Recent Advances on the Role of Brain-Derived Neurotrophic Factor (BDNF) in Neurodegenerative Diseases

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(12), P. 6827 - 6827

Published: June 19, 2022

Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal survival and growth. The signaling cascades initiated by BDNF its receptor the key regulators of synaptic plasticity, which plays important role in learning memory formation. Changes levels pathways have been identified several neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s Huntington’s linked with symptoms course these diseases. This review summarizes current understanding well underlying molecular mechanism. therapeutic potential treatment is also discussed, hope discovering new avenues

Language: Английский

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The role of brain derived neurotrophic factor in central nervous system

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: Sept. 8, 2022

Brain derived neurotrophic factor (BDNF) has multiple biological functions which are mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) and p75 neurotrophin receptor, involving in physiological pathological processes throughout life. The diverse presence activity BDNF indicate its potential role pathogenesis, progression treatment both neurological psychiatric disorders. This review is to provide a comprehensive assessment current knowledge future directions BDNF-associated research central nervous system (CNS), with an emphasis on as well effects CNS diseases, including depression, Alzheimer’s disease, Parkinson’s Huntington’s amyotrophic lateral sclerosis, cerebral ischemic stroke.

Language: Английский

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Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis

Journal of Neuroinflammation, Journal Year: 2023, Volume and Issue: 20(1)

Published: Nov. 27, 2023

As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks premature death other medical conditions for patients. Neuroinflammation is abnormal immune response in brain, its correlation with MDD receiving increasing attention. has been reported to be involved through distinct neurobiological mechanisms, among which dysregulation neurogenesis dentate gyrus (DG) hippocampus (HPC) The DG two niches adult mammalian neurotrophic factors are fundamental regulators this process. cell types mediating neuroinflammation include microglia, astrocytes, oligodendrocytes, meningeal leukocytes, peripheral cells selectively penetrate blood-brain barrier infiltrate into inflammatory regions. This review summarizes functions affected by during progression corresponding influences on memory patients model animals.

Language: Английский

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Neurobiological Highlights of Cognitive Impairment in Psychiatric Disorders

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1217 - 1217

Published: Jan. 22, 2022

This review is focused on several psychiatric disorders in which cognitive impairment a major component of the disease, influencing life quality. There are plenty data proving that accompanies and even underlies some disorders. In addition, sources provide information biological background problems associated with mental illness. scientific aims to summarize current knowledge about neurobiological mechanisms people schizophrenia, depression, mild dementia (including Alzheimer’s disease).The provides prevalence illness markers.

Language: Английский

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Intranasal delivery of BDNF-loaded small extracellular vesicles for cerebral ischemia therapy

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 357, P. 1 - 19

Published: March 28, 2023

Mesenchymal stem cells (MSCs) have shown promise for the therapy of cerebral ischemia in animal studies and clinical trials, yet their application still faces many challenges. Utilizing small extracellular vesicles (sEVs) may overcome these In study, we overexpressed brain-derived neurotrophic factor (BDNF) cultured MSCs purified sEVs using anion exchange chromatography. an ischemic stroke mouse model, selectively targeted peri-infarct region after intranasal administration, BDNF loading enhanced efficacy improved functional behavior, neural repair indicated by infarct volume reduction, increased neurogenesis, angiogenesis, synaptic plasticity, fiber preservation, as well decreased inflammatory-cytokine expression glial response. Intranasal administration BDNF-sEVs resulted upregulation neuroprotection-related genes downregulation inflammation-related genes, treatment activated BDNF/TrkB signaling brain. Transcriptomic proteomic analysis disclosed abundant proteins miRNAs involved neuroprotection anti-inflammation, showed different characteristics from sEVs. conclusion, delivery sEVs-loaded is a promising alternative strategy ischemia.

