M2 macrophages in kidney disease: biology, therapies, and perspectives

Kidney International, Journal Year: 2019, Volume and Issue: 95(4), P. 760 - 773

Published: March 2, 2019

Language: Английский

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Wnt signaling pathway in aging-related tissue fibrosis and therapies

Ageing Research Reviews, Journal Year: 2020, Volume and Issue: 60, P. 101063 - 101063

Published: April 6, 2020

Language: Английский

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Advances in the role of STAT3 in macrophage polarization

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 4, 2023

The physiological processes of cell growth, proliferation, differentiation, and apoptosis are closely related to STAT3, it has been demonstrated that aberrant STAT3 expression an impact on the onset progression a number inflammatory immunological disorders, fibrotic diseases, malignancies. In order produce necessary biological effects, macrophages (M0) can be polarized into pro-inflammatory (M1) anti-inflammatory (M2) types in response various microenvironmental stimuli. signaling is involved macrophage polarization, research effect polarization gained attention recent years. provide references for treatment investigation disorders this review compiles pertinent pathways associated with from many fundamental studies.

Language: Английский

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Macrophage autophagy in macrophage polarization, chronic inflammation and organ fibrosis

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 6, 2022

As the essential regulators of organ fibrosis, macrophages undergo marked phenotypic and functional changes after injury. These in macrophage phenotype function can result maladaptive repair, causing chronic inflammation development pathological fibrosis. Autophagy, a highly conserved lysosomal degradation pathway, is one major players to maintain homeostasis through clearing protein aggregates, damaged organelles, invading pathogens. Emerging evidence has shown that autophagy plays an role polarization, inflammation, Because high heterogeneity different organs, types may play roles Here, we review current understanding fibrosis highlight potential treatment Finally, important unresolved issues this field are briefly discussed. A better mechanisms contribute developing novel therapies for inflammatory diseases

Language: Английский

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Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 239 - 239

Published: Jan. 20, 2023

Reducing oxidative stress stands at the center of a prevention and control strategy for mitigating cellular senescence aging. Kidney disease is characterized by premature aging syndrome, to find modulator targeting against stress, mitochondrial dysfunction, in kidney cells could be great significance prevent progression this disease. This review focuses on pathogenic mechanisms related appearance damage dysfunction In scenario, anti-aging Klotho protein plays crucial role modulating signaling pathways involving manganese-containing superoxide dismutase (Mn-SOD) transcription factors FoxO Nrf2, known antioxidant systems, other function regulators, such as uncoupling 1 (UCP1), B-cell lymphoma-2 (BCL-2), Wnt/β-catenin, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha), factor EB, (TFEB), (PPAR-gamma). Therefore, postulated very promising new target future therapeutic strategies mitochondria abnormalities, patients.

Language: Английский

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Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Oct. 9, 2023

Abstract Cancer remains the leading cause of death around world. In cancer treatment, over 50% patients receive radiotherapy alone or in multimodal combinations with other therapies. One adverse consequences after radiation exposure is occurrence radiation-induced tissue fibrosis (RIF), which characterized by abnormal activation myofibroblasts and excessive accumulation extracellular matrix. This phenotype can manifest multiple organs, such as lung, skin, liver kidney. In-depth studies on mechanisms have shown that a variety signals immune cells release cytokines, intracellular cGAS/STING, oxidative stress response, metabolic reprogramming proteasome pathway are involved myofibroblasts. Tissue extremely harmful to patients' health requires early diagnosis. addition traditional serum markers, histologic imaging tests, diagnostic potential nuclear medicine techniques emerging. Anti-inflammatory antioxidant therapies treatments for fibrosis. Recently, some promising therapeutic strategies emerged, stem cell therapy targeted However, incomplete knowledge hinders treatment this disease. Here, we also highlight mechanistic, directions

Language: Английский

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Signaling pathways in macrophages: molecular mechanisms and therapeutic targets

