Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials

Nutrients, Journal Year: 2022, Volume and Issue: 14(2), P. 256 - 256

Published: Jan. 7, 2022

Despite the ongoing vaccination efforts, there is still an urgent need for safe and effective treatments to help curb debilitating effects of COVID-19 disease. This systematic review aimed investigate efficacy supplemental curcumin treatment on clinical outcomes inflammation-related biomarker profiles in patients. We searched PubMed, Scopus, Web Science, EMBASE, ProQuest, Ovid databases up 30 June 2021 find studies that assessed curcumin-related compounds mild severe Six were identified which showed supplementation led a significant decrease common symptoms, duration hospitalization deaths. In addition, all these intervention amelioration cytokine storm thought be driving force cases. was seen as (p < 0.05) proinflammatory cytokines such IL1β IL6, with concomitant increase anti-inflammatory cytokines, including IL-10, IL-35 TGF-α. Taken together, findings suggested exerts its beneficial through at least partial restoration pro-inflammatory/anti-inflammatory balance. conclusion, may offer efficacious option improving disease outcomes. highlight point future should employ larger cohorts patients different settings standardized preparations compounds.

Language: Английский

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Outcomes of patients with HIV and COVID-19 co-infection: a systematic review and meta-analysis

AIDS Research and Therapy, Journal Year: 2022, Volume and Issue: 19(1)

Published: Jan. 14, 2022

Abstract Background Data on the association of human immunodeficiency virus (HIV) infection with adverse outcomes in patients COVID-19 are conflicting. This systematic review and meta-analysis aimed to summarize available information risk hospitalization, severe disease, death attributable HIV COVID-19. Methods PubMed, EMBASE, Web Science, SCOPUS were searched through October 25, 2021, identify relevant studies, without language restriction. A random-effects model was used pool estimates. Results We included 44 studies reporting from 38,971,065 The pooled prevalence among 26.9 ‰ (95% CI 22.7–31.3) significantly higher conducted Africa compared those elsewhere (118.5‰ [95% 84.8–156.9, 11 studies] vs 10.9‰ 8.8–13.2, 27 studies]). In analyses unadjusted odds ratio, HIV-positive individuals more likely be admitted hospital (OR: 1.49; 95% 1.01–2.21, 6 studies) HIV-negative individuals. adjusted (for age sex) analyses, associated an increased (hazard ratio: 1.76, 1.31–2.35, 2 studies). However, not severity disease 1.28; 0.77–2.13, 13 studies), or 0.81; 0.47; 1.41, 23 ratio. Conclusion Our findings suggest that have admission for seems independently mortality patient analysis. this evidence derived only two studies.

Language: Английский

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SARS-CoV-2-associated lymphopenia: possible mechanisms and the role of CD147

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 4, 2024

T lymphocytes play a primary role in the adaptive antiviral immunity. Both lymphocytosis and lymphopenia were found to be associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While indicates an active anti-viral response, is sign of poor prognosis. T-cells, essence, rarely express ACE2 receptors, making cause cell depletion enigmatic. Moreover, emerging strains posed immunological challenge, potentially alarming for next pandemic. Herein, we review how possible indirect direct key mechanisms could contribute SARS-CoV-2-associated-lymphopenia. The fundamental mechanism inflammatory cytokine storm elicited by viral infection, which alters host metabolism into more acidic state. This "hyperlactic acidemia" together suppresses T-cell proliferation triggers intrinsic/extrinsic apoptosis. SARS-CoV-2 infection also results shift from steady-state hematopoiesis stress hematopoiesis. Even low expression, presence cholesterol-rich lipid rafts on activated T-cells may enhance entry syncytia formation. Finally, indicate participation other receptors or auxiliary proteins that can work alone concert mechanisms. Therefore, address CD147-a novel route-for its new variants. CD147 not only expressed but it interacts co-partners orchestrate various biological processes. Given these features, appealing candidate pathogenicity. Understanding molecular cellular behind SARS-CoV-2-associated-lymphopenia will aid discovery potential therapeutic targets improve resilience our immune system against this rapidly evolving virus.

