Coronavirus Disease 2019 (COVID-19) Pandemic across Africa: Current Status of Vaccinations and Implications for the Future

Vaccines, Journal Year: 2022, Volume and Issue: 10(9), P. 1553 - 1553

Published: Sept. 17, 2022

The introduction of effective vaccines in December 2020 marked a significant step forward the global response to COVID-19. Given concerns with access, acceptability, and hesitancy across Africa, there is need describe current status vaccine uptake continent. An exploratory study was undertaken investigate these aspects, challenges, lessons learnt Africa provide future direction. Senior personnel 14 African countries completed self-administered questionnaire, descriptive analysis data. Vaccine roll-out commenced March 2021 most countries. COVID-19 vaccination coverage varied from low Cameroon Tanzania up 39.85% full Botswana at end 2021; that is, all doses advocated by initial protocols versus total population, rates increasing 58.4% June 2022. greatest increase people being fully vaccinated observed Uganda (20.4% increase), (18.5% Zambia (17.9% increase). Most were obtained through WHO-COVAX agreements. Initially, prioritised for healthcare workers (HCWs), elderly, adults co-morbidities, other at-risk groups, now commencing among children administering booster doses. Challenges included irregular supply considerable arising misinformation fuelled social media activities. Overall, fair reasonable access countries, enhanced government initiatives. must be addressed context-specific interventions, including proactive programmes HCWs, medical journalists, public.

Language: Английский

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Factors Influencing the Intention and Uptake of COVID-19 Vaccines on the African Continent: A Scoping Review

Vaccines, Journal Year: 2023, Volume and Issue: 11(4), P. 873 - 873

Published: April 20, 2023

The COVID-19 pandemic is a severe concern worldwide, particularly in Africa. Vaccines are crucial the fight against pandemic. This scoping review examined existing literature from 2020 to 2022 on individual, interpersonal, and structural barriers facilitators vaccination within Africa facilitate more informed health promotion interventions improve vaccine uptake. was conducted using Arksey O’Malley’s five-stage methodological framework. A comprehensive search undertaken 2021 six electronic databases: EBSCOhost, PubMed, Web of Science, ProQuest, WorldCat Discovery, Google Scholar. Data collected, charted into themes, summarized standard data extraction sheet Microsoft Excel. total forty (n = 40) published academic articles were reviewed, with many Nigeria 10), followed by Ethiopia 5) Ghana 4) rest elsewhere Thematic narratives used report themes: attitudes perceptions about vaccines, intention uptake vaccines; factors associated uptake; socio-demographic determinants affecting information sources for vaccines. ranged 25% 80.9%, resulting suboptimal rate (54.2%) African continent. Factors that promoted acceptance included confidence vaccines desire protect people. Age, education, gender most common significantly acceptance. Most studies revealed considerable exist Concerns potential side effects, ineffectiveness, perceived lack information, inaccessibility among unwillingness receive strongly correlated being female. Mass social media main regarding To encourage uptake, governments should pay attention refuting misinformation through integrated community-based approaches, such as creating messages convey than just information.

Language: Английский

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COVID-19 Vaccine Uptake and Associated Factors in Sub-Saharan Africa: Evidence from a Community-Based Survey in Tanzania

Vaccines, Journal Year: 2023, Volume and Issue: 11(2), P. 465 - 465

Published: Feb. 17, 2023

COVID-19 is a major public health threat associated with the increased global burden of infectious diseases, mortality, and enormous economic loss to countries communities. Safe efficacious vaccines are crucial in halting pandemic. We assessed vaccine uptake factors among community members from eight regions Tanzania. The interviewer-administered questionnaire collected data. Multiple logistic regression models determined uptake. median age 3470 respondents was 37 years (interquartile range 29-50 years) 66% them were females. Only 18% had received vaccine, ranging 8% Dar es Salaam 37% Simiyu regions. A third (34%) those vaccinated people did not know which they given. Significantly higher rates aged 30+ years, males, history infection. Unfavorable perceptions about safety efficacy lowered Setting-specific interventions innovations critical improving uptake, given observed differences between Efforts needed increase women younger less than 30 years. Knowledge-based should enhance understanding available vaccines, benefits, target groups, availability.

