Non-SCFA microbial metabolites associated with fiber fermentation and host health

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Language: Английский

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INVITED REVIEW: Impact of Maternal Health and Nutrition on the Microbiome and Immune Development of Neonatal Calves

Journal of Dairy Science, Journal Year: 2024, Volume and Issue: 107(10), P. 7504 - 7519

Published: May 31, 2024

This comprehensive review highlights the intricate interplay between maternal factors and co-development of microbiome immune system in neonatal calves. Based on human mouse studies, multiple prenatal postnatal influence this process by altering host-associated microbiomes (gut, respiratory tract, skin), microbial colonization trajectories, priming systems (mucosal systemic). emphasizes importance early-life exposure, highlighting that work synergy with further fine-tuning immunity. In cattle, there is a general lack research to identify effect early calves tract) its impact system. Past studies have primarily investigated effects passive transfer immunity at birth. The vital for lifelong health production cattle. Therefore, beyond traditional focus an essential step endeavor. Calf reports diverse bacterial communities newborns, which affected colostrum feeding method immediately after contrast reporting strong link infant communities, evidence clearly define cow-to-calf transmission Maternal exposure has been shown promote beneficial bacteria Nonetheless, calf lacks links development An in-depth understanding will improve management pregnant cows raise immune-fit It investigate conditions nutrition during pregnancy gut through collaboration among researchers from fields such as microbiology, immunology, nutrition, veterinary science, epidemiology.

Language: Английский

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Dietary fibre optimisation in support of global health

Microbial Biotechnology, Journal Year: 2024, Volume and Issue: 17(8)

Published: Aug. 1, 2024

Abstract The human gut microbiota influences its host via multiple molecular pathways, including immune system interactions, the provision of nutrients and regulation physiology. Dietary fibre plays a crucial role in maintaining healthy as primary nutrient energy source. Industrialisation has led to massive decrease habitual intake recent times, intakes across world are below national recommendations. This goes hand with other factors industrialised societies that may negatively affect microbiota, such medication increased hygiene. Non‐communicable diseases on rise urbanised optimisation dietary can help improve global health prevent disease. Early life interventions shape developing counteract malnutrition, both context nations an overabundance cheap, highly processed foods, well Low‐ Middle‐Income Countries (LMICs). Adequate should, however, be maintained course promote health. Here we will discuss current state research consider different intervention approaches.

Language: Английский

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Oxidative Stress, Gut Microbiota, and Extracellular Vesicles: Interconnected Pathways and Therapeutic Potentials

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3148 - 3148

Published: March 28, 2025

Oxidative stress (OS) and gut microbiota are crucial factors influencing human health, each playing a significant role in the development progression of chronic diseases. This review provides comprehensive analysis complex interplay between these two factors, focusing on how an imbalance reactive oxygen species (ROS) antioxidants leads to OS, disrupting cellular homeostasis contributing range conditions, including metabolic disorders, cardiovascular diseases, neurological cancer. The microbiota, diverse community microorganisms residing gastrointestinal tract, is essential for regulating immune responses, pathways, overall health. Dysbiosis, composition, closely associated with inflammation, dysfunction, various highlights influences influenced by complicating pathophysiology many conditions. Furthermore, emerging evidence has identified extracellular vesicles (EVs) as critical facilitators crosstalk OS microbiota. EVs also play signaling host tissues, modulating processes. function holds promise targeted therapies aimed at restoring microbial balance mitigating OS. Personalized therapeutic approaches, probiotics, antioxidants, fecal transplantation-based strategies, can be used address OS-related diseases improve health outcomes. Nonetheless, further research needed study molecular mechanisms underlying interactions potential innovative interventions offer novel strategies managing enhancing

Language: Английский

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A comprehensive update on the immunoregulatory mechanisms of Akkermansia muciniphila : insights into active ingredients, metabolites, and nutrient-driven modulation

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: Oct. 16, 2024

Akkermansia muciniphila (A. muciniphila) has gained recognition as a pioneering probiotic, exhibiting considerable potential to enhance immune conditions across both humans and animals. The health benefits of A. are attributed its various components, including outer membrane proteins (PilQ Amuc_1100), secreted (P9 AmTARS), extracellular vesicles, metabolites such SCFAs, ornithine lipids, γ-aminobutyric acid, cobalamin, inosine. dynamic control the mucus layer by plays crucial role in regulating intestinal mucosal immunity. Furthermore, modulates function interacting with macrophages, dendritic cells, T lymphocytes, Paneth cells. Increasing abundance gut through nutritional strategies represents safe effective means augment function. Various polyphenols, oligosaccharides, polysaccharides have been shown elevate levels this bacterium, thereby contributing favorable immunoregulatory outcomes. This paper delves into latest research advancements related probiotic mechanisms provides an overview current understanding how responds nutrients. These insights offer theoretical foundation for utilization immunoregulation.

