Evidence-based Complementary and Alternative Medicine, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 30

Published: Aug. 16, 2021

Microbial resistance has progressed rapidly and is becoming the leading cause of death globally. The spread antibiotic-resistant microorganisms been a significant threat to successful therapy against microbial infections. Scientists have become more concerned about possibility return pre-antibiotic era. Thus, searching for alternatives fight necessity. Some bacteria are naturally resistant antibiotics, while others acquire mainly by misuse antibiotics emergence new variants through mutation. Since ancient times, plants represent source drugs alternative medicine fighting diseases. Plants rich sources valuable secondary metabolites, such as alkaloids, quinones, tannins, terpenoids, flavonoids, polyphenols. Many studies focus on plant metabolites potential antibiotic discovery. They required structural properties can act different mechanisms. This review analyses strategies produced multidrug-resistant explores phytochemicals from classes with documented antimicrobial action bacteria, either alone or in combination traditional antibiotics.

Language: Английский

Citations

133
Electrospun chitosan oligosaccharide/polycaprolactone nanofibers loaded with wound-healing compounds of Rutin and Quercetin as antibacterial dressings DOI

Liuzhu Zhou,

Ling Cai, Hongjie Ruan

et al.

International Journal of Biological Macromolecules, Journal Year: 2021, Volume and Issue: 183, P. 1145 - 1154

Published: May 6, 2021

Language: Английский

Citations

127
Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria DOI Creative Commons
Ronit Vogt Sionov, Doron Steinberg

Microorganisms, Journal Year: 2022, Volume and Issue: 10(6), P. 1239 - 1239

Published: June 16, 2022

Chronic and recurrent bacterial infections are frequently associated with the formation of biofilms on biotic or abiotic materials that composed mono- multi-species cultures bacteria/fungi embedded in an extracellular matrix produced by microorganisms. Biofilm is, among others, regulated quorum sensing (QS) which is interbacterial communication system usually two-component systems (TCSs) secreted autoinducer compounds activate signal transduction pathways through interaction their respective receptors. Embedded biofilms, bacteria protected from environmental stress stimuli, they often show reduced responses to antibiotics, making it difficult eradicate infection. Besides penetration antibiotics intricate structure sessile biofilm-embedded metabolic activity them intrinsically less sensitive antibiotics. Moreover, express elevated levels efflux pumps extrude thereby reducing intracellular levels. Some involved secretion QS biofilm-related materials, besides being important for removing toxic substances bacteria. pump inhibitors (EPIs) have been shown both prevent biofilm sensitize suggesting a relationship between these processes. Additionally, quenchers may affect antibiotic susceptibility. Thus, targeting elements regulate might be promising approach combat antibiotic-resistant infections.

Language: Английский

Citations

112
The Role of Quercetin, a Flavonoid in the Management of Pathogenesis Through Regulation of Oxidative Stress, Inflammation, and Biological Activities DOI Creative Commons
Hajed Obaid Alharbi,

Mohammad Alshebremi,

Ali Yousif Babiker

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 151 - 151

Published: Jan. 20, 2025

Quercetin, a flavonoid found in vegetables and fruits, has been extensively studied for its health benefits disease management. Its role the prevention of various pathogenesis well-documented, primarily through ability to inhibit oxidative stress, inflammation, enhance endogenous antioxidant defense mechanisms. Electronic databases such as Google Scholar, Scopus, PubMed, Medline, Web Science were searched information regarding quercetin pathogeneses. The included literature comprised experimental studies, randomized controlled trials, epidemiological studies related quercetin, while editorials, case analyses, theses, letters excluded. It reported have wide range including hepatoprotective, antidiabetic, anti-obesity, neuroprotective, cardioprotective, wound healing, antimicrobial, immunomodulatory effects, achieved modulation biological activities. Additionally, numerous vitro vivo shown that quercetin’s efficacies cancer management involve inhibiting cell signaling pathways, cycle, angiogenesis, activating pathways tumor suppressor genes, inducing apoptosis. This review aims provide comprehensive understanding this outlines sources nanoformulations, applications management, along with key findings from important clinical trial studies. Limited data safety mechanism action are available. is conduct more trials gain deeper disease-preventive potential, mechanisms action, safety, optimal therapeutic dosages. Furthermore, research based on nanoformulations should be performed minimize/overcome hindrance associated bioavailability, rapid degradation, toxicity.

