CircRNAs in cancer metabolism: a review

Journal of Hematology & Oncology, Journal Year: 2019, Volume and Issue: 12(1)

Published: Sept. 4, 2019

Altered energy metabolism is a hallmark of tumors aiming at supplying necessary nutrients for tumorigenesis and development. These redirected metabolic pathways associated with carbohydrate, lipid amino acid are orchestrated not only by carcinogenic proteins but non-coding RNAs. Among them, circular RNA (circRNA), as kind novel identified RNAs, has become the focus attention. Through binding corresponding microRNAs or directly contacting proteins, circRNA plays primarily important role in regulating cellular metabolism. Herein, we analyze emerging findings select circRNAs contributing to mutant glycolysis, lipogenesis lipolysis, glutam inolysis, oxidative respiration deepen understanding about cancer regulatory network. In addition, also discuss possibility exerting their functions via exosomes stem cells. Owing unique structures wide impacts, may help reap huge fruits developing clinical treatments targeting

Language: Английский

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Preclinical and Clinical Development of Noncoding RNA Therapeutics for Cardiovascular Disease

Circulation Research, Journal Year: 2020, Volume and Issue: 126(5), P. 663 - 678

Published: Feb. 27, 2020

RNA modulation has become a promising therapeutic approach for the treatment of several types disease. The emerging field noncoding RNA-based therapies now come to attention cardiovascular research, in which it could provide valuable advancements comparison current pharmacotherapy such as small molecule drugs or antibodies. In this review, we focus on studies conducted mainly large-animal models, including pigs, rabbits, dogs, and nonhuman primates. obstacles promises targeting long RNAs circRNAs modalities humans are specifically discussed. We also describe novel ex vivo methods based human cells tissues, engineered heart tissues living myocardial slices that help bridging gap between models clinical applications future. Finally, summarize antisense oligonucleotide have already been approved by Food Drug Administration mRNAs discuss progress trials. Additional factors, drug chemistry, formulations, different routes administration, advantages drugs, included present review. Recently, first miRNA-based inhibitory strategies tested failure patients well healthy volunteers study effects wound healing (NCT04045405; NCT03603431). summary, combination targets, with cells/tissues, new delivery techniques will likely lead significant development next-generation therapeutics

Language: Английский

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Roles of circular RNAs in immune regulation and autoimmune diseases

Cell Death and Disease, Journal Year: 2019, Volume and Issue: 10(7)

Published: June 26, 2019

Abstract Circular RNAs (circRNAs), as a novel class of endogenously expressed non-coding (ncRNAs), have high stability and often present tissue-specific expression evolutionary conservation. Emerging evidence has suggested that circRNAs play an essential role in complex human pathologies. Notably, circRNAs, important gene modulators the immune system, are strongly associated with occurrence development autoimmune diseases. Here, we focus on roles cells regulation, highlighting their potential biomarkers biological functions diseases, such systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), primary biliary cholangitis (PBC), psoriasis, aiming at providing new insights into diagnosis therapy these

Language: Английский

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Mechanisms of circRNA/lncRNA-miRNA interactions and applications in disease and drug research

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114672 - 114672

Published: April 13, 2023

In recent years, breakthroughs in bioinformatics have been made with the discovery of many functionally significant non-coding RNAs (ncRNAs). The these ncRNAs has further demonstrated multi-level characteristics intracellular gene expression regulation, which plays an important role assisting diagnosis, guiding clinical drug use and determining prognosis treatment process various diseases. microRNAs (miRNAs), long (lncRNAs), circular (circRNAs) are three major types that interact each other. Studies shown lncRNAs circRNAs can sponge miRNAs, thereby influencing normal physiological processes regulating mRNA and, thus, state cells. This paper summarizes mechanism action research progress ncRNA seven modalities. summary is intended to provide new ideas for diagnosing treating diseases researching developing drugs.

Language: Английский

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Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics

Pharmacology & Therapeutics, Journal Year: 2018, Volume and Issue: 196, P. 15 - 43

Published: Nov. 13, 2018

Language: Английский

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Revealing new landscape of cardiovascular disease through circular RNA-miRNA-mRNA axis

Genomics, Journal Year: 2019, Volume and Issue: 112(2), P. 1680 - 1685

Published: Oct. 15, 2019

Language: Английский

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RETRACTED ARTICLE: Circular RNA circ_0003204 inhibits proliferation, migration and tube formation of endothelial cell in atherosclerosis via miR-370-3p/TGFβR2/phosph-SMAD3 axis

Journal of Biomedical Science, Journal Year: 2020, Volume and Issue: 27(1)

Published: Jan. 3, 2020

Abstract Background Circular RNAs (circRNAs) represent a class of non-coding (ncRNAs) which are widely expressed in mammals and tissue-specific, some could act as critical regulators the atherogenesis cerebrovascular disease. However, underlying mechanisms by circRNA regulates ectopic phenotype endothelial cells (ECs) atherosclerosis remain largely elusive. Methods CCK-8, transwell, wound healing Matrigel assays were used to assess cell viability, migration tube formation. QRT-qPCR Immunoblotting examine targeted gene expression different groups. The binding sites miR-370-3p (miR-370) with TGFβR2 or hsa_circ_0003204 (circ_0003204) predicted using series bioinformatic tools, validated dual luciferase assay RNA immunoprecipitation (RIP) assay. localization circ_0003204 miR-370 ECs investigated fluorescence situ hybridization (FISH). Gene function pathways enriched through Metascape set enrichment analysis (GSEA). association extracellular vesicles (EVs) clinical characteristics patients multiple statistical analysis. Results Circ_0003204, mainly located cytoplasm human aorta (HAECs), was upregulated ox-LDL-induced HAECs. Functionally, inhibited proliferation, formation HAECs exposed ox-LDL. Mechanically, promote protein its downstream phosph-SMAD3 sponging miR-370, 3′ untranslated region (UTR) TGFβR2. Furthermore, plasma EVs cerebral atherosclerosis, represented potential biomarker for diangnosis prognosis atherogenesis. Conclusions Circ_0003204 novel stimulator inactivation atherosclerosis.

Language: Английский

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Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects

GeroScience, Journal Year: 2019, Volume and Issue: 41(4), P. 419 - 439

Published: Aug. 1, 2019

Language: Английский

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Circular RNAs in kidney disease and cancer

Nature Reviews Nephrology, Journal Year: 2021, Volume and Issue: 17(12), P. 814 - 826

Published: Aug. 11, 2021

Language: Английский

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Insights into the regulatory role of circRNA in angiogenesis and clinical implications

Atherosclerosis, Journal Year: 2020, Volume and Issue: 298, P. 14 - 26

Published: Feb. 25, 2020

Language: Английский

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