HLA-DQ2/8 and COVID-19 in Celiac Disease: Boon or Bane DOI Creative Commons
Aaron Lerner, Carina Benzvi, Aristo Vojdani

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(12), P. 2977 - 2977

Published: Dec. 13, 2023

The SARS-CoV-2 pandemic continues to pose a global threat. While its virulence has subsided, it persisted due the continual emergence of new mutations. Although many high-risk conditions related COVID-19 have been identified, understanding protective factors remains limited. Intriguingly, epidemiological evidence suggests low incidence COVID-19-infected CD patients. present study explores whether their genetic background, namely, associated HLA-DQs, offers protection against severe outcomes. We hypothesize that HLA-DQ2/8 alleles may shield patients from and subsequent effects, possibly memory CD4 T cells primed by previous exposure human-associated common cold coronaviruses (CCC) higher affinity those allele's groove. In this context, we examined potential cross-reactivity between epitopes CCC assessed binding (BA) these HLA-DQ2/8. Using computational methods, analyzed sequence similarity four distinct CCC. Of 924 unique immunodominant 15-mer with at least 67% identity, 37 exhibited significant BA HLA-DQ2/8, suggesting effect. various mechanisms might explain role in COVID-19-afflicted If substantiated, insights could enhance our gene-environment enigma viral-host relationship, guiding therapeutic innovations ongoing pandemic.

Language: Английский

Implications of cytokine genes polymorphisms in Jordanian patients with obsessive compulsive disorder DOI Creative Commons
Ahmad M. Khalil,

Manal W. Khrais,

Khaled M. Al-Qaoud

et al.

Egyptian Journal of Medical Human Genetics, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 14, 2025

Abstract Background Obsessive–compulsive disorder (OCD) is a common and often highly debilitating chronic neuropsychiatric condition. There substantial evidence that immune system genetic changes are involved in OCD pathogenesis. Only few studies have been encountered the literature this field. We aimed at providing experimental for single nucleotide polymorphisms (SNPs) candidate cytokine genes etiology of OCD. Methods A total 52 patients 54 healthy controls were randomly recruited from Jordanian population. Age ranged between 16 55 years (35.5 ± 13.72 33.5 10.48 years) controls, respectively. Five polymorphic positions four interleukin (IL-1β; rs16944 rs1143634, IL-6; rs1800795, IL-10; rs1800896 rs1800795) genotyped using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) method. The tumor necrosis factor-α (TNF-α) SNP (rs1800629) DNA was sequenced by Sanger obtained data analyzed GraphPad Prism Results no statistically significant differences alleles genotypes opposite groups. However, there positive association incidence studied non-OCD individuals. two SNPs (IL-1β + 3954 C > T TNF-α-308 G A) more predominant positively correlated with higher risk women. In contrast, link gender occurrence mutant other IL-1β (− 511 T); IL-6 174 C); IL-10 1082 G); 819 robust males than corresponding females. Conclusion observed different groups may be due to an tested samples rather true association. But, possibility critical effect still exists. One might want explore further repeating study larger sample size.

Language: Английский

Citations

0
Autoimmune hepatitis under the COVID-19 veil: an analysis of the nature of potential associations DOI Creative Commons
Chaojie Yu, Wenrui Wang, Qian Zhang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 31, 2025

In recent years, the novel coronavirus infectious disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has led to over 670 million infections and nearly 7 deaths worldwide. The global pandemic of COVID-19 precipitated a significant public health crisis. prevalence liver function abnormalities associated with SARS-CoV-2 is as high 53% among healthy individuals or patients autoimmune hepatitis (AIH) shows positive correlation severity; moreover, specific adaptive immune responses can influence trajectory outcomes COVID-19. For instance, may impact autoimmunity through mechanisms such excessive stimulation molecular mimicry, particularly in genetically predisposed individuals. Currently, overall mutational trend indicates heightened infectivity evasion capabilities. Consequently, vaccination remains crucial for universal protection against this disease. Nevertheless, alongside widespread implementation programs globally, an increasing number cases have been documented where appears trigger new-onset hepatitis; yet definitive evidence still pending elucidation regarding causality. review, we analyse clinical-immunological characteristics, risks progression, prognosis AIH infected SARS-CoV-2; discuss detrimental effects exerted on hepatic function; summarise attributes leading AIH; well provide insights into how interfere processes. We continue underscore significance while aiming enhance awareness concerning potential it-this could facilitate better management strategies diseases along appropriate adjustments protocols. Although precise triggering mechanism linking COVID-19-related events unclear, existing suggests that relationship far from coincidental.

