Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(20), P. 7777 - 7777

Published: Oct. 21, 2020

Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively studied neurotrophins in mammalian brain. BDNF signals through tropomycin receptor kinase B (TrkB) low affinity p75 neurotrophin (p75NTR). plays an important role proper growth, development, plasticity glutamatergic GABAergic synapses modulation neuronal differentiation, it influences serotonergic dopaminergic neurotransmission. acts as paracrine autocrine factor, on both pre-synaptic post-synaptic target sites. It crucial transformation synaptic activity into long-term memories. considered instructive mediator functional structural central nervous system (CNS), influencing dendritic spines and, at least hippocampus, adult neurogenesis. Changes rate neurogenesis spine density can influence several forms learning memory contribute to depression-like behaviors. The possible roles highlighted this review focus effect antidepressant therapies BDNF-mediated plasticity. Moreover, we will data that illustrate a potent protective able confer protection against neurodegeneration, particular Alzheimer’s disease. Finally, give evidence how involvement pathogenesis brain glioblastoma has emerged, thus opening new avenues for treatment deadly cancer.

Language: Английский

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BDNF as a Promising Therapeutic Agent in Parkinson’s Disease

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(3), P. 1170 - 1170

Published: Feb. 10, 2020

Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration. In animal models of Parkinson’s disease (PD), BDNF enhances the survival dopaminergic neurons, improves neurotransmission motor performance. Pharmacological therapies PD are symptom-targeting, their effectiveness decreases with progression disease; therefore, new therapeutical approaches needed. Since, in both patients models, decreased level was found nigrostriatal pathway, it has been hypothesized that may serve as a therapeutic agent. Direct delivery exogenous into patient’s brain did not relieve symptoms disease, nor attempts to enhance expression gene therapy. Physical training neuroprotective PD. This effect is mediated, at least partly, by BDNF. Animal studies revealed physical activity increases tropomyosin receptor kinase B (TrkB) expression, leading inhibition neurodegeneration through induction transcription factors genes related neuronal proliferation, survival, inflammatory response. review focuses on evidence increasing due modulation or exercise could be considered adjunctive therapy

Language: Английский

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BDNF signaling in context: From synaptic regulation to psychiatric disorders

Cell, Journal Year: 2021, Volume and Issue: 185(1), P. 62 - 76

Published: Dec. 27, 2021

Language: Английский

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Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function

Nutrients, Journal Year: 2019, Volume and Issue: 11(11), P. 2579 - 2579

Published: Oct. 25, 2019

Cognitive dysfunction is linked to chronic low-grade inflammatory stress that contributes cell-mediated immunity in creating an oxidative environment. Food a vitally important energy source; it affects brain function and provides direct energy. Several studies have indicated high-fat consumption causes overproduction of circulating free fatty acids systemic inflammation. Immune cells, acids, cytokines reach the hypothalamus initiate local inflammation through processes such as microglial proliferation. Therefore, role diet (HFD) promoting neurodegeneration worthy further discussion. Of particular interest this article, we highlight associations molecular mechanisms HFD modulation cognitive deficits. Taken together, better understanding impairment following would provide useful approach for prevention dysfunction.

Language: Английский

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Nutrition, Physical Activity, and Other Lifestyle Factors in the Prevention of Cognitive Decline and Dementia

Nutrients, Journal Year: 2021, Volume and Issue: 13(11), P. 4080 - 4080

Published: Nov. 15, 2021

Multiple factors combined are currently recognized as contributors to cognitive decline. The main independent risk factor for impairment and dementia is advanced age followed by other determinants such genetic, socioeconomic, environmental factors, including nutrition physical activity. In the next decades, a rise in cases expected due largely aging of world population. There no hitherto effective pharmaceutical therapies treat age-associated dementia, which underscores crucial role prevention. A relationship among diet, activity, lifestyle with function has been intensively studied mounting evidence supporting these development decline chief cause disability globally. Several dietary patterns, foods, nutrients have investigated this regard, some encouraging disappointing results. This review presents current effects components, supplements, sleep social engagement on prevention or delay onset age-related dementia.

