Food Research International, Journal Year: 2024, Volume and Issue: 198, P. 115368 - 115368
Published: Nov. 17, 2024
Language: Английский
Science China Life Sciences, Journal Year: 2022, Volume and Issue: 65(12), P. 2354 - 2454
Published: Sept. 2, 2022
Language: Английский
Citations
243
Journal of Ovarian Research, Journal Year: 2023, Volume and Issue: 16(1)
Published: April 6, 2023
Ovarian aging is a natural and physiological process characterized by loss of quantity quality oocyte or follicular pool. As it generally accepted that women are born with finite follicle pool will go through constant decline without renewing, which, together decreased quality, makes severe situation for who advanced age but desperate healthy baby. The aim our review was to investigate mechanisms leading ovarian discussing both extra- intra- factors identify genetic characteristics aging. were identified as extra-ovarian alternation hypothalamic-pituitary-ovarian axis intra-ovarian ovary itself, including telomere, mitochondria, oxidative stress, DNA damage, protein homeostasis, aneuploidy, apoptosis autophagy. Moreover, here we reviewed related Genome-wide association studies (GWAS studies) from 2009 2021 next generation sequencing (NGS) primary insufficiency (POI) in order describe It reasonable wish more reliable anti-aging interventions the exploration genetics being progressing.
Language: Английский
Citations
64
Endocrine Reviews, Journal Year: 2022, Volume and Issue: 43(6), P. 1074 - 1096
Published: May 21, 2022
Abstract Emerging studies indicate that the Hippo pathway, a highly conserved pathway regulates organ size control, plays an important role in governing ovarian physiology, fertility, and pathology. Specific to ovary, spatiotemporal expression of major components signaling cascade are observed throughout reproductive lifespan. Observations from multiple species begin elucidate functional diversity molecular mechanisms ovary addition identification interactions with other pathways responses various external stimuli. play roles follicle growth activation, as well steroidogenesis, by regulating several key biological processes through cell proliferation, migration, differentiation, fate determination. Given importance these processes, dysregulation contributes loss follicular homeostasis disorders such polycystic syndrome (PCOS), premature insufficiency, cancers. This review highlights what is currently known about core including development, oocyte maturation, while identifying areas for future research better understand multifunctional health biology.
Language: Английский
Citations
59
Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13
Published: Aug. 19, 2022
Progressive loss of physiological integrity and accumulation degenerative changes leading to functional impairment increased susceptibility diseases are the main features aging. The ovary, key organ that maintains female reproductive endocrine function, enters aging earlier faster than other organs has attracted extensive attention from society. Ovarian is mainly characterized by progressive decline in number quality oocytes, regulatory mechanisms which have yet be systematically elucidated. This review discusses hallmarks further highlight characteristics ovarian attempt explore its clinical symptoms underlying mechanisms. Finally, intervention strategies related elaborated, especially potential role stem cells cryopreservation embryos, or tissue delay
Language: Английский
Citations
43
Aging Cell, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
ABSTRACT With advancing age, significant changes occur in the female reproductive system, most notable of which is decline oocyte quality, a key factor affecting fertility. However, mechanisms underlying aging remain poorly understood. In this study, we obtained oocytes from aged and young mice performed single‐cell transcriptome sequencing, comparing our findings with existing proteomic analyses. Our analysis revealed that one primary characteristics disruption calcium ion homeostasis. Specifically, identified two genes involved process, Calb1 Rpl23 . Experimental validation demonstrated knockdown CALB1 led to reduced levels endoplasmic reticulum mitochondria, resulting mitochondrial dysfunction meiotic defects. Further experiments suggested RPL23 may function as downstream gene CALB1, its caused dysfunction, excessive accumulation reactive oxygen species (ROS), spindle assembly Notably, overexpression these partially rescued maternal age‐related defective phenotypes, underscoring their crucial roles aging. This study provides comprehensive understanding specific mouse at resolution, supported by experimental validation, offers new directions potential targets for future research into health issues.
Language: Английский
Citations
2
Aging Cell, Journal Year: 2022, Volume and Issue: 21(2)
Published: Jan. 7, 2022
Abstract Decline in ovarian reserve with aging is associated reduced fertility and the development of metabolic abnormalities. Once mitochondrial homeostasis imbalanced, it may lead to poor reproductive cell quality aging. However, Phosphoglycerate translocase 5 (PGAM5), located membrane, necroptosis, apoptosis, mitophagy, although underlying mechanisms remain unknown. Therefore, we attempted uncover whether high phosphoglycerate mutant enzyme family member (PGAM5) expression female infertility cumulus cells, aims find out mechanism action PGAM5. We found that PGAM5 highly expressed positively aging, has potential help maintain regulate dynamics reprogramming granulosa ovaries aged mice, elderly patients. undergoes activation group translocated outer membrane mitochondria, co‐regulating DRP1; thereby increasing fission. A significant reduction mitochondria group, a serious imbalance, energy, causing metabolism shift toward glycolysis, were also reported. Since eliminated, function cells are partially reversed. total 70 patients undergoing vitro fertilization (IVF) treatment recruited this clinical study. The negatively correlated pregnancy rate infertile Hence, immense be used as diagnostic marker.
