Molecules and Cells, Journal Year: 2022, Volume and Issue: 45(9), P. 640 - 648
Published: Aug. 24, 2022
CD133, also known as prominin-1, was first identified a biomarker of mammalian cancer and neural stem cells. Previous studies have shown that the
Language: Английский
Frontiers in Neuroscience, Journal Year: 2019, Volume and Issue: 13
Published: Nov. 29, 2019
Salt (sodium chloride) is an essential dietary requirement, but excessive consumption has long-term adverse consequences. A high-salt diet (HSD) increases the risk of chronic diseases such as cardiovascular conditions and diabetes also associated with poor sleep quality. Little known, however, about neural circuit mechanisms that mediate HSD-induced changes. In this study, we sought to identify effects HSD on related Drosophila. Strikingly, found causes young Drosophila exhibit a fragmented phenotype similar normal aging individuals. Importantly, further showed slightly impairs circadian rhythms changes are dependent rhythm system. addition, demonstrated dopaminergic-system dependent. Together, these results provide insight into how elevated salt in can affect
Language: Английский
Citations
16
Memetic Computing, Journal Year: 2023, Volume and Issue: 15(2), P. 237 - 257
Published: May 13, 2023
Abstract Modelling the biology behind animal behaviour has attracted great interest in recent years. Nevertheless, neuroscience and artificial intelligence face challenge of representing emulating robots. Consequently, this paper presents a biologically inspired motivational model to control biological functions autonomous robots that interact with emulate human behaviour. The is intended produce fully autonomous, natural, can adapt both familiar unexpected situations human–robot interactions. primary contribution present novel methods for modelling robot’s internal state generate deliberative reactive behaviour, how it perceives evaluates stimuli from environment, role emotional responses. Our architecture emulates essential such as neuroendocrine responses, circadian ultradian rhythms, motivation, affection, social Neuroendocrinal substances sleep, wakefulness, emotion. Deficits these processes regulate affective states, significantly influencing decision-making and, therefore, its We evaluated by observing long-term robot Mini while interacting people. experiment assessed varied evolved depending on variables external situations, adapting different conditions. outcomes show an appropriate cope deficits controlling sleep–wake cycle, stress, when acting
Language: Английский
Citations
5
Biology, Journal Year: 2023, Volume and Issue: 12(10), P. 1294 - 1294
Published: Sept. 28, 2023
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. The management PD a challenging aspect for general physicians and neurologists. It characterized by progressive loss dopaminergic neurons. Impaired α-synuclein secretion dopamine release may cause mitochondrial dysfunction perturb energy metabolism, subsequently altering activity survival neurons, thus perpetuating process in PD. While etiology remains multifactorial, emerging research indicates crucial role circadian its pathogenesis. Researchers have revealed that sleep disorders are among subjects disruption rhythms can increase risk Hence, understanding findings biology from translational important reducing neurodegeneration improving quality life. In this review, we discuss intricate relationship between cellular metabolism summarizing evidence animal models human studies. Understanding metabolic basis shed light on novel therapeutic approaches to restore rhythm, preserve function, ameliorate progression. Further investigation into complex interplay rhythm pathogenesis essential development targeted therapies interventions alleviate burden debilitating disorder.
Language: Английский
Citations
4
Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e37130 - e37130
Published: Aug. 29, 2024
Language: Английский
Citations
1
Molecules and Cells, Journal Year: 2022, Volume and Issue: 45(9), P. 640 - 648
Published: Aug. 24, 2022
CD133, also known as prominin-1, was first identified a biomarker of mammalian cancer and neural stem cells. Previous studies have shown that the
Language: Английский
Citations
7