A Novel 2x2D Radial Basis Functions-based Interpolation for Short Acquisition Time and Relaxed Frame Rate Ultrasound Localization Microscopy DOI Creative Commons
Sajjad Afrakhteh, Giulia Tuccio, Libertario Demi

et al.

IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control, Journal Year: 2024, Volume and Issue: 71(12: Breaking the Resolution), P. 1855 - 1867

Published: Dec. 1, 2024

Ultrasound localization microscopy (ULM) has become a potent technique for microvascular imaging using ultrasound waves. However, one major challenge is the high frame rate and lengthy acquisition time needed to produce super-resolved (SR) images. To overcome this, our goal relax shorten this while preserving SR image quality, thereby enhancing ULM's clinical applicability. end, we propose two distinct strategies: first, suggest acquiring data at lower followed by applying reconstruction compensate lost information due low imaging. Secondly, tackle prolonged time, compressing compression ratio (CR), which can degrade quality reduced temporal information. mitigate temporally upsample in-phase-quadrature (IQ) factor equal CR after compressed acquisition. Additionally, introduce novel bi-directional (2x2D) interpolation radial basis function (RBF)-based estimate unknown values in 3D IQ (x-z-t), resolution. The rationale behind 2x2D its ability integrate spatiotemporal from orthogonal x-t z-t planes, effectively addressing anisotropies non-uniformities microbubble motion. This approach improves of microbubbles' dynamics interpolating along both x z directions. method was tested on rat brain ratkidney datasets recorded 1kHz, demonstrating relaxing 100 Hz (using first strategy) reduction 3 4 second maintaining comparable original uncompressed data, including density velocity maps.

Language: Английский

Multiple Ischemic Strokes in a Patient Treated with Lecanemab: A Case Report DOI Creative Commons

Hajar Alammar,

Daniel A. Llano

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Background Amyloid-lowering therapy has been previously associated with the formation of cerebral edema and/or microhemorrhage, often picked up on MRI and referred to as amyloid-related imaging abnormalities, or ARIA. Case presentation: We describe a case patient Alzheimer’s Disease treated amyloid-lowering drug lecanemab who developed both ARIA-H ARIA-E, multiple ischemic infarctions. Conclusion This finding, in conjunction previous reports infarction setting anti-amyloid therapy, suggests that may predispose individuals hemorrhagic infarction. result is discussed context microvascular pathology known occur Disease.

Language: Английский

Citations

0
An Early Progression Biomarker in Glioblastoma: Microcirculatory Heterogeneity on Ultrasound Localization Microscopy DOI
Xing Hu, Gaobo Zhang, Xiandi Zhang

et al.

Ultrasound in Medicine & Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Microvascular heterogeneity exploration in core and invasive zones of orthotopic rat glioblastoma via ultrasound localization microscopy DOI Creative Commons
Xing Hu, Gaobo Zhang, Yong Wang

et al.

European Radiology Experimental, Journal Year: 2025, Volume and Issue: 9(1)

Published: March 5, 2025

We studied the microvascular structure and function of in situ glioblastoma using ultrasound localization microscopy (ULM). The vivo study was conducted via craniotomy six Sprague-Dawley rats. Capillary pattern, capillary hemodynamics, functional quantitative parameters were compared among tumor core, invasive zone, normal brain tissue with ex micro-computed tomography (micro-CT) scanning electron microscopy. Correlations between histopathological vascular density (VD-H), proliferation index, maturity index (VMI-H) evaluated. Kruskal-Wallis H, ANOVA, Mann-Whitney U, Pearson, Spearman correlation statistics used. Compared to zone exhibited higher microvascularity structural disorder complexity, increased hemodynamic heterogeneity, local blood flow perfusion (p ≤ 0.033), slightly lower average velocity = 0.873). Significant differences observed across all 0.001). ULM demonstrated microstructural resolution micro-CT a nonsignificant difference correlated VD-H (r 0.781, p < Vessel diameter 0.960, 0.001), curvature 0.438, 0.047), 0.487, 0.025), volume 0.858, 0.001) index. Vascular -0.444, 0.044) fractal dimension -0.933, VMI-H. provided high-resolution, noninvasive imaging microvascularity, offering insights into structural/functional abnormalities. technology based on ultrafast can accurately quantify microvessels glioblastoma, providing new method for evaluating effectiveness antiangiogenic therapy visualizing disease progression. This may facilitate early therapeutic assessment. reliably captures structures features Micro-CT validated its non-invasion characterization. is expected effectively evaluate anti-vascular response.

Language: Английский

Citations

0
Deep Learning in Ultrasound Localization Microscopy: Applications and Perspectives DOI
Brice Rauby, Paul Xing, Maxime Gasse

et al.

IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control, Journal Year: 2024, Volume and Issue: 71(12: Breaking the Resolution), P. 1765 - 1784

Published: Sept. 17, 2024

Ultrasound Localization Microscopy (ULM) is a novel super-resolution imaging technique that can image the vasculature in vivo at depth with resolution far beyond conventional limit of diffraction. By relying on localization and tracking clinically approved microbubbles injected blood stream, ULM provide not only anatomical visualization but also hemodynamic quantification microvasculature different tissues. Various deep-learning approaches have been proposed to address challenges including denoising, improving microbubble localization, estimating flow velocity or performing aberration correction. Proposed deep learning methods often outperform their counterparts by quality reducing processing time. In addition, robustness high concentrations lead reduced acquisition times ULM, addressing major hindrance clinical application. Herein, we propose comprehensive review diversity applications focusing assuming sparse distribution. We first an overview how existing studies vary constitution datasets tasks targeted model. take deeper look into numerous improve since they differ highly formulation optimization problem, evaluation, network architectures. finally discuss current limitations these methods, as well promises potential for future.

