Causal relationship between Alzheimer's disease and retinal nerve fiber layer thickness, visual disturbance: a two-sample Mendelian randomization study. DOI Creative Commons
Xuan Han, Xiaojuan Su,

Jinyan Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

Abstract Alzheimer's disease (AD) is a chronic, progressive, irreversible degenerative disorder of the central nervous system caused by multiple factors.Previous studies have demonstrated that patients with AD experience visual disturbances and reduced retinal nerve fiber layer (RNFL) thickness in early stages. If causal relationship can be established between as well RNFL thickness, then diagnosed changes.To investigate we conducted Mendelian randomization study.In this MR study, main approach was inverse variance weighted (IVW) evaluate robustness results via sensitivity analysis. The IVW revealed no significant evidence supporting association (P = 0.283, odds ratio [OR] [95% confidence interval (CI)] 0.926[0.806-1.065]) disturbances(P 0.205, 1.070[0.964-1.187]) .Consequently, potential for diagnosing early-stage through alterations remains controversial.

Language: Английский

Aging-associated sensory decline and Alzheimer’s disease DOI Creative Commons

Suji Hong,

Seung Hyun Baek, Mitchell K.P. Lai

et al.

Molecular Neurodegeneration, Journal Year: 2024, Volume and Issue: 19(1)

Published: Dec. 4, 2024

Abstract Multisensory decline is common as people age, and aging the primary risk of Alzheimer’s Disease (AD). Recent studies have begun to shed light on possibility that age-related sensory could accelerate AD pathogenesis, or be a prodromal indicator AD. Sensory impairments, specifically in taste smell, often emerge before cognitive symptoms AD, indicating their potential early biomarkers. Olfactory dysfunction has been frequently associated with may offer valuable insights into detection. Hearing impairment significantly but its causal impact progression remains unclear. The review also discusses visual tactile deficits including retinal thinning changes perception, highlighting links disease progression. Focusing molecular mechanisms, explores roles amyloid-β (Aβ) accumulation tau protein pathology bidirectional relationship In summary, evidence presented conclusively supports advocating for an integrated approach understanding decline, enhance detection, implementing preventive strategies, developing therapeutic interventions This underscores significance health addressing neurodegenerative diseases, particularly

Language: Английский

Citations

5
Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease DOI Open Access
Lídia Sánchez-Puebla, Rosa de Hoz, Elena Salobrar‐García

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8221 - 8221

Published: July 27, 2024

In Alzheimer's disease (AD), transgenic mouse models have established links between abnormalities in the retina and those brain.

Language: Английский

Citations

4
Non-Invasive Retinal Biomarkers for Early Diagnosis of Alzheimer’s Disease DOI Creative Commons
Snježana Kaštelan, Antonela Gverović Antunica,

Velibor Puzović

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 283 - 283

Published: Jan. 24, 2025

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of the brain associated with ageing and most prevalent form dementia, affecting an estimated 55 million people worldwide, projections suggesting this number will exceed 150 by 2050. With its increasing prevalence, AD represents significant global health challenge potentially serious social economic consequences. Diagnosing particularly challenging as it requires timely recognition. Currently, there no effective therapy for AD; however, certain medications may help slow progression. Existing diagnostic methods such magnetic resonance imaging (MRI), computed tomography (CT), positron emission (PET), biomarker analysis in cerebrospinal fluid tend to be expensive invasive, making them impractical widespread use. Consequently, research into non-invasive biomarkers that enable early detection screening crucial area contemporary clinical investigation. One promising approach diagnosis retinal imaging. As extension central nervous system, retina offers distinctive opportunity structure function assessment. Considering their shared embryological origins vascular immunological similarities between eye brain, alterations indicate pathological changes including those specifically related AD. Studies suggest structural retina, within neuronal network blood vessels, act markers cerebral caused These have potential diagnosis. Since typically diagnosed only after loss has occurred, identifying could intervention prevent Non-invasive techniques, optical coherence (OCT) OCT angiography, provide accessible linked This review article focuses on Investigating connections processes significantly enhance diagnosis, monitoring, treatment AD, paving way new therapeutic approaches.

