Pharmacy Information, Journal Year: 2024, Volume and Issue: 13(04), P. 334 - 340
Published: Jan. 1, 2024
Language: Английский
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0313962 - e0313962
Published: Dec. 3, 2024
Cancer cells are known to express the Warburg effect—increased glycolysis and formation of lactic acid even in presence oxygen—as well as high glutamine uptake. In tumors, cancer surrounded by collagen, immune cells, neoangiogenesis. Whether collagen formation, neoangiogenesis, inflammation associated with effect needs be established. Metabolic modelling has proven a tool choice understand biological reality better make silico predictions. Elementary Flux Modes (EFMs) essential for conducting an unbiased decomposition metabolic model into its minimal functional units. EFMs can investigated using our tool, aspefm , innovative approach based on logic programming where constraints incorporated. These allow networks characterized regardless their size. Using human cell containing markers, we derived subset relevance effect. Within this model, analysis provided more adequate results than parsimonious flux balance sampling. Upon further inspection, EFM best linear regression fit lines exometabolomics data was selected. The pathway, presenting effect, synthesis, angiogenesis, release showed that production possible directly de novo from uptake without extracellular import glycine proline, collagen’s main constituents.
Language: Английский
Citations
1
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: July 2, 2024
This study aims to assess the current research status, focus areas, and developmental trends in nasopharyngeal carcinoma (NPC) through a bibliometric analysis. Articles focusing on NPC published from 2000 2023 were retrieved Web of Science database. VOSviewer CiteSpace used for visual A total 14516 related publications retrieved. There has been steady increase number NPC-related 2023. China was dominant country this field with 8948 papers (61.64%), followed by USA (2234, 15.39%). Sun Yat-sen University most influential institution, while Ma J prolific author. Furthermore, Head And Neck-journal For The Sciences Specialties Of Neck journal. International Journal Radiation Oncology Biology Physics had highest citation counts. "Introduction chemotherapy", "Concurrent "Epithelial-mesenchymal transition", "Cancer stem cells", "MicroRNAs", "LncRNA", "Exosomes", "Biomarker" common keywords. reference "Chen YP, 2019, Lancet" citations strong outbreak value. past two decades have witnessed significant NPC. optimization treatment mode is widely studied aspect at present. mechanism occurrence development favorable diagnostic therapeutic targets are hotspots future.
Language: Английский
Citations
1
Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(21)
Published: Nov. 1, 2024
ABSTRACT Background Melanoma, a highly aggressive skin cancer, is characterized by rapid progression and high metastatic potential, presenting significant challenges in clinical oncology. A critical aspect of melanoma biology its metabolic reprogramming, which supports tumor growth, survival, therapeutic resistance. Objective This review aims to explore the key molecular mechanisms driving alterations their implications for developing strategies. Methods Pubmed search was conducted analyze literature discussing Warburg effect, mitochondrial dysfunction, enhanced lipid metabolism, epigenetic modifications, microenvironment. Results Metabolic reprogramming proliferation, survival. Understanding these complex dynamics provides valuable insights targeted Conclusion Potential interventions aimed at disrupting metabolism highlight promise precision medicine improving treatment outcomes cutaneous By targeting vulnerabilities, novel approaches could significantly enhance management prognosis melanoma.
Language: Английский
Citations
0
Pharmacy Information, Journal Year: 2024, Volume and Issue: 13(04), P. 334 - 340
Published: Jan. 1, 2024
Language: Английский
Citations
0