Language: Английский

Citations

0
IFNL1 rs30461 polymorphism as a risk factor for COVID-19 severity: A cross-sectional study DOI
Maha O. Hammad, Mahmoud M. Alseoudy,

Asmaa M. Borg

et al.

Cytokine, Journal Year: 2024, Volume and Issue: 176, P. 156500 - 156500

Published: Jan. 24, 2024

Language: Английский

Citations

3
The role of inflammatory gene polymorphisms in severe COVID-19: a review DOI Creative Commons
J Yip, Adrian Oo,

Yan Ling Ng

et al.

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Dec. 20, 2024

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global healthcare systems and spurred extensive research efforts over past three years. One critical aspect of disease is intricate interplay between virus host immune response, particularly role inflammatory gene expression in severe COVID-19. While numerous previous studies have explored genetic polymorphisms COVID-19, specifically focusing on genes their associations with severity remains limited. This review explores relationship outcomes within key genes. By investigating impact variations responses, which include cytokine production downstream signalling pathways, we aim to provide a comprehensive overview how contribute variability presentation. Through an in-depth analysis existing literature, shed light potential therapeutic targets personalized approaches that may enhance our understanding pathogenesis treatment strategies.

Language: Английский

Citations

2
HLA-DQ2/8 and COVID-19 in celiac disease: Boon or Bane DOI Open Access
Aaron Lerner, Carina Benzvi, Aristo Vojdani

et al.

Published: Nov. 17, 2023

The SARS-CoV-2 pandemic continues to pose a global threat. While its virulence has subsided, it persisted due the continual emergence of new mutations. Although many high-risk conditions related COVID-19 have been identified, understanding protective factors remains limited. Intriguingly, epidemiological evidence suggests low incidence COVID-19-infected CD patients. present study explores whether their genetic background, namely associated HLA-DQs, offers protection against severe outcomes. We hypothesize that HLA-DQ 2/8 alleles may shield patients from and subsequent effects, possibly memory CD4 T cells primed by previous exposure human-associated common cold coronaviruses (CCC) higher affinity those allele's groove. In this context, we examined potential cross-reactivity between epitopes CCC assessed binding (BA) these 2/8. Using computational methods, analyzed sequence similarity four distinct CCC. Of 924 unique immunodominant 15-mer with at least 67% identity, 37 exhibited significant BA 2/8, suggesting effect. various mechanisms might explain role HLA-DQ2/8 in COVID-19-afflicted If substantiated, insights could enhance our gene-environment enigma viral-host relationship, guiding therapeutic innovations ongoing pandemic.

Language: Английский

Citations

2
HLA-DQ2/8 and COVID-19 in Celiac Disease: Boon or Bane DOI Creative Commons
Aaron Lerner, Carina Benzvi, Aristo Vojdani

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(12), P. 2977 - 2977

Published: Dec. 13, 2023

The SARS-CoV-2 pandemic continues to pose a global threat. While its virulence has subsided, it persisted due the continual emergence of new mutations. Although many high-risk conditions related COVID-19 have been identified, understanding protective factors remains limited. Intriguingly, epidemiological evidence suggests low incidence COVID-19-infected CD patients. present study explores whether their genetic background, namely, associated HLA-DQs, offers protection against severe outcomes. We hypothesize that HLA-DQ2/8 alleles may shield patients from and subsequent effects, possibly memory CD4 T cells primed by previous exposure human-associated common cold coronaviruses (CCC) higher affinity those allele's groove. In this context, we examined potential cross-reactivity between epitopes CCC assessed binding (BA) these HLA-DQ2/8. Using computational methods, analyzed sequence similarity four distinct CCC. Of 924 unique immunodominant 15-mer with at least 67% identity, 37 exhibited significant BA HLA-DQ2/8, suggesting effect. various mechanisms might explain role in COVID-19-afflicted If substantiated, insights could enhance our gene-environment enigma viral-host relationship, guiding therapeutic innovations ongoing pandemic.

Language: Английский

Citations

1