Genes,
Journal Year:
2023,
Volume and Issue:
14(7), P. 1420 - 1420
Published: July 10, 2023
The
role
of
genetics
as
a
predisposing
factor
related
to
an
increased
risk
developing
long
COVID
symptomatology
is
under
debate.
aim
the
current
secondary
analysis
was
identify
association
between
Apolipoprotein
E
(ApoE)
gene,
gene
affecting
cholesterol
metabolism
and
previously
associated
with
higher
SARS-CoV-2
infection
COVID-19
severity,
development
in
cohort
individuals
who
had
been
hospitalized
by
infection.
Unstimulated
whole
saliva
samples
were
collected
from
287
survivors.
Three
genotypes
ApoE
(ApoE
ε2,
ε3,
ε4)
obtained
based
on
combination
rs429358
rs7412
polymorphisms.
Participants
asked
self-report
presence
any
post-COVID
symptom
face-to-face
interview
at
17.8
±
5.2
months
after
hospital
discharge
medical
records
obtained.
Each
participant
reported
3.0
(1.9)
symptoms.
Overall,
no
significant
differences
symptoms
observed
depending
genotype
ε4).
ε4
genotype,
albeit
did
not
appear
predispose
for
our
Virology Journal,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: Dec. 20, 2024
The
COVID-19
pandemic,
caused
by
the
novel
coronavirus
SARS-CoV-2,
has
profoundly
impacted
global
healthcare
systems
and
spurred
extensive
research
efforts
over
past
three
years.
One
critical
aspect
of
disease
is
intricate
interplay
between
virus
host
immune
response,
particularly
role
inflammatory
gene
expression
in
severe
COVID-19.
While
numerous
previous
studies
have
explored
genetic
polymorphisms
COVID-19,
specifically
focusing
on
genes
their
associations
with
severity
remains
limited.
This
review
explores
relationship
outcomes
within
key
genes.
By
investigating
impact
variations
responses,
which
include
cytokine
production
downstream
signalling
pathways,
we
aim
to
provide
a
comprehensive
overview
how
contribute
variability
presentation.
Through
an
in-depth
analysis
existing
literature,
shed
light
potential
therapeutic
targets
personalized
approaches
that
may
enhance
our
understanding
pathogenesis
treatment
strategies.
British Journal of Biomedical Science,
Journal Year:
2023,
Volume and Issue:
80
Published: Jan. 20, 2023
Background:
Single
nucleotide
polymorphisms
provide
information
on
individuals’
potential
reactions
to
environmental
factors,
infections,
diseases,
as
well
various
therapies.
A
study
SNPs
that
influence
SARS-CoV-2
susceptibility
and
severity
may
a
predictive
tool
for
COVID-19
outcomes
improve
the
customized
coronavirus
treatment.
Aim:
To
evaluate
role
of
human
leukocyte
antigens
DP/DQ
IFNλ4
among
Egyptian
patients.
Participants
Methods:
The
involved
80
patients
with
severe
COVID-19,
mild
non-infected
healthy
volunteers.
Genotyping
allelic
discrimination
HLA-DPrs3077
(G/A),
HLA-DQrs7453920
(A/G),
rs73555604
(C/T)
were
performed
using
real-time
PCR.
Results:
Ages
47.9
±
8,
44.1
12.1,
45.8
10
years
in
severe,
persons.
There
was
statistically
significant
association
between
male
gender
(
p
=
0.002).
increase
frequency
HLA-DPrs3077G,
HLA-DQrs7453920A,
IFNλ4rs73555604C
alleles
when
compared
other
groups
<
0.001).
Coexistence
these
same
individual
increases
by
many
folds
Univariate
multivariate
logistic
regression
analysis
studied
parameters
showed
old
age,
gender,
non-vaccination,
HLA-DQ
rs7453920AG+AA,
HLA-DPrs3077GA+GG,
IFNλ4rs73555604CT+CC
genotypes
are
independent
risk
factors
Conclusion
:
rs7453920A,
could
be
used
markers
severity.
Genes,
Journal Year:
2023,
Volume and Issue:
14(7), P. 1420 - 1420
Published: July 10, 2023
The
role
of
genetics
as
a
predisposing
factor
related
to
an
increased
risk
developing
long
COVID
symptomatology
is
under
debate.
aim
the
current
secondary
analysis
was
identify
association
between
Apolipoprotein
E
(ApoE)
gene,
gene
affecting
cholesterol
metabolism
and
previously
associated
with
higher
SARS-CoV-2
infection
COVID-19
severity,
development
in
cohort
individuals
who
had
been
hospitalized
by
infection.
Unstimulated
whole
saliva
samples
were
collected
from
287
survivors.
Three
genotypes
ApoE
(ApoE
ε2,
ε3,
ε4)
obtained
based
on
combination
rs429358
rs7412
polymorphisms.
Participants
asked
self-report
presence
any
post-COVID
symptom
face-to-face
interview
at
17.8
±
5.2
months
after
hospital
discharge
medical
records
obtained.
Each
participant
reported
3.0
(1.9)
symptoms.
Overall,
no
significant
differences
symptoms
observed
depending
genotype
ε4).
ε4
genotype,
albeit
did
not
appear
predispose
for
our