Language: Английский

Citations

3
3D ultrasound localization microscopy of the nonhuman primate brain DOI Creative Commons
Paul Xing, Vincent Perrot, Adan‐Ulises Dominguez‐Vargas

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 111, P. 105457 - 105457

Published: Dec. 20, 2024

Language: Английский

Citations

3
Super-resolution ultrasound imaging reveals temporal cerebrovascular changes with disease progression in female 5×FAD mouse model of Alzheimer's disease: correlation with pathological impairments DOI Creative Commons
Haoming Lin, Z M Wang,

Yingtao Liao

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 108, P. 105355 - 105355

Published: Sept. 17, 2024

Language: Английский

Citations

2
Lifespan Super-Resolution Ultrasound Imaging Reveals Temporal Evolution of Cerebrovascular Alterations in the 5×FAD Mouse Model of Alzheimer's Disease: Correlation with Pathological Impairments DOI
Haoming Lin, Z M Wang,

Yingtao Liao

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

1
Amyloid-β as a Key Player in Cerebrovascular Dysfunction in Alzheimer's Disease DOI Creative Commons
Gustavo Trevizani Stelzer, Ricardo A. S. Lima-Filho

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(27), P. e0663242024 - e0663242024

Published: July 3, 2024

Alzheimer's disease (AD) is the most prevalent cause of dementia in elderly. AD neuropathology mainly characterized by accumulation intracellular aggregates protein tau and extracellular amyloid-β (Aβ) peptide, form soluble oligomers insoluble plaques. Cerebrovascular disorder (CVD) a further hallmark causes decreased blood flow perfusion, deterioration blood–brain barrier (BBB), loss microvasculature (Zlokovic, 2011). Risk factors for CVD substantially overlap include diabetes hypertension. The two-hit hypothesis suggests that damage to brain vessels (hit one) can lead BBB dysfunction, hypoperfusion, availability energy substrates, increased production reduced clearance Aβ—leading Aβ two), thereby rendering milieu vulnerable neuronal dysfunction neurodegeneration In line with this hypothesis, changes cerebral local hypoxia/ischemia have been observed early patients mild cognitive impairment (MCI), who are at high risk Moreover, hypoxia signaling increases transcription activity β-secretase γ-secretase, two enzymes involved (reviewed Salminen et al., 2017). Notably, both related morphological functional vasculature mouse models AD. deposits within small amyloid angiopathy (CAA), vascular feature Conversely, CAA may aggravate impair aggregates, accelerating pathology 2011; Aged mice overexpressing P301L (Tg4510), variant associated frontotemporal dementia, show abnormal vessel morphology, including … Correspondence should be addressed Gustavo T. Stelzer gustavo.stelzer{at}bioqmed.ufrj.br or Ricardo A. S. Lima-Filho rfilho{at}bioqmed.ufrj.br.

Language: Английский

Citations

1
Background Noise Removal in Non-Contrast- Enhanced Ultrasound Microvasculature Imaging Using Combined Collaborative, Morphological, and Vesselness Filtering DOI Creative Commons

Soroosh Sabeti,

Mostafa Fatemi, Azra Alizad

et al.

IEEE Access, Journal Year: 2024, Volume and Issue: 12, P. 116150 - 116161

Published: Jan. 1, 2024

Suppression of background noise in clutter filtered contrast-free ultrasound microvasculature images is an important step towards better visualization, accurate segmentation, and subsequent morphological analysis vascular structures. While different approaches to tackling this problem have been proposed, the use denoising vessel-enhancing filters has proven be a straightforward effective scheme. In paper, we propose multi-stage removal framework, suited images, comprising sequential implementation three modes suppressing intensifying patterns, namely self-similarity based collaborative filtering, mathematical morphology denoising, Hessian vessel enhancement. We evaluate effects each filtering stage framework using in-vitro phantom data compare performance with number existing approaches, as well absence suppression techniques, in-vivo from human subjects. The results indicate that suggested method is, many cases, capable complete removal, zeroing out most regions, improving signal-to-noise ratio contrast-to-noise other regions by tens dB compared methods.

Language: Английский

Citations

0
Capillary-scale Microvessel Imaging with High-frequency Ultrasound Localization Microscopy in Mouse Brain DOI
Matthew R. Lowerison, Yike Wang, Bing‐Ze Lin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

Abstract Ultrasound localization microscopy is a super-resolution vascular imaging technique which has garnered substantial interest as tool for small animal neuroimaging, neuroscience research, and the characterization of pathologies. In pursuit increasingly high-fidelity reconstructions microvasculature, there remains several outstanding questions concerning this sub-diffraction technology, including accurate reconstruction microvessels approaching capillary scale pragmatic challenges associated with long data acquisition times. context neurovascular imaging, we posit that increasing ultrasound frequency straightforward approach to enable higher concentrations microbubble contrast agents, thus likelihood microvascular/capillary mapping decreasing duration. We demonstrate results in improved ULM fidelity more efficient due smaller point-spread function easier localize, can achieve localizable concentration within same unit volume tissue. A select example vivo capillary-level demonstrated highest probe, implications neuroscientists investigating microvascular disease states, regulation, brain development. High yielding spatial resolution 7.1μm, measured by Fourier ring correlation, throughout entire depth brain, highlighting technology highly relevant neuroimaging research.

Language: Английский

Citations

0