Osteoarthritis and Cartilage,
Journal Year:
2024,
Volume and Issue:
32(11), P. 1358 - 1370
Published: July 1, 2024
Synovitis
is
a
widely
accepted
sign
of
osteoarthritis
(OA),
characterised
by
tissue
hyperplasia,
where
increased
infiltration
immune
cells
and
proliferation
resident
fibroblasts
adopt
pro-inflammatory
phenotype,
the
production
mediators
that
are
capable
sensitising
activating
sensory
nociceptors,
which
innervate
joint
tissues.
As
such,
it
important
to
understand
cellular
composition
synovium
their
involvement
in
pain
sensitisation
better
inform
development
effective
analgesics.
Arthritis & Rheumatology,
Journal Year:
2023,
Volume and Issue:
75(10), P. 1770 - 1780
Published: April 25, 2023
Osteoarthritis
(OA)
is
a
leading
cause
of
chronic
pain,
yet
OA
pain
management
remains
poor.
Age
the
strongest
predictor
development,
and
mechanisms
driving
are
unclear.
We
undertook
this
study
to
characterize
age-associated
changes
in
knee
OA,
pain-related
behaviors,
dorsal
root
ganglion
(DRG)
molecular
phenotypes
mice
both
sexes.
Osteoarthritis and Cartilage,
Journal Year:
2023,
Volume and Issue:
32(4), P. 355 - 364
Published: Dec. 23, 2023
Inflammation,
both
locally
in
the
joint
and
systemic,
is
nowadays
considered
among
mechanisms
involved
osteoarthritis
(OA).
However,
this
concept
has
not
always
been
generally
accepted.
In
fact,
for
long
OA
described
as
a
relatively
simple
degeneration
of
articular
cartilage
result
wear
tear
only.
narrative
review,
we
present
what
our
understanding
was
at
time
inaugural
release
Osteoarthritis
Cartilage
about
30
years
ago
discuss
set
pivotal
papers
that
changed
view
on
role
inflammation
development.
Furthermore,
briefly
current
involvement
OA.
Next,
use
example
TGF-β
signaling
to
show
how
might
influence
processes
manner
beyond
interaction
ligand
receptor
leading
inflammatory
catabolic
mediators.
Finally,
should
be
done
future
bring
field
forward.
The Journal of Experimental Medicine,
Journal Year:
2023,
Volume and Issue:
221(2)
Published: Dec. 20, 2023
In
dorsal
root
ganglia
(DRG),
macrophages
reside
close
to
sensory
neurons
and
have
largely
been
explored
in
the
context
of
pain,
nerve
injury,
repair.
However,
we
discovered
that
most
DRG
interact
with
monitor
vasculature
by
sampling
macromolecules
from
blood.
Characterization
revealed
a
specialized
endothelial
bed
transformed
molecular,
structural,
permeability
properties
along
arteriovenous
axis
was
covered
macrophage-interacting
pericytes
fibroblasts.
Macrophage
phagocytosis
spatially
aligned
peak
permeability,
process
regulated
enhanced
caveolar
transcytosis
cells.
Profiling
immune
landscape
two
subsets
perivascular
distinct
transcriptome,
turnover,
function.
CD163+
self-maintained
locally,
specifically
participated
monitoring,
displayed
responses
during
peripheral
inflammation,
were
conserved
mouse
man.
Our
work
provides
molecular
explanation
for
blood-DRG
barrier
identifies
an
unappreciated
role
as
integral
components
DRG-neurovascular
unit.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 29, 2023
Pain
imposes
a
significant
urden
on
patients,
affecting
them
physically,
psychologically,
and
economically.
Despite
numerous
studies
the
pathogenesis
of
pain,
its
clinical
management
remains
suboptimal,
leading
to
under-treatment
many
pain
patients.
Recently,
research
role
macrophages
in
processes
has
been
increasing,
offering
potential
for
novel
therapeutic
approaches.
Macrophages,
being
indispensable
immune
cells
innate
system,
exhibit
remarkable
diversity
plasticity.
However,
majority
primarily
focused
contributions
M1
promoting
pain.
During
late
stage
tissue
damage
or
inflammatory
invasion,
typically
transition
into
M2
macrophages.
In
recent
years,
growing
evidence
highlighted
relief.
this
review,
we
summarize
mechanisms
involved
macrophage
polarization
discuss
their
emerging
roles
Notably,
appear
be
key
players
multiple
endogenous
pathways
that
promote
We
further
analyze
through
which
may
alleviate
Science Signaling,
Journal Year:
2023,
Volume and Issue:
16(784)
Published: May 9, 2023
Although
largely
confined
to
the
airways,
SARS-CoV-2
infection
has
been
associated
with
sensory
abnormalities
that
manifest
in
both
acute
and
chronic
phenotypes.
To
gain
insight
on
molecular
basis
of
these
abnormalities,
we
used
golden
hamster
model
characterize
compare
effects
influenza
A
virus
(IAV)
nervous
system.
We
detected
transcripts
but
no
infectious
material
cervical
thoracic
spinal
cord
dorsal
root
ganglia
(DRGs)
within
first
24
hours
intranasal
infection.
SARS-CoV-2–infected
hamsters
exhibited
mechanical
hypersensitivity
was
milder
prolonged
compared
observed
IAV-infected
hamsters.
RNA
sequencing
analysis
DRGs
1
4
days
after
suggested
perturbations
predominantly
neuronal
signaling
animals
as
opposed
type
I
interferon
animals.
Later,
31
infection,
a
neuropathic
transcriptome
emerged
from
animals,
which
coincided
SARS-CoV-2–specific
hypersensitivity.
These
data
revealed
potential
targets
for
pain
management,
including
binding
protein
ILF3,
validated
murine
models.
This
work
elucidates
transcriptomic
signatures
triggered
by
may
underlie
short-
long-term
abnormalities.
The Journal of Experimental Medicine,
Journal Year:
2024,
Volume and Issue:
221(5)
Published: April 12, 2024
Physiological
pain
serves
as
a
warning
of
exposure
to
danger
and
prompts
us
withdraw
from
noxious
stimuli
prevent
tissue
damage.
Pain
can
also
alert
an
infection
or
organ
dysfunction
aids
in
locating
such
malfunction.
However,
there
are
instances
where
is
purely
pathological,
unresolved
following
inflammation
injury
the
nervous
system,
this
be
debilitating
persistent.
We
now
appreciate
that
immune
cells
integral
both
physiological
pathological
pain,
consequence,
not
strictly
neuronal
phenomenon.
Here,
we
discuss
recent
findings
on
how
skin,
nerve,
dorsal
root
ganglia,
spinal
cord
interact
with
somatosensory
neurons
mediate
pain.
innate
adaptive
cells,
by
releasing
various
ligands
mediators,
contribute
initiation,
modulation,
persistence,
resolution
modalities
Finally,
propose
neuroimmune
axis
attractive
target
for
treatment,
but
challenges
objectively
quantifying
preclinically,
variable
sex
differences
presentation,
well
adverse
outcomes
associated
system
all
need
considered
development
immunotherapies
against
