Treatment of 95 post-Covid patients with SSRIs

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 2, 2023

After Covid-19 infection, 12.5% develops post-Covid-syndrome (PCS). Symptoms indicate numerous affected organ systems. a year, chronic fatigue, dysautonomia and neurological neuropsychiatric complaints predominate. In this study, 95 PCS patients were treated with selective serotonin reuptake inhibitors (SSRIs). This study used an exploratory questionnaire found that two-thirds of had reasonably good to strong response on SSRIs, over quarter moderate response, while 10% reported no response. Overall, experienced substantial improved well-being. Brainfog sensory overload decreased most, followed by fatigue dysautonomia. Outcomes measured three different measures correlated strongly each other. The SSRIs in conditions was explained seven possible neurobiological mechanisms based recent literature integrated already existing knowledge. Important for understanding these is the underlying biochemical interaction between various neurotransmitter systems parts immune system, their dysregulation PCS. main link appears be metabolic kynurenine pathway (KP) which interacts extensively system. KP uses same precursor as serotonin: tryptophan. overactive maintains inflammation causes lack Finally, potential avenues future research advance line clinical are discussed.

Language: Английский

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Early treatment with fluvoxamine, bromhexine, cyproheptadine, and niclosamide to prevent clinical deterioration in patients with symptomatic COVID-19: a randomized clinical trial

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 70, P. 102517 - 102517

Published: March 14, 2024

Repurposed drugs with host-directed antiviral and immunomodulatory properties have shown promise in the treatment of COVID-19, but few trials studied combinations these agents. The aim this trial was to assess effectiveness affordable, widely available, repurposed used combination for which may be particularly relevant low-resource countries.

Language: Английский

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Repurposing selective serotonin reuptake inhibitors for severity of COVID-19: A population-based study

European Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 71, P. 96 - 108

Published: April 4, 2023

The World Health Organization has proposed that a search be made for alternatives to vaccines the prevention and treatment of COVID-19, with one such alternative being selective serotonin reuptake inhibitors (SSRIs). This study thus sought assess: impact previous SSRI antidepressants on severity COVID-19 (risk hospitalisation, admission an intensive care unit [ICU], mortality), its influence susceptibility SARS-CoV-2 progression severe COVID-19. We conducted population-based multiple case-control in region north-west Spain. Data were sourced from electronic health records. Adjusted odds ratios (aORs) 95%CIs calculated using multilevel logistic regression. collected data total 86,602 subjects: 3060 cases PCR+, 26,757 non-hospitalised PCR+ 56,785 controls (without PCR+). Citalopram displayed statistically significant decrease risk hospitalisation (aOR=0.70; 95% CI 0.49-0.99, p = 0.049) (aOR=0.64; 0.43-0.96, 0.032). Paroxetine was associated mortality (aOR=0.34; 0.12 - 0.94, 0.039). No class effect observed SSRIs overall, nor any other found remaining SSRIs. results this large-scale, real-world indicate that, citalopram, could candidate drug repurposed as preventive aimed at reducing patients' progressing stages disease.

Language: Английский

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The impact of preexisting psychiatric disorders and antidepressant use on COVID-19 related outcomes: a multicenter study

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(6), P. 2462 - 2468

Published: April 17, 2023

Language: Английский

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Lithium and the risk of severe COVID-19 infection: A retrospective population-based register study

Journal of Psychosomatic Research, Journal Year: 2025, Volume and Issue: 190, P. 112053 - 112053

Published: Feb. 13, 2025

Language: Английский

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Timing of selective serotonin reuptake inhibitor use and risk for preterm birth and related adverse events: with a consideration of the COVID-19 pandemic period

The Journal of Maternal-Fetal & Neonatal Medicine, Journal Year: 2024, Volume and Issue: 37(1)

Published: Jan. 2, 2024

Objective There is uncertainty around the safety of SSRIs for treating depression during pregnancy. Nevertheless, use has been gradually increasing, especially COVID-19 pandemic period. We aimed to (1) characterize maternal rate and in a recent 10-year period, (2) address confounding by indication, as well socioeconomic environmental factors, (3) evaluate associations timing SSRI exposure pregnancy with risk preterm birth (PTB), low birthweight (LBW), small gestational age (SGA) infants among women before

Language: Английский

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Is There such a Thing as Post-Viral Depression?: Implications for Precision Medicine

Biomolecules & Therapeutics, Journal Year: 2024, Volume and Issue: 32(6), P. 659 - 684

