Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with risk of rheumatoid arthritis in the U.S. adult population

Environmental Health, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 13, 2024

Abstract Background Per- and polyfluoroalkyl substances (PFAS) are known environmental contaminants with immunosuppressive properties. Their connection to rheumatoid arthritis (RA), a condition influenced by the immune system, is not well studied. This research explores association between PFAS exposure RA prevalence. Methods utilized data from NHANES, encompassing sample of 10,496 adults 2003–2018 cycles, focusing on serum levels several PFAS. The presence was determined based self-reports. study used multivariable logistic regression assess relationship individual risk, adjusting for covariates calculate odds ratios (ORs). combined effects mixtures were evaluated using BKMR, WQS regression, quantile g-computation. Additionally, sex-specific associations explored through stratified analysis. Results Higher PFOA (OR = 0.88, 95% CI: 0.79, 0.98), PFHxS 0.91, 0.83, 1.00), PFNA 0.87, 0.77, PFDA 0.89, 0.81, 0.99) concentration related lower RA. Sex-specific analysis in single chemical models indicated significant inverse only evident females. BKMR did show an obvious pattern estimates across mixture. outcomes sex-stratified g-computation demonstrated that increase mixture associated decreased females (OR: 0.76, 0.62, 0.92). We identified interaction term WQS*sex 100 repeated hold out Notably, higher significantly reduced (mean OR 0.93, 0.98). Conclusions indicates potential various their observed relationships statistically but males. These findings contribute growing body evidence indicating may have effects.

Language: Английский

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Transformation fate of bisphenol A in aerobic denitrifying cultures and its coercive mechanism on the nitrogen transformation pathway

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 120816 - 120816

Published: Jan. 1, 2025

Language: Английский

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Maternal Exposure to Ozone During Implantation Promotes a Feminized Transcriptomic Profile in the Male Adolescent Liver

Endocrinology, Journal Year: 2025, Volume and Issue: 166(3)

Published: Jan. 27, 2025

Maternal exposure to ozone during implantation results in reduced fetal weight gain rats. Offspring from ozone-exposed dams demonstrate sexually dimorphic risks high-fat diet feeding adolescence. To better understand the adolescent hepatic metabolic landscape following growth restriction, RNA sequencing was performed characterize effects of ozone-induced restriction on male and female offspring. Pregnant Long-Evans rats were exposed filtered air or 0.8 ppm for 4 hours both gestation days 5 6 (n = 6/group). At approximately postnatal day 48, liver tissue obtained Peri-implantation dam had greater gene expression offspring than females. Interestingly, heatmaps these differentially expressed genes suggested that a transcriptomic pattern like Using set highly female-predominant 390), 57% upregulated dams. Upregulated canonical pathways included sirtuin orexin signaling, estrogen receptor integration energy metabolism. Relatively few altered associated with endpoints sexual maturity, signifying likely source observed feminization not attributed sex hormones. This study provides initial evidence utero may increase risk Additional work is needed further relationship between developmental undernutrition liver.

Language: Английский

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Concentrations of Serum Per- and Polyfluoroalkyl Substances and Lipid Health in Adolescents: A Cross-Sectional Study from the Korean National Environmental Health Survey 2018–2020

Toxics, Journal Year: 2025, Volume and Issue: 13(2), P. 91 - 91

Published: Jan. 25, 2025

Emerging evidence indicates that environmental exposure to per- and polyfluoroalkyl substances (PFASs) may influence lipid metabolism, though studies on adolescents remain scarce. This study aimed investigate the association between PFAS mixture profiles in Korean adolescents. Using data from National Environmental Health Survey (2018–2020), we analyzed 824 aged 12–17 years. Serum concentrations of PFAS, including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic (PFOS), perfluorononanoic (PFNA), perfluorohexane (PFHxS), perfluorodecanoic (PFDeA), were assessed. In multivariate regression models, PFDeA PFNA positively associated with elevated total cholesterol low-density lipoprotein levels, was hypercholesterolemia risk boys. girls, higher high-density lower triglycerides, no significant observed. Bayesian kernel machine demonstrated positive associations boys but not girls. The quantile g-computation model also an odds ratio (OR) 1.47 (95% CI: 0.99–2.19, p = 0.057) for boys, suggesting borderline statistical significance. These findings suggest disrupt elevating adolescents, particularly

Language: Английский

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Exposure to pesticides, persistent and non − persistent pollutants in French 3.5-year-old children: Findings from comprehensive hair analysis in the ELFE national birth cohort

Environment International, Journal Year: 2024, Volume and Issue: 190, P. 108881 - 108881

Published: July 7, 2024

Exposure to endocrine disruptors during early childhood poses significant health risks. This study examines the exposure levels of French 3.5-year-old children various persistent and non-persistent pollutants pesticides using hair analysis as part ELFE national birth cohort. Differences in sex geographical location among were investigated ppossible determinants exposure.

Language: Английский

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Environmental Pollutants, Occupational Exposures, and Liver Disease

Seminars in Liver Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Environmental pollutants significantly impact liver disease development, progression, and outcomes. This review examines the complex relationship between environmental exposures pathology, from malignant conditions like hepatocellular carcinoma to steatotic cholestatic diseases. Key factors include air pollutants, volatile organic compounds, persistent heavy metals, per- polyfluoroalkyl substances. These compounds can act through multiple mechanisms, including endocrine disruption, metabolic perturbation, oxidative stress, direct hepatotoxicity. The of these is often modified by such as sex, diet, genetic predisposition. Recent research has revealed that even low-level certain chemicals affect health, particularly when combined with other risk factors. emergence exposomics a tool promises enhance our understanding how influence disease. Importantly, exposure effects vary demographic socioeconomic factors, highlighting justice concerns. Implementation this knowledge in clinical practice requires new diagnostic approaches, healthcare system adaptations, increased awareness among medical professionals. In conclusion, provides comprehensive examination current evidence linking discusses implications for public health policy.

