Nature Neuroscience,
Journal Year:
2023,
Volume and Issue:
26(2), P. 251 - 258
Published: Jan. 9, 2023
Sensory
cortices
can
be
affected
by
stimuli
of
multiple
modalities
and
are
thus
increasingly
thought
to
multisensory.
For
instance,
primary
visual
cortex
(V1)
is
influenced
not
only
images
but
also
sounds.
Here
we
show
that
the
activity
evoked
sounds
in
V1,
measured
with
Neuropixels
probes,
stereotyped
across
neurons
even
mice.
It
independent
projections
from
auditory
resembles
hippocampal
formation,
which
receives
little
direct
input.
Its
low-dimensional
nature
starkly
contrasts
high-dimensional
code
V1
uses
represent
images.
Furthermore,
this
sound-evoked
precisely
predicted
small
body
movements
elicited
each
sound
trials
Thus,
neural
apparently
multisensory
may
simply
arise
signals
associated
internal
state
behavior.
Nature Neuroscience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
Responding
appropriately
to
potential
threats
before
they
materialize
is
critical
avoiding
disastrous
outcomes.
Here
we
examine
how
threat-coping
behavior
regulated
by
the
tail
of
striatum
(TS)
and
its
dopamine
input.
Mice
were
presented
with
a
threat
(a
moving
object)
while
pursuing
rewards.
Initially,
mice
failed
obtain
rewards
but
gradually
improved
in
later
trials.
We
found
that
TS
promoted
avoidance
threat,
even
at
expense
reward
acquisition.
Furthermore,
activity
D1
receptor-expressing
neurons
prediction.
In
contrast,
D2
suppressed
facilitated
overcoming
threat.
Dopamine
axon
activation
not
only
potentiated
responses
novel
sensory
stimuli
also
boosted
them
acutely.
These
results
demonstrate
an
opponent
interaction
TS,
modulated
dopamine,
dynamically
regulates
threats.
During
foraging
threat–reward
conflicts
mice,
modulates
two
competing
neuron
types
for
flexible
coping,
from
initial
eventual
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: Feb. 15, 2021
Abstract
Animals
exhibit
innate
defense
behaviors
in
response
to
approaching
threats
cued
by
the
dynamics
of
sensory
inputs
various
modalities.
The
underlying
neural
circuits
have
been
mostly
studied
visual
system,
but
remain
unclear
for
other
Here,
utilizing
sounds
with
increasing
(vs.
decreasing)
loudness
mimic
looming
receding)
objects,
we
find
that
elicit
stereotypical
sequential
defensive
reactions:
freezing
followed
flight.
Both
require
activity
auditory
cortex,
particular
sustained
type
responses,
are
differentially
mediated
corticostriatal
projections
primarily
innervating
D2
neurons
tail
striatum
and
corticocollicular
superior
colliculus,
respectively.
behavioral
transition
from
flight
can
be
attributed
differential
temporal
striatal
collicular
their
responses
sound
stimuli.
Our
results
reveal
an
essential
role
control.
Cell Reports,
Journal Year:
2022,
Volume and Issue:
40(7), P. 111222 - 111222
Published: Aug. 1, 2022
Perception
of
threats
is
essential
for
survival.
Previous
findings
suggest
that
parallel
pathways
independently
relay
innate
threat
signals
from
different
sensory
modalities
to
multiple
brain
areas,
such
as
the
midbrain
and
hypothalamus,
immediate
avoidance.
Yet
little
known
about
whether
how
multi-sensory
cues
are
integrated
conveyed
each
modality
amygdala,
a
critical
area
perception
learning.
Here,
we
report
neurons
expressing
calcitonin
gene-related
peptide
(CGRP)
in
parvocellular
subparafascicular
nucleus
thalamus
external
lateral
parabrachial
brainstem
respond
various
negative
valence
central
respectively.
Both
CGRP
populations
their
amygdala
projections
required
aversive
memory
formation.
The
identification
unified
may
provide
insights
into
developing
therapeutic
candidates
fear-related
disorders.
Scientific Reports,
Journal Year:
2021,
Volume and Issue:
11(1)
Published: April 15, 2021
Abstract
Environmental
contexts
can
inform
animals
of
potential
threats,
though
it
is
currently
unknown
how
context
biases
the
selection
defensive
behavior.
Here
we
investigated
context-dependent
flight
responses
with
a
Pavlovian
serial-compound
stimulus
(SCS)
paradigm
that
evokes
freeze-to-flight
transitions.
Similar
to
previous
work
in
mice,
show
male
and
female
rats
display
flight-like
behavior
SCS
paradigm.
Flight
was
dependent
on
contextual
fear
insofar
as
only
evoked
shock-associated
reduced
conditioning
after
extinction.
expressed
white
noise
regardless
temporal
order
within
compound.
Nonetheless,
received
unpaired
trials
did
not
SCS,
indicating
associative.
Finally,
pharmacological
inactivation
two
brain
regions
critical
expression
fear,
central
nucleus
amygdala
(CeA)
bed
stria
terminalis
(BNST),
attenuates
both
responses.
All
these
effects
were
similar
rats.
This
demonstrates
summate
cued
innate
drive
high
state
transition
from
post-encounter
circa-strike
modes.