Language: Английский

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COVID-19 Vaccine Acceptance Differences Among Unvaccinated Foreign- and United States-Born Persons: A Cross-Sectional Study, 2021

Annals of Epidemiology, Journal Year: 2025, Volume and Issue: 103, P. 21 - 27

Published: Feb. 6, 2025

To investigate the association between nativity and COVID-19 vaccine acceptance its interaction with race/ethnicity, education, English proficiency. Differences in among propensity-score matched foreign- US-born persons using 2021 California Health Interview Survey Data were measured a survey-weighted multivariable logistic regression model terms average predicted probabilities and: A total of 4,234,655 (8504 unweighted) met inclusion criteria; 2251,279 (53 %) foreign-born (1,983,376 US-born), 55 % all Hispanic/Latino, 22 Non-Hispanic White, 17 Asian/Pacific Islander, 3.6 Black/African American, 2.5 categorized as 'Other'. Foreign-born status was significantly associated greater odds (adjusted ratio [aOR], 2.81 [95 %CI, 1.16-6.83]). Hispanic had probability compared to their counterparts (average difference, +0.11 +0.023, +0.20]). poor proficiency lower versus (APD, -0.081, -0.43, 0.27]). Nativity acceptance, this relationship varied by race/ethnicity These findings may be used direct future interventions aimed at improving vaccination rates.

Language: Английский

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Rural–urban differentials in the factors associated with knowledge on and acceptance of the COVID-19 vaccine in the second wave of the pandemic among adults in Northern Ghana

Deleted Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 3, 2025

Language: Английский

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Determinants of COVID-19 vaccine uptake among Nigerians: evidence from a cross-sectional national survey

Archives of Public Health, Journal Year: 2023, Volume and Issue: 81(1)

Published: May 26, 2023

Abstract Background COVID-19 ranks as one of the largest public health threats in recent times. It is associated with huge health, economic and social consequences. Although vaccination an effective control measure, vaccine uptake has been suboptimal many low/middle income countries. Hence this study assessed factors influencing among Nigerian households. Data methods This analyzed secondary data from High-Frequency Phone Survey Households that was collected by National Bureau Statistics between November 2021 January 2022. Relevant were using descriptive statistical tools Multivariate Regression model. Results Out 2370 respondents, only 32.8% respondents vaccinated against COVID-19. Respondents living urban areas (34.4%) had a higher level relative to those rural Nigeria (30.9%). model revealed adults aged ≥ 60 years (OR 2.20; p = 0.012), primary 1.72; 0.032), 1.77; 0.025) tertiary education 3.03; < 0.001), access insurance 1.68; 0.004), who obtained information workers 3.92; government 3.22; mass media 1.75; 0.003) more likely be vaccinated. Also, North Central 2.02; East 1.48; 0.039), South West 2.63; 1.49; 0.031) regions odds being Conclusions The recommends increased campaigns advocacy for regions. Persons no formal younger persons 18–29 should targeted vaccine-related given they less Dissemination relevant through sources, encouraged so positively influence decisions receive vaccines citizens.

Language: Английский

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Conspiracy narratives and vaccine hesitancy: a scoping review of prevalence, impact, and interventions

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 29, 2024

Language: Английский

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Different configurations of SARS-CoV-2 spike protein delivered by integrase-defective lentiviral vectors induce persistent functional immune responses, characterized by distinct immunogenicity profiles

