Circular RNAs in glioblastoma DOI
Elham Ghadami,

Mahjoobeh Jafari,

Masoumeh Razipour

et al.

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: unknown, P. 120003 - 120003

Published: Oct. 1, 2024

Language: Английский

Circular RNAs in cancer DOI Creative Commons
Yang Guo, Qiang Huang,

Heng Yu

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(2)

Published: Feb. 1, 2025

Abstract Circular RNA (circRNA), a subtype of noncoding RNA, has emerged as significant focus in research due to its distinctive covalently closed loop structure. CircRNAs play pivotal roles diverse physiological and pathological processes, functioning through mechanisms such miRNAs or proteins sponging, regulation splicing gene expression, serving translation templates, particularly the context various cancers. The hallmarks cancer comprise functional capabilities acquired during carcinogenesis tumor progression, providing conceptual framework that elucidates nature malignant transformation. Although numerous studies have elucidated role circRNAs cancers, their functions development chemoradiotherapy resistance remain unexplored clinical applications circRNA‐based translational therapeutics are still infancy. This review provides comprehensive overview circRNAs, covering biogenesis, unique characteristics, functions, turnover mechanisms. We also summarize involvement relevance biomarkers therapeutic targets, especially thyroid (TC). Considering potential fascination therapeutics, “Ying‐Yang” dynamic regulations TC warrant vastly dedicated investigations.

Language: Английский

Citations

1
The Glioblastoma CircularRNAome DOI Open Access
Alexandru Tirpe, Cristian Streianu,

Stefana Maria Tirpe

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14545 - 14545

Published: Sept. 26, 2023

Glioblastoma remains one of the most aggressive cancers brain, warranting new methods for early diagnosis and more efficient treatment options. Circular RNAs (circRNAs) are rather entities with increased stability compared to their linear counterparts that interact proteins act as microRNA sponges, among other functions. Herein, we provide a critical overview recently described glioblastoma-related circRNAs in literature, focusing on roles glioblastoma cancer cell proliferation, survival, migration, invasion metastasis, metabolic reprogramming, therapeutic resistance. The main regulating processes due regulatory essential oncogenic pathways, including MAPK, PI3K/AKT/mTOR, Wnt, which influenced by various circRNAs. present work pictures wide implication glioblastoma, thus highlighting potential future biomarkers targets/agents.

Language: Английский

Citations

9
The Role of the Dysregulation of circRNAs Expression in Glioblastoma Multiforme DOI
Yafei Wang, Ying Yu, Jiahua Yu

et al.

Journal of Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 75(1)

Published: Jan. 22, 2025

Language: Английский

Citations

0
circFOXK2 Stabilizes STMN1 mRNA via PABPC1 to Promote the Progression of NSCLC DOI Creative Commons
Wei Chen, Weijun Zhao,

Xianqiao Wu

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(5)

Published: Feb. 27, 2025

Lung cancer has a notably high incidence and mortality rate, understanding its occurrence development is crucial for effective treatment. Circular RNA closely associated with tumor progression, playing role in tumorigenesis by regulating gene expression influencing cell proliferation apoptosis. This study aims to explore the circFOXK2 NSCLC elucidate underlying mechanisms. qRT-PCR Western Blot analyzed expressions of circFOXK2, STMN1, PABPCA lines, as well their relationships. The roles STMN1 proliferation, invasion, migration cells were assessed through CCK8, EDU, Transwell experiments. pulldown assays mass spectrometry elucidated RNA-binding proteins circFOXK2. Subcutaneous tail vein lung metastasis experiments impact on growth vivo. In this study, we identified which significantly overexpressed NSCLC, bioinformatics screening. Elevated levels enhance cells. Furthermore, such co-IP spectrometry, found that interacts PABPC1 form complex, correlates positively progression tumors. Simultaneously, circFOXK2/PABPC1 complex increases stability mRNA, thereby promoting transcription translation STMN1. Our experimental results indicate oncogenic effect requires assistance summary, have demonstrated significant NSCLC.

Language: Английский

Citations

0
Directed Circularization of a Short RNA DOI
Cathrin E. Hansen,

Danilo Springstubbe,

Sabine Müller

et al.

Methods in molecular biology, Journal Year: 2024, Volume and Issue: unknown, P. 209 - 226

Published: Jan. 1, 2024

Language: Английский

Citations

1
Hedgehog pathway and cancer: A new area (Review) DOI
Deyi Shen, Yuwei Xia, Yuhan Fu

et al.

Oncology Reports, Journal Year: 2024, Volume and Issue: 52(3)

Published: July 10, 2024

Language: Английский

Citations

1
Circular RNAs in glioblastoma DOI
Elham Ghadami,

Mahjoobeh Jafari,

Masoumeh Razipour

et al.

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: unknown, P. 120003 - 120003

Published: Oct. 1, 2024

Language: Английский

Citations

0