Language: Английский
Citations
37
Aging, Journal Year: 2023, Volume and Issue: 15(1), P. 246 - 260
Published: Jan. 9, 2023
The female reproductive system is quite sensitive to regulation, and external environmental stimuli may cause oxidative stress which in turn lead accelerated aging programmed cell death cells. aim of this study was investigate whether or not mitoquinone (MitoQ) could resist ROS-induced apoptosis human granulosa cells mouse oocytes. We found that the MitoQ treatment significantly reduced production reactive oxygen species (ROS) imbalance mitochondrial membrane potential. prevented an excessive fragmentation by upregulating Drp1 S637 decreasing phosphorylation. More importantly, maintained aerobic respiration anaerobic regulating reprogramming intracellular energy metabolism, enhanced cellular ATP production. effectively expressions AIFM1 PGAM5, key molecules whose were reversed only but also Our findings suggest can ameliorate deterioration caused ROS reprogram providing protection against apoptosis. presence help protecting germ under vitro culture conditions.
Language: Английский
Citations
23
Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 13
Published: Jan. 4, 2023
Premature ovarian failure (POF), or premature insufficiency (POI), is a multifactorial and heterogeneous disease characterized by amenorrhea, decreased estrogen levels increased female gonadotropin levels. The incidence of POF increasing annually, has become one the main causes infertility in women childbearing age. etiology pathogenesis are complex have not yet been clearly elucidated. In addition to genetic factors, an number studies revealed that epigenetic changes play important role occurrence development POF. However, we found very few papers summarized variations POF, systematic analysis this topic therefore necessary. article, reviewing analyzing most relevant literature research field, expound on relationship between DNA methylation, histone modification non-coding RNA expression We also analyzed how environmental factors affect through modulation. Additionally, discuss potential biomarkers treatment targets for anticipate our paper may provide new therapeutic clues improving function maintaining fertility patients.
Language: Английский
Citations
17
WIREs Mechanisms of Disease, Journal Year: 2023, Volume and Issue: 15(5)
Published: May 29, 2023
Abstract Follicular microenvironment is paramount in the acquisition of oocyte competence, which dependent on two interconnected and interdependent processes: nuclear cytoplasmic maturation. Extensive research conducted human model systems has provided evidence that those processes are disturbed with female aging. In fact, advanced maternal age (AMA) associated a lower chance pregnancy live birth, explained by age‐related decline quality/competence. This largely been attributed to mitochondria, essential for maturation, fertilization, embryo development; mitochondrial dysfunction leading oxidative stress, responsible damage, suboptimal intracellular energy levels, calcium disturbance, meiotic spindle alterations, may result aneuploidy. Nuclear‐related mechanisms justify increased aneuploidy include deoxyribonucleic acid (DNA) loss chromosomal cohesion, assembly checkpoint dysfunction, recombination errors, telomere attrition. On other hand, age‐dependent maturation failure related altered biogenesis, morphology, distribution, activity, dynamics, dysmorphic smooth endoplasmic reticulum alterations cytoskeleton. Furthermore, reproductive somatic cells also experience effects aging, including DNA compromising crosstalk between granulosa/cumulus oocytes, affected gap junctions. Old oocytes seem therefore mature an microenvironment, changes metabolites, ribonucleic (RNA), proteins, lipids. Overall, understanding implicated quality will allow establishment emerging biomarkers potential therapeutic anti‐aging strategies. article categorized under: Reproductive System Diseases > Molecular Cellular Physiology
Language: Английский
Citations
17
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13144 - 13144
Published: Dec. 6, 2024
The efficacy of assisted reproductive technologies (ARTs) in older women remains constrained, largely due to an incomplete understanding the underlying pathophysiology. This review aims consolidate current knowledge on age-associated mitochondrial alterations and their implications for ovarian aging, with emphasis causes DNA (mtDNA) mutations, repair mechanisms, future therapeutic directions. Relevant articles published up 30 September 2024 were identified through a systematic search electronic databases. free radical theory proposes that reactive oxygen species (ROS) inflict damage mtDNA impair function essential ATP generation oocytes. Oocytes face prolonged pressure persisting five decades. MtDNA exhibits limited capacity double-strand break repair, heavily depending poly ADP-ribose polymerase 1 (PARP1)-mediated single-strand breaks. process depletes nicotinamide adenine dinucleotide (NAD⁺) ATP, creating detrimental cycle where continued further compromises oocyte functionality. Interventions interrupt this destructive may offer preventive benefits. In conclusion, cumulative burden mutations demands can lead depletion elevate risk aneuploidy, ultimately contributing ART failure women.
Language: Английский
Citations
9