Published: Oct. 21, 2024

Viral infections are increasingly recognized as triggers for depressive disorders, particularly following the SARS-CoV-2 pandemic and rise of long COVID. Viruses such Herpes Simplex Virus (HSV), Epstein-Barr (EBV), Cytomegalovirus (CMV), Human Immunodeficiency (HIV) linked to depression through complex neurobiological mechanisms. These include immune system dysregulation, chronic inflammation, neurotransmitter imbalances that affect brain function mood regulation. activation leads release pro-inflammatory cytokines, resulting in neuroinflammation associated symptoms. Furthermore, specific viruses can disrupt systems, including serotonin, dopamine, glutamate, all which essential stabilization. The unique interactions different with these systems underscore need virus-specific therapeutic approaches. Current broad-spectrum treatments often overlook precise pathways involved post-viral depression, reducing their efficacy. This review emphasizes understand create tailored interventions directly address effects induced by each type virus. may immunomodulatory target persistent antiviral therapies reduce viral load, or neuroprotective strategies restore balance. Precision medicine offers promising avenues effective management virus-induced providing patient-specific approaches biological mechanisms involved. By focusing on development targeted treatments, this aims pave way a new era psychiatric care fully addresses root causes infections.

Language: Английский

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Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19

Biology, Journal Year: 2023, Volume and Issue: 12(9), P. 1269 - 1269

Published: Sept. 21, 2023

Multiple studies have reported new or exacerbated persistent resistant hypertension in patients previously infected with COVID-19. We used literature-based discovery to identify and prioritize multi-scalar explanatory biology that relates Cross-domain text mining of 33+ million PubMed articles within a comprehensive knowledge graph was performed using SemNet 2.0. Unsupervised rank aggregation determined which concepts were most relevant utilizing the normalized HeteSim score. A series simulations identified directly related COVID-19 connected via one three renin–angiotensin–aldosterone system hub nodes (mineralocorticoid receptor, epithelial sodium channel, angiotensin I receptor). The top-ranking relating included: cGMP-dependent protein kinase II, MAP3K1, haspin, ral guanine nucleotide exchange factor, N-(3-Oxododecanoyl)-L-homoserine lactone, aspartic endopeptidases, metabotropic glutamate receptors, choline-phosphate cytidylyltransferase, tyrosine phosphatase, tat genes, MAP3K10, uridine kinase, dicer enzyme, CMD1B, USP17L2, FLNA, exportin 5, somatotropin releasing hormone, beta-melanocyte stimulating pegylated leptin, beta-lipoprotein, corticotropin, growth hormone-releasing peptide 2, pro-opiomelanocortin, alpha-melanocyte prolactin, thyroid poly-beta-hydroxybutyrate depolymerase, CR 1392, BCR-ABL fusion gene, high density lipoprotein sphingomyelin, pregnancy-associated murine 1, recQ4 helicase, immunoglobulin heavy chain variable domain, aglycotransferrin, host cell factor C1, ATP6V0D1, imipramine demethylase, TRIM40, H3C2 COL1A1+COL1A2 QARS VPS54, TPM2, MPST, EXOSC2, ribosomal S10, TAP-144, gonadotropins, human gonadotropin hormone beta-lipotropin, octreotide, salmon calcitonin, des-n-octanoyl ghrelin, liraglutide, gastrins. Concepts mapped six physiological themes: altered endocrine function, 23.1%; inflammation cytokine storm, 21.3%; lipid metabolism atherosclerosis, 17.6%; sympathetic input blood pressure regulation, 16.7%; entry virus, 14.8%; unknown, 6.5%.

Language: Английский

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Cortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(12), P. 1666 - 1666

Published: Dec. 1, 2023

After recovering from the acute COVID-19 illness, a substantial proportion of people continue experiencing post-acute sequelae (PASC), also termed “long COVID”. Their quality life is adversely impacted by persistent cognitive dysfunction and affective distress, but underlying neural mechanisms are poorly understood. The present study recruited group mostly young, previously healthy adults (24.4 ± 5.2 years age) who experienced PASC for almost 6 months following mild illness. Confirming prior evidence, they reported noticeable memory attention deficits, brain fog, depression/anxiety, fatigue, other symptoms potentially suggestive excitation/inhibition imbalance. Proton magnetic resonance spectroscopy (1H-MRS) was used to examine neurochemical aspects cell signaling with an emphasis on GABA levels in occipital cortex. participants were compared control (CNT) matched demographics, intelligence, array variables. Controlling tissue composition, biological sex, alcohol intake, had lower GABA+/water than CNT, which correlated depression poor sleep quality. mediation analysis revealed that impact partly mediated GABA+/water, indicative cortical hyperexcitability as mechanism. In addition, N-acetylaspartate (NAA) tended be group, possibly suggesting compromised neuronal integrity. Persistent neuroinflammation may contribute pathogenesis PASC-related neurocognitive dysfunction.

Language: Английский

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Die Bedeutung von Antidepressiva bei COVID-19 und Long-COVID – Ein Scoping-Review Update

Fortschritte der Neurologie · Psychiatrie, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Introduction Preclinically, fluvoxamine and other antidepressants (AD) exerted antiviral anti-inflammatory properties also against SARS-COV-2. Therfore, It makes sense to test the clinical effect of AD COVID-19 Long COVID.

Language: Английский

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