A retrospective case-control study on menstrual cycle changes following COVID-19 vaccination and disease

iScience, Journal Year: 2023, Volume and Issue: 26(4), P. 106401 - 106401

Published: March 15, 2023

There has been increasing public concern that COVID-19 vaccination causes menstrual disturbance regarding the relative effect of compared to SARS-CoV-2 infection. Our objectives were test potential risk factors for reporting cycle changes following and compare parameters disease. We performed a secondary analysis retrospective online survey conducted in UK March 2021. In pre-menopausal vaccinated participants (n = 4,989), 18% reported after their first vaccine injection. The prevalence any was higher women who smoke, have history disease, or are not using estradiol-containing contraceptives. second sample including both unvaccinated 12,579), alone associated with abnormal parameters, while disease an increased heavier bleeding, "missed" periods, inter-menstrual bleeding.

Language: Английский

---

Ovarian function after COVID-19: long-term effects and vaccine safety in ART patients

Journal of Assisted Reproduction and Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Language: Английский

---

Timing of Coronavirus Disease 2019 (COVID-19) Vaccination and Effects on Menstrual Cycle Changes

Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 27, 2024

OBJECTIVE: To assess whether menstrual cycle timing (follicular or luteal phase) of coronavirus disease 2019 (COVID-19) vaccine administration is associated with length changes. METHODS: We used prospectively collected (2021–2022) tracking data from 19,497 reproductive-aged users the application “Natural Cycles.” identified was delivered in follicular phase and also included an unvaccinated control group. Our primary outcome adjusted within-individual change (in days) average three cycles before first vaccination (individuals group were assigned a notional date). assessed changes second clinically significant (8 days more) occurred either cycle. RESULTS: Most individuals younger than age 35 years (80.1%) North America (28.6%), continental Europe (33.5%), United Kingdom (31.7%). In vaccinated group, majority received mRNA (63.8% full sample). Individuals experienced 1-day longer dose COVID-19 compared their prevaccination (first dose: 1.00 day [98.75% CI, 0.88–1.13], 1.11 0.93–1.29]); those no (respectively, −0.09 −0.26 to 0.07], 0.06 −0.16 0.29], 0.08 −0.10 0.27], 0.17 −0.04 0.38]). Those during more likely experience more; 6.8%) (3.3% 5.0%, respectively; P <.001). CONCLUSION: vaccine–related increases are receipt half phase).

Language: Английский

---

Clinical Spectrum of Long COVID: Effects on Female Reproductive Health

Viruses, Journal Year: 2024, Volume and Issue: 16(7), P. 1142 - 1142

Published: July 16, 2024

The COVID-19 pandemic caused by SARS-CoV-2 has presented numerous health challenges, including long-term COVID, which affects female reproductive health. This review consolidates the current research on impact of menstrual cycle, ovarian function, fertility, and overall gynecological study emphasizes role angiotensin-converting enzyme receptors in viral entry subsequent tissue-specific pathological effects. It also explores potential influence long COVID hormonal balance immune responses, contributing to irregularities impaired function. findings indicate a higher prevalence among women, highlighting substantial implications for need sex-sensitive longitudinal studies. Enhanced surveillance targeted are essential develop effective interventions that prioritize women's well-being following infection. advocates sex-informed approach ongoing healthcare strategies, aiming provide up-to-date pertinent data providers general public, ultimately improving outcomes females affected COVID.

Language: Английский

---

Innovative Approaches to Menstruation and Fertility Tracking Using Wearable Reproductive Health Technology: Systematic Review

Journal of Medical Internet Research, Journal Year: 2023, Volume and Issue: 26, P. e45139 - e45139

Published: Oct. 27, 2023

Emerging digital health technology has moved into the reproductive market for female individuals. In past, mobile apps have been used to monitor menstrual cycle using manual entry. New technological trends involve use of wearable devices track fertility by assessing physiological changes such as temperature, heart rate, and respiratory rate.