Language: Английский

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Cytokine Storms in COVID-19, Hemophagocytic Lymphohistiocytosis, and CAR-T Therapy

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(4), P. e253455 - e253455

Published: April 7, 2025

Importance Cytokine storm (CS) is a hyperinflammatory syndrome causing multiorgan dysfunction and high mortality, especially in patients with malignant hematologic neoplasms. Triggers include neoplasm–associated hemophagocytic lymphohistiocytosis (MN-HLH), cytokine release from chimeric antigen receptor T-cell therapy (CAR-T CRS), COVID-19, but the underlying mechanisms of inflammation their impact on outcomes are poorly understood. Objective To delineate inflammatory patterns characterizing different CS etiologies association clinical outcomes. Design, Setting, Participants This retrospective cohort study was conducted at MD Anderson Cancer Center Houston, Texas, between March 1, 2020, November 20, 2022, using software-as-a-service Syntropy Foundry Platform. were neoplasms who developed COVID-19 (COVID-CS), MN-HLH, or CAR-T CRS. Exposure Diagnostic criteria for COVID-CS based surging markers (interleukin-6, C-reactive protein, ferritin), while diagnosis MN-HLH CRS followed established guidelines. Main Outcomes Measures The compared levels, characteristics, survival across 3 cohorts focused markers, times, key factors associated identified through univariate multivariable analyses. Results A total 671 met inclusion criteria. Of those, 220 (33%) had CRS, 227 (34%) COVID-CS, 224 MN-HLH. Patients predominantly male (435 [65%]), 461 (69%) White, significant differences median age 63 [IQR, 54-71] years; 52-72] 55 41-65] P &amp;lt; .001) as well number admission days cancer type cohorts. Marked variations levels observed, exhibiting highest (eg, TNF-α, 105 pg/mL 38-201 pg/mL] vs 23 17-42 COVID-CS) lowest fibrinogen albumin levels. showed substantially longer times (hazard ratio [HR], 2.93; 95% CI, 1.95-4.41) (HR, 8.12; 5.51-12.00). Clustering analysis overlapping formed distinct cluster. Conclusions Relevance syndromes found immune responses within each cohort. emphasize importance early timely intervention.

Language: Английский

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Cytokine Profiling in Different SARS-CoV-2 Genetic Variants

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(22), P. 14146 - 14146

Published: Nov. 16, 2022

This study is a successor of our previous work concerning changes in the chemokine profile infection that are associated with different SARS-CoV-2 genetic variants. The goal was to take into account both virus and host immune system by assessing concentrations cytokines patients infected variants (ancestral Wuhan strain, Alpha, Delta Omicron). Our performed on 340 biological samples taken from COVID-19 healthy donors timespan between May 2020 April 2022. We genotyping nasopharyngeal swabs, which followed assessment cytokines' concentration blood plasma. noted out nearly 30 cytokines, only four showed stable elevation independently variant (IL-6, IL-10, IL-18 IL-27), we believe them be 'constant' markers for infection. Cytokines were studied as potential biomarkers lose their diagnostic value evolves, specter targets predictive models narrowing. So far, IL-18, IL-27) consistent rise virus. Although findings scientific interest, still consider inconclusive; further investigation comparison responses required.

Language: Английский

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RNA Sequencing in COVID-19 patients identifies neutrophil activation biomarkers as a promising diagnostic platform for infections

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(1), P. e0261679 - e0261679

Published: Jan. 26, 2022

Infection with the SARS-CoV2 virus can vary from asymptomatic, or flu-like moderate disease, up to critically severe. Severe termed COVID-19, involves acute respiratory deterioration that is frequently fatal. To understand highly variable presentation, and identify biomarkers for disease severity, blood RNA COVID-19 patient in an intensive care unit was analyzed by whole transcriptome sequencing. Both infection severity of syndrome were associated 25-fold increased expression neutrophil-related transcripts, such as neutrophil defensin 1 (DEFA1), 3-5-fold reductions T cell related transcripts receptor (TCR). The DEFA1 level detected viremia 95.5% sensitivity, when measured ddPCR RNA. Purified CD15+ neutrophils patients abundance showed striking increases nuclear DNA staining DAPI. Concurrently, they >10-fold higher elastase activity than normal controls, correcting their abundance, still 5-fold per cell. Despite activity, extremely low plasma same patients. Collectively, data supports model decreased suggests levels both involved extracellular traps (NETs), may be informative host immune after viral infection.

Language: Английский

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COVID19 biomarkers: What did we learn from systematic reviews?

