Exploring Therapeutic Potential of Catalase: Strategies in Disease Prevention and Management

Biomolecules, Journal Year: 2024, Volume and Issue: 14(6), P. 697 - 697

Published: June 14, 2024

The antioxidant defense mechanisms play a critical role in mitigating the deleterious effects of reactive oxygen species (ROS). Catalase stands out as paramount enzymatic antioxidant. It efficiently catalyzes decomposition hydrogen peroxide (H

Language: Английский

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A Comprehensive Review of Free Radicals, Oxidative Stress, and Antioxidants: Overview, Clinical Applications, Global Perspectives, Future Directions, and Mechanisms of Antioxidant Activity of Flavonoid Compounds

Journal of Chemistry, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 21

Published: May 31, 2024

Absorption​ of free radicals in the body cannot be done by antioxidant compounds originating from human body, so exogenous antioxidants are required to help their natural action. Oxidative stress can caused an imbalance radical inhibitors and accumulation that enter cellular structures. Synthetic found external not primary choice because they harmful carcinogenic. Therefore, using ingredients provides a necessary alternative constructing novel antioxidants. Recent studies have highlighted critical analysis evaluation flavonoids unique class secondary metabolites plants used communities as traditional therapeutics with proven bioactivity. This could support new discoveries based on various herbal medicines addition, functional effectiveness against radicals. In this review, there several strengths discussion. First, study takes comprehensive approach covering aspects, including properties sources radicals, oxidative relation different diseases, defense mechanisms, specific mechanisms flavonoids. Second, focus antioxidants, especially flavonoids, also discussion about clinical applications studies, limitations, global perspectives, future research directions become references selection medicines. But, constraints should considered when interpreting findings review. mechanism is only discussed general one example compound (flavonoid) has potential antioxidant. lack regarding relationship between diseases Third, limited number investigated some discussed.

Language: Английский

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The Role of Potential Oxidative Biomarkers in the Prognosis of Acute Ischemic Stroke and the Exploration of Antioxidants as Possible Preventive and Treatment Options

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6389 - 6389

Published: March 28, 2023

Ischemic strokes occur when the blood supply to a part of brain is interrupted or reduced due arterial blockage, and it often leads damage cells death. According myriad experimental studies, oxidative stress an important pathophysiological mechanism ischemic stroke. In this narrative review, we aimed identify how alterations biomarkers could suggest severity-reflecting diagnosis stroke these interactions may provide new molecular targets for neuroprotective therapies. We performed eligibility criteria-based search on three main scientific databases. found that patients with acute are characterized by increased markers levels, such as total antioxidant capacity, F2-isoprostanes, hydroxynonenal, perchloric acid oxygen radical absorbance capacity (ORACTOT ORACPCA), malondialdehyde (MDA), myeloperoxidase, urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine. Thus, causing significant associated cellular damage. The assessment be useful in diagnosing stroke, finding its causes, predicting severity outcomes, reducing impact structures brain, guiding preventive treatment towards antioxidant-based therapy novel therapeutic alternatives.

Language: Английский

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Antioxidants from microalgae and their potential impact on human well-being

Published: May 31, 2024

In recent times, there has been a revolutionary surge in antioxidant research, with focus on harnessing microalgae to enhance wellness and extend human longevity. Microalgae, diverse group of unicellular photosynthetic organisms, have emerged as promising sources natural antioxidants due their ability synthesize various bioactive compounds, including carotenoids, polyphenols, tocopherols. These play pivotal role scavenging free radicals reducing oxidative stress, known contributors aging chronic diseases. This review provides an over-view advancements understanding microalgae’s potential, covering biochemical composition, extraction techniques, purification methods. Moreover, it delves into compelling vitro vivo studies showcasing microalgae-derived antioxidants’ protective effects against damage, inflammation, cardiovascular diseases, neurodegenerative disorders. The sustainable cultivation controlled environments further supports the potential for large-scale production commercialization compounds. As continue revolutionize they hold immense promise developing novel preventive therapeutic strategies promote health wellbeing.

Language: Английский

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Recent advances in the analytical methods for quantitative determination of antioxidants in food matrices

Food Chemistry, Journal Year: 2024, Volume and Issue: 463, P. 141348 - 141348

Published: Sept. 19, 2024

Language: Английский

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Phytochemical Analysis and Profiling of Antioxidants and Anticancer Compounds from Tephrosia purpurea (L.) subsp. apollinea Family Fabaceae

Molecules, Journal Year: 2023, Volume and Issue: 28(9), P. 3939 - 3939

Published: May 7, 2023

Tephorosia purpurea subsp. apollinea was extracted with methanol and n-hexane to obtain sub-fractions. The chemical compounds identified GC-MS HPLC in T. extracts showed antioxidant anticancer properties. activities were investigated using DDPH ABTS assays, MTT assay, respectively. Stigmasta-5,24(28)-dien-3-ol, (3 β,24Z)-, 9,12,15-octadecatrienoic acid methyl ester, phytol, chlorogenic acid, quercetin the major detected apollinea. These possessed extract properties radical scavenging of 84% 94%, respectively, relative ascorbic trolox. effects against cancer cell lines MCF7 (IC50 = 102.8 ± 0.6 μg/mL), MG63 118.3 2.5 T47D 114.7 1.0 HeLa 196.3 2.3 PC3 117.7 1.1 μg/mL) greater than its U379 248.4 7.5 μg/mL). However, it had no adverse on normal cells (WI38) 242.9 1.8 Therefore, active constituents presented can be isolated studied for their potential breast, cervical, prostate cancers osteosarcoma.