Language: Английский

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Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction

Translational Neurodegeneration, Journal Year: 2023, Volume and Issue: 12(1)

Published: Feb. 27, 2023

Abstract Physical exercise is of great significance for maintaining human health. Exercise can provide varying degrees benefits to cognitive function at all stages life cycle. Currently, with the aging world’s population and increase expectancy, dysfunction has gradually become a disease high incidence, which accompanied by neurodegenerative diseases in elderly individuals. Patients often exhibit memory loss, aphasia weakening orientation once diagnosed, are unable have normal life. Cognitive largely affects physical mental health, reduces quality life, causes economic burden society. At present, most interventions aimed maintain current level delay deterioration cognition. In contrast, as nonpharmacological therapy advantages its nontoxicity, low cost universal application. The molecular mechanisms underlying effect on cognition complex, studies been extensively centered neural plasticity, direct target brain. addition, mitochondrial stability energy metabolism essential brain status. Meanwhile, organ-brain axis responds induces release cytokines related this review, we summarize latest evidence effects cognition, point out directions future research.

Language: Английский

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Kaempferol, a potential neuroprotective agent in neurodegenerative diseases: From chemistry to medicine

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115215 - 115215

Published: July 24, 2023

Neurodegenerative diseases (NDDs) encompass a range of conditions that involve progressive deterioration and dysfunction the nervous system. Some common NDDs include Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), amyotrophic lateral sclerosis (ALS). Although significant progress has been made in understanding pathological mechanisms recent years, development targeted effective drugs for their treatment remains challenging. Kaempferol is flavonoid whose derivatives kaempferol-O-rhamnoside, 3-O-β-rutinoside/6-hydroxykaempferol 3,6-di-O-β-d-glucoside, kaempferide. Emerging studies have suggested kaempferol its possess neuroprotective properties may potential therapeutic benefits NDDs. Here, we aimed to provide theoretical basis use clinical We systematically reviewed literature PubMed, Web Science, Science Direct databases until June 2022 using search terms "kaempferol," "kaempferol derivatives," "NDDs," "pharmacokinetics," "biosynthesis" according reporting items systematic review (PRISMA) standard. Based on combined results vivo vitro studies, summarize basic targets management AD, PD, HD, ALS. exert role mainly by preventing deposition amyloid fibrils (such as Aβ, tau, α-synuclein), inhibiting microglia activation, reducing release inflammatory factors, restoring mitochondrial membrane prevent oxidative stress, protecting blood-brain barrier, specific enzyme activities cholinesterase). are promising natural agents. By determining pharmacological mechanism, be new candidate

Language: Английский

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The gut-brain axis involved in polystyrene nanoplastics-induced neurotoxicity via reprogramming the circadian rhythm-related pathways

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 458, P. 131949 - 131949

Published: June 29, 2023

Language: Английский

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The Potential Health Benefits of Gallic Acid: Therapeutic and Food Applications

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 1001 - 1001

Published: Aug. 18, 2024

Gallic acid (GA), a phenolic found in fruits and vegetables, has been consumed by humans for centuries. Its extensive health benefits, such as antimicrobial, antioxidant, anticancer, anti-inflammatory, antiviral properties, have well-documented. GA's potent antioxidant capabilities enable it to neutralize free radicals, reduce oxidative stress, protect cells from damage. Additionally, GA exerts anti-inflammatory effects inhibiting inflammatory cytokines enzymes, making potential therapeutic agent diseases. It also demonstrates anticancer properties cancer cell growth promoting apoptosis. Furthermore, offers cardiovascular lowering blood pressure, decreasing cholesterol, enhancing endothelial function, which may aid the prevention management of This review covers chemical structure, sources, identification quantification methods, biological GA, along with its applications food. As research progresses, future appears promising, uses functional foods, pharmaceuticals, nutraceuticals aimed at improving overall preventing disease. However, ongoing innovation are necessary fully understand address current challenges, establish mainstay nutritional interventions.

Language: Английский

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Nerve Growth Factor and the Role of Inflammation in Tumor Development

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(2), P. 965 - 989

Published: Jan. 23, 2024

Nerve growth factor (NGF) plays a dual role both in inflammatory states and cancer, acting as pro-inflammatory oncogenic an anti-inflammatory pro-apoptotic mediator context-dependent way based on the signaling networks its interaction with diverse cellular components within microenvironment. This report aims to provide summary subsequent review of literature NGF regulating microenvironment tumor cell growth, survival, death. The inflammation tumorigenesis component system, various respective microenvironments, ability cause epigenetic changes, treatment cancer have been highlighted this paper.

Language: Английский

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