Language: Английский

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The potential mechanism of postoperative cognitive dysfunction in older people

Experimental Gerontology, Journal Year: 2019, Volume and Issue: 130, P. 110791 - 110791

Published: Nov. 22, 2019

Postoperative cognitive dysfunction (POCD) is a common disorder following surgery, which seriously threatens the quality of patients' life, especially older people. Accumulating attention has been paid to POCD worldwide in pace with popularization anesthesia/surgery. The development medical humanities and rehabilitation medicine sets higher demands on accurate diagnosis safe treatment system POCD. Although research full swing, underlying pathogenesis still inconclusive due these conflicting results controversial evidence. Generally, closely related neuropsychiatric diseases such as dementia, depression Alzheimer's disease molecular pathways. Researchers have come up various hypotheses reveal mechanisms POCD, including neuroinflammation, oxidative stress, autophagy disorder, impaired synaptic function, lacking neurotrophic support, etc. Recent work focused mechanism people thoroughly reviewed summed here, concerning changes peripheral circulation, pathological pathways central nervous (CNS), microbiota-gut-brain axis brain regions. Accordingly, this article provides better perspective understand situation people, conductive uncover exploit reasonable strategy

Language: Английский

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Exercise-Induced Neuroplasticity: A Mechanistic Model and Prospects for Promoting Plasticity

The Neuroscientist, Journal Year: 2018, Volume and Issue: 25(1), P. 65 - 85

Published: April 21, 2018

Aerobic exercise improves cognitive and motor function by inducing neural changes detected using molecular, cellular, systems level neuroscience techniques. This review unifies the knowledge gained across various techniques to provide a comprehensive profile of mechanisms that mediate exercise-induced neuroplasticity. Using model neuroplasticity, this emphasizes sequence events accompany exercise, ultimately promote in human performance. is achieved differentiating between neuroplasticity induced acute versus chronic aerobic exercise. Furthermore, experimental considerations influence opportunity observe humans. These include modifiable factors associated with intervention nonmodifiable such as biological sex, ovarian hormones, genetic variations, fitness level. To maximize beneficial effects health, disease, following injury, future research should continue explore identifies some fundamental gaps may serve guide area.

Language: Английский

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Sexual dimorphism in predisposition to Alzheimer's disease

Neurobiology of Aging, Journal Year: 2018, Volume and Issue: 70, P. 308 - 324

Published: April 17, 2018

Language: Английский

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Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring

Environment International, Journal Year: 2020, Volume and Issue: 144, P. 105811 - 105811

Published: Aug. 29, 2020

Human biomonitoring (HBM) studies have demonstrated widespread and daily exposure to bisphenol A (BPA). Moreover, BPA structural analogues (e.g. BPS, BPF, BPAF), used as replacements, are being increasingly detected in human biological matrices. some of its classified endocrine disruptors suspected contributing adverse health outcomes such altered reproduction neurodevelopment, obesity, metabolic disorders among other developmental chronic impairments. One the aims H2020 European Biomonitoring Initiative (HBM4EU) is implementation effect biomarkers at large scales future HBM a systematic standardized way, order complement data with mechanistically-based early effects. This review aimed identify prioritize existing for BPA, well provide relevant mechanistic outcome pathway (AOP) information cover knowledge gaps better interpret biomarker data. comprehensive literature search was performed PubMed all epidemiologic published last 10 years addressing potential relationship between bisphenols alterations parameters. total 5716 references were screened, out which, 119 full-text articles analyzed tabulated detail. work provides first an overview epigenetics, gene transcription, oxidative stress, reproductive, glucocorticoid thyroid hormones, allergy/immune previously studied. Then, promising related neurodevelopmental reproductive including brain-derived neurotrophic factor (BDNF), kisspeptin (KiSS), expression nuclear receptors prioritized, providing insights based on vitro, animal AOP information. Finally, omics technologies discovery implications risk assessment discussed. To best our knowledge, this effort comprehensively bisphenol-related purposes.

Language: Английский

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Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics

Frontiers in Psychiatry, Journal Year: 2021, Volume and Issue: 12

Published: Sept. 10, 2021

Clinical studies suggest the therapeutic potential of psychedelics, including ayahuasca, DMT, psilocybin, and LSD, in stress-related disorders. These substances induce cognitive, antidepressant, anxiolytic, antiaddictive effects suggested to arise from biological changes similar conventional antidepressants or rapid-acting substance ketamine. The proposed route is by inducing brain neuroplasticity. This review attempts summarize evidence that psychedelics neuroplasticity focusing on psychedelics' cellular molecular after single repeated administration. When behavioral parameters are encountered selected studies, pathways will be linked effects. Additionally, knowledge gaps underlying biology clinical outcomes highlighted. literature searched yielded 344 results. Title abstract screening reduced sample 35; eight were included other sources, full-text resulted final selection 16 preclinical four studies. Studies ( n = 20) show a administration psychedelic produces rapid plasticity mechanisms molecular, neuronal, synaptic, dendritic level. expression plasticity-related genes proteins, Brain-Derived Neurotrophic Factor (BDNF), changed resulting latter more complexity, which outlasted acute psychedelic. Repeated directly stimulated neurogenesis increased BDNF mRNA levels up month treatment. Findings current demonstrate adaptations related those run parallel potentially them. Future (pre)clinical research might focus deciphering specific mechanism activated different long-term increase our understanding these compounds.

Language: Английский

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