Language: Английский

Citations

8
An alternative approach to combat multidrug-resistant bacteria: new insights into traditional Chinese medicine monomers combined with antibiotics DOI Creative Commons

Cunchun Dai,

Ying Liu,

Fan Lv

et al.

Advanced Biotechnology, Journal Year: 2025, Volume and Issue: 3(1)

Published: Feb. 7, 2025

Language: Английский

Citations

4
Exploring the antivirulence potential of phenolic compounds to inhibit quorum sensing in Pseudomonas aeruginosa DOI
Emília Maria França Lima, Felipe Alves de Almeida, Uelinton Manoel Pinto

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(2)

Published: Jan. 11, 2025

Language: Английский

Citations

2
Revised Title - Quercetin Combined with Ciprofloxacin and Gentamicin Inhibits Biofilm Formation and Virulence in Staphylococcus aureus. DOI
Sanghamitra Goswami, Manisha Ghosh, Roy Sk

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: 200, P. 107297 - 107297

Published: Jan. 14, 2025

Language: Английский

Citations

2
Exploring the Scope of Traditional Chinese Medicinal Plants in battle of antibiotic resistance – A comprehensive review DOI Creative Commons
S. Bhunia, S. A. Mallick, A. Mondal

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2025, Volume and Issue: 14, P. 100574 - 100574

Published: Jan. 15, 2025

Language: Английский

Citations

2
Effects of Traditional Chinese Medicine and its Active Ingredients on Drug-Resistant Bacteria DOI Creative Commons
Jimin Li, Shanshan Feng, Xin Liu

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: June 2, 2022

The increasing and widespread application of antibacterial drugs makes antibiotic resistance a prominent growing concern in clinical practice. emergence multidrug-resistant bacteria presents global threat. However, the development use novel agents involves time-consuming costly challenges that may lead to yet further drug resistance. More recently, researchers have turned traditional Chinese medicine stem rise pathogens. Many studies shown medicines significant bacteriostatic bactericidal effects, with advantage low Some which when combined antibiotics, also demonstrated activity by synergistic effect. Traditional has variety active components, including flavonoids, alkaloids, phenols, quinones, can inhibit growth drug-resistant be used combination antibiotics treat various bacterial infections. We reviewed interaction between ingredients antibiotic-resistant bacteria. At present, flavonoids alkaloids are been most widely studied, against show its antimicrobial on bacteria, enhance susceptibility potentially reduce required dosage rate Our results provide direction for finding developing alternative methods counteract offering new therapeutic strategy tackling

Language: Английский

Citations

54
Biotechnological Applications and Health-Promoting Properties of Flavonols: An Updated View DOI Open Access
Teresa Gervasi,

Antonella Calderaro,

Davide Barreca

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1710 - 1710

Published: Feb. 1, 2022

Flavonols are a subclass of natural flavonoids characterized by remarkable number biotechnological applications and health-promoting properties. They attract researchers' attention due to many epidemiological studies supporting their usage. phytochemicals commonly present in our diet, being ubiquitous the plant kingdom and, particular, relatively very abundant fruits vegetables. All these aspects make flavonols candidates choice for valorization products, based on presence different chemical structures, each one specific features capable influencing biological targets inside living organisms manners. In this review, we analyzed biochemical physiological characteristics focalizing most promising compounds shed some light increasing utilization processing industries, as well suitable employment improve overall wellness humankind.

Language: Английский

Citations

46