Role of Neurotropic Viruses in Brain Metastasis of Breast Cancer: Mechanisms and Therapeutic Implications DOI

Ziran Qiu,

Xinyu Liu, Wenqing Cao

et al.

Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(5)

Published: Sept. 1, 2024

ABSTRACT Neurotropic viruses have been implicated in altering the central nervous system microenvironment and promoting brain metastasis of breast cancer through complex interactions involving viral entry mechanisms, modulation blood–brain barrier, immune evasion, alteration tumour microenvironment. This narrative review explores molecular mechanisms by which neurotropic such as Herpes Simplex Virus, Human Immunodeficiency Japanese Encephalitis Rabies Virus facilitate metastasis, focusing on their ability to disrupt barrier integrity, modulate responses, create a permissive environment for metastatic cell survival growth within system. Current therapeutic implications challenges targeting prevent or treat are discussed, highlighting need innovative strategies multidisciplinary approaches virology, oncology, immunology.

Language: Английский

Glial Perturbation in Metal Neurotoxicity: Implications for Brain Disorders DOI Creative Commons
Olayemi K. Ijomone, Ukwubile Ileje Inelo, Vivian O. Aneke

et al.

Neuroglia, Journal Year: 2025, Volume and Issue: 6(1), P. 4 - 4

Published: Jan. 6, 2025

Overexposure of humans to heavy metals and essential poses a significant risk for the development neurological neurodevelopmental disorders. The mechanisms through which these exert their effects include generation reactive oxygen species, mitochondrial dysfunction, activation inflammatory pathways, disruption cellular signaling. function glial cells in brain maintenance homeostasis cannot be overlooked. are particularly susceptible metal-induced neurotoxicity. Accumulation promotes microglial activation, triggering responses that can coincide with other neurotoxicity, inducing alteration synaptic transmission, cognitive deficit, neuronal damage. In this review, we highlighted role dysfunction some selected neurodegenerative diseases We further dive into how exposure such as nickel, manganese, methyl mercury, cadmium, iron, arsenic, lead affect functions microglia, astrocytes, oligodendrocytes they on relation Potential therapeutic interventions use new improved chelating agents antioxidant therapies might approach alleviating perturbations.

Language: Английский

Citations

3
The Interplay between Glioblastoma Cells and Tumor Microenvironment: New Perspectives for Early Diagnosis and Targeted Cancer Therapy DOI Creative Commons
Assunta Virtuoso, Giuseppa D’Amico, Federica Scalia

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(4), P. 331 - 331

Published: March 29, 2024

Glioblastoma multiforme (GBM) stands out as the most tremendous brain tumor, constituting 60% of primary cancers, accompanied by dismal survival rates. Despite advancements in research, therapeutic options remain limited to chemotherapy and surgery. GBM molecular heterogeneity, intricate interaction with tumor microenvironment (TME), non-selective treatments contribute neoplastic relapse. Diagnostic challenges arise from advanced-stage detection, necessitating exploration novel biomarkers for early diagnosis. Using data literature a bioinformatic tool, current manuscript delineates interplay between human GBM, astrocytes, myeloid cells, underscoring selected protein pathways belonging astroglia lineage, which can be considered targeted therapies. Moreover, pivotal role extracellular vesicles (EVs) orchestrating favorable cancer progression is highlighted, suggesting their utility identifying

Language: Английский

Citations

10
The complexity of immune evasion mechanisms throughout the metastatic cascade DOI

Nicole M. Haynes,

Thomas B Chadwick, Belinda S. Parker

et al.

Nature Immunology, Journal Year: 2024, Volume and Issue: 25(10), P. 1793 - 1808

Published: Sept. 16, 2024

Language: Английский

Citations

10
The dual roles of serotonin in antitumor immunity DOI Creative Commons
Yingru Zhang, Yan Wang

Pharmacological Research, Journal Year: 2024, Volume and Issue: 205, P. 107255 - 107255

Published: June 12, 2024

Research has shown that a significant portion of cancer patients experience depressive symptoms, often accompanied by neuroendocrine hormone imbalances. Depression is frequently associated with decreased levels serotonin the alternate name 5-hydroxytryptamine (5-HT), leading to common use selective reuptake inhibitors (SSRIs) as antidepressants. However, role in tumor regulation remains unclear, its expression displaying varied effects across different types tumors. Tumor initiation and progression are closely intertwined immune function human body. Neuroimmunity, an interdisciplinary subject, played unique study relationship between psychosocial factors tumors their mechanisms recent years. This article offers comprehensive review serotonin's regulatory roles onset progression, well impacts on cells microenvironment. The aim stimulate further research discover novel targets for treatment.

Language: Английский

Citations

6
Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies DOI Creative Commons
Min‐Hee Yi, Jinkyung Lee,

Subin Moon

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 216 - 216

Published: Jan. 16, 2025

Background: Brain cancers represent a formidable oncological challenge characterized by their aggressive nature and resistance to conventional therapeutic interventions. The tumor microenvironment has emerged as critical determinant of progression treatment efficacy. Within this complex ecosystem, microglia macrophages play fundamental roles, forming intricate networks with peripheral immune cell populations, particularly T cells. precise mechanisms underlying microglial interactions cells contributions immunosuppression remain incompletely understood. Methods: This review comprehensively examines the cellular dialogue between in two prominent brain malignancies: primary glioblastoma secondary metastases. Results: Through comprehensive current scientific literature, we explore nuanced through which microglial-T modulate growth responses. Conclusions: Our analysis seeks unravel communication pathways that potentially underpin progression, ultimate goal illuminating novel strategies for cancer intervention.