MedComm, Journal Year: 2023, Volume and Issue: 4(5)

Published: Sept. 11, 2023

Abstract Macrophages play diverse roles in development, homeostasis, and immunity. Accordingly, the dysfunction of macrophages is involved occurrence progression various diseases, such as coronavirus disease 2019 atherosclerosis. The protective or pathogenic effect that exert different conditions largely depends on their functional plasticity, which regulated via signal transduction Janus kinase–signal transducer activator transcription, Wnt Notch pathways, stimulated by environmental cues. Over past few decades, molecular mechanisms signaling pathways have been gradually elucidated, providing more alternative therapeutic targets for diseases treatment. Here, we provide an overview basic physiology expound regulatory within them. We also address crucial role pathogenesis including autoimmune, neurodegenerative, metabolic, infectious cancer, with a focus advances macrophage‐targeted strategies exploring modulation components regulators pathways. Last, discuss challenges possible solutions therapy clinical applications. hope this comprehensive review will directions further research targeting macrophage are promising to improve efficacy

Language: Английский

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Tumor-derived Exosomal ENO2 Modulates Polarization of Tumor-associated Macrophages through Reprogramming Glycolysis to Promote Progression of Diffuse Large B-cell Lymphoma

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(3), P. 848 - 863

Published: Jan. 1, 2024

Macrophages can be polarized into functional classically activated (M1) or alternatively (M2) phenotype. Tumor-associated macrophages (TAMs) mainly exhibit M2 Previous works determined that up-regulation of enolase 2 (ENO2) in diffuse large B-cell lymphoma (DLBCL) cells promote to an M2-like phenotype, thereby consequently promoting the progression DLBCL. Exosomes are a subset extracellular vesicles, carrying various bioactive molecules, mediate signals transduction and regulate immune cells. In our study, we investigated role related mechanisms DLBCL-derived exosomal ENO2 regulating macrophage polarization during DLBCL

Language: Английский

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From Acute to Chronic: Unraveling the Pathophysiological Mechanisms of the Progression from Acute Kidney Injury to Acute Kidney Disease to Chronic Kidney Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1755 - 1755

Published: Feb. 1, 2024

This article provides a thorough overview of the biomarkers, pathophysiology, and molecular pathways involved in transition from acute kidney injury (AKI) disease (AKD) to chronic (CKD). It categorizes biomarkers AKI into stress, damage, functional markers, highlighting their importance early detection, prognosis, clinical applications. review also highlights links between renal pathophysiological mechanisms underlying AKD, including hypoperfusion, sepsis, nephrotoxicity, immune responses. In addition, various molecules play pivotal roles inflammation hypoxia, triggering maladaptive repair, mitochondrial dysfunction, system reactions, cellular senescence cells. Key signaling pathways, such as Wnt/β-catenin, TGF-β/SMAD, Hippo/YAP/TAZ, promote fibrosis impact function. The renin-angiotensin-aldosterone (RAAS) triggers cascade leading fibrosis, with aldosterone exacerbating oxidative stress changes that fibrosis. evidence suggests RAS inhibitors may protect against CKD progression, especially post-AKI, though more extensive trials are needed confirm full impact.

Language: Английский

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Targeting Wnt/β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 26, 2024

Wound healing is a tightly regulated process that ensures tissue repair and normal function following injury. It modulated by activation of pathways such as the transforming growth factor-beta (TGF-β), Notch, Wnt/β-catenin signaling pathways. Dysregulation this causes poor wound healing, which leads to fibrosis ulcerative wounds. The pathway involved in all phases primarily proliferative phase for formation granulation tissue. This review focuses on role its transcriptional regulation target genes. crosstalk between Wnt/β-catenin, TGF-β pathways, well deregulation chronic wounds are also considered, with special focus diabetic ulcers. Lastly, we discuss current prospective therapies wounds, primary strategies photobiomodulation

Language: Английский

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