Experimental Brain Research, Journal Year: 2021, Volume and Issue: 240(1), P. 9 - 25
Published: Oct. 25, 2021
Language: Английский
Journal of Clinical Investigation, Journal Year: 2020, Volume and Issue: 130(12), P. 6555 - 6570
Published: Aug. 25, 2020
The dorsal medial prefrontal cortex (dmPFC) has been recognized as a key cortical area for nociceptive modulation. However, the underlying neural pathway and function of specific cell types remain largely unclear. Here, we show that lesions in dmPFC induced an algesic anxious state. Using multiple tracing methods including rabies-based transsynaptic method, outlined excitatory descending from to ventrolateral periaqueductal gray (vlPAG). Specific activation dmPFC/vlPAG by optogenetic manipulation produced analgesic antianxiety effects mouse model chronic pain. Inhibitory neurons were specifically activated using chemogenetic approach, which logically state under both normal pain conditions. Antagonists GABAA receptor (GABAAR) or mGluR1 applied dmPFC, effects. In summary, results our study suggest might participate maintenance thresholds behaviors conditions, while silencing suppressing be involved initial stages emergence anxiety-like behaviors.
Language: Английский
Citations
100
Neuron, Journal Year: 2020, Volume and Issue: 107(6), P. 1029 - 1047
Published: Aug. 4, 2020
Language: Английский
Citations
91
Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)
Published: Feb. 15, 2021
Abstract Animals exhibit innate defense behaviors in response to approaching threats cued by the dynamics of sensory inputs various modalities. The underlying neural circuits have been mostly studied visual system, but remain unclear for other Here, utilizing sounds with increasing (vs. decreasing) loudness mimic looming receding) objects, we find that elicit stereotypical sequential defensive reactions: freezing followed flight. Both require activity auditory cortex, particular sustained type responses, are differentially mediated corticostriatal projections primarily innervating D2 neurons tail striatum and corticocollicular superior colliculus, respectively. behavioral transition from flight can be attributed differential temporal striatal collicular their responses sound stimuli. Our results reveal an essential role control.
Language: Английский
Citations
77
Science, Journal Year: 2022, Volume and Issue: 378(6626), P. 1336 - 1343
Published: Dec. 22, 2022
The primary motor cortex (M1) is involved in the control of voluntary movements and extensively mapped this capacity. Although M1 implicated modulation pain, underlying circuitry causal underpinnings remain elusive. We unexpectedly unraveled a connection from to nucleus accumbens reward through layer 6-mediodorsal thalamus pathway, which specifically suppresses negative emotional valence associated coping behaviors neuropathic pain. By contrast, 5 neurons connect with specific cell populations zona incerta periaqueductal gray suppress sensory hypersensitivity without altering pain affect. Thus, employs distinct, layer-specific pathways attune aversive-emotional components can be exploited for purposes relief.
Language: Английский
Citations
64
Frontiers in Systems Neuroscience, Journal Year: 2022, Volume and Issue: 16
Published: May 13, 2022
The cerebellum is emerging as a powerful regulator of cognitive and affective processing memory in both humans animals has been implicated disorders. How the supports function remains poorly understood. short-latency (just few milliseconds) functional connections that were identified between amygdala-a structure crucial for emotion valence-more than four decades ago raise exciting, yet untested, possibility cerebellum-amygdala pathway communicates information important emotion. major hurdle rigorously testing this lack knowledge about anatomy connectivity pathway. Our initial anatomical tracing studies mice excluded existence direct monosynaptic connection amygdala. Using transneuronal techniques, we have novel disynaptic circuit cerebellar output nuclei basolateral This recruits understudied intralaminar thalamus node. ex vivo optophysiology super-resolution microscopy, provide first evidence functionality pathway, thus offering missing mechanistic link discovery provides blueprint key limbic system. As such, it requisite step toward obtaining new emotion, fundamentally advancing understanding neurobiology which perturbed mental autism spectrum
Language: Английский
Citations
44
Neuron, Journal Year: 2023, Volume and Issue: 111(9), P. 1486 - 1503.e7
Published: March 8, 2023
Language: Английский
Citations
40
Cell, Journal Year: 2023, Volume and Issue: 186(1), P. 162 - 177.e18
Published: Jan. 1, 2023
The cortex influences movement by widespread top-down projections to many nervous system regions. Skilled forelimb movements require brainstem circuitry in the medulla; however, logic of cortical interactions with these neurons remains unexplored. Here, we reveal a fine-grained anatomical and functional map between anterior (AC) medulla mice. Distinct regions generate three-dimensional synaptic columns tiling lateral medulla, topographically matching dorso-ventral positions postsynaptic tuned distinct action phases. Although medial AC (MAC) terminates ventrally connects forelimb-reaching-tuned its silencing impairs reaching, (LAC) dorsally positioned food handling, handling. Cortico-medullary also extend collaterals other subcortical structures through segregated channel interaction logic. Our findings precise alignment location, function, specific forelimb-action-tuned neurons, thereby clarifying principles two key beyond.
Language: Английский
Citations
30
Neuron, Journal Year: 2023, Volume and Issue: 111(5), P. 727 - 738.e8
Published: Jan. 6, 2023
Top-down projections convey a family of signals encoding previous experiences and current aims to the sensory neocortex, where they converge with external bottom-up information enable perception memory. Whereas top-down control has been attributed excitatory pathways, existence, connectivity, content inhibitory remain elusive. Here, we combine synaptic two-photon calcium imaging, circuit mapping, cortex-dependent learning, chemogenetics in mice identify GABAergic afferents from subthalamic zona incerta as major source input neocortex. Incertocortical transmission undergoes robust plasticity during learning that improves transfer mediates behavioral Unlike incertocortical form disinhibitory encodes learned relevance bidirectional manner rapid appearance negative responses serves main driver changes stimulus representation. Our results therefore reveal distinctive contribution long-range (dis)inhibitory computational flexibility neocortical circuits.
Language: Английский
Citations
28
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: May 12, 2023
Abstract Chronic kidney disease (CKD) and heart failure (HF) are highly prevalent, aggravate each other, account for substantial mortality. However, the mechanisms underlying cardiorenal interaction role of afferent nerves their precise central pathway remain limited. Here, we combined virus tracing techniques with optogenetic to map a polysynaptic linking subfornical organ (SFO) thereby paraventricular nucleus (PVN) rostral ventrolateral medulla that modulates sympathetic outflow. This kidney-brain neural circuit was overactivated in mouse models CKD or HF subsequently enhanced discharge both model. Interruption by deafferentation, selective deletion angiotensin II type 1a receptor (AT1a) SFO, silence kidney-SFO SFO-PVN projection decreased lessened structural damage dysfunction HF. Thus, activate drives nervous system accelerate progression organs. These results demonstrate crucial connections engaging interactions under physiological conditions. suggests novel therapies targeting this circuit.
Language: Английский
Citations
23
Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(9), P. 1529 - 1540
Published: July 31, 2023
Language: Английский
Citations
23