International Trends in Antidepressant Consumption: a 10-year Comparative Analysis (2010–2020)

Psychiatric Quarterly, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract The present study aims to analyze country-specific antidepressant consumption rates across 30 OECD countries, comparing them with the average from 2010 2020. This analysis examines annual variations in and identifies potential trends over time. Using a retrospective observational design, employs pooled secondary data countries. A time trend was conducted assess overall linear quadratic trends, modeling variation Defined Daily Dose (DDD) per 1,000 inhabitants Findings reveal significant increase most mean DDD value rose 52.42 69.5 Three distinct patterns emerged: linear, concave, convex. While 15 countries exhibited increase, five showed plateauing trend, others experienced exponential growth convex trajectory. Denmark only country show decline consumption, whereas Norway displayed no change These results underscore notable rise use alongside trajectories. By assessing national rates, this highlights importance of international collaboration addressing mental health challenges optimizing healthcare accessibility outcomes.

Language: Английский

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The Economics of Treatment for Depression

Annual Review of Public Health, Journal Year: 2023, Volume and Issue: 45(1), P. 527 - 551

Published: Dec. 15, 2023

The global prevalence of depression has risen over the past three decades across all socioeconomic groups and geographic regions, with a particularly rapid increase in among adolescents (aged 12-17 years) United States. Depression imposes large health, economic, societal costs, including reduced life span quality life, medical educational attainment workplace productivity. A wide range treatment modalities for are available, but disparities access driven by lack culturally tailored options, stigma, provider shortages, other barriers. This review highlights need comparative research to better understand treatments' relative efficacy, cost-effectiveness, scalability, potential heterogeneity efficacy country cultural contexts. To address growing burden depression, mental health policy could consider reducing restrictions on supply providers, implementing digital interventions, promoting healthy lifestyles.

Language: Английский

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Prescriptions of antidepressants and anxiolytics in France 2012–2022 and changes with the COVID-19 pandemic: interrupted time series analysis

BMJ Mental Health, Journal Year: 2024, Volume and Issue: 27(1), P. e301026 - e301026

Published: Jan. 1, 2024

Background Depression and anxiety have increased in prevalence since the start of COVID-19 pandemic. Objective To evaluate consumption antidepressants anxiolytics from 2012 to 2022 pandemic’s potential impact France. Methods We conducted an interrupted time series analysis routine drug sales data (Medic'AM) all French outpatient pharmacies 2022. investigated trends defined daily doses sold per 1000 inhabitants (DDD/TID) related expenditures before after pandemic onset relation with stringency mitigation measures. Analyses were performed descriptively using segmented linear regression, autoregressive integrated moving average models. Findings From 2019, overall monthly antidepressant (+0.02 DDD/TID) while anxiolytic decreased (−0.07 DDD/TID). With onset, there was a relevant persisting trend increase (+0.20 DDD/TID month) for overall, estimated excess 112.6 May 2020 until December Anxiolytic elevated February throughout but returned expected levels by 2022, 33.8 DDD/TID. There no evident association between or sales. Conclusions This study showed protracted increases temporary. Clinical implications provide evidence that may had long-lasting consequences on treatment depression disorders, requiring further actions researchers policy-makers address this public mental health crisis.

Language: Английский

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Internet and Telephone Support for Discontinuing Long-Term Antidepressants

