Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: March 7, 2024
Abstract
Colorectal
cancer
(CRC)
is
a
malignancy
that
widely
prevalent
worldwide.
Due
to
its
unsatisfactory
treatment
outcome
and
extremely
poor
prognosis,
many
studies
on
the
molecular
mechanisms
pathological
of
CRC
have
been
published
in
recent
years.
The
tumor
microenvironment
(TME)
an
important
feature
tumorigenesis
one
hallmarks
development.
Metabolic
reprogramming
currently
hot
topic
research,
this
provided
insights
into
In
particular,
metabolic
causes
changes
composition
energy
nutrients
TME.
Furthermore,
it
can
alter
complex
crosstalk
between
immune
cells
associated
factors,
such
as
macrophages
T
cells,
which
play
roles
TME,
turn
affecting
escape
tumors
by
altering
surveillance.
review,
we
summarize
several
metabolism-related
processes
tumors.
Our
results
showed
regulated
influences
development
CRC.
Science Advances,
Journal Year:
2023,
Volume and Issue:
9(49)
Published: Dec. 6, 2023
Adenosine
5'-triphosphate
citrate
lyase
(ACLY)
is
a
cytosolic
enzyme
that
converts
into
acetyl-coenzyme
A
for
fatty
acid
and
cholesterol
biosynthesis.
ACLY
up-regulated
or
activated
in
many
cancers,
targeting
by
inhibitors
holds
promise
as
potential
cancer
therapy.
However,
the
role
of
immunity
regulation
remains
poorly
understood.
Here,
we
show
inhibition
up-regulates
PD-L1
immune
checkpoint
expression
cells
induces
T
cell
dysfunction
to
drive
immunosuppression
compromise
its
antitumor
effect
immunocompetent
mice.
Mechanistically,
causes
polyunsaturated
(PUFA)
peroxidation
mitochondrial
damage,
which
triggers
DNA
leakage
activate
cGAS-STING
innate
pathway.
Pharmacological
genetic
overcomes
resistance
anti-PD-L1
therapy
cGAS-dependent
manner.
Furthermore,
dietary
PUFA
supplementation
mirrors
enhanced
efficacy
blockade
inhibition.
These
findings
reveal
an
immunomodulatory
provide
combinatorial
strategies
overcome
immunotherapy
tumors.
Cell,
Journal Year:
2024,
Volume and Issue:
187(19), P. 5336 - 5356.e30
Published: Aug. 12, 2024
Tumors
growing
in
metabolically
challenged
environments,
such
as
glioblastoma
the
brain,
are
particularly
reliant
on
crosstalk
with
their
tumor
microenvironment
(TME)
to
satisfy
high
energetic
needs.
To
study
intricacies
of
this
metabolic
interplay,
we
interrogated
heterogeneity
TME
using
single-cell
and
multi-omics
analyses
identified
rewired
tumor-associated
macrophage
(TAM)
subpopulations
pro-tumorigenic
properties.
These
TAM
subsets,
termed
lipid-laden
macrophages
(LLMs)
reflect
cholesterol
accumulation,
epigenetically
rewired,
display
immunosuppressive
features,
enriched
aggressive
mesenchymal
subtype.
Engulfment
cholesterol-rich
myelin
debris
endows
subsets
TAMs
acquire
an
LLM
phenotype.
Subsequently,
LLMs
directly
transfer
myelin-derived
lipids
cancer
cells
LXR/Abca1-dependent
manner,
thereby
fueling
heightened
demands
glioblastoma.
Our
work
provides
in-depth
understanding
immune-metabolic
interplay
during
progression,
laying
a
framework
unveil
targetable
vulnerabilities
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Oct. 9, 2024
Metabolism,
including
glycolysis,
oxidative
phosphorylation,
fatty
acid
oxidation,
and
other
metabolic
pathways,
impacts
the
phenotypes
functions
of
immune
cells.
The
regulation
system
is
important
in
pathogenesis
progression
numerous
diseases,
such
as
cancers,
autoimmune
diseases
diseases.
concept
immunometabolism
was
introduced
over
a
decade
ago
to
elucidate
intricate
interplay
between
metabolism
immunity.
definition
has
expanded
from
chronic
low-grade
inflammation
reprogramming
cells
various
With
being
proposed
developed,
can
be
gradually
summarized
becomes
more
clearer.
In
context
many
cancer,
disease,
occurs
inducing
proinflammatory
or
anti-inflammatory
effects.
phenotypic
functional
changes
caused
by
further
affect
development
Based
on
experimental
results,
targeting
cellular
promising
therapy.
this
review,
we
focus
introduce
their
pathways
reprogramming,
summarize
how
these
effects
We
thoroughly
explore
targets
treatments
based
existing
studies.
challenges
translating
results
into
clinical
applications
field
are
also
summarized.
believe
that
better
understanding
health
will
improve
management
most
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: March 7, 2024
Abstract
Colorectal
cancer
(CRC)
is
a
malignancy
that
widely
prevalent
worldwide.
Due
to
its
unsatisfactory
treatment
outcome
and
extremely
poor
prognosis,
many
studies
on
the
molecular
mechanisms
pathological
of
CRC
have
been
published
in
recent
years.
The
tumor
microenvironment
(TME)
an
important
feature
tumorigenesis
one
hallmarks
development.
Metabolic
reprogramming
currently
hot
topic
research,
this
provided
insights
into
In
particular,
metabolic
causes
changes
composition
energy
nutrients
TME.
Furthermore,
it
can
alter
complex
crosstalk
between
immune
cells
associated
factors,
such
as
macrophages
T
cells,
which
play
roles
TME,
turn
affecting
escape
tumors
by
altering
surveillance.
review,
we
summarize
several
metabolism-related
processes
tumors.
Our
results
showed
regulated
influences
development
CRC.