Language: Английский

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Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: primary and secondary gene responses with links to disease progression

Toxicological Sciences, Journal Year: 2024, Volume and Issue: 200(2), P. 324 - 345

Published: May 6, 2024

Constitutive androstane receptor (CAR, Nr1i3), a liver nuclear and xenobiotic sensor, induces drug, steroid, lipid metabolizing enzymes, stimulates hypertrophy hyperplasia, ultimately, hepatocellular carcinogenesis. The mechanisms linking early CAR responses to later disease development are poorly understood. Here we show that exposure of CD-1 mice TCPOBOP (1,4-bis[2-(3,5-dichloropyridyloxy)]benzene), halogenated xenochemical selective agonist ligand, pericentral steatosis marked by hepatic accumulation cholesterol neutral lipid, elevated circulating alanine aminotransferase, indicating hepatocyte damage. TCPOBOP-induced was weaker in the region but stronger periportal females compared with males. Early (1 day) transcriptional were enriched for CAR-bound primary response genes, lipogenesis metabolism oxidative stress protection pathways; late (2 weeks) included many binding-independent secondary enrichment macrophage activation, immune response, cytokine reactive oxygen species production. Late upstream regulators specific TCPOBOP-exposed male linked proinflammatory carcinoma progression. administered weekly using high corn oil vehicle induced carbohydrate-responsive transcription factor (MLXIPL)-regulated target dysregulated mitochondrial respiratory translation regulatory pathways, more advanced pathology. Overall, recapitulates histological gene expression changes characteristic emerging steatotic disease, including nonparenchymal cells indicative transition state. Upstream both genes include novel biomarkers foreign chemical-induced metabolic dysfunction-associated disease.

Language: Английский

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Adipose tissue as target of environmental toxicants: focus on mitochondrial dysfunction and oxidative inflammation in metabolic dysfunction-associated steatotic liver disease

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Abstract Obesity, diabetes, and their cardiovascular hepatic comorbidities are alarming public health issues of the twenty-first century, which share mitochondrial dysfunction, oxidative stress, chronic inflammation as common pathophysiological mechanisms. An increasing body evidence links combined exposure to multiple environmental toxicants with occurrence severity metabolic diseases. Endocrine disruptors (EDs) ubiquitous chemicals or mixtures persistent deleterious effects on living organisms beyond endocrine system impairment; in particular, those known metabolism-disrupting (MDCs), increase risk pathologies adult organism its progeny. Being largely lipophilic, MDCs mainly target adipose tissue elicit dysfunction by interfering bioenergetics, biogenesis, dynamics and/or other functions. Plastics, when broken down into micro- nano-plastics (MNPs), have been detected several human tissues, including liver. The harmful interplay between inflammatory redox processes, mutually interact a positive feed-back loop, hence term ("OxInflammation"), occurs both at systemic organ level. In liver tissue, oxinflammation contributes progression dysfunction-associated steatotic disease (MASLD). Moreover, it has reported that individuals MASLD may be more susceptible (mainly, related mitochondria) EDs/MDCs MNPs play role development disease. While systematically investigated major for ambient chemicals, surprisingly, less information is available literature respect tissue. this narrative review, we delve current most studied (bisphenols, polychlorinated biphenyls, phthalates, tolylfluanid tributyltin, per-fluoroalkyl polyfluoroalkyl substances, heavy metals MNPs), summarize address dysregulated mitochondria oxinflammation, particularly setting MASLD.

Language: Английский

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Sex-specific effects of acute chlordane exposure in the context of steatotic liver disease, energy metabolism and endocrine disruption

Food and Chemical Toxicology, Journal Year: 2023, Volume and Issue: 180, P. 114024 - 114024

Published: Sept. 4, 2023

Language: Английский

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Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: Primary and secondary gene responses with links to disease progression

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 20, 2024

Abstract Constitutive Androstane Receptor (CAR, Nr1i3 ), a liver nuclear receptor and xenobiotic sensor, induces drug, steroid lipid metabolizing enzymes, stimulates hypertrophy hyperplasia, ultimately, hepatocellular carcinogenesis. The mechanisms linking early CAR responses to subsequent disease development are poorly understood. Here we show that exposure of CD-1 mice TCPOBOP, halogenated xenochemical selective agonist ligand, pericentral steatosis marked by hepatic accumulation cholesterol neutral lipid, elevated circulating alanine aminotransferase levels, indicating hepatocyte damage. TCPOBOP-induced was weaker in the region but stronger periportal females compared males. Early (1-day) TCPOBOP transcriptional were enriched for CAR-bound primary response genes, metabolism oxidative stress protection pathways; late (2-wk) included many binding-independent secondary with enrichment immune response, macrophage activation, cytokine reactive oxygen species production. Late upstream regulators specific TCPOBOP-exposed male linked pro-inflammatory carcinoma progression. administered weekly using high corn oil vehicle activated carbohydrate-responsive transcription factor (MLXIPL)-regulated target dysregulated mitochondrial respiratory translation regulatory pathways, induced more advanced pathology. Thus, recapitulates histological gene expression changes characteristic emerging steatotic disease, including non-parenchymal cells indicative transition state. Upstream both include novel biomarkers foreign chemical-induced metabolic dysfunction-associated disease.

Language: Английский

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