Hypothesis: Pulmonary Afferent Activity Patterns During Slow, Deep Breathing Contribute to the Neural Induction of Physiological Relaxation

Frontiers in Physiology, Journal Year: 2019, Volume and Issue: 10

Published: Sept. 13, 2019

Control of respiration provides a powerful voluntary portal to entrain and modulate central autonomic networks. Slowing deepening breathing as relaxation technique has shown promise in variety cardiorespiratory stress-related disorders, but few studies have investigated the physiological mechanisms conferring its benefits. Recent evidence suggests that at frequency near 0.1 Hz (6 breaths per minute) promotes behavioral baroreflex resonance effects maximize heart rate variability. Breathing around this appears elicit resonant coherent features neuro-mechanical interactions optimize function. Here we explore neurophysiology slow, deep propose coincident respiratory baroreceptor afferent activity cycling An important role is assigned preferential recruitment slowly-adapting pulmonary afferents (SARs) during prolonged inhalations project discrete areas brainstem within nucleus solitary tract (NTS) initiate inhibitory actions on downstream targets. Conversely, exhalations terminate SAR activate arterial baroreceptors via increases blood pressure stimulate, through NTS projections, parasympathetic outflow heart. Reciprocal afferent-evoked combine enhance sympathetic inhalation exhalation, respectively. This leads pronounced variability phase with cycle (respiratory sinus arrhythmia) improved ventilation-perfusion matching. relay neurons extensively network encode pattern may anxiety, arousal, attention. In our model, rhythms also support expression slow cortical induce functional state alert relaxation, and, nasal respiration-based olfactory signaling, recruit hippocampal pathways boost memory consolidation. Collectively, assert neurophysiological processes recruited cognitive therapeutic outcomes obtained various mind-body practices. Future are required better understand physio-behavioral involved, including animal models control for confounding factors such expectancy biases.

Language: Английский

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PreBötzinger complex neurons drive respiratory modulation of blood pressure and heart rate

eLife, Journal Year: 2020, Volume and Issue: 9

Published: June 15, 2020

Heart rate and blood pressure oscillate in phase with respiratory activity. A component of these oscillations is generated centrally, neurons entraining the activity pre-sympathetic parasympathetic cardiovascular neurons. Using a combination optogenetic inhibition excitation vivo situ rats, as well neuronal tracing, we demonstrate that preBötzinger Complex (preBötC) neurons, which form kernel for inspiratory rhythm generation, directly modulate Specifically, inhibitory preBötC cardiac neuron whilst excitatory sympathetic vasomotor activity, generating heart respiration. Our data reveal yet more functions entrained to preBötC, role cardiorespiratory oscillations. The findings have implications pathologies, such hypertension failure, where entrainment diminished exaggerated.

Language: Английский

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Defining the Rhythmogenic Elements of Mammalian Breathing

Physiology, Journal Year: 2018, Volume and Issue: 33(5), P. 302 - 316

Published: Aug. 15, 2018

Breathing's remarkable ability to adapt changes in metabolic, environmental, and behavioral demands stems from a complex integration of its rhythm-generating network within the wider nervous system. Yet, this complicates identification specific rhythmogenic elements. Based on principles learned smaller rhythmic networks invertebrates, we define criteria that identify elements mammalian breathing discuss how they interact produce robust, dynamic breathing.

Language: Английский

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Optogenetic stimulation of pre–Bötzinger complex reveals novel circuit interactions in swallowing–breathing coordination

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(29)

Published: July 14, 2022

The coordination of swallowing with breathing, in particular inspiration, is essential for homeostasis most organisms. While much has been learned about the neuronal network critical inspiration mammals, pre-Bötzinger complex (preBötC), little known how this interacts swallowing. Here we activate within preBötC excitatory neurons (defined as

Language: Английский

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Parabrachial tachykinin1-expressing neurons involved in state-dependent breathing control

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Feb. 21, 2023

Abstract Breathing is regulated automatically by neural circuits in the medulla to maintain homeostasis, but breathing also modified behavior and emotion. Mice have rapid patterns that are unique awake state distinct from those driven automatic reflexes. Activation of medullary neurons control does not reproduce these patterns. By manipulating transcriptionally defined parabrachial nucleus, we identify a subset express Tac1 , Calca gene exerts potent precise conditional awake, anesthetized, via projections ventral intermediate reticular zone medulla. Activating drives frequencies match physiological maximum through mechanisms differ underlie breathing. We postulate this circuit important for integration with state-dependent behaviors emotions.

Language: Английский

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Role of the postinspiratory complex in regulating swallow–breathing coordination and other laryngeal behaviors

eLife, Journal Year: 2023, Volume and Issue: 12

Published: June 5, 2023

Breathing needs to be tightly coordinated with upper airway behaviors, such as swallowing. Discoordination leads aspiration pneumonia, the leading cause of death in neurodegenerative disease. Here, we study role postinspiratory complex (PiCo) coordinating breathing and Using optogenetic approaches freely anesthetized ChATcre:Ai32, Vglut2cre:Ai32 intersectional recombination ChATcre:Vglut2FlpO:ChR2 mice reveals PiCo mediates protective behaviors. Activation during inspiration or beginning postinspiration triggers swallow behavior an all-or-nothing manner, while there is a higher probability for stimulating only laryngeal activation when activated further into expiration. Laryngeal dependent on stimulation duration. Sufficient bilateral necessary preserving physiological motor sequence since few neurons unilateral blurred behavioral responses. We believe acts interface between pattern generator preBötzinger coordinate breathing. Investigating PiCo’s coordination will aid understanding discoordination neurological diseases.

