Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(47), P. 7899 - 7901
Published: Nov. 22, 2023
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the aggregation of β-amyloid and tau. While cognitive impairment primary clinical manifestation AD, patients also experience noncognitive symptoms, such as disordered sleep. These include sleep loss
Language: Английский
Sleep And Breathing, Journal Year: 2025, Volume and Issue: 29(1)
Published: Feb. 21, 2025
Language: Английский
Citations
1
Medicine, Journal Year: 2025, Volume and Issue: 104(5), P. e41346 - e41346
Published: Jan. 31, 2025
One third of a person's life is in state sleep, and good sleep quality one the indicators health. Long-term insomnia has great impact on patients' life, physical mental state. Especially elderly, long-term will induce variety chronic diseases, seriously affecting life. Because characteristics physiological structure elderly its unique different from that young. This article reviews terms symptom, pathogenesis treatment. By elaborating senile insomnia, we hope to provide ideas for clinical treatment insomnia.
Language: Английский
Citations
0
Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17
Published: Feb. 4, 2025
Sleep disturbances are common in Alzheimer’s disease (AD) and AD-related dementia (ADRD). We performed a sleep study on Tg-SwDI mice, cerebral amyloid angiopathy (CAA) model, age-matched wild-type (WT) control mice. The results showed that at 12 months of age, the hemizygous mice spent significantly more time non-rapid eye movement (NREM) (44.6 ± 2.4% versus 35.9 2.5% WT) had much shorter average length wake bout during dark (active) phase (148.5 8.7 s 203.6 13.0 WT). Histological analysis revealed stark decreases orexin immunoreactive (orexin-IR) neuron number soma size these (cell number: 2187 97.1 3318 137.9 WT. size: 109.1 8.1 μm 2 160.4 6.6 WT), while melanin-concentrating hormone (MCH) (MCH-IR) neurons remained unchanged 4256 273.3 4494 326.8 220.1 13.6 202.0 7.8 apoptotic cell death marker cleaved caspase-3 (Caspase-3-IR) percentage orexin-IR was higher than WT controls. This selective loss could be associated with abnormal phenotype Further studies needed to determine cause cells relevant effects cognition impairments this mouse model microvascular amyloidosis.
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)
Published: March 8, 2025
We examine the relationship between sleep, glymphatics and Alzheimer's disease (AD), recent work questioning glymphatic clearance during sleep. highlight a need for understanding and/or other mechanism of review flow measurement methods. Further, we explore dual orexin receptor antagonists (DORAs) potential to mitigate AD sleep disturbances enhance clearance. Further research could elucidate linkage DORAs, improved reducing pathophysiology.
Language: Английский
Citations
0
eNeuro, Journal Year: 2024, Volume and Issue: 11(6), P. ENEURO.0004 - 24.2024
Published: June 1, 2024
Sleep disruption and impaired synaptic processes are common features in neurodegenerative diseases, including Alzheimer's disease (AD). Hyperphosphorylated Tau is known to accumulate at neuronal synapses AD, contributing synapse dysfunction. However, it remains unclear how sleep pathology interact contribute cognitive decline. Here, we examined sex-specific onset consequences of loss AD/tauopathy model PS19 mice. Using a piezoelectric home-cage monitoring system, showed mice exhibited early-onset progressive hyperarousal, selective dark-phase disruption, apparent 3 months females 6 males. the Morris water maze test, report that chronic (CSD) accelerated decline hippocampal spatial memory males only. Hyperarousal occurs well advance robust forebrain burden becomes 6–9 months. To determine whether causal link exists between hyperphosphorylation, correlation behavior Tau, or exposed acute While confirm driver hyperphosphorylation neurons locus ceruleus, were unable show any synapses. Despite finding hyperarousal appears earlier females, female cognition was resilient effects disruption. We conclude interacts with accelerate greater vulnerability
Language: Английский
Citations
2
Nature Cardiovascular Research, Journal Year: 2024, Volume and Issue: 3(11), P. 1284 - 1300
Published: Nov. 8, 2024
Language: Английский
Citations
2
Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(6), P. 4260 - 4289
Published: April 30, 2024
Experimental laboratory research has an important role to play in dementia prevention. Mechanisms underlying modifiable risk factors for are promising targets prevention but difficult investigate human populations due technological constraints and confounds. Therefore, controlled experiments models such as transgenic rodents, invertebrates vitro cultured cells increasingly used test strategies which target them prevent dementia. This review provides overview of experimental into 15 established putative factors: less early-life education, hearing loss, depression, social isolation, life stress, hypertension, obesity, diabetes, physical inactivity, heavy alcohol use, smoking, air pollution, anesthetic exposure, traumatic brain injury, disordered sleep. It explores how have been, can be, address questions about that cannot readily be addressed studies. HIGHLIGHTS: Modifiable Interrogation mechanisms is populations. Studies using diverse revealing mechanisms. We factors. Laboratory science contribute uniquely
Language: Английский
Citations
1
F&S Science, Journal Year: 2024, Volume and Issue: 5(3), P. 225 - 231
Published: June 15, 2024
Objective To study whether male infertility and insomnia share genetic risk variants, to identify any molecular, cellular biological interactions between these traits. Design The in silico was performed. Two lists of genetics variants were manually curated through a literature review, 1 those associated with the other insomnia. Genes assigned compose (454 genes) (921 genes)-associated gene lists. Subjects Not applicable. Intervention Main Outcome Measures Enrichment pathways protein-protein interaction (PPI) analysis. Results Twenty-eight genes common both lists, representing greater overlap than would be expected by chance. In 28 contained intersection list, there significant enrichment related kinesin binding. A PPI analysis using list as input retrieved 25 nodes indicated that 2 them kinesin-related proteins (PLEKHM2 KCL1). Conclusions shared genes, highlighted this study, suggest further functional investigations into interplay fertility sleep are warranted.
Language: Английский
Citations
1
Published: Sept. 3, 2024
This review examines the complex relationship between sleep, glymphatic system and Alzheimer’s disease (AD) pathogenesis. It explores recent work calling into question mechanism of clearance during thus for further research to understand mechanisms and/or uncover true sleep. Methods measuring flow are reviewed, suggesting that magnetic resonance imaging (MRI) may be best approach resolve this controversy. Furthermore, therapeutic potential dual orexin receptor antagonists (DORAs) in mitigating sleep disturbances associated with AD. DORAs promote thereby enhance regardless precise (glymphatic or other), offering a promising avenue slowing AD progression improving long term patient outcomes. More is crucial elucidate linkage DORAs, improved facilitating remediation pathophysiology.
Language: Английский
Citations
1
Current Neurology and Neuroscience Reports, Journal Year: 2023, Volume and Issue: 23(11), P. 727 - 734
Published: Oct. 13, 2023
Language: Английский
Citations
3