Antimicrobial potential of strontium against bacteria associated with peri-implantitis DOI Open Access
Hatem Alshammari

Published: Jan. 1, 2023

Dental implants are nowadays a standard treatment to replace missing teeth and restore function aesthetics. However, biological complications associated with implants, e.g., peri-implant infections, common jeopardize the success of treatment. The main aim this thesis was explore strontium (Sr) as possible prevention strategy against since Sr has been shown have antibacterial action also promote titanium (Ti) implant osseointegration. In thesis, systematic appraisal literature about antimicrobial potential Sr-functionalized Ti surfaces for oral applications performed, followed by series in vitro studies assessing micro-organisms peri-implantitis. Study I, resulted an initial list 1081 potentially relevant publications, where from nine publications met inclusion criteria. Most included showed that exerted limited immediate (i.e., 24 h) effect, likely due low ion release; effect biofilm inhibition Streptococcus aureus observed at both early late timepoints, adequate release. II assessed, vitro, five different concentrations soluble Sr(OH)2 (100, 10, 1, 0.1, 0.01 mM) 6 mono-species bacteria (Streptococcusmitis, Staphylococcus epidermidis, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Escherichia coli, Fusobacterium nucleatum) terms cell growth, minimal inhibitory concentration (MIC), viability. agar diffusion test, zones were only 0.01, 1 mM P. gingivalis. Growth planktonic cultures achieved 10 all species tested. viability assay, 100 potent bactericidal S. mitis, A. E. It thus concluded properties III assessed early- bacteriostatic wafers on peri-implantitis (E. coli,S. aureus, oralis, Actinomyces naeslundii, Parvimonas micra, P.gingivalis F. after 2 hours, multispecies day 3, 6. wafers, compared controls, statistically significant less viable cells mono- tests. Number colony forming units (CFUs) within significantly higher time-points evaluation coli 1. Gingipain activity ones, qPCR gingivalis comprised 15% total 6, while it remained below detection levels Sr-coated wafers. IV, impact surface roughness (turned vs moderately rough) bacterial (S. nucleatum, coli), grown consortia, vitro. Bacterial formation, well as, proteolytic reduction number nonfunctionalized times investigation Higher found non-functionalized disks ones. Sr-functionalised notable growth remined undetected time points disks. turned had slightly release rough first sustained up 15 days. Overall, data generated projects indicate exerts is worthwhile further infections.

Language: Английский

History of periodontitis as a risk factor for implant failure and incidence of peri‐implantitis: A systematic review, meta‐analysis, and trial sequential analysis of prospective cohort studies DOI Creative Commons
Matteo Serroni, Wenche S. Borgnakke,

Luigi Romano

et al.

Clinical Implant Dentistry and Related Research, Journal Year: 2024, Volume and Issue: 26(3), P. 482 - 508

Published: May 8, 2024

Abstract Introduction Dental implants are widely employed as dependable replacements for lost teeth. However, it is crucial to establish, solely through prospective cohort studies, whether a history of periodontitis indeed constitutes significant risk factor implant failure. Methods A systematic literature search was conducted in October 2022 several electronic databases with subsequent manual updates. Only original studies evaluating the (loss) rate ≥1 year after loading were included. Logarithmic ratio and weighted mean differences calculated. Study results summarized using random effects meta‐analyses evaluated by trial sequential analyses. The Newcastle‐Ottawa scale study bias GRADE approach assessed certainty/quality evidence. Results total 14 publications reporting on 12 Low evidence due absence randomized clinical trials revealed significantly greater odds failure patients at follow‐ups both ≤5 years (RR = 1.62; 95% CI: 1.71–2.37; p 0.013) >5 2.26; 1.12–4.53; 0.023). incidence peri‐implantitis 4.09; 1.93–8.58; < 0.001) (WM) marginal bone loss (WM difference 0.75 mm; 0.18–1.31; 0.05) statistically periodontally compromised group, whereas there no between two groups peri‐implant probing depth. Conclusion can be considered incident failure, peri‐implantitis, loss.

Language: Английский

Citations

17
Biomaterials science and surface engineering strategies for dental peri-implantitis management DOI Creative Commons

Ya-Meng Yu,

Yupu Lu,

Ting Zhang

et al.

Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)

Published: May 13, 2024

Abstract Peri-implantitis is a bacterial infection that causes soft tissue inflammatory lesions and alveolar bone resorption, ultimately resulting in implant failure. Dental implants for clinical use barely have antibacterial properties, colonization biofilm formation on the dental are major of peri-implantitis. Treatment strategies such as mechanical debridement antibiotic therapy been used to remove plaque. However, it particularly important prevent occurrence peri-implantitis rather than treatment. Therefore, current research spot has focused improving properties implants, construction specific micro-nano surface texture, introduction diverse functional coatings, or application materials with intrinsic properties. The aforementioned surfaces can be incorporated bioactive molecules, metallic nanoparticles, other components further enhance osteogenic accelerate healing process. In this review, we summarize recent developments biomaterial science modification applied inhibit facilitate bone-implant integration. Furthermore, summarized obstacles existing process laboratory reach clinic products, propose corresponding directions future perspectives, so provide insights into rational design aim balance efficacy, biological safety, property.

Language: Английский

Citations

15
Saliva biofilm-derived outer membrane vesicles regulate biofilm formation and immune response of oral epithelial cells on titanium surfaces DOI
Baoxin Huang, Chun Liu, Jieting Yang

et al.

Clinical Oral Investigations, Journal Year: 2024, Volume and Issue: 28(1)

Published: Jan. 4, 2024

Language: Английский

Citations

5
Osteogenic Potential of Magnesium Oxide Nanoparticles in Bone Regeneration: A Systematic Review DOI Open Access

Sankari Malaiappan,

Johnisha Harris

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: March 4, 2024

Guided bone regeneration (GBR) plays a crucial role in the augmentation of alveolar bone, especially cases dental implants. The main principle behind using membranes guided tissue (GTR) is to prevent epithelial downgrowth as well connective on root surface. However, lack some major properties, such osteogenic and antimicrobial properties. Magnesium (Mg) one biodegradable materials that gaining interest because its favourable mechanical properties biocompatibility. It also possesses pro-osteogenic significant inhibition biofilm formation maturation. These features have attracted increasing magnesium oxide nanoparticles GBR membrane applications. This systematic review assesses potential periodontal regeneration. literature search used PubMed, PubMed Central, Medline, Cochrane databases examine reviews published till March 2023. Seven articles were included based selection criteria. We all vitro vivo clinical studies seven provided evidence nanoparticles, when incorporated any substrate, showed higher terms alkaline phosphatase levels, volume fraction, mineral density. optimum concentration can be an ideal additive various substrates promote Because most conducted calvarial defects, further should focus only related

Language: Английский

Citations

5
Current Data on Oral Peri-Implant and Periodontal Microbiota and Its Pathological Changes: A Systematic Review DOI Creative Commons

Virginie Gazil,

Octave Nadile Bandiaky, Emmanuelle Renard

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 10(12), P. 2466 - 2466

Published: Dec. 14, 2022

The 5- and 10-year implant success rates in dentistry are nearly 90%. Prevalence of peri-implant diseases is 10% for peri-implantitis 50% mucositis. To better understand these inflammatory pathologies infectious origin, it important to know if the composition microbiota comparable with periodontal healthy pathological conditions. New generation sequencing (NGS) a recent metagenomic method that analyzes overall microorganisms present an ecological niche by exploiting their genome. These methods two types: 16S rRNA shotgun technique. For several years, they have been used explore oral, periodontal, and, more specifically, microbiota. aim this systematic review analyze results new explorations comparing patients diseased sites microbiological characteristics peri-implantitis. A knowledge would enable us optimize our therapeutic strategies. An electronic search was performed using medical databases PubMed/Medline, Cochrane Library, ScienceDirect, Periodontology 2000. selected articles were published between January 2015 March 2021. Inclusion criteria included clinical studies exclusively or sequencing, enrolled populations free systemic pathology, without substantial bias. Eight reviewed. All them exclusively. assessment demonstrates specific character comparison Indeed, defined dysbiotic bacterial communities vary from one individual another, including known periodontopathogens such as Porphyromonas gingivalis (P.g.) genera less mentioned disease pattern Filifactor alocis. Examination reveals differences under conditions terms diversity composition. drift preserved diseases, but when different types sites, has specificity presence bacteria proper relative proportions present.

Language: Английский

Citations

19
Efficacy of indocyanine green and methylene blue mediated-photodynamic therapy on peri-implant outcomes among diabetics with peri-implant mucositis DOI
Hussain D. Alsayed, Ishfaq A. Bukhari,

Rawan Alsaif

et al.

