Osteomyelitis and non-coding RNAS: A new dimension in disease understanding

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 255, P. 155186 - 155186

Published: Feb. 2, 2024

Language: Английский

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Exploring extracellular RNA as drivers of chemotherapy resistance in cancer

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Jan. 21, 2025

Language: Английский

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Noncoding RNA (ncRNA)-mediated regulation of TLRs: critical regulator of inflammation in tumor microenvironment

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)

Published: March 31, 2025

Language: Английский

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Exosomal ncRNAs in liquid biopsies for lung cancer

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 565, P. 119983 - 119983

Published: Oct. 3, 2024

Language: Английский

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Circular RNAs in the KRAS pathway: Emerging players in cancer progression

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155259 - 155259

Published: March 11, 2024

Language: Английский

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Connecting the Dots: LncRNAs in the KRAS Pathway and Cancer

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 262, P. 155570 - 155570

Published: Aug. 29, 2024

Language: Английский

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Noncoding RNAs in the COVID-19 Saga: An Untold Story

Viral Immunology, Journal Year: 2024, Volume and Issue: 37(6), P. 269 - 286

Published: July 5, 2024

Language: Английский

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Non-Coding RNA: A Key Regulator in the Glutathione-GPX4 Pathway of Ferroptosis

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(4), P. 1222 - 1234

Published: May 20, 2024

Ferroptosis, a form of regulated cell death, has emerged as crucial process in diverse pathophysiological states, encompassing cancer, neurodegenerative ailments, and ischemia-reperfusion injury. The glutathione (GSH)-dependent lipid peroxidation pathway, chiefly governed by peroxidase 4 (GPX4), assumes an essential part driving ferroptosis. GPX4, the principal orchestrator ferroptosis, garnered significant attention across cardiovascular, neuroscience domains over past decade. Noteworthy investigations have elucidated indispensable functions ferroptosis numerous diseases, including tumorigenesis, wherein robust within cells can impede tumor advancement. Recent research underscored complex regulatory role non-coding RNAs (ncRNAs) regulating GSH-GPX4 network, thus influencing cellular susceptibility to This exhaustive review endeavors probe into multifaceted processes which ncRNAs control network Specifically, we delve miRNAs, lncRNAs, circRNAs GPX4 expression impacting Moreover, discuss clinical implications dysregulated interactions between several conditions, underscoring their capacity viable targets for therapeutic intervention. Additionally, explores emerging strategies aimed at targeting modulate pathway manipulate advantage. A comprehensive understanding these intricate networks furnishes insights innovative avenues diseases associated with perturbed thereby laying groundwork interventions ferroptosis-related pathological conditions.

Language: Английский

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Ferroptosis and circular RNAs: new horizons in cancer therapy.

PubMed, Journal Year: 2024, Volume and Issue: 23, P. 570 - 599

Published: Jan. 1, 2024

Cancer poses intricate challenges to treatment due its complexity and diversity. Ferroptosis circular RNAs (circRNAs) are emerging as innovative therapeutic avenues amid the evolving landscape of cancer therapy. Extensive investigations into circRNAs reveal their diverse roles, ranging from molecular regulators pivotal influencers ferroptosis in cell lines. The results underscore significance modulating pathways that impact crucial aspects development, including survival, proliferation, metastasis. A detailed analysis delineates these pathways, shedding light on mechanisms through which influence ferroptosis. Building upon recent experimental findings, study evaluates potential targeting induce By identifying specific associated with etiology cancer, this paves way for development targeted therapeutics exploit vulnerabilities cells. This review consolidates existing understanding circRNAs, emphasizing role therapy providing impetus ongoing research dynamic field. See also graphical abstract(Fig. 1).

Language: Английский

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Beyond the Genome: Deciphering the Role of MALAT1 in Breast Cancer Progression

Current Genomics, Journal Year: 2024, Volume and Issue: 25(5), P. 343 - 357

Published: May 23, 2024

The MALAT1, a huge non-coding RNA, recently came to light as multifaceted regulator in the intricate landscape of breast cancer (BC) progression. This review explores functions and molecular interactions shedding on its profound implications for understanding BC pathogenesis advancing therapeutic strategies. article commences by acknowledging global impact pressing need insights into underpinnings. It is stated that core lncRNA MALAT1 has range roles both healthy diseased cell functions. this unravels MALAT1's role progression, elucidating participation critical processes like resistance, invasion, relocation, proliferating cells therapy. mechanisms through which modulates gene expression, interacts with other molecules, influences signalling pathways. Furthermore, paper emphasizes clinical significance possible prognostic diagnostic biomarker. Concluding forward-looking note, highlights broader biology, such connections therapy resistance metastasis. underscores deeper investigations these pave way precision medicine approaches. pivotal progression deciphering beyond genome, offering disease potential targeted interventions.

Language: Английский

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