Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 49 - 62
Published: Oct. 4, 2024
Language: Английский
BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)
Published: June 21, 2024
Abstract Background Dental pathogens play a crucial role in oral health issues, including tooth decay, gum disease, and infections, recent research suggests link between these cancer initiation progression. Innovative therapeutic approaches are needed due to antibiotic resistance concerns treatment limitations. Methods We synthesized analyzed piperine-coated zinc oxide nanoparticles (ZnO-PIP NPs) using UV spectroscopy, SEM, XRD, FTIR, EDAX. Antioxidant antimicrobial effectiveness were evaluated through DPPH, ABTS, MIC assays, while the anticancer properties assessed on KB squamous carcinoma cells. Results ZnO-PIP NPs exhibited significant antioxidant activity of 50 µg/mL against dental pathogens, indicating strong properties. Interaction analysis revealed high binding affinity with pathogens. showed dose-dependent cells, upregulating apoptotic genes BCL2, BAX, P53. Conclusions This approach offers multifaceted solution combatting both infections cancer, showcasing their potential for advancement healthcare. It is essential acknowledge limitations challenges associated use ZnO clinical applications. These may include regarding nanoparticle toxicity, biocompatibility, long-term safety. Further rigorous testing warranted address issues ensure safe effective translation into practice.
Language: Английский
Citations
14
Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 660 - 660
Published: May 28, 2024
Curcumin (Curcumin) belongs to the polyphenol family. It is extracted by drying root of a plant Asian origin, belonging Zingiberaceae The best-known species Curcumincuma Longa. has been recognized as having great therapeutic powers since ancient times. Studies on curcumin have confirmed its powerful antioxidant properties, preventing both formation free radicals and their neutralization, anti-inflammatory, antibacterial, immunological, neuroprotective well being regulator intestinal microbiota with beneficial effects clinical manifestations metabolic syndrome. Our study aimed highlight how all these aspects could benefit oral health, improving course pathological processes. effect mouthwashes, curcumin-based gels regulation bacterial plaque in control gingivitis, was largely comparable that using 0.20% chlorhexidine, fewer side effects. Being highly hydrophobic substance, it high permeability cross cell membrane. Bioavailability increases when combined liposoluble substances (e.g., olive oil) piperine, which improves absorption. also negligible degree toxicity, making an excellent alternative use gold standard products for disinfection.
Language: Английский
Citations
10
Medicina, Journal Year: 2025, Volume and Issue: 61(1), P. 84 - 84
Published: Jan. 7, 2025
Background and objectives: Due to the regeneration potential of growth factors (GFs) platelet concentrates (PCs), facial rejuvenation has been a major area attention in esthetic medicine. The effectiveness safety PCs GFs promoting face are examined this systematic review, which is complemented by case series. essential for collagen production dermal matrix remodeling, while PCs, like Platelet-Rich Plasma (PRP), abundant bioactive chemicals that promote tissue healing cellular regeneration. Materials Methods: A comprehensive literature search was performed on PubMed, Web Science, Scopus, focusing human clinical trials published between February 2019 2024 related PRP esthetics. Results: Thirteen studies met inclusion criteria were analyzed. Conclusions: review summarizes most recent data patient outcomes, treatment regimens, possible hazards. series goes with it shows real-world examples how improve skin elasticity, texture, general appearance little negative side effects. These results highlight use as minimally invasive procedures.
Language: Английский
Citations
1
Ceramics International, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
1
Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 113 - 113
Published: Dec. 28, 2023
In recent years, orthodontics, a specialized branch of dentistry, has evolved considerably in terms both techniques and materials used. Aimed at correcting dental malocclusions craniofacial anomalies, it improves the functionality aesthetics face oral cavity. However, orthodontic treatment, its developmental stages, may induce oxidative stress (O.S.) phenomena, with an increase production reactive oxygen species (ROS), damaging periodontal tissues involved, affecting short-, medium- long-term results. Studies on antioxidant effects natural products (e.g., resveratrol, green tea, turmeric, etc.) medical field have aroused considerable interest years. A systematic literature review was conducted PubMed, Scopus, Web Science databases using (N.P.s), O.S., as keywords. The study aims to consider determinants ROS occurring during treatment possibility being able control neutralize biochemical phenomena by restoring physiological process which balance between ability body’s system them is favor latter.
Language: Английский
Citations
21
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 5133 - 5133
Published: June 13, 2024
Aim: Cytokines are crucial low-molecular-weight proteins involved in immune responses. This systematic review highlights the need for in-depth studies on cytokines’ biological mechanisms, providing insights into disease onset and potential therapeutic strategies. Materials methods: A comprehensive literature search identified 18 relevant articles, emphasizing multifaceted role of cytokines orthodontic treatment (OT). The quality assessment using ROBINS-I tool ensures a rigorous evaluation included studies, contributing to overall reliability findings. Results Conclusions: explores intricate relationship between OT. exhibit different properties, influencing cellular activities through autocrine, paracrine, endocrine activities. OT, aimed at achieving stable occlusion, induces tension compression periodontal ligament (PDL), triggering cytokine release. Proinflammatory play inflammation, bone soft tissue metabolism. Studies show elevated levels gingival crevicular fluid (GCF) after force application. choice devices, such as self-ligating brackets, influences concentrations, indicating importance attachment design. Further research promises enhance practices, optimize patient care.
Language: Английский
Citations
5
BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 24, 2025
Language: Английский
Citations
0
Materials, Journal Year: 2025, Volume and Issue: 18(8), P. 1863 - 1863
Published: April 18, 2025
This systematic review evaluates the clinical effectiveness of hyaluronic acid (HA) in periodontal therapy, oral surgery, and temporomandibular joint (TMJ) disorders. Background. HA, a biocompatible glycosaminoglycan with anti-inflammatory regenerative properties, is increasingly used dentistry to enhance healing, reduce pain, support regeneration. However, its efficacy compared conventional treatments remains debated. Materials Methods. A search was conducted following PRISMA guidelines across PubMed, Scopus, Web Science databases (2015–2025). Twenty-one studies, including randomized controlled trials (RCTs) case-control were analyzed for outcomes related pain reduction, tissue regeneration, functional recovery. HA improved attachment levels, reduced probing depth, enhanced wound healing therapy surgery. It accelerated after extractions frenectomies. TMJ disorder studies showed mixed results, some reporting relief improvement, while others found no significant advantage over platelet-rich plasma (PRP) or corticosteroids. Variability formulations protocols influenced outcomes. promising adjunct healing. role treatment uncertain. Further RCTs standardized are needed determine optimal application.
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 542 - 542
Published: April 22, 2024
The goal of this review is to shed light on the management orofacial discomfort after a cancer diagnosis in head and neck region. A search was conducted PubMed, Scopus, Web Science identify studies postoperative pain control oral cancer. included open-access research, investigations into management, randomized clinical trials, retrospective studies, case-control prospective English-written full-text publications. Exclusion criteria animal studies; vitro off-topic reviews, case reports, letters, or comments; non-English language. Three reviewers independently accessed databases assigned quality rating chosen articles. explores patients; highlighting persistent opioid use; efficacy adjuvant drugs, such as gabapentin; multimodal approach. It emphasizes need for personalized recognizing individual perception tailoring interventions. Integrating pharmacological non-pharmacological strategies crucial comprehensive management. also serves guide future emphasizing standardized methodologies diverse participant populations.
Language: Английский
Citations
3