Photodiagnosis and Photodynamic Therapy, Journal Year: 2023, Volume and Issue: 42, P. 103344 - 103344

Published: Feb. 24, 2023

Language: Английский

Citations

11
Biofouling on titanium implants: a novel formulation of poloxamer and peroxide for in situ removal of pellicle and multi-species oral biofilm DOI Creative Commons
Badra Hussain, Roger Simm, Jaime Bueno

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Eradicating biofouling from implant surfaces is essential in treating peri-implant infections, as it directly addresses the microbial source for infection and inflammation around dental implants. This controlled laboratory study examines effectiveness of four commercially available debridement solutions '(EDTA (Prefgel®), NaOCl (Perisolv®), H2O2 (Sigma-Aldrich) Chlorhexidine (GUM® Paroex®))' removing acquired pellicle, preventing pellicle re-formation a multi-species oral biofilm growing on titanium surface, compare results with effect novel formulation peroxide-activated 'Poloxamer gel (Nubone® Clean)'. Evaluation removal was conducted using scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy photoelectron to assess surface morphology, elemental composition chemical composition. Hydrophilicity assessed through contact angle measurements. The model included Streptococcus oralis, Fusobacterium nucleatum Aggregatibacter actinomycetemcomitans, reflecting natural microbiome's complexity. Biofilm biomass quantified safranin staining, viability evaluated confocal laser microscopy, SEM used morphological analyses biofilm. Results indicated that while no single agent completely eradicated biofilm, gel' activated 'H2O2' exhibited promising results. It minimized re-contamination by significantly lowering angle, indicating enhanced hydrophilicity. combination also showed notable reduction carbon contaminants, suggesting effective organic residues addition effectively reducing viable bacterial counts. In conclusion, + H2O2' emerged decontamination strategy diseases. underlines importance tailoring treatment methods unique challenges diseases necessity combining decontaminating strategies established mechanical cleaning procedures optimal management

Language: Английский

Citations

4
Correlation of Body Mass Index With Severity of Periodontitis: A Cross‐Sectional Study DOI Creative Commons
Arvina Rajasekar, Maria Maddalena Marrapodi, Diana Russo

et al.

Clinical and Experimental Dental Research, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 1, 2025

This study aimed to assess the relationship between body mass index (BMI) classification and severity of periodontitis, recognizing that both obesity periodontitis involve chronic inflammatory processes, which may exacerbate one another. A cross-sectional was conducted on a convenience sample 162 consecutive outpatients who reported Department Periodontics, Saveetha Dental College Hospitals in Chennai from March 2023 September 2023. Age, gender, Russell's periodontal index, BMI were recorded. The association age, BMI, analyzed using linear-by-linear χ2 association. Ordinal logistic regression analysis employed odds ratio (OR) with periodontitis. statistically significant observed (p < 0.05). Participants aged 35-60 years had an OR 1.305 for severe (95% CI: 0.754-1.561). Males exhibited higher risk (OR: 1.171; 95% 0.894-2.485). Obese participants showed 1.417 compared overweight 0.683; 0.817-1.629). Severe more prevalent among obese individuals, followed by individuals. Obesity be considered potential indicator development progression

Language: Английский

Citations

0
Peri-implantitis after 40 years: Evidence, mechanisms, and implications: A mapping review DOI

Steven Sadowsky

Journal of Prosthetic Dentistry, Journal Year: 2023, Volume and Issue: unknown

Published: March 1, 2023

Language: Английский

Citations

9
Vacuum Ultraviolet (VUV) Light Photofunctionalization to Induce Human Oral Fibroblast Transmigration on Zirconia DOI Creative Commons

Toshikatsu Suzumura,

Takanori Matsuura, Keiji Komatsu

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(21), P. 2542 - 2542

Published: Oct. 29, 2023

Soft tissue adhesion and sealing around dental maxillofacial implants, related prosthetic components, crowns are a clinical imperative to prevent adverse outcomes of periodontitis periimplantitis. Zirconia is often used fabricate implant components crowns. Here, we hypothesized that UV treatment zirconia would induce unique behaviors in fibroblasts favor the establishment soft seal. Human oral were cultured on specimens confluency before placing second specimen (either untreated or treated with one minute 172 nm vacuum (VUV) light) next first separated by gap 150 µm. After seven days culture, only transmigrated onto VUV-treated zirconia, forming 2.36 mm volume zone 5.30 leading edge. Cells migrating enlarged, robust formation multidirectional cytoplastic projections, even day seven. Fibroblasts also horizontally placed 45° 60° tilted specimens, latter configurations compromising initial attachment proliferation. However, VUV mitigated negative impact tilting, higher tilt angles increasing difference cellular behavior between control specimens. Fibroblast size, perimeter, diameter greater than exclusively zirconia. reduced surface elemental carbon induced superhydrophilicity, confirming removal hydrocarbon pellicle. Similar effects observed glazed silica surfaces. One-minute photofunctionalization therefore promotes human fibroblast proliferation, especially under challenging culture conditions, induces specimen-to-specimen transmigration sustainable for at least days.

Language: Английский

Citations

7