Language: Английский

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Impact of maternal high‐fat diet on offspring gut microbiota during short‐term high‐fat diet exposure in mice

Physiological Reports, Journal Year: 2024, Volume and Issue: 12(21)

Published: Nov. 1, 2024

Abstract Alterations in the gut microbiome have been linked to obesity, with maternal high‐fat diet (HF) playing a role shaping offspring composition. However, sex‐specific responses HF and impact of subsequent dietary challenges remain unclear. This study investigated effects on microbiota structure predicted functional profile response short‐term postnatal exposure focus responses. Female male control (C) or were weaned onto C diet. Offspring euthanized at 13 weeks age cecal contents collected for bacterial taxonomic profiling. Maternal reduced α‐diversity, notably Sex‐specific differences observed microbial composition potential. Furthermore, influence community potential varied depending led increased relative abundance Corynebacterium female decreased Akkermansia Roseburia offspring. These findings underscore sexually dimorphic nature function, implications developmental programming metabolic health.

Language: Английский

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YWHAZ and TBP are potential reference gene candidates for qPCR analysis of response to radiation therapy in colorectal cancer

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 9, 2023

Abstract The expression profiles of conventional reference genes (RGs), including ACTB and GAPDH, used in quantitative real-time PCR (qPCR), vary depending on tissue types environmental conditions. We searched for suitable RGs qPCR to determine the response radiotherapy colorectal cancer (CRC) cell lines, organoids, patient-derived tissues. Ten CRC lines (Caco-2, COLO 205, DLD-1, HCT116, HCT-15, HT-29, RKO, SW1116, SW480, SW620) organoids were selected irradiated with 2, 10 or 21 grays (Gy) based previous related studies conducted over last decade. stability 14 housekeeping (HKGs; ACTB, B2M, G6PD, GUSB, HMBS, HPRT1, IPO8, PGK1, PPIA, TBP, TFRC, UBC , YWHAZ) after irradiation was evaluated using RefFinder raw quantification cycle (Cq) values obtained from samples before irradiation. HKGs also paired fresh frozen tissues formalin-fixed, paraffin-embedded patients chemoradiotherapy. YWHAZ TBP encoding 14-3-3-zeta protein TATA-binding more stable than other 12 findings suggest that are potential RG candidates normalizing results experiments.

Language: Английский

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Maternal influences on offspring food allergy

Immunological Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 14, 2024

Summary The prevalence of allergies has been globally escalating. While could appear at any age, they often develop in early life. However, the significant knowledge gap field is mechanisms by which affect certain people but not others. Investigating factors and events neonatal life that have a lasting impact on determining susceptibilities children to area investigation as it promotes understanding immune system mediates tolerance versus allergies. This review focuses research over recent 10 years regarding potential maternal influence offspring with view food allergy, potentially life‐threatening cause anaphylaxis. role breast milk, diet, antibodies, microbiota suggested key regulating are discussed here. We also suggest future expand our maternal–offspring interactions pathogenesis allergy.

Language: Английский

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Systematic Insights into the Relationship between the Microbiota–Gut–Brain Axis and Stroke with the Focus on Tryptophan Metabolism

Metabolites, Journal Year: 2024, Volume and Issue: 14(8), P. 399 - 399

Published: July 24, 2024

Stroke, as a serious cerebral vascular disease with high incidence and rates of disability mortality, has limited therapeutic options due to the narrow time window. Compelling evidence highlighted significance gut microbiota gut-brain axis critical regulatory factors affecting stroke. Along microbiota-gut-brain axis, tryptophan metabolism further acquires increasing attention for its intimate association central nervous system diseases. For purpose exploring potential role in stroke providing systematic insights into intricate connection pathological procedure stroke, this review first summarized practical relationship between by compiling latest case-control research. Then, well interaction were comprehensively elucidated on basis basic anatomical structure physiological function. Based crosstalk microbiota-gut-brain, we focused from three major metabolic pathways, namely, kynurenine pathway, serotonin microbial within axis. Moreover, effects appreciated elaborated here, which is scarcely found other reviews. Hopefully, illustration mechanisms pathways along will inspire more translational research perspectives, paid promising pharmaceutical target order reduce risk mitigate progression, ameliorate prognosis.

Language: Английский

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Maternal high fat diet exposure modifies amniotic fluid metabolites and expands group 3 innate lymphoid cells dependent on the maternal microbiome and MyD88-signaling

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 18, 2024

Background Maternal high fat diet (mHFD) exposure expands IL-17 producing group 3 innate lymphoid cells (IL17 +ve ILC3) in the small intestine of neonatal murine offspring and increases their susceptibility to intestinal inflammation. How mHFD modulates immunity fetal remains unclear. Methods Dams were exposed 60% or maintained on regular (RD) prior during mating. Amniotic fluid (AF) was collected mid-pregnancy metabolites examined by global non-targeted mass spectrometry conventional wild-type (WT) germ-free pregnant dams. Offspring delivered C-section vaginally fecal contents for major bacterial phyla lamina propria (LP) flow cytometry. Susceptibility inflammation determined using a lipopolysaccharide platelet-activating factor model (LPS/PAF) WT, MyD88 deficient offspring. Neonatal pups HFD RD AF gavage LP Results We identified differentially produced when compared conventionally raised mice, with no difference seen mice. delivery phenotype expansion IL17 ILC3 increased In addition, had at birth 2 weeks life, which not KO mice mHFD. Germ-free protected from induced LPS/PAF injury expansion, demonstrating that maternal microbiome are prenatally necessary Furthermore, introduction sufficient expand intestine. Conclusion Our findings indicate interacts modify signal via

Language: Английский

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