Journal of Applied Polymer Science,
Journal Year:
2021,
Volume and Issue:
139(12)
Published: Nov. 14, 2021
Abstract
Poly(lactic
acid)
(PLA)
stands
out
as
the
most
promising
biodegradable
alternative
to
conventional
petrochemical‐based
polymers
for
manufacturing
of
high‐performance
materials
applied
in
medicine,
pharmacy,
food,
textile,
and
electronic
industry.
This
review
was
aimed
present
up‐to‐date
technologies
PLA
processing
including
melt
blending
molding,
hot
extrusion,
3D
printing,
foaming,
impregnation,
thermally
induced
phase
separation,
nano‐
microparticles
preparation,
wet
dry
spinning
processes.
In
addition,
effect
parameters
polymer
characteristics
on
properties
final
material
elaborated.
Diverse
possibilities
tailor
PLA‐based
by
variation
concentration,
solvent
selection,
drying
method,
pressure
temperature,
incorporation
bioactive
components,
so
were
highlighted.
The
examples
relations
between
methods,
parameters,
end‐product
are
given
a
better
understanding
all
aspects
that
need
be
perceived
fabrication
with
required
performances.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(6), P. 1153 - 1153
Published: March 14, 2022
Synthetic
biopolymers
are
effective
cues
to
replace
damaged
tissue
in
the
engineering
(TE)
field,
both
for
vitro
and
vivo
application.
Among
them,
poly-l-lactic
acid
(PLLA)
has
been
highlighted
as
a
biomaterial
with
tunable
mechanical
properties
biodegradability
that
allows
fabrication
of
porous
scaffolds
different
micro/nanostructures
via
various
approaches.
In
this
review,
we
discuss
structure
PLLA,
its
main
properties,
most
recent
advances
overcoming
hydrophobic,
synthetic
nature,
which
limits
biological
signaling
protein
absorption.
With
aim,
PLLA-based
can
be
exposed
surface
modification
or
combined
other
biomaterials,
such
natural
polymers
bioceramics.
Further,
technologies,
phase
separation,
electrospinning,
3D
printing,
scrutinized
along
applications
employed
repair
strategies.
Overall,
review
focuses
on
PLLA
TE
finally
affording
an
insight
into
future
directions
challenges
address
improvement
scaffold
properties.
Forces in Mechanics,
Journal Year:
2021,
Volume and Issue:
3, P. 100016 - 100016
Published: March 20, 2021
Nowadays,
polymer
parts
made
by
additive
manufacturing
methods
(AM)
have
multiple
applications
in
various
industries.
Different
parameters
affect
the
print
quality
of
and
subsequently
their
mechanical
properties.
In
this
study,
effect
direction
3D-printing
on
high-cycle
bending
fatigue
properties
fused
deposition
modeling
(FDM)
method
has
been
investigated.
The
standard
samples
test
were
printed
both
horizontal
vertical
directions
two
polymers,
PLA
ABS.
thickness
each
layer
was
0.15
mm
infill
percentage
50%.
rotary
performed
under
conditions
fully-reversed
stress-controlled
loading
at
different
stress
levels.
results
included
amplitude
versus
lifetime
FDM
3D-printed
ABS
polymers.
Besides,
scanning
electron
microscopy
(SEM)
image
fracture
surface
also
depicted
after
testing.
Results
showed
that
specimens
had
better
lifetimes
than
ones
samples.
Moreover,
strength
higher
direction.
direction,
material
level
found
to
be
statistically
significant
factors
from
analysis
variances.
SEM
demonstrated
beach
marks
fibers
(3D-printed
filaments)
specimen,
which
proved
cyclic
loadings.
Then,
cleavage
facets
result
brittle
fracture.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(16), P. 9206 - 9206
Published: Aug. 16, 2022
Skeletal-related
disorders
such
as
arthritis,
bone
cancer,
osteosarcoma,
and
osteoarthritis
are
among
the
most
common
reasons
for
mortality
in
humans
at
present.
Nanostructured
scaffolds
have
been
discovered
to
be
more
efficient
regeneration
than
macro/micro-sized
because
they
sufficiently
permit
cell
adhesion,
proliferation,
chemical
transformation.
Nanofibrous
mimicking
artificial
extracellular
matrices
provide
a
natural
environment
tissue
owing
their
large
surface
area,
high
porosity,
appreciable
drug
loading
capacity.
Here,
we
review
recent
progress
possible
future
prospective
electrospun
nanofibrous
engineering.
Electrospun
demonstrated
promising
potential
using
variety
of
nanomaterials.
This
focused
on
crucial
role
biological
applications,
including
drug/growth
factor
delivery
regeneration.
Natural
synthetic
polymeric
extensively
inspected
regenerate
tissue.
