The prefrontal cortex, pathological anxiety, and anxiety disorders

Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 47(1), P. 260 - 275

Published: Aug. 16, 2021

Language: Английский

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Neural circuits regulating prosocial behaviors

Neuropsychopharmacology, Journal Year: 2022, Volume and Issue: 48(1), P. 79 - 89

Published: June 14, 2022

Language: Английский

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How adverse childhood experiences get under the skin: A systematic review, integration and methodological discussion on threat and reward learning mechanisms

eLife, Journal Year: 2024, Volume and Issue: 13

Published: July 16, 2024

Adverse childhood experiences (ACEs) are a major risk factor for the development of multiple psychopathological conditions, but mechanisms underlying this link poorly understood. Associative learning encompasses key through which individuals learn to important environmental inputs emotional and behavioral responses. ACEs may impact normative maturation associative processes, resulting in their enduring maladaptive expression manifesting psychopathology. In review, we lay out systematic methodological overview integration available evidence proposed association between threat reward processes. We summarize results from literature search (following PRISMA guidelines) yielded total 81 articles (threat: n=38, reward: n=43). Across fields, behaviorally, observed converging pattern aberrant with history ACEs, independent other sample characteristics, specific ACE types, outcome measures. Specifically, blunted was reflected reduced discrimination safety cues, primarily driven by diminished responding conditioned cues. Furthermore, attenuated manifested accuracy rate tasks involving acquisition contingencies. Importantly, emerged despite substantial heterogeneity assessment operationalization across both fields. conclude that represent mechanistic route become physiologically neurobiologically embedded ultimately confer greater closing, discuss potentially fruitful future directions research field, including considerations.

Language: Английский

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Arsenic Exposure Induces Neural Cells Senescence and Abnormal Lipid Droplet Accumulation Leading to Social Memory Impairment in Mice

Environmental Pollution, Journal Year: 2025, Volume and Issue: 368, P. 125779 - 125779

Published: Jan. 31, 2025

Language: Английский

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A cross-sectional study of the major risk factor at different levels of cognitive performance within Chinese-origin middle-aged and elderly individuals

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 349, P. 377 - 383

Published: Jan. 8, 2024

Senior citizens suffering from cognitive impairment (CI) are on the East Asia rise. Multiple variables could lead to inter-/intra-individual cognition effectiveness variations, though previous research efforts did not consider weighting issues.

Language: Английский

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Modeling the early stages of Alzheimer’s disease by administering intracerebroventricular injections of human native Aβ oligomers to rats

Acta Neuropathologica Communications, Journal Year: 2022, Volume and Issue: 10(1)

Published: Aug. 16, 2022

Abstract Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative characterized by the accumulation of aggregated amyloid beta (Aβ) hyperphosphorylated tau along with slow decline in cognitive functions. Unlike advanced AD, initial steps AD pathophysiology have been poorly investigated, partially due to limited availability animal models focused on early, plaque-free stages disease. The aim this study was evaluate early behavioral, anatomical molecular alterations wild-type rats following intracerebroventricular injections human Aβ oligomers (AβOs). Bioactive nondemented control brain tissue extracts were using ELISA proteomics approaches. Following bilateral infusion, underwent behavioral testing, including elevated plus maze, social recognition test, Morris water maze Y-maze within 6 weeks postinjection. An analysis structure performed manganese-enhanced MRI. Collected tissues analyzed stereology, immunohistochemistry, qPCR. No sensorimotor deficits affecting motor performance different tasks observed, nor spatial memory disturbed rats. In contrast, significant impairment became evident at 21 days This deficit associated significantly decreased volume lateral entorhinal cortex tendency toward decrease total volume. Significant increase cleaved caspase-3-positive cells, microglial activation proinflammatory responses accompanied altered expression synaptic markers observed hippocampus immunohistochemical qPCR approaches Our data suggest that AβO-injected might be determined neuroinflammatory synaptopathy. infusion native oligomeric rat represents feasible tool model events AD.

Language: Английский

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Unlocking NAC’s potential ATF4 and m6A dynamics in rescuing cognitive impairments in PTSD

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(2)

Published: Feb. 15, 2025

Language: Английский

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Social buffering during fear extinction rescues long-term trauma-induced memory and emotional behavioral alterations in rats

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 21, 2025

Language: Английский

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Adolescent Development in Unprecedented Times: A Comparative Study of Theory of Mind Before and After COVID-19

Adolescents, Journal Year: 2025, Volume and Issue: 5(2), P. 11 - 11

Published: April 3, 2025

The coronavirus disease of 2019 (COVID-19) pandemic represented a significant global event that disrupted the typical social lives adolescents. Studies show negatively impacted adolescent well-being. Very little is known about social–cognitive implications wide-scale distancing, school closures, and transition to digital modes communication for This study aims compare affective Theory Mind (ToM), self-esteem, self-perceptions before after COVID-19 pandemic. Drawing on existing data, this compared two distinct but comparable samples Data from pre-COVID-19 sample were collected in 2016/2017 year (N = 145, 60.7% female 39.3% male, mean age 13.38 years. post-COVID-19 over 2021/2022 107 participants, 51% female, 48% 1% genderqueer, 13 years). Independent-sample t-tests two-tailed correlational analysis used associations changes ToM, self-perceptions, self-esteem between samples. main findings includes declines ToM post-COVID-19, specifically related perception negative affect. Further, perceived self-worth behavioural conduct declined Implications social–emotional learning future research are discussed.

Language: Английский

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Effects of the social environment on vertebrate fitness and health in nature: Moving beyond the stress axis

Hormones and Behavior, Journal Year: 2022, Volume and Issue: 145, P. 105232 - 105232

Published: July 16, 2022

Language: Английский

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