Neuromodulatory treatments for psychiatric disease: A comprehensive survey of the clinical trial landscape

Brain stimulation, Journal Year: 2021, Volume and Issue: 14(5), P. 1393 - 1403

Published: Aug. 27, 2021

BackgroundNumerous neuromodulatory therapies are currently under investigation or in clinical use for the treatment of psychiatric conditions.Objective/hypothesisWe sought to catalogue past and present human research studies on neuromodulation identify relevant trends this field.MethodsClinicalTrials.gov (https://www.clinicaltrials.gov/) International Clinical Trials Registry Platform (https://www.who.int/ictrp/en/) were queried March 2020 trials assessing outcome disorders. Relevant categorized by variables such as modality, country, brain target, publication status, design, funding source.ResultsFrom 72,086 initial search results, 1252 unique identified. The number registered annually has consistently increased. Half all active a quarter have translated publications. largest proportion involved depression (45%), schizophrenia (18%), substance disorders (14%). spanned 37 countries; China, second contributor (13%) after United States (28%), increased its output substantially recent years. Over 75% non-convulsive non-invasive modalities (e.g., transcranial magnetic stimulation), while convulsive electroconvulsive therapy) invasive deep stimulation) less represented. 72% featured approved cleared interventions. Characteristic inter-modality differences observed with respect enrollment size, trial design/phase, funding. Dorsolateral prefrontal cortex accounted over half focal targets. examining biological correlates increased.Conclusion(s)These results provide comprehensive overview state research, revealing growing scope internationalism field.

Language: Английский

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Nonlinear Ultrasound Imaging Modeled by a Westervelt Equation

SIAM Journal on Applied Mathematics, Journal Year: 2022, Volume and Issue: 82(2), P. 408 - 426

Published: March 14, 2022

We consider the ultrasound imaging problem governed by a nonlinear wave equation of Westervelt type with variable speed. show that coefficient nonlinearity can be recovered uniquely from knowledge Dirichlet-to-Neumann map. Our proof is based on second order linearization and use Gaussian beam solutions to reduce inversion weighted geodesic ray transform. propose an algorithm report results numerical implementation solve in transmission setting frequency domain.

Language: Английский

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Overcoming Neuroanatomical Mapping and Computational Barriers in Human Brain Synaptic Architecture

Neuroinformatics, Journal Year: 2025, Volume and Issue: 23(2)

Published: Feb. 25, 2025

Language: Английский

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Noninvasive neuromodulation of the prefrontal cortex in mental health disorders

Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 47(1), P. 361 - 372

Published: July 16, 2021

Language: Английский

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Best Practices and Methodological Strategies for Addressing Generalizability in Neuropsychological Assessment

Journal of Pediatric Neuropsychology, Journal Year: 2023, Volume and Issue: 9(2), P. 47 - 63

Published: May 15, 2023

Language: Английский

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