Differences in Puberty of Girls before and during the COVID-19 Pandemic

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(8), P. 4733 - 4733

Published: April 14, 2022

In the COVID-19 pandemic, there was an increase in consultations for precocious puberty. We aim to analyze differences female puberty before and during pandemic. A cross-sectional analytical study designed at Pediatric Endocrinology Clinic of University Hospital Federal Maranhão São Luis, Brazil. included 55 girls with puberty, 22 who started pandemic 33 Clinical, anthropometric, laboratory imaging variables were compared between groups. Statistics performed determine if a statistical difference Girls had higher Z-scores weight (1.08 ± 1.29 versus 0.69 0.83;

Language: Английский

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Precocious puberty under stressful conditions: new understanding and insights from the lessons learnt from international adoptions and the COVID-19 pandemic

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: May 2, 2023

Neuro-biological variations in the timing of sexual maturation within a species are part an evolved strategy that depend on internal and external environmental conditions. An increased incidence central precocious puberty (CPP) has been described both adopted "covid-19 pandemic" children. Until recently, it was hypothesised triggers for CPP internationally children were likely to be better nutrition, greater stability, improved psychological wellbeing. However, following data collected during after coronavirus (COVID-19) global pandemic, other possibilities must considered. In society with high levels child wellbeing, threat life presented by unknown potentially serious disease stressful environment created lockdowns public health measures could trigger earlier pubertal as evolutionary response favour early reproduction. The main driver rates rapidly progressive pandemic have "fear stress" schools households. many children, may triggered effects living without normal social contact, using PPE, being near adults concerned about financial issues fear getting ill. features time progression similar those observed This review considers mechanisms regulating focus neurobiological mechanisms, analyses searching common yet unconsidered factors attempt identify which acted triggers. particular, we stress potential factor activation hypothalamic-pituitary-gonadal axis its correlation rapid maturation.

Language: Английский

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Current evidence on the impact of the COVID-19 pandemic on paediatric endocrine conditions

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 5, 2022

Severe acute respiratory coronavirus 2 (SARS-CoV-2) interacts with the host cells through its spike protein by binding to membrane enzyme angiotensin-converting (ACE2) and it can have a direct effect on endocrine function as ACE2 is expressed in many glands organs function. Furthermore, several conditions features that might increase risk of SARS-CoV-2 infection severity course infection, obesity for underlying chronic increased inflammatory status metabolic derangement, possible changes thyroid Vitamin D has immunomodulatory effects, deficiency negative effects. Adrenal insufficiency excess glucocorticoids affect immune also besides metabolism. This review aims analyze rationale fear effects SARS-Cov-2 endocrinological disorders, study influence pre-existing disorders actual data childhood. Currently, concerning during pandemic are scarce childhood aspects definite conclusions cannot be drawn, however, properly managed patients adrenal at present re-assuring. Too little attention been paid further studies may helpful. The available support need adequate vitamin supplementation, caution obese patients, monitoring hospitalized confirm an awareness campaign frequency precocious puberty, rapidly progressive puberty menarche. lifestyle, incidence overweight change timing lead hypothesize there ovarian dysfunction, example polycystic disease, derangements next years, future we facing fertility problems. prompts cautious maintain surveillance.

Language: Английский

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The effects of the covid-19 pandemic on puberty: a cross-sectional, multicenter study from Turkey

˜The œItalian Journal of Pediatrics/Italian journal of pediatrics, Journal Year: 2022, Volume and Issue: 48(1)

Published: Aug. 13, 2022

Abstract Backgrounds During the Coronavirus-19 disease (Covid-19) pandemic it was observed that number of girls presenting with early puberty had increased. The aim this study to carry out a retrospective evaluation characteristics who been referred for precocious in five different pediatric endocrinology units, before and during pandemic. Methods participants comprised 359 were assigned into 2 groups pre-pandemic group ( n :214) :145). Those :99) medical records follow-up period classified 3 subgroups according time presentation visits (group-1: first admission visit pandemic, group-2: group-3: pandemic). Results age at pubertal onset both significantly lower than those group(8.1 vs 8.6, p : < 0.001,7.7 7.9, :0.013, respectively). There no significant difference between body mass index standard deviation scores (BMI-SDS) values (0.57 0.51, :0.430). initiation rate suppression therapy higher compared (7.7%vs 27.5%), groups-2 & group-1, (20%&44%vs 8%). Conclusion Our research showed occurred earlier previous year, need increased