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(6), P. e2418383 - e2418383

Published: June 24, 2024

Importance There is significant concern regarding increasing long-term antidepressant treatment for depression beyond an evidence-based duration. Objective To determine whether adding internet and telephone support to a family practitioner review consider discontinuing safe more effective than alone. Design, Setting, Participants In this cluster randomized clinical trial, 131 UK practices were between December 1, 2018, March 31, 2022, with remote computerized allocation 12 months of follow-up. researchers aware allocation, but analysis was blind. adults who receiving antidepressants 1 year first episode or 2 years recurrent currently well enough discontinuation wished do so at low risk relapse. Of 6725 patients mailed invitations, 330 (4.9%) eligible consented. Interventions Internet self-management support, codesigned coproduced practitioners. Main Outcomes Measures The primary (safety) outcome 6 (prespecified complete-case analysis), testing noninferiority the intervention under points on 9-item Patient Health Questionnaire (PHQ-9). Secondary outcomes (testing superiority) discontinuation, anxiety, quality life, withdrawal symptoms, mental well-being, enablement, satisfaction, use health care services, adverse events. Analyses main performed basis, multiple imputation sensitivity intention-to-treat basis. Results participants recruited (325 inclusion; 178 in 147 control practices; mean [SD] age baseline, 54.0 [14.9] years; 223 women [68.6%]), 276 (83.6%) followed up months, 240 (72.7%) months. proved noninferior; (SD) PHQ-9 scores slightly lower arm (4.0 [4.3] vs 5.0 [4.7]; adjusted difference, −1.1; 95% CI, −2.1 −0.1; P = .03) not significantly different (adjusted −0.9 (95% −1.9 0.1; .08). By had been discontinued by 66 145 (45.5%) provided data 54 129 (41.9%) odds ratio, 1.02; 0.52-1.99; .96). arm, symptoms less severe, well-being better compared arm; differences small significant. no other outcomes; 28 179 (15.6%) 22 151 (14.6%) experienced Conclusions Relevance trial possible rate did increase. Improvements also small. harms. Family appeared 40% willing discontinue. Trial Registration ISRCTN registry Identifiers: ISRCTN15036829 (internal pilot trial) ISRCTN12417565 (main

Language: Английский

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Intimate Partner Violence and Subsequent Depression in Women: A Systematic Review and Meta‐Analysis of Longitudinal Studies

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 1, 2025

ABSTRACT Introduction Intimate partner violence (IPV) and depression are global health concerns with high prevalence rates substantial negative impacts on individuals the wider community. Women particularly vulnerable to both IPV victimization depressive disorders, recognized worldwide as priorities for women's health. The aim of this systematic review meta‐analysis was determine whether recent longitudinal empirical evidence supports exposure a contributing factor subsequent onset in women. Methods A search performed August 2024 Medline , PsychInfo EBSCOHost databases studies published after year 2013, 1193 were identified. Studies included if they written English measured an independent variable dependent variable. excluded not separately from other variables or did report primary quantitative data. Eleven 118,544 female participants met inclusion criteria review. Results Ten 11 reviewed reported statistically significant positive association between random effects used generate pooled odds ratios nine estimates, which demonstrated that survivors have significantly increased developing ( OR = 1.92, (95% CI: 1.28, 2.86); although, there heterogeneity across I 2 98.3%, p < 0.001). high‐income, industrialized countries, limits application these findings. Conclusions These findings suggest may be one many factors However, variability definition inconsistent adjustment confounders firm conclusions. strategies prevent could play role reducing depression. They also support screening clinical approaches effectiveness IPV‐related intervention strategies.

Language: Английский

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Shared and unique transcriptomic signatures of antidepressant and probiotics action in the mammalian brain

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: June 6, 2024

Language: Английский

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Uncovering antidepressant prescription patterns: a three-year analysis of outpatient trends

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 3, 2025

Antidepressants (ADs) are prescribed for various conditions, including neurological and rheumatoid diseases. This study aims to analyze ADs prescribing trends in Iranian outpatients over three years, with a focus on age, sex, class. A retrospective cohort was conducted using prescription data from the Health Insurance Organization (IHIO) between March 2021 2024. The dataset included 8,924,431 prescriptions 3,524,273 patients who received at least one ADs. were classified into four groups: tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), norepinephrine (SNRIs), atypical processed via cross-industry standard process mining analyzed multivariate logistic regression model. SSRIs most commonly class, accounting 63.71% of prescriptions, sertraline being common drug (24.65%). Females accounted 66.11% patient population. increased females more likely receive TCAs SNRIs than males, had higher rates use. revealed notable increase Iran, particularly among women older individuals. Continued monitoring is crucial optimizing outcomes, especially vulnerable groups such as elderly

Language: Английский

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Analyzing anxiety and treatment trends using google trends: validation of epidemiologic studies and forecasting

Quality & Quantity, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

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Global burden of antidepressant-associated seizures from 1967 to 2023: A comparative analysis of the international pharmacovigilance database

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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General polypharmacy, psychotropic polypharmacy, attitudes of patients on psychotropic deprescribing, and associated factors in adult psychiatric outpatients: a survey study in a comprehensive specialized hospital, northwest Ethiopia

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 8, 2025

Language: Английский

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