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 5, 2023

Several COVID-19 vaccine strategies utilizing new formulations for the induction of neutralizing antibodies (nAbs) and T cell immunity are still under evaluation in preclinical clinical studies. Here we used Simian Immunodeficiency Virus (SIV)-based integrase defective lentiviral vector (IDLV) delivering different conformations membrane-tethered Spike protein mouse immunogenicity model, with aim inducing persistent nAbs against multiple SARS-CoV-2 variants concern (VoC). modifications included prefusion-stabilizing double proline (2P) substitutions, mutations at furin cleavage site (FCS), D614G mutation truncation cytoplasmic tail (delta21) ancestral Beta (B.1.351) Spike, latter to markedly improve IDLV membrane-tethering. BALB/c mice were injected once forms or recombinant trimeric 2P substitutions FCS association a squalene-based adjuvant. Anti-receptor binding domain (RBD) Abs, responses detected up six months from single immunization escalating doses vaccines all mice, but levels kinetics. Results indicated that combined modifications, outperformed other candidates terms level both Abs soon after persistence over time, showing best capacity neutralize formerly circulating VoC Alpha, Beta, Gamma Delta. Although present, lowest response was Omicron (BA.1, BA.2 BA.4/5), suggesting magnitude immune evasion may be related higher genetic distance as by increased number amino acid acquired during virus evolution.

Language: Английский

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Parental acceptance of typhoid conjugate vaccine for children aged 6 months to 15 years in an outbreak setting of Lyari Town Karachi, Pakistan

Vaccine, Journal Year: 2023, Volume and Issue: 41(37), P. 5376 - 5382

Published: July 17, 2023

This study aimed to evaluate the parental acceptance of Typhoid Conjugate Vaccine (TCV) and determine predictors TCV vaccination status among children in an outbreak setting extensively drug resistant (XDR) typhoid fever Karachi, Pakistan.A cross-sectional survey using WHO recommended rapid vaccine coverage assessment technique was conducted. Out 11, four union councils (UCs) Lyari Town were randomly selected. A parent or primary caretaker from eligible household interviewed. Data collected a locally validated attitudes scale (VAS). Sum scores calculated for VAS. higher score denoted negative perceptions regarding vice versa. Multivariable logistic regression performed status.Based on 14-item VAS, 78.0 % parents had between 0 <40 22 ≥40. VAS significantly associated with odds receiving during campaign (adjusted Odds Ratio (aOR): 1.30; 95 Confidence Interval (CI): 1.02, 1.66). The whose aware ongoing area (aOR: 4.57; CI: 2.93, 7.12) expressed willingness get their child vaccinated against 2.54; 1.82, 3.55).Parental awareness campaign, positive perception towards found be children. Appropriately structured pre-vaccination campaigns focused childhood targeted are necessary improve awareness, attitude behavior vaccination.

Language: Английский

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Knowledge, risk perception and uptake of COVID-19 vaccination among internally displaced persons in complex humanitarian emergency setting, Northeast Nigeria

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 28, 2024

Abstract Background Owing to crowded and unsanitary conditions, internally displaced persons (IDPs) have an increased risk of COVID-19 infection. Adoption preventive measures among this population is premised on accurate information, adequate knowledge, perception. We assessed knowledge perception investigated the association between measures, including vaccination IDPs in Northeast Nigeria. Methods conducted a cross-sectional study during July–December 2022 sampled 2,175 using stratified sampling. utilized 12-point assessment tool evaluate knowledge. Participants who scored ≥ 6 points were considered used 30-item Risk Behavior Diagnosis Scale assess evaluated each item 5-point Likert scale. divided into categories by median scale scores. performed weighted logistic regression analysis identify factors associated with Pearson’s chi-squared Rao-Scott adjustment was determine relationship measures. Results Of participants, 55.7% 18–39 years old, 70.9% females, 81.7% had no formal education. Among IDPs, 32.0% (95% CI: 28.8 – 35.0) 51.3% 47.8 54.8) perceived as high. Moreover, 46.3% 42.8 50.0) received one dose vaccine, 33.1% 29.8 36.0) two doses. Adequate (Adjusted Odds Ratio (AOR) = 2.10, [95% 1.46 3.03]) post-primary education (AOR 3.20, 1.59 6.46]) Furthermore, high significantly wearing face masks (χ 2 106.32, p -value < .001), practicing hand hygiene 162.24, physical distancing 60.84, .001) uptake 46.85, .001). Conclusions This revealed gaps perception, but demonstrated significant practices. Health communication should be intensified improve elicit stronger enhance

Language: Английский

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