Causal Relationship and Potential Common Pathogenic Mechanisms Between Alopecia Areata and Related Cancer DOI Creative Commons
Zexin Zhu,

Xiaoxue Wang

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2024, Volume and Issue: Volume 17, P. 2911 - 2921

Published: Dec. 1, 2024

Alopecia areata (AA) is an autoimmune skin disease. Observational studies have reported association between AA and cancer. However, the causal relationship cancer has not been reported. We employed a two-sample Mendelian randomization (MR) study to assess causality 17 subtypes of cancers.

Language: Английский

Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases DOI Creative Commons

Eman K. E. Anwer,

Muhammad Ajagbe,

Mohamed Sherif

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 100 - 100

Published: Jan. 3, 2025

The gut microbiota, a dynamic ecosystem of trillions microorganisms, produces secondary metabolites that profoundly influence host health. Recent research has highlighted the significant role these metabolites, particularly short-chain fatty acids, indoles, and bile in modulating immune responses, impacting epigenetic mechanisms, contributing to disease processes. In gastrointestinal (GI) cancers such as colorectal, liver, gastric cancer, microbial can drive tumorigenesis by promoting inflammation, DNA damage, evasion. Conversely, same hold therapeutic promise, potentially enhancing responses chemotherapy immunotherapy even directly suppressing tumor growth. addition, play crucial roles infectious susceptibility resilience, mediating pathways impact pathogen resistance. By consolidating recent insights into microbiota's shaping health, this review underscores potential targeting microbiome-derived for treating GI diseases calls further microbiome-based interventions.

Language: Английский

Citations

1
Causal effect of gut microbiota on pancreatic cancer: A Mendelian randomization and colocalization study DOI Creative Commons
Xin Li, Zhihai Liang

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(8)

Published: March 25, 2024

Abstract The causal relationship between gut microbiota (GM) and pancreatic cancer (PC) remains unclear. This study aimed to investigate the potential genes underlying this mechanism. GM Genome‐wide association (GWAS) summary data were from MiBioGen consortium. PC GWAS National Human Genome Research Institute‐European Bioinformatics Institute (NHGRI‐EBI) Catalogue. To detect PC, we implemented three complementary Mendelian randomization (MR) methods: Inverse Variance Weighting (IVW), MR‐Egger Weighted Median, followed by sensitivity analyses. Furthermore, integrated with blood cis‐expression quantitative trait loci (eQTLs) cis‐DNA methylation QTL (mQTLs) using Summary data‐based Randomization (SMR) methods. integration prioritize GM‐affecting through SMR analysis of two molecular traits. cis‐eQTLs cis‐mQTLs summarized Cancer Atlas (TCGA) data. Through colocalization cis‐QTLs data, identified common that influence both PC. Our found a including four protective five risk‐associated [Inverse p < 0.05]. No significant heterogeneity instrumental variables (IVs) or horizontal pleiotropy was found. gene SVBP as traits (FDR<0.05, P_HEIDI>0.05). Additionally, genes, MCM6 RPS26, implicated in interaction based on (PPH4>0.5). In summary, provides evidence for future research at developing suitable therapeutic interventions disease prevention.

Language: Английский

Citations

8
Association between the gut microbiota, inflammatory factors, and colorectal cancer: evidence from Mendelian randomization analysis DOI Creative Commons

Mingwei Ma,

Zicheng Zheng,

Jie Li

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: March 18, 2024

Colorectal cancer (CRC) is one of the most common malignant tumors primarily affecting individuals over age 50 years. Recent studies have suggested that dysbiosis gut microbiota, a community microorganisms in human gut, closely associated with occurrence and development CRC. Additionally, inflammatory factors (IFs) also been reported to play significant role However, causal relationships between IFs, CRC remain unclear. In this study, we performed Mendelian randomization (MR) analysis using publicly available genome-wide association study (GWAS) data explore relationship The microbiota GWAS were obtained from MiBioGen while IFs derived comprehensive three independent cohorts. Causal was conducted appropriate instrumental variables (IVs) statistical models. MR revealed negative correlation Lachnospiraceae species risk, positive observed Porphyromonadaceae species, UCG010 genus, Lachnospira Sellimonas genus risk. IL-10 These findings suggest might be an increased risk specific bacterial groups may crucial Using analysis, as well CRC, provide important clues for potential roles regulation factor control prevention treatment

Language: Английский

Citations

5
Parabacteroides johnsonii Inhibits the Onset and Progression of Colorectal Cancer by Modulating the Gut Microbiota DOI
Jing Liu, Yong Zhang, Li‐Yan Xu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Background Colorectal cancer (CRC) is the third most prevalent malignant tumor and second leading cause of cancer-related deaths globally. The genus Parabacteroides an important component gut microbiota. P. distasonis goldsteinii are reported probiotics, their roles in CRC have been investigated related studies. However, association between johnsonii remains unknown. Methods (10–42) Lactococcus formosensis (22–2) were isolated from healthy human feces. 25 mice that demonstrated normal feeding activity randomly assigned to four groups : control (NC group), model (IC (PJ L. (LO group). Colonic tissues IC, PJ, LO colon NC group then collected for HE staining immunohistochemical staining. Fecal samples during hyperproliferative adenoma phases Metagenomic sequencing metabolite analysis. Results intervention reduced number slowed growth colonic tumors, improved histological scores, decreased microenvironmental inflammation levels. composition intestinal flora with cancer, increased microbial species diversity, maintained microbiota stability. Furthermore, abundance Bifidobacterium pseudolongum Lactobacillus, which play a role ameliorating AOM/DSS-induced dysbiosis. affected metabolic pathways, including amino sugar degradation galactose metabolism, sphingolipid synthesis, acid polyphenol synthesis tryptophan metabolism pathway as primary being affected. Conclusion Our study profiled administration reduces tumors lower staging by modulating its metabolites at early stages.

Language: Английский

Citations

0
Unraveling the causal link: fatty acids and inflammatory bowel disease DOI Creative Commons
Yi Zhou, Zhenhua Zhou

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 25, 2024

Previous observational studies have revealed the strong relationship between fatty acids (FA) and inflammatory bowel disease (IBD). Nonetheless, due to inherent limitations of retrospective research, causality two has not been clearly established.

Language: Английский

Citations

0
Causal Relationship and Potential Common Pathogenic Mechanisms Between Alopecia Areata and Related Cancer DOI Creative Commons
Zexin Zhu,

Xiaoxue Wang

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2024, Volume and Issue: Volume 17, P. 2911 - 2921

Published: Dec. 1, 2024

Alopecia areata (AA) is an autoimmune skin disease. Observational studies have reported association between AA and cancer. However, the causal relationship cancer has not been reported. We employed a two-sample Mendelian randomization (MR) study to assess causality 17 subtypes of cancers.

Language: Английский

Citations

0