Language: Английский

---

Associations Among Menstrual Cycle Length, Coronavirus Disease 2019 (COVID-19), and Vaccination

Obstetrics and Gynecology, Journal Year: 2023, Volume and Issue: 143(1), P. 83 - 91

Published: Aug. 10, 2023

To assess whether coronavirus disease 2019 (COVID-19) is associated with menstrual cycle length changes and, if so, how that compares those undergoing vaccination or no event (control).We conducted a retrospective cohort analysis in which we analyzed prospectively tracked cycle-length data from users of period tracker application who also responded to survey regarding COVID-19 symptoms and vaccination. We restricted our sample aged 16-45 years, normal lengths (24-38 days) regular tracking behavior during the five cycles around similar time for experiencing (control group). calculated within-user change (days) three consecutive preevent average (either vaccination, disease, neither; 1-3) (cycle 4) postevent 5) cycles. used mixed-effects models estimate age- country-adjusted difference across groups.We included 6,514 110 countries representing 32,570 (COVID-19 symptoms: 1,450; vaccination: 4,643; control: 421). The experienced 1.45-day adjusted increase 4 compared their (95% CI 0.86-2.04). vaccinated group 1.14-day vaccine) 0.60-1.69). control (neither vaccine nor disease) 0.68-day decrease -1.18 -0.19) period. Post hoc tests showed significant differences magnitude between cohorts. In both cohorts, disappeared cycle.Experiencing small These resolve quickly within next cycle.

Language: Английский

---

Host factors of SARS-CoV-2 in infection, pathogenesis, and long-term effects

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: May 22, 2024

SARS-CoV-2 is the causative virus of devastating COVID-19 pandemic that results in an unparalleled global health and economic crisis. Despite unprecedented scientific efforts therapeutic interventions, fight against continues as rapid emergence different variants concern increasing challenge long COVID-19, raising a vast demand to understand pathomechanisms its long-term sequelae develop strategies beyond per se . Notably, addition itself, replication cycle clinical severity also governed by host factors. In this review, we therefore comprehensively overview pathogenesis from perspective factors host-virus interactions. We sequentially outline pathological implications molecular interactions between multi-organ multi-system summarize current agents targeting for treating these diseases. This knowledge would be key identification new pathophysiological aspects mechanisms, development actionable targets tackling sequelae.

Language: Английский

---

COVID-19 and abnormal uterine bleeding: potential associations and mechanisms

Clinical Science, Journal Year: 2024, Volume and Issue: 138(4), P. 153 - 171

Published: Feb. 1, 2024

Abstract The impact of COVID-19 on menstruation has received a high level public and media interest. Despite this, uncertainty exists about the advice that women people who menstruate should receive in relation to expected SARS-CoV-2 infection, long COVID or vaccination menstruation. Furthermore, mechanisms leading these reported menstrual changes are poorly understood. This review evaluates published literature its bleeding, discussing strengths limitations studies. We present evidence consistent with infection having an association bleeding parameters appears less significant. An overview physiology known causes abnormal uterine (AUB) is provided before potential which may underpin disturbance COVID-19, highlighting areas for future scientific study. Finally, consideration given effect have including ovarian sex hormones acute severity susceptibility variation symptoms across cycle. Understanding current addressing gaps our knowledge this area essential inform health policy, direct treatment facilitate development new therapies, reduce improve quality life those experiencing COVID.

Language: Английский

---

Menstrual disturbance associated with COVID-19 vaccines: A comprehensive systematic review and meta-analysis

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(5), P. e0320162 - e0320162

Published: May 16, 2025

The relationship between COVID-19 vaccines and menstrual disturbance is unclear, in part because researchers have measured different outcomes (e.g., delays vs. changes to cycle length) with various study designs. Menstrual disruption could be a decisive factor people's willingness accept the vaccine. We searched Medline, Embase, Web of Science for studies investigating length, flow volume, post-menopausal bleeding, unexpected or intermenstrual bleeding. Data were analyzed using fixed-effects meta-analysis Shore's adjusted confidence intervals heterogeneity. Seventeen >1·9 million participants analyzed. found 19% greater risk increase length as compared unvaccinated people pre-vaccination time-periods (summary relative (sRR): 1·19; 95% CI: 1·11-1·26; n = 23,718 participants). was same Pfizer-BioNTech (sRR: 1·15; 1·05-1·27; 16,595) Moderna 1·05-1·25; 7,523), similar AstraZeneca 1·27; 1·02-1·59; 532), higher Janssen 1·69; 1·14-2·52; 751) In first after vaccination, increased by

Language: Английский

---

Bloody stressed! A systematic review of the associations between adulthood psychological stress and menstrual cycle irregularity

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 163, P. 105784 - 105784

Published: June 29, 2024

Language: Английский

---