Language: Английский

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Inspiratory and sigh breathing rhythms depend on distinct cellular signalling mechanisms in the preBötzinger complex

The Journal of Physiology, Journal Year: 2024, Volume and Issue: 602(5), P. 809 - 834

Published: Feb. 14, 2024

Abstract Breathing behaviour involves the generation of normal breaths (eupnoea) on a timescale seconds and sigh order minutes. Both rhythms emerge in tandem from single brainstem site, but whether how cell population can generate two disparate remains unclear. We posit that recurrent synaptic excitation concert with depression cellular refractoriness gives rise to eupnoea rhythm, whereas an intracellular calcium oscillation is slower by orders magnitude rhythm. A mathematical model capturing these dynamics simultaneously generates frequencies, which be separately regulated physiological parameters. experimentally validated key predictions regarding signalling. All vertebrate brains feature network oscillator drives breathing pump for regular respiration. However, air‐breathing mammals compliant lungs susceptible collapse, rhythmogenic may have refashioned ubiquitous signalling systems produce second rhythm (for sighs) prevents atelectasis without impeding eupnoea. image Key points simplified activity‐based preBötC inspiratory neuron population. Inspiration attributable canonical excitatory mechanism. Sigh emerges The predicts perturbations uptake release across endoplasmic reticulum counterintuitively accelerate decelerate rhythmicity, respectively, was validated. Vertebrate evolution adapted existing mechanisms slow oscillations needed optimize pulmonary function mammals.

Language: Английский

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Trpm4 ion channels in pre-Bötzinger complex interneurons are essential for breathing motor pattern but not rhythm

PLoS Biology, Journal Year: 2019, Volume and Issue: 17(2), P. e2006094 - e2006094

Published: Feb. 21, 2019

Inspiratory breathing movements depend on pre-Bötzinger complex (preBötC) interneurons that express calcium (Ca2+)-activated nonselective cationic current (ICAN) to generate robust neural bursts. Hypothesized be rhythmogenic, reducing ICAN is predicted slow down or stop breathing; its contributions motor pattern would reflected in the magnitude of (output). We tested role(s) using reverse genetic techniques diminish putative ion channels Trpm4 Trpc3 preBötC neurons vivo. Adult mice transduced with Trpm4-targeted short hairpin RNA (shRNA) progressively decreased tidal volume breaths yet surprisingly increased frequency, often followed by gasping and fatal respiratory failure. Mice Trpc3-targeted shRNA survived no changes breathing. Patch-clamp field recordings from mouse slices also showed an increase frequency a decrease bursts presence antagonist 9-phenanthrol, whereas pyrazole-3 (pyr-3) inconsistent effects effect frequency. These data suggest mediates ICAN, whose influence contradicts direct role rhythm generation. conclude Trpm4-mediated indispensable for output but not rhythmogenic core mechanism central generator.

Language: Английский

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Respiratory disorders of Parkinson’s disease

Journal of Neurophysiology, Journal Year: 2021, Volume and Issue: 127(1), P. 1 - 15

Published: Nov. 24, 2021

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in substantia nigra, mainly affecting people over 60 yr age. Patients develop both classic symptoms (tremors, muscle rigidity, bradykinesia, and postural instability) nonclassical (orthostatic hypotension, neuropsychiatric deficiency, sleep disturbances, respiratory disorders). Thus, patients with PD can have a significantly impaired quality life, especially when they do not multimodality therapeutic follow-up. The alterations associated this syndrome are main cause mortality PD. They be classified as peripheral caused disorders upper airways or muscles involved breathing central triggered functional deficits important located brainstem control. Currently, there little research describing these disorders, therefore, no well-established knowledge about subject, making treatment difficult. In review, history pathology data changes obtained thus far will addressed.

Language: Английский

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Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 25, 2024

Abstract About half of the neurons in parabrachial nucleus (PB) that are activated by CO 2 located external lateral (el) subnucleus, express calcitonin gene-related peptide (CGRP), and cause forebrain arousal. We report here, male mice, most remaining -responsive adjacent central (PBcl) Kölliker-Fuse (KF) PB subnuclei transcription factor FoxP2 many these project to respiratory sites medulla. PBcl show increased intracellular calcium during wakefulness REM sleep response elevated NREM sleep. Photo-activation increases respiration, whereas either photo-inhibition or genetic deletion PB/KF reduces stimulation without preventing awakening. Thus, augmenting PBcl/KF patients with apnea combination inhibition PBel CGRP may avoid hypoventilation minimize EEG arousals.

Language: Английский

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