Language: Английский

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Endogenous and Exogenous Antioxidants as Agents Preventing the Negative Effects of Contrast Media (Contrast-Induced Nephropathy)

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(8), P. 1077 - 1077

Published: July 28, 2023

The use of conventional contrast media for diagnostic purposes (in particular, Gd-containing and iodinated agents) causes a large number complications, the most common which is contrast-induced nephropathy. It has been shown that after exposure to agents, oxidative stress often occurs in patients, especially people suffering from various diseases. Antioxidants human body can diminish pathological consequences by suppressing stress. This review considers research studies on role antioxidants preventing negative agents diagnostics (mainly nephropathy) clinical trials different antioxidant drugs against Composite antioxidant/contrast systems as theranostic are also considered.

Language: Английский

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Comparative Analysis of the Antioxidant, Antidiabetic, Antibacterial, Cytoprotective Potential and Metabolite Profile of Two Endophytic Penicillium spp.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 248 - 248

Published: Jan. 22, 2023

The current study assessed the metabolite abundance, alpha (α)-amylase and α-glucosidase inhibitory, antioxidant, antibacterial activity of ethyl acetate extract (EAE) endophytic Penicillium lanosum (PL) radiatolobatum (PR). A higher yield was found in EAE-PR with a total phenolic content 119.87 ± 3.74 mg GAE/g DW flavonoid 16.26 1.95 QE/g DW. inhibited α-amylase scavenged ABTS+ radicals half-maximal inhibitory concentration (IC50) 362.5 37.5 µg/mL, respectively. Compared EAE-PL, exhibited against Gram-positive Gram-negative pathogens. Treatment (1000 µg/mL) did not cause significant toxicity HEK-293 cell line compared to control cells (p < 0.05). treatments (250–1000 showed cytoprotective effects toward H2O2-stressed ascorbic acid (AA). UHPLC-Q-TOF-MS/MS analysis revealed presence thiophene (C13H8S), limonene (C10H16), phenylacetic (C8H8O2) EAE-PR. Furthermore, these compounds demonstrated substantial interactions diabetes (α-amylase α-glucosidase), oxidative stress (NADPH-oxidase), bacteria (D-alanine D-alanine ligase)-related enzymes/proteins evidenced silico molecular docking analysis.

Language: Английский

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Exploration of antioxidant activities, microstructural properties, and fatty acid composition of three cyanobacteria species

Biocatalysis and Agricultural Biotechnology, Journal Year: 2024, Volume and Issue: 56, P. 103015 - 103015

Published: Jan. 5, 2024

Language: Английский

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Insights into the antioxidant, anti-inflammatory and anti-microbial potential of Nigella sativa essential oil against oral pathogens

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 24, 2024

Oral disorders can exert systemic ramifications beyond their localized effects on dental tissues, implicating a wide array of physiological conditions. The utilization essential oils (EOs) for protection oral health represents longstanding practice. Consequently, in this investigation, oil derived from Nigella sativa seeds (NSEO) underwent isolation via the hydro-distillation process, followed by comprehensive evaluation its antioxidant, anti-inflammatory, anti-fungal, antibacterial activities, and cytocompatibility. isolated NSEO manifested as pale-yellow substance was found to harbor diverse spectrum bioactive constituents, including steroids, triterpenoids, flavonoids, phenols, proteins, alkaloids, tannin, sesquiterpenoid hydrocarbons, monoterpenoid alcohol, ketone (thymoquinone). Notably, total phenolic content (TPC) flavonoid (TFC) were quantified at 641.23 μg GAE/gm 442.25 QE/g, respectively. Furthermore, exhibited concentration-dependent inhibition protein denaturation, HRBC membrane stabilization, hemolysis inhibition. Comparative analysis revealed that chlorhexidine (CHX) 0.2% displayed substantial compared aspirin. While CHX demonstrated analogous activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, showcased heightened efficacy Lactobacillus acidophilus Candida albicans. Additionally, pronounced periodontal pathogens such Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia. Importantly, no cytotoxicity observed human gingival fibroblast cell lines. These findings underscore potential potent antifungal agent management microbial pathogens, thereby offering avenues development innovative therapies targeting inflammatory Nevertheless, further investigations are imperative unlock full therapeutic repertoire.

Language: Английский

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