The use of propolis in dentistry, oral health, and medicine: A review

Journal of Oral Biosciences, Journal Year: 2021, Volume and Issue: 63(1), P. 23 - 34

Published: Jan. 18, 2021

Language: Английский

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Benefits of Natural Antioxidants on Oral Health

Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1309 - 1309

Published: June 20, 2023

In recent years, special attention has been paid to the correlation between oxidation–reduction mechanisms and human health. The free radicals produced via physiological cellular biochemical processes are major contributors oxidation phenomena. Their instability is cause of damage. Free radical reactive oxygen species containing best-known ones. body neutralises harmful effects production endogenous antioxidants (superoxide dismutase, catalase, glutathione, melatonin). field study nutraucetics found antioxidant capacity in substances such as vitamins A, B, C, E, coenzyme Q-10, selenium, flavonoids, lipoic acid, carotenoids, lycopene contained some foods. There several areas investigation that aim research interaction species, exogenous antioxidants, microbiota promote increased protection peroxidation macromolecules (proteins, lipids) by maintaining a dynamic balance among make up microbiota. this scoping review, we map scientific literature on oxidative stress related oral microbiota, use natural counteract it, assess volume, nature, characteristics, type studies available date, suggest possible gaps will emerge from analysis.

Language: Английский

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Brazilian red propolis reduces orange-complex periodontopathogens growing in multispecies biofilms

Biofouling, Journal Year: 2019, Volume and Issue: 35(3), P. 308 - 319

Published: March 16, 2019

This study investigated the antimicrobial effects of ethanolic extract Brazilian red propolis (BRP) on multispecies biofilms. A seven-day-old subgingival biofilm with 32 species was grown in a Calgary device. Biofilms were treated BRP (1,600, 800, 400 and 200 μg ml−1) twice day for 1 min, starting from 3. Chlorhexidine (0.12%) dilution-vehicle used as positive negative controls, respectively. On 7, metabolic activity microbial composition biofilms by DNA-DNA hybridization determined. The viability data analyzed one-way ANOVA followed Tukey's post hoc, whereas transformed via BOX-COX using Dunnett's hoc. (1,600 decreased 45%, no significant difference chlorhexidine-treated samples. chlorhexidine significantly reduced levels 14 bacterial compared to vehicle control. Taken together, showed promising properties which may be useful periodontal disease

Language: Английский

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Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(14), P. 4988 - 4988

Published: July 15, 2020

Propolis is a natural resinous material produced by bees and has been used in folk medicines since ancient times. Due to it possessing broad spectrum of biological activities, gained significant scientific commercial interest over the last two decades. As result searching 122 publications reported up end 2019, we assembled unique compound database consisting 578 components isolated from both honey bee propolis stingless propolis, analyzed chemical space diversity these compounds. The results demonstrated that are valuable sources for pharmaceutical nutraceutical development.

Language: Английский

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Investigation of the relationship between apical periodontitis and host modulation provided by nutritional supplement: a study in rats

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 4, 2025

Traditional treatments often involve chemotherapeutic agents; however, immune modulation agents, such as probiotics, propolis, Vitamin E, and vegetable oils, may offer alternative approaches to reduce inflammation bone damage. In this study, we aimed investigate the effect of various host agents (probiotics, oils) on loss in a rat model experimental apical periodontitis (AP). Eight-week-old Sprague-Dawley rats (n = 79) were used. AP was induced by exposing coronal pulp mandibular right first molar. Rats divided into seven groups: Control, AP, + Vegetable Oil, Probiotic, Propolis, Physiological Serum. The administered daily for 30 days. Serum calcium, phosphorus, alkaline phosphatase levels measured, along with histopathological immunohistochemical evaluations. Statistical analyses conducted using one-way ANOVA Tukey's test (p < 0.05). E oil significantly reduced 33% 28%, respectively, compared group 0.0001 both). Probiotics fibrosis 36% 0.0002), all except propolis showed lower serum calcium 0.0017) than group. Osteoblastic activity higher groups 0.0366), whereas both vitamin resulted 20% reduction osteoclastic 0.0389). No significant abscess formation observed 0.2610). Compared group, RANKL supplemented 28-50% 0.0036). Specific nutritional supplements effectively AP. These findings suggest potential these improving endodontic treatment outcomes. Further studies are required explore their clinical application.

Language: Английский

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Propolis Affects Pseudomonas aeruginosa Growth, Biofilm Formation, eDNA Release and Phenazine Production: Potential Involvement of Polyphenols

Microorganisms, Journal Year: 2020, Volume and Issue: 8(2), P. 243 - 243

Published: Feb. 12, 2020

Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen responsible for a wide range of clinical conditions, from mild infections to life-threatening nosocomial biofilm-associated diseases, which are particularly severe in susceptible individuals. The aim this vitro study was assess the effects Albanian propolis on several virulence-related factors P. aeruginosa, such as growth ability, biofilm formation, extracellular DNA (eDNA) release and phenazine production. To end, processed using three different solvents extracted polyphenolic compounds were identified by means high performance liquid chromatography coupled electrospray ionization mass spectrometry (HPLC-ESI-MS) analysis. As assessed bioluminescence-based assay, among extracts, ethanol (EtOH) extract most effective inhibiting both microbial followed propylene glycol (PG) polyethylene 400 (PEG 400) extracts. Furthermore, exposure EtOH caused decrease eDNA Finally, caffeic acid phenethyl ester (CAPE) quercetin decreased upon bacteria. Overall, our data add new insights anti-microbial properties natural compound, against aeruginosa. potential implications these findings will be discussed.

