Neurotrophin regulation of neural circuit development and function

Nature reviews. Neuroscience, Journal Year: 2012, Volume and Issue: 14(1), P. 7 - 23

Published: Dec. 20, 2012

Language: Английский

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BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity

Cellular and Molecular Neurobiology, Journal Year: 2017, Volume and Issue: 38(3), P. 579 - 593

Published: June 16, 2017

Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and extensively studied neurotrophins in mammalian brain. Among its prominent functions, can mention control neuronal glial development, neuroprotection, modulation both short- long-lasting synaptic interactions, which are critical for cognition memory. A wide spectrum processes controlled by BDNF, sometimes contradictory effects action be explained based on specific pattern synthesis, comprising several intermediate biologically active isoforms that bind to different types receptor, triggering signaling pathways. The functions BDNF must discussed close relation stage brain cellular components nervous tissue, as well molecular mechanisms signal transduction activated under physiological pathological conditions. In this review, we briefly summarize current state knowledge regarding impact regulation neurophysiological processes. importance future studies aimed at disclosing activation pathways, neuro- gliogenesis, plasticity highlighted.

Language: Английский

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The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

Cellular Signalling, Journal Year: 2014, Volume and Issue: 26(12), P. 2694 - 2701

Published: Aug. 28, 2014

Language: Английский

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Psychedelics Promote Structural and Functional Neural Plasticity

Cell Reports, Journal Year: 2018, Volume and Issue: 23(11), P. 3170 - 3182

Published: June 1, 2018

Atrophy of neurons in the prefrontal cortex (PFC) plays a key role pathophysiology depression and related disorders. The ability to promote both structural functional plasticity PFC has been hypothesized underlie fast-acting antidepressant properties dissociative anesthetic ketamine. Here, we report that, like ketamine, serotonergic psychedelics are capable robustly increasing neuritogenesis and/or spinogenesis vitro vivo. These changes neuronal structure accompanied by increased synapse number function, as measured fluorescence microscopy electrophysiology. induced appear result from stimulation TrkB, mTOR, 5-HT2A signaling pathways could possibly explain clinical effectiveness these compounds. Our results underscore therapeutic potential and, importantly, identify several lead scaffolds for medicinal chemistry efforts focused on developing plasticity-promoting compounds safe, effective, treatments

Language: Английский

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BDNF – a key transducer of antidepressant effects

Neuropharmacology, Journal Year: 2015, Volume and Issue: 102, P. 72 - 79

Published: Nov. 11, 2015

Language: Английский

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Rare De Novo Variants Associated with Autism Implicate a Large Functional Network of Genes Involved in Formation and Function of Synapses

Neuron, Journal Year: 2011, Volume and Issue: 70(5), P. 898 - 907

Published: June 1, 2011

Language: Английский

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Branching out: mechanisms of dendritic arborization

Nature reviews. Neuroscience, Journal Year: 2010, Volume and Issue: 11(5), P. 316 - 328

Published: April 20, 2010

Language: Английский

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Postsynaptic BDNF‐TrkB signaling in synapse maturation, plasticity, and disease

Developmental Neurobiology, Journal Year: 2010, Volume and Issue: 70(5), P. 304 - 322

Published: Feb. 22, 2010

Abstract Brain‐derived neurotrophic factor (BDNF) is a prototypic neurotrophin that regulates diverse developmental events from the selection of neural progenitors to terminal dendritic differentiation and connectivity neurons. We focus here on activity‐dependent synaptic regulation by BDNF its receptor, full length TrkB. BDNF‐TrkB signaling involved in transcription, translation, trafficking proteins during various phases development has been implicated several forms plasticity. These functions are carried out combination three cascades triggered when binds TrkB: The mitogen‐activated protein kinase (MAPK), phospholipase Cγ (PLC PLCγ), phosphatidylinositol 3‐kinase (PI3K) pathways. MAPK PI3K play crucial roles both translation and/or induced activity, whereas PLCγ intracellular Ca 2+ can drive transcription via cyclic AMP C. Conversely, abnormal neurodegenerative diseases perturb function. will discuss current state understanding context plasticity with postsynaptic cell close evidence basic mechanisms function still need be understood effectively treat genetic disruptions these pathways cause devastating neurodevelopmental diseases. © 2010 Wiley Periodicals, Inc. Develop Neurobiol

Language: Английский

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Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(20), P. 7777 - 7777

Published: Oct. 21, 2020

Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively studied neurotrophins in mammalian brain. BDNF signals through tropomycin receptor kinase B (TrkB) low affinity p75 neurotrophin (p75NTR). plays an important role proper growth, development, plasticity glutamatergic GABAergic synapses modulation neuronal differentiation, it influences serotonergic dopaminergic neurotransmission. acts as paracrine autocrine factor, on both pre-synaptic post-synaptic target sites. It crucial transformation synaptic activity into long-term memories. considered instructive mediator functional structural central nervous system (CNS), influencing dendritic spines and, at least hippocampus, adult neurogenesis. Changes rate neurogenesis spine density can influence several forms learning memory contribute to depression-like behaviors. The possible roles highlighted this review focus effect antidepressant therapies BDNF-mediated plasticity. Moreover, we will data that illustrate a potent protective able confer protection against neurodegeneration, particular Alzheimer’s disease. Finally, give evidence how involvement pathogenesis brain glioblastoma has emerged, thus opening new avenues for treatment deadly cancer.

Language: Английский

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The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

Journal of Neuroscience, Journal Year: 2009, Volume and Issue: 29(21), P. 6964 - 6972

Published: May 27, 2009

Understanding molecular mechanisms mediating epileptogenesis is critical for developing more effective therapies epilepsy. We recently found that the mammalian target of rapamycin (mTOR) signaling pathway involved in epileptogenesis, and mTOR inhibitors prevent epilepsy a mouse model tuberous sclerosis complex. Here, we investigated potential role rat temporal lobe initiated by status epilepticus. Acute kainate-induced seizures resulted biphasic activation pathway, as evident an increase phospho-S6 (P-S6) expression. An initial rise P-S6 expression started approximately 1 h after seizure onset, peaked at 3-6 h, returned to baseline 24 both hippocampus neocortex, reflecting widespread stimulation acute activity. After resolution epilepticus, second was observed only, which 3 d, 5-10 persisted several weeks kainate injection, correlating with development chronic within hippocampus. The inhibitor rapamycin, administered before kainate, blocked phases seizure-induced decreased neuronal cell death, neurogenesis, mossy fiber sprouting, spontaneous Late treatment, termination phase reduced sprouting but not neurogenesis or death. These findings indicate mediates have antiepileptogenic effects this model.

Language: Английский

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