We
mainly
significant
impact
composite
adhesion
function,
different
composites
organic/inorganic
nanoparticles
with
nanofiber
scaffolds.
analysis
provides
an
overview
scaffold-based
strategies;
however,
same
concepts
can
applied
other
organ
tactics.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Journal Year:
2023,
Volume and Issue:
142, P. 105848 - 105848
International Journal of Extreme Manufacturing,
Journal Year:
2023,
Volume and Issue:
5(3), P. 032014 - 032014
Published: June 9, 2023
Porous
and
functionally
graded
materials
have
seen
extensive
applications
in
modern
biomedical
devices-allowing
for
improved
site-specific
performance;
their
appreciable
mechanical,
corrosive,
biocompatible
properties
are
highly
sought
after
lightweight
high-strength
load-bearing
orthopedic
dental
implants.
Examples
of
such
porous
metals,
ceramics,
polymers.
Although,
easy
to
manufacture
lightweight,
polymers
do
not
inherently
exhibit
the
required
mechanical
strength
hard
tissue
repair
or
replacement.
Alternatively,
ceramics
brittle
possess
fatigue
resistance.
On
other
hand,
metals
shown
tailorable
strength,
resistance,
toughness.
Thereby,
a
significant
interest
investigating
manufacturing
challenges
has
taken
place
recent
years.
Past
research
that
once
advantages
metallic
structures
implant
industry
been
realized,
biological
biomechanical
compatibility-with
host
bone-has
followed
up
with
methodical
research.
Various
methods
discussed
compared
this
review,
specifically,
how
process
influences
microstructure,
composition,
porosity,
biocompatibility,
properties.
Most
studies
review
related
bone
applications;
however,
understanding
these
investigations
may
also
be
extended
devices
beyond
field.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(17), P. 6213 - 6213
Published: Aug. 24, 2023
The
introduction
of
new
materials
for
the
production
various
types
constructs
that
can
connect
directly
to
tissues
has
enabled
development
such
fields
science
as
medicine,
tissue,
and
regenerative
engineering.
implementation
these
materials,
called
biomaterials,
contributed
a
significant
improvement
in
quality
human
life
terms
health.
This
is
due
constantly
growing
availability
implants,
prostheses,
tools,
surgical
equipment,
which,
thanks
their
specific
features
biocompatibility,
appropriate
mechanical
properties,
ease
sterilization,
high
porosity,
ensure
an
living.
Biodegradation
ensures,
among
other
things,
ideal
rate
regenerated
tissue.
Current
tissue
engineering
medicine
strategies
aim
restore
function
damaged
tissues.
current
gold
standard
autografts
(using
patient’s
accelerate
healing),
but
limitations
limited
procurement
certain
tissues,
long
operative
time,
donor
site
morbidity
have
warranted
search
alternative
options.
use
biomaterials
this
purpose
attractive
option
number
being
developed
tested
rapidly.
Acta Biomaterialia,
Journal Year:
2023,
Volume and Issue:
168, P. 1 - 21
Published: July 15, 2023
3D-printed
composite
scaffolds
have
emerged
as
an
alternative
to
deal
with
existing
limitations
when
facing
bone
reconstruction.
The
aim
of
the
study
was
systematically
review
feasibility
using
PLA/bioceramic
manufactured
by
3D-printing
technologies
grafting
materials
in
preclinical
vivo
studies.
Electronic
databases
were
searched
specific
search
terms,
and
thirteen
manuscripts
selected
after
screening.
synthesis
carried
out
mainly
extrusion-based
techniques.
Likewise,
hydroxyapatite
most
used
bioceramic
for
synthesizing
composites
a
PLA
matrix.
Among
studies,
seven
conducted
rats
six
rabbits,
but
high
variability
that
exists
regarding
experimental
process
made
it
difficult
compare
them.
Regarding
results,
PLA/Bioceramic
shown
be
biocompatible
mechanically
resistant.
Preclinical
studies
elucidated
ability
grafts,
allowing
growing
without
adverse
reactions.
In
conclusion,
PLA/Bioceramics
been
demonstrated
promising
treating
defects.
Nevertheless,
more
care
should
taken
designing
performing
trials,
since
lack
standardization
processes,
which
prevents
comparison
results
reduces
quality
information.
polylactic
acid/bioceramic
Since
animal
models
represent
mandatory
step
clinical
translation,
present
manuscript
analyzed
discussed
not
only
those
aspects
related
selection
material,
implants
their
characterization.
But
provides
new
approach
understand
how
design
perform
well
analysis
methods,
may
affect
obtained
covering
authors'
knowledgebase
from
veterinary
medicine
biomaterial
science.
Thus,
this
aims
trials.
