Therapeutic Advances in Chronic Disease,
Journal Year:
2020,
Volume and Issue:
11
Published: Jan. 1, 2020
Aging
leads
to
a
high
burden
on
society,
both
medically
and
economically.
Cellular
senescence
plays
an
essential
role
in
the
initiation
of
aging
age-related
diseases.
Recent
studies
have
highlighted
therapeutic
value
senescent
cell
deletion
natural
many
disorders.
However,
strategies
for
manipulating
cellular
are
still
at
early
stage
development.
Among
these
strategies,
drugs
that
target
arguably
most
highly
anticipated.
Many
recent
demonstrated
variety
exhibit
healthy
effects.
In
this
review,
we
summarize
different
types
promoting
-
such
as
senolytics,
senescence-associated
secretory
phenotype
(SASP)
inhibitors,
nutrient
signaling
regulators
provide
update
their
potential
merits.
Taken
together,
our
review
synthesizes
advancements
potentialities
with
regard
clinical
implications.
PubMed,
Journal Year:
2020,
Volume and Issue:
19, P. 1017 - 1037
Published: Jan. 1, 2020
Osteoporosis
is
a
metabolic
bone
disease
that,
on
cellular
level,
results
from
osteoclastic
resorption
not
compensated
by
osteoblastic
formation.
This
causes
bones
to
become
weak
and
fragile,
thus
increasing
the
risk
of
fractures.
Traditional
pathophysiological
concepts
osteoporosis
focused
endocrine
mechanisms
such
as
estrogen
or
vitamin
D
deficiency
well
secondary
hyperparathyroidism.
However,
research
over
last
decades
provided
exiting
new
insights
into
contributing
onset
osteoporosis,
which
go
far
beyond
this.
Selected
interactions
between
immune
system,
gut
microbiome,
senescence
are
reviewed
in
this
article.
Furthermore,
an
overview
currently
available
medications
including
antiresorptive
forming
drugs
outlook
potential
future
treatment
options
given.
Experimental & Molecular Medicine,
Journal Year:
2021,
Volume and Issue:
53(11), P. 1689 - 1696
Published: Nov. 1, 2021
Abstract
Osteoarthritis
(OA)
is
the
most
common
form
of
arthritis.
It
characterized
by
progressive
destruction
articular
cartilage
and
development
chronic
pain
constitutes
a
considerable
socioeconomic
burden.
Currently,
pharmacological
treatments
mostly
aim
to
relieve
OA
symptoms
associated
with
inflammation
pain.
However,
increasing
understanding
pathology,
several
potential
therapeutic
targets
have
been
identified,
enabling
disease-modifying
drugs
(DMOADs).
By
targeting
inflammatory
cytokines,
matrix-degrading
enzymes,
Wnt
pathway,
OA-associated
pain,
DMOADs
successfully
modulate
degenerative
changes
in
osteoarthritic
cartilage.
Moreover,
regenerative
approaches
counterbalance
loss
matrix
stimulating
chondrogenesis
endogenous
stem
cells
anabolism
chondrocytes.
Emerging
strategies
include
senolytic
or
RNA
therapeutics
eliminate
cellular
molecular
sources
factors
driving
OA.
This
review
describes
current
developmental
status
corresponding
results
from
preclinical
clinical
trials
discusses
emerging
treat
Aging and Disease,
Journal Year:
2022,
Volume and Issue:
13(1), P. 103 - 103
Published: Jan. 1, 2022
Aging
is
a
prominent
risk
factor
for
cardiovascular
diseases,
which
the
leading
cause
of
death
around
world.
Recently,
cellular
senescence
has
received
potential
attention
as
promising
target
in
preventing
including
acute
myocardial
infarction,
atherosclerosis,
cardiac
aging,
pressure
overload-induced
hypertrophy,
heart
regeneration,
hypertension,
and
abdominal
aortic
aneurysm.
Here,
we
discuss
mechanisms
underlying
describe
involvement
senescent
cells
(including
cardiomyocytes,
endothelial
cells,
vascular
smooth
muscle
fibroblasts/myofibroblasts
T
cells)
age-related
diseases.
Then,
highlight
targets
(SIRT1
mTOR)
that
regulating
disorders.
Furthermore,
review
evidence
can
exert
both
beneficial
detrimental
implications
diseases
on
context-dependent
manner.
Finally,
summarize
emerging
pro-senescent
or
anti-senescent
interventions
their
therapeutic
Radiation Oncology,
Journal Year:
2023,
Volume and Issue:
18(1)
Published: Jan. 13, 2023
Abstract
The
limitation
of
cancer
radiotherapy
does
not
derive
from
an
inability
to
ablate
tumor,
but
rather
do
so
without
excessively
damaging
critical
tissues
and
organs
adversely
affecting
patient’s
quality
life.
Although
cellular
senescence
is
a
normal
consequence
aging,
there
increasing
evidence
showing
that
the
radiation-induced
in
both
tumor
adjacent
contributes
recurrence,
metastasis,
resistance
therapy,
while
chronic
senescent
cells
tissue
organ
are
source
many
late
effects.
In
this
review,
we
discuss
how
identify
using
various
bio-markers
role
so-called
senescence-associated
secretory
phenotype
characteristics
on
pathogenesis
We
also
therapeutic
options
eliminate
either
senolytics
and/or
senostatics.
Finally,
discussion
reprogramming
presented,
another
promising
avenue
improve
gain
radiotherapy.
Advanced Science,
Journal Year:
2020,
Volume and Issue:
7(23)
Published: Oct. 19, 2020
Aging
is
a
physiological
decline
in
both
structural
homeostasis
and
functional
integrity,
progressively
affecting
organismal
health.
A
major
hallmark
of
aging
the
accumulation
senescent
cells,
which
have
entered
state
irreversible
cell
cycle
arrest
after
experiencing
inherent
or
environmental
stresses.
Although
cellular
senescence
essential
several
events,
it
plays
detrimental
role
large
array
age-related
pathologies.
Recent
biomedical
advances
specifically
targeting
cells
to
improve
healthy
aging,
alternatively,
postpone
natural
diseases,
strategy
termed
senotherapy,
attracted
substantial
interest
scientific
medical
communities.
Challenges
for
research
are
highlighted
potential
avenues
that
can
be
leveraged
therapeutic
interventions
control
disorders
current
era
precision
medicine.