Language: Английский

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Incidence of central precocious puberty more than doubled during COVID-19 pandemic: Single-center retrospective review in the United States

Frontiers in Pediatrics, Journal Year: 2022, Volume and Issue: 10

Published: Nov. 30, 2022

The frequency of new visits for precocious puberty increased during the Covid-19 pandemic in pediatric endocrinology clinic at Rady Children's Hospital San Diego, CA, US. A few recent studies have shown an increase Central Precocious Puberty (CPP) other centers this pandemic. This study evaluated change incidence CPP cases requiring treatment with GnRH agonist (GnRHa) and compared it to pre-pandemic years.

Language: Английский

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Pediatric Cholecystectomy Case Volume and Complexity Following the COVID-19 Pandemic

PEDIATRICS, Journal Year: 2025, Volume and Issue: 155(3)

Published: Feb. 21, 2025

Historically, cholecystectomy was infrequently performed in children. Lifestyle changes, delays health care access, and increases childhood obesity occurred during the COVID-19 pandemic. The impact of these shifts on need for are poorly understood. We evaluate trends case volume among children A multi-institutional retrospective cohort study conducted ages 18 years younger who underwent from January 1, 2016, to July 31, 2022, at 10 children's hospitals. Differences mix before pandemic were identified using bivariate comparisons interrupted time series analysis. Overall, 4282 identified: 2122 2160 Most female (74.2%) with a median age 15 (IQR, 13.0-16.0 years). proportion Hispanic (55.0% vs 60.1%; P = .01) patients, body mass index (BMI) (26.0 27.1; < .001), (BMI > 30) (30.8% 37.4%; .001) increased Predicted monthly 40 100 Patients transferred an outside hospital (21.3% 28.5%; .001). Significant acute cholecystitis (12.2% 17.3%; choledocholithiasis (12.8% 16.5%; gallstone pancreatitis (10.6% 12.4%; .064), chronic (1.4% 3.2%; also occurred. On analysis, change month-to-month count significantly (Figure 1; which persisted after exclusion patients. Pediatric complexity These findings may be secondary changes health, transfer patterns, highlighting burden

Language: Английский

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Back to normal? A retrospective study on stimulation test and endocrinological diagnosis before, during and after COVID-19 pandemics

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: May 5, 2025

Introduction The COVID-19 pandemic disrupted healthcare systems, affecting consultations and diagnostics. In pediatric endocrinology, referral patterns shifted, with increased central precocious puberty (CPP) diagnoses decreased growth hormone deficiency (GHD) evaluations. This study examines trends in stimulation tests, referrals, from 2019 to 2023 assess the pandemic’s impact on endocrinology. Methods retrospective analyzed tests performed at Institute for Maternal Child Health IRCCS “Burlo Garofolo,” Trieste, Italy, 2023, divided into pre-pandemic (2019–March 2020), (March 2020–January 2022), post-pandemic (February 2022–December 2023) phases. Results A total of 1,526 were conducted 1,042 patients. Tests per day remained stable (pre-pandemic: 0.84; pandemic: 0.82; post-pandemic: 0.85). Arginine Stimulation Test (ATT), most frequent test (31%), during (20%, p&lt;0.001), while LHRH (LHRHT) 22% 28% (p&lt;0.001), becoming requested test. Diagnosis rates GHD CPP stable, but proportion females diagnosed significantly (91% vs. 69%, p=0.022). testing declined (p=0.018) post-pandemic, returned levels. Conclusion altered diagnostic patterns, reduced evaluations reflecting limited access. Post-pandemic recovery suggests a resolution delays. temporary surge cases, likely influenced by pandemic-related lifestyle changes, subsided aligning trends. To date, no other studies have reported similar variations incidence pandemic.