Language: Английский

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The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application

BioMed Research International, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 26

Published: Aug. 2, 2022

Herbal and chemical products are used for oral care biofilm treatment also have been reported to be controversial in the massive trials conducted this regard. The present review is aimed at evaluating potential of relevant herbal comparing their outcomes conventional summarizing current state evidence antibiofilm properties different by studies from past eleven years. Chlorhexidine gluconate (CHX), essential oils (EOs), acetylpyridinium chloride were, respectively, most commonly studied agents included studies. As confirmed all systematic reviews, CHX EO significantly control plaque formation gingival indices. Fluoride another interesting reagent that has shown promising results health improvement, but quality needs refined. synergy between natural plants should targeted future accede new, efficient, healthy anticaries strategies. Moreover, discover biofilm-interfering or biofilm-inhibiting activities, effective clinical needed. In article, therapeutic applications herbal/chemical materials infections discussed recent years (2010-2022).

Language: Английский

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Isolation of phenolic compounds from eco‐friendly white bee propolis: Antioxidant, wound‐healing, and anti‐Alzheimer effects

Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 12(3), P. 1928 - 1939

Published: Dec. 7, 2023

Abstract This study presents the first findings regarding extraction, isolation, enzyme inhibition, and antioxidant activity. The oral mucosal wound‐healing process was investigated using propolis water extract (PWE) incubation with gingival fibroblast cells concluded that effective on pattern compared to untreated controls. Additionally, phenolic compounds (fraxetin, apigenin, galangin, pinobanksin, chrysin, etc.) were isolated from propolis, their chemical structures elucidated comprehensive spectroscopic methods. anti‐Alzheimer potential activities of PWE some screened revealing inhibitory effects acetylcholinesterase (AChE) IC 50 values ranging 0.45 ± 0.01 1.15 0.03 mM, as well remarkable free‐radical scavenging metal reduction capacities. results suggest these can be used therapeutic agents due properties AChE. It also for purposes since its effect is promising.

Language: Английский

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Comparative evaluation of propolis mouthwash with 0.2% chlorhexidine mouthwash as an adjunct to mechanical therapy in improving the periodontitis among perimenopausal women: a randomized controlled trial

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 5, 2024

Abstract Objective To evaluate the efficacy of Propolis mouthwash compared to chlorhexidine as an adjunct mechanical therapy in improving clinical parameters perimenopausal women with chronic periodontitis. Methodology A double-blind, randomized, controlled trial was conducted by recruiting 144 subjects mild moderate After scaling and root planning, were allocated two treatment groups: 0.2% 20% propolis twice daily for six weeks. Clinical such pocket probing depth (PPD), attachment loss (CAL) bleeding on (BOP) analysed at baseline, weeks, 12 Result The mean value PPD group 4.67 reduced 4.01 weeks 3.59 While group, baseline 4.65 4.44 4.25 respectively. CAL 4.45. This 4.15 3.77 For 4.80, which 4.50 4.19 77.20, decreased 46.30 14.60 final visit. In 77.30 49.60 22.80 subsequent visits. Conclusion study concludes that both positively improve parameters; however, is significantly more effective BOP. Trial registration ID: NCT05870059, Date Registration: 02/02/2022. ( https://beta.clinicaltrials.gov/study/NCT05870059 ).

Language: Английский

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Comparative effectiveness of Propolis with chlorhexidine mouthwash on gingivitis – a randomized controlled clinical study

BMC Complementary Medicine and Therapies, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 6, 2024

Abstract Background To assess and compare the effectiveness of propolis mouthwash with chlorhexidine in reduction plaque gingivitis. Methods A single centre, latin-square cross-over, double masked, randomized controlled clinical trial was conducted on 45 chronic generalized gingivitis subjects who were chosen from dental clinic MAHSA University, Malaysia. total randomly assigned into one three different groups ( n = 15 each) using a computer-generated random allocation sequence: Group Propolis mouthwash; B Chlorhexidine C Placebo mouthwash. Supragingival gingival inflammation assessed by full mouth Plaque index (PI) (GI) at baseline after 21 days. The study divided phases, each phase lasted for days separated washout period between them. Groups A, treated 0.2% Propolis, Chlorhexidine, mouthwash, respectively, I. instructed to use twice daily 1 min On day 22 nd , recalled measurement PI GI. After I, crossed over as dictated Latin square design II III. Results At baseline, intergroup comparison revealed no statistically significant difference p > 0.05). 21, one-way ANOVA < 0.001) GI 0.001). Bonferroni post-hoc test showed P 0.001), higher mean scores group compared placebo groups. Conclusions demonstrated improvement health reduction. Thus, it could be used an effective herbal alternative Trial registration retrospectively registered 25/07/2019 clinicaltrials.gov its identifier is NCT04032548.

Language: Английский

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