Language: Английский

Citations

0
Deciphering the Blood–Brain Barrier Paradox in Brain Metastasis Development and Therapy DOI Open Access
John Peters,

Chubei Teng,

Kang Peng

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 298 - 298

Published: Jan. 17, 2025

Gatekeeper or accomplice? That is the paradoxical role of blood-brain barrier (BBB) in developing brain metastasis (BM). BM occurs when cancerous cells from primary cancer elsewhere body gain ability to metastasize and invade parenchyma despite formidable defense BBB. These metastatic manipulate BBB's components, changing them gatekeepers accomplices that aid their progression into tissue. This dual BBB-as both a protective system potential facilitator cells-highlights its complexity. Even with therapy such as chemotherapy, usually recurs due BBB limiting crossing drugs via efflux transporters; therefore, treatment efficacy limited. The pathophysiology also complex, our understanding interplay between components still needs be improved. However, advancements clinical research are helping bridge knowledge gap, which essential for effective therapy. By targeting neurovascular unit polarization microglia, astrocytes, pericytes, by utilizing technological tools like focused ultrasound transiently disrupt therapeutic nanoparticles improve drug delivery efficiency tissue, we can better address this pathology. narrative review delves latest literature analyze manifestation explores avenues BBB-tumor cell interaction.

Language: Английский

Citations

0
Mechanistic role of stromal cancer-associated fibroblasts in tumorigenesis and brain metastasis: highlighting drug resistance and targeted therapy DOI
Md Rashedunnabi Akanda,

Umme Lubaba,

Md Khalesur Rahman

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155918 - 155918

Published: March 1, 2025

Language: Английский

Citations

0
Multifaceted interactions between cancer cells and glial cells in brain metastasis DOI Creative Commons

Kojiro Ishibashi,

Eishu Hirata

Cancer Science, Journal Year: 2024, Volume and Issue: 115(9), P. 2871 - 2878

Published: July 11, 2024

Abstract Cancer brain metastasis has a poor prognosis, is commonly observed in clinical practice, and the number of cases increasing as overall cancer survival improves. However, experiments mouse models have shown that itself an inefficient process. One reason for this inefficiency microenvironment, which differs significantly from other organs, making it difficult cells to adapt. The microenvironment consists unique resident cell types such neurons, oligodendrocytes, astrocytes, microglia. Accumulating evidence over past decades suggests interactions between glial can positively or negatively influence development metastasis. Nevertheless, elucidating complex remains challenging, part due limitations existing experimental culture. In review, we first provide overview culture methods then examine recent discoveries regarding metastatic surrounding cells, with special focus on astrocytes Finally, discuss future perspectives understanding multifaceted treatment tumors.

Language: Английский

Citations

2
Lipocalin-2 promotes breast cancer brain metastasis by enhancing tumor invasion and modulating brain microenvironment DOI Creative Commons
Yang Zhao,

Xiaogen Tang,

Tingting Lei

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Aug. 12, 2024

Breast cancer is the leading diagnosed in women globally, with brain metastasis emerging as a major cause of death, particularly human epidermal growth factor receptor 2 positive and triple-negative breast subtypes. Comprehensive understanding molecular foundations central nervous system metastases imperative for evolution efficacious treatment strategies. Lipocalin-2 (LCN2), secreted iron transport protein multiple functions, has been linked to progression (BCBM). In primary tumors, LCN2 promotes proliferation angiogenesis cells, triggers epithelial-mesenchymal transition, interacts matrix metalloproteinase-9, thereby facilitating reorganization extracellular enhancing cell invasion migration. microenvironment, undermines blood-brain barrier facilitates tumor seeding by modulating behavior key cellular components. summary, this review meticulously examines fuel role BCBM cascade, investigates potential mechanisms involved. It highlights both therapeutic target biomarker, indicating that interventions targeting may offer improved outcomes patients afflicted BCBM.

Language: Английский

Citations

2
Exerkines mitigating Alzheimer's disease progression by regulating inflammation: Focusing on macrophage/microglial NLRP3 inflammasome pathway DOI Creative Commons

Jaehwan Cheon,

Soon-Yong Kwon, Mikyung Kim

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

Abstract Recent research highlights the critical role of inflammation in accelerating amyloid beta and phosphorylated tubulin‐associated protein tau cascade Alzheimer's disease (AD) progression. Emerging evidence suggests that exercise influences AD by modulating inflammatory responses. We conducted a comprehensive search across multiple online databases. Our approach focused on previous recent studies exploring links among inflammation, AD, effects exercise, specifically targeting articles books published English. pointed out extends from periphery to central nervous system, facilitated macrophage/microglial NLRP3 (nucleotide‐binding domain, leucine rich–containing family, pyrin domain–containing 3) inflammasome signaling, which exacerbates classical mechanisms. Moreover, we provided further insights into modulation signaling through exerkines, may contribute mitigating development. These deepen our understanding mechanisms offer potential for identifying key therapeutic targets biomarkers crucial effective management treatment. Highlights Inflammation is potentially linked acceleration pathogenesis, including pathways involving tau, mediated pro‐inflammatory cytokines. Inflammation, initiated nucleotide‐binding 3 (NLRP3) pathway within M1‐type macrophages/microglia, neuroinflammation Exercise has reduce development influencing via exerkines.

Language: Английский

Citations

2