Language: Английский

Citations

0
Artificial Intelligence for Predicting Progression and Personalizing Healthcare to Alzheimer's Disease Patients DOI

I F T I Khar Ali,

Vijaya Kittu Manda

Advances in healthcare information systems and administration book series, Journal Year: 2025, Volume and Issue: unknown, P. 155 - 190

Published: Jan. 10, 2025

This chapter explains the use of Deep Learning Models from Artificial Intelligence (AI) that take Structural and Functional Magnetic Resonance Imaging (S/FMRI) data to classify Alzheimer's disease (AD) progression stages. Early accurate diagnosis AD is necessary for timely intervention, treatment planning, providing personalized healthcare. Current limitations in diagnostic methods necessitate using AI such as Convolutional Neural Networks (CNN) Recurrent (RNN) extract features MRI develop models predicting Mild Cognitive Impairment (MCI), AD, Dementia. Initial results a case study applied methodology demonstrated improved classification accuracy over traditional accurately classifying stages developing patient care. With more refinement technologies progress, these computational approaches can drastically positively change Healthcare professionals benefit this by understanding how be implemented deal with neurodegenerative diseases.

Language: Английский

Citations

0
Comparative Performance Analysis of ML Models for AD Diagnosis: Using Clinical and Cognitive Assessment Data DOI

Manasi Maridevarmath,

Shreya Dugani,

Uddhav Mense

et al.

Transactions of Indian National Academy of Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Language: Английский

Citations

0
Genetic and Epigenetic Biomarkers Linking Alzheimer’s Disease and Age-Related Macular Degeneration DOI Open Access
Snježana Kaštelan,

Tamara Nikuševa-Martić,

Daria Pašalić

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7271 - 7271

Published: July 2, 2024

Alzheimer's disease (AD) represents a prominent neurodegenerative disorder (NDD), accounting for the majority of dementia cases worldwide. In addition to memory deficits, individuals with AD also experience alterations in visual system. As retina is an extension central nervous system (CNS), loss retinal ganglion cells manifests clinically as decreased acuity, narrowed field, and reduced contrast sensitivity. Among extensively studied disorders, age-related macular degeneration (AMD) shares numerous aging processes risk factors NDDs such cognitive impairment that occurs AD. Histopathological investigations have revealed similarities pathological deposits found brain patients AMD. Cellular demonstrate similar associations organelles signaling pathways tissues. Despite these similarities, there are distinct genetic backgrounds underlying diseases. This review comprehensively explores differences between AMD The purpose this discuss parallels terms pathophysiology, genetics, epigenetics.

Language: Английский

Citations

3
Sensory impairments and the risk of cognitive decline and dementia across sex, age, and regions: Longitudinal insights from Europe DOI Creative Commons
Sören Möller, Jesper Lykkegaard, Rikke Syrak Hansen

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2024, Volume and Issue: 127, P. 105584 - 105584

Published: July 26, 2024

Language: Английский

Citations

3
The Impact of High-Dose Fish Oil Supplementation on Mfsd2a, Aqp4, and Amyloid-β Expression in Retinal Blood Vessels of 5xFAD Alzheimer’s Mouse Model DOI Open Access
Irena Jovanović Macura, Desanka Milanović, Vesna Tešić

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9400 - 9400

Published: Aug. 29, 2024

In patients with Alzheimer’s disease (AD) and in animal models, the increased accumulation of amyloid β (Aβ) retinal blood vessels strongly correlates brain deposits cognitive decline. The Aβ may result from impaired transcytosis a dysfunctional ocular glymphatic system AD. High-dose fish oil (FO) supplementation has been shown to significantly change expression major facilitator superfamily domain-containing protein 2a (Mfsd2a), key regulator transcytosis, Aquaporin 4 (Aqp4), an essential component retinas WT mice. We examined Mfsd2a Aqp4 4-month-old 5xFAD female mice supplemented high-dose FO for three weeks. There was significant increase compared control Additionally, observed retinas, indicative system, decreased. Simultaneously, reduced following supplementation. These findings suggest that could serve as adjunct developing new treatments aimed at improving regulation or function AD retina.

Language: Английский

Citations

1
Causal relationship between Alzheimer's disease and retinal nerve fiber layer thickness, visual disturbance: a two-sample Mendelian randomization study. DOI Creative Commons
Xuan Han, Xiaojuan Su,

Jinyan Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

Abstract Alzheimer's disease (AD) is a chronic, progressive, irreversible degenerative disorder of the central nervous system caused by multiple factors.Previous studies have demonstrated that patients with AD experience visual disturbances and reduced retinal nerve fiber layer (RNFL) thickness in early stages. If causal relationship can be established between as well RNFL thickness, then diagnosed changes.To investigate we conducted Mendelian randomization study.In this MR study, main approach was inverse variance weighted (IVW) evaluate robustness results via sensitivity analysis. The IVW revealed no significant evidence supporting association (P = 0.283, odds ratio [OR] [95% confidence interval (CI)] 0.926[0.806-1.065]) disturbances(P 0.205, 1.070[0.964-1.187]) .Consequently, potential for diagnosing early-stage through alterations remains controversial.

Language: Английский

Citations

0