Language: Английский

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Implicating factors in the increase in cases of central precocious puberty (CPP) during the COVID-19 pandemic: Experience of a tertiary centre of pediatric endocrinology and review of the literature

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 30, 2022

Sexual development is a complex mechanism activated by the hypothalamic-pituitary-gonadal axis. Over last one hundred years there has been decline in age at puberty onset industrialised countries. Some Italian studies showed an increase diagnoses of Central Precocious Puberty (CPP) during COVID-19 pandemic. It thus supposed that this period was increased impact factors can influence pubertal development. Our retrospective monocentric study aimed to confirm existence phenomenon and analysed possible related factors. We retrospectively evaluated clinical, laboratory, radiological ultrasound (US) data 154 girls referred our Tertiary Centre Paediatric Endocrinology from January 2019 April 2021 for different forms Puberty. subdivided cases into subgroups according final diagnosis: CPP, Early (EP), isolated thelarche pubarche. The observation into: Period 1, before lockdown (1 – 8 March 2020) 2, following months (9 2020 30 2021). 2 further divided “restrictive period” (Period 2.1) (March 14 June 2020, which schools were closed) “less restrictive 2.2) (15 regarding use electronic devices group with CPP diagnosed we compared control group. show number new months, previous period. also detected higher PCs smartphones percentage presence endometrial rhyme pelvic Based on assume environmental effect timing calls attention such as food, stress. will need better understand data.

Language: Английский

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COVID-19 pandemic phases and female precocious puberty: The experience of the past 4 years (2019 through 2022) in an Italian tertiary center

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 28, 2023

Since the outbreak of COVID-19 pandemic, several centers pediatric endocrinology worldwide have observed a significant increase in number girls presenting with precocious or early puberty. We aimed to compare incidence rates female puberty before and during different phases pandemic.We retrospectively analyzed all consultations recorded outpatient clinic database Endocrinology Unit Bambino Gesù Children's Hospital, Rome, Italy, from lockdown start March 2020 up September 2020, comparison same months 2019, 2021 2022. Age, height, weight, body mass index, Tanner's pubertal stage bone age at presentation, birth ethnicity, family history central (CPP), maternal menarche, adoption were retrieved clinical records. Serum levels follicle-stimulating hormone (FSH), luteinizing (LH) both baseline after gonadotropin-releasing (GnRH) stimulation, basal estradiol collected.In 78 suspected referred for endocrinological consultation, compared 202 158 112 A proportion diagnosed rapidly progressive CPP was 2019 (86/202 vs. 18/78, p<0.01). In following periods 2022, gradual decrease cases evident, so much that not significantly (56/158 35/112 p=0.054 p=0.216 respectively, 2019).Our research suggests drastic lifestyle changes, such as those imposed by lockdown, consequent stress may affect regulation timing. The remarkable first pandemic wave seems be reduced concurrently resumption daily activities. These data seem support hypothesis direct relationship between profound life-style changes related rise cases.

Language: Английский

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Navigating Pubertal Goldilocks: The Optimal Pace for Hierarchical Brain Organization

Advanced Science, Journal Year: 2024, Volume and Issue: 11(21)

Published: March 15, 2024

Abstract Adolescence is a timed process with an onset, tempo, and duration. Nevertheless, the temporal dimension, especially pace of maturation, remains insufficiently studied aspect developmental progression. The primary objective to estimate precise influence pubertal maturational tempo on configuration associative brain regions. To this end, connection between stages level hierarchical organization large‐scale networks in 12‐13‐year‐old females analyzed. Skeletal maturity used as proxy for progress. degree defined by difference bone age chronological age. assess brain, dynamic closed eye resting state high‐density electroencephalography (EEG) alpha frequency range Different levels order are captured measured asymmetry directionality information flow different calculated EEG‐based entropy production participant groups then compared accelerated, average, decelerated maturity. Results indicate that average trajectory optimally aligns cerebral order, both accelerated timelines result diminished cortical organization. This suggests “Goldilocks rule” development favoring particular tempo.

Language: Английский

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