Methods in enzymology on CD-ROM/Methods in enzymology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Nature Aging, Journal Year: 2022, Volume and Issue: 2(12), P. 1112 - 1129
Published: Dec. 22, 2022
Language: Английский
Citations
100
Nature Aging, Journal Year: 2023, Volume and Issue: 3(11), P. 1372 - 1386
Published: Oct. 16, 2023
Language: Английский
Citations
84
Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 84, P. 101833 - 101833
Published: Dec. 22, 2022
Language: Английский
Citations
46
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: June 27, 2023
Aging is an inevitable process influenced by genetics, lifestyles, and environments. With the rapid social economic development in recent decades, proportion of elderly has increased rapidly worldwide, many aging-related diseases have shown upward trend, including nervous system diseases, cardiovascular metabolic cancer. The rising burden become urgent global health challenge requires immediate attention solutions. Natural products been used for a long time to treat various human diseases. primary cellular pathways that mediate longevity-extending effects natural involve nutrient-sensing pathways. Among them, sirtuin, AMP-activated protein kinase, mammalian target rapamycin, p53, insulin/insulin-like growth factor-1 signaling are most widely studied. Several studies reviewed individual compounds on aging along with underlying mechanisms. from food sources, such as polyphenols, saponins, alkaloids, polysaccharides, classified antiaging promote prolong life via In this article, we several recently identified potential properties highlighted their molecular discovery use dietary supplements can prevent multiple humans will be beneficial. Thus, review provides theoretical background existing agents.
Language: Английский
Citations
28
Exploration of Targeted Anti-tumor Therapy, Journal Year: 2024, Volume and Issue: 5(1), P. 187 - 207
Published: Feb. 28, 2024
Cancer is the leading cause of death globally superseded only by cardiovascular diseases, and novel strategies to overcome therapeutic resistance against existing cancer treatments are urgently required. Myeloid-derived suppressor cells (MDSCs) immature myeloid with potent immunosuppressive capacity well-established anti-tumour effectors such as natural killer (NK cells) T thereby promoting initiation progression. Critically, MDSCs readily identified in almost all tumour types human patients, numerous studies past decade have recognised their role contributing four pillars modern treatment, namely surgery, chemotherapy, radiotherapy immunotherapy. suppress immunity through a plethora mechanisms including well-characterised arginase 1 (Arg1), inducible nitric oxide synthase (iNOS) reactive oxygen species (ROS)-mediated pathways, along several other more recently discovered. largely absent healthy homeostatic states predominantly exist pathological conditions, making them attractive targets. However, lack specific markers for date greatly hindered development, currently there no clinically approved drugs that specifically target MDSCs. Methods deplete inhibit function will be crucial advancing treatment resistance. This review provides detailed overview current understandings behind MDSC-mediated suppression immunity, discusses potential MDSC
Language: Английский
Citations
9
Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)
Published: Feb. 5, 2025
Abstract Neuroinflammation is closely linked to aging, which damages the structure and function of brain. It caused by intricate interactions immune cells in aged brain, such as dysregulated glial dysfunctional astrocytes. Aging-associated chronic low inflammation, referred neuroinflammaging, shows an upregulated proinflammatory response. Autophagy senescence play crucial roles moderators aging neuroinflammatory responses. The neuroimmune system, dystrophic cells, release factors alter blood-brain barrier, causing a landscape. Chronic inflammation combined with deteriorating neurons exacerbate neurological disorders decline cognitive function. This review highlights neuroinflammaging mechanism associated interplay central nervous system cellular senescence, autophagy regulation brain's under conditions. Moreover, microglia peripheral process brain have also been discussed. Determining treatment targets comprehending mechanisms that influence necessary decrease neuroinflammation.
Language: Английский
Citations
1
Antioxidants, Journal Year: 2022, Volume and Issue: 11(11), P. 2189 - 2189
Published: Nov. 5, 2022
Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) are ocular diseases. Because their pathogenesis is unclear, it challenging combat Cellular senescence cellular response characterized by cell cycle arrest. an important contributor aging diseases through the alteration secretion senescence-associated secretory phenotypes. As driver stress-induced premature senescence, oxidative stress triggers inducing markers via reactive oxygen species mitochondrial dysfunction. In this review, we focused on mechanism retinal cells its role AMD.
Language: Английский
Citations
32
Poultry Science, Journal Year: 2023, Volume and Issue: 102(9), P. 102879 - 102879
Published: June 18, 2023
Spermidine have been reported a role in antioxidative, antiaging, and antiinflammatory. Oxidative stress causes granulosa cell (GC) apoptosis, follicular atresia, impairs poultry reproductive functions. Studies found that autophagy is the protective mechanism against antioxidant apoptosis cells. However, relationship between spermidine-induced autophagy, oxidative stress, goose GCs remains unclear. In this study, we investigated to mediate spermidine effects on alleviation of GCs. Follicular were treated with combination 3-Nitropropanoic acid (3-NPA), rapamycin (RAPA), chloroquine (CQ) or hydrogen peroxide, RAPA, CQ. upregulated ratio LC3-II/I, inhibited accumulation p62 protein, induced autophagy. 3-NPA treatment significantly increased ROS production, MDA content, SOD activity, cleaved CASPASE-3 protein expression, decreased BCL-2 expression by 3-NPA. addition, peroxide-induced was spermidine. inhibitory effect eliminated under chloroquine. Our results demonstrated relieved inducing indicating has great potential maintain proteostasis sustain viability geese.
Language: Английский
Citations
19
Antioxidants, Journal Year: 2023, Volume and Issue: 12(7), P. 1424 - 1424
Published: July 14, 2023
The aim of this study was to compile a detailed phytochemical profile and assess the antioxidant properties bee-collected pollen (PBP) obtained from corn poppy (Papaver rhoeas L.) plants. To achieve this, lipid fraction prepared for quantifying fatty acids using GC-FID. Extractable alkaline-hydrolysable PBP fractions (obtained defatted sample) were used determine qualitative quantitative profiles phenolic compounds, phenylamides alkaloids UHPLC/Q-ToF-MS. Additionally, various spectrophotometric assays (TAC, FRP, CUPRAC, DPPH⦁) conducted evaluate properties. Phenolic compounds more present in extractable than fraction. Luteolin predominant compound fraction, followed by tricetin derivatives kaempferol. This presents one first reports on quantification aglycone outside Myrtaceae plant family. exhibited different profile, with significantly lower amount phenolics. Kaempferol/derivatives, specific like ferulic 5-carboxyvanillic acids, (epi)catechin 3-O-gallate Regarding phenylamides, demonstrated diverse range these bioactive notable abundance spermine derivatives. In contrast, hydrolysable contained six spermidine derivative. examined also revealed presence seventeen alkaloids, belonging benzylisoquinoline, berberine isoquinoline classes. fatty-acid confirmed prevalence unsaturated acids. Furthermore, both significant activity, showing particularly high activity. Among conducted, CUPRAC assay highlighted exceptional ability PBP’s reduce cupric ions.
Language: Английский
Citations
18
The Journal of Nutritional Biochemistry, Journal Year: 2024, Volume and Issue: 125, P. 109569 - 109569
Published: Jan. 5, 2024
Language: Английский
Citations
7