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Dec. 13, 2022

The coronavirus disease 2019 (COVID19) pandemic continues to represent a substantial public health concern. It can rapidly progress severe disease, with poor prognosis and high mortality risk. An early diagnosis specific prognostic tools help healthcare providers start interventions promptly, understand the likely identify treat timely individuals develop enhanced Here we focused on an impressive set of systematic reviews meta-analyses that were performed since COVID19 summarized their results related levels hematologic, inflammatory, immunologic biomarkers as well markers cardiac, respiratory, hepatic, gastrointestinal renal systems association progression, severity mortality. evidence outlines significance biomarkers, including inflammatory immunological parameters (C-reactive protein, procalcitonin, interleukin-6), hematological (lymphocytes count, neutrophil-to-lymphocyte ratio, D-dimer, ferritin, red blood cell distribution width), cardiac (troponin, CK-MB, myoglobin), liver (AST, ALT, total bilirubin, albumin) lung injury (Krebs von den Lungen-6) be used aid identification high-risk patients prediction serious outcomes, mortality, in COVID19. Thus, these should essential for risk stratification adequate intervention improving outcomes patients.

Language: Английский

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Diagnostic accuracy of interleukin-6 in multiple diseases: An umbrella review of meta-analyses

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e27769 - e27769

Published: March 1, 2024

ObjectiveThis review aims to conduct a comprehensive study of the diagnostic accuracy interleukin-6 (IL-6) for multiple diseases by utilizing existing systematic reviews and meta-analyses.MethodsWe performed thorough search Embase, Web Science, PubMed, Cochrane Database Systematic Reviews up April 2023 gather meta-analyses that investigate IL-6. To assess methodological quality studies, we employed Assessing Methodological Quality Reviews-2 Grading Recommendations, Assessment, Development Evaluation criteria.ResultsWe included 34 out 3024 articles retrieved from search. These covered 9 categories International Classification Diseases-11. Studies rated as "Critically Low" or "Very in assessment process were excluded, resulting total 6 encompassed sepsis, colorectal cancer, tuberculous pleural effusion (TPE), endometriosis, among others. Among these diseases, IL-6 demonstrated relatively high potential accurately identifying TPE endometriosis.ConclusionsIL-6 exhibited favorable across suggesting its reliable biomarker near future. Substantial evidence supported accuracy, particularly cases endometriosis.

Language: Английский

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Plasma biomarkers for systemic inflammation in COVID‐19 survivors

PROTEOMICS - CLINICAL APPLICATIONS, Journal Year: 2022, Volume and Issue: 16(5)

Published: Aug. 5, 2022

Abstract Background While the majority of COVID‐19 patients fully recover from infection and become asymptomatic, a significant proportion survivors experience broad spectrum symptoms lasting weeks to months post‐infection, phenomenon termed “post‐acute sequelae (PASC).” The aim this study is determine whether inflammatory proteins are dysregulated can serve as potential biomarkers for systemic inflammation in survivors. Methods We determined levels plasma 22 coronavirus disease 2019 (COVID‐19) long haulers (COV‐LH), asymptomatic (COV‐AS), healthy subjects (HS) using an Olink proteomics assay assessed results by beads‐based multiplex immunoassay. Results Compared HS, we found that still exhibited inflammation, evidenced changes multiple both COV‐LH COV‐AS. CXCL10 was only protein significantly upregulated compared with COV‐AS HS. Conclusions Our indicate several remain aberrantly might biomarker typify COV‐LH. Further characterization these signature molecules improve understanding long‐term impacts provide new targets diagnosis treatment PASC.

Language: Английский

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The role of extracellular histones in COVID‐19

Journal of Internal Medicine, Journal Year: 2022, Volume and Issue: 293(3), P. 275 - 292

Published: Nov. 16, 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had spread from China and, within months, became a global pandemic. infection this disease can cause diversity of symptoms ranging asymptomatic to distress with an increased risk vascular hyperpermeability, pulmonary inflammation, extensive lung damage, and thrombosis. One the host defense systems against 2019 (COVID-19) is formation neutrophil extracellular traps (NETs). Numerous studies on have revealed presence elevated levels NET components, such as cell-free DNA, histones, elastase, myeloperoxidase, in plasma, serum, tracheal aspirates COVID-19 patients. Extracellular major component NETs, are clinically very relevant they represent promising biomarkers drug targets, given that several identified histones key mediators onset progression various diseases, including COVID-19. However, role per se remains relatively underexplored. Histones nuclear proteins be released into space via apoptosis, necrosis, or then regarded cytotoxic damage-associated molecular patterns potential damage tissues impair organ function. This review will highlight mechanisms histone-mediated cytotoxicity focus play Thereby, paper facilitates bench-to-bedside view cytotoxicity, its COVID-19, targets for future theranostics clinical treatment

Language: Английский

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