Marine Drugs,
Journal Year:
2020,
Volume and Issue:
18(7), P. 372 - 372
Published: July 19, 2020
In
this
study,
we
found
that
E.
prolifera
extract
(EAEP)
exhibits
neuroprotective
effects
in
oxidative
stress-induced
neuronal
cells.
EAEP
improved
cell
viability
as
well
attenuated
the
formation
of
intracellular
reactive
oxygen
species
(ROS)
and
apoptotic
bodies
glutamate-treated
hippocampal
cells
(HT-22).
Furthermore,
expression
brain-derived
neurotrophic
factor
(BDNF)
antioxidant
enzymes
such
heme
oxygenase-1
(HO-1),
NAD(P)H
quinine
oxidoreductase-1
(NQO-1),
glutamate–cysteine
ligase
catalytic
subunit
(GCLC)
via
tropomyosin-related
kinase
receptor
B/
protein
B
(TrkB/Akt)
signaling
pathway.
contrast,
pre-incubation
K252a,
a
TrkB
inhibitor,
or
MK-2206,
an
Akt-selective
ameliorated
These
results
suggest
protects
against
apoptosis
by
upregulating
BDNF
activation
TrkB/Akt
conclusion,
effect
EAEP,
which
is
rich
carotenoid-derived
compounds,
may
justify
its
application
food
supplement
prevention
treatment
neurodegenerative
disorders.
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(6), P. 1784 - 1784
Published: May 24, 2021
Mounting
evidence
support
the
potential
benefits
of
functional
foods
or
nutraceuticals
for
human
health
and
diseases.
Black
cumin
(Nigella
sativa
L.),
a
highly
valued
nutraceutical
herb
with
wide
array
benefits,
has
attracted
growing
interest
from
health-conscious
individuals,
scientific
community,
pharmaceutical
industries.
The
pleiotropic
pharmacological
effects
black
cumin,
its
main
bioactive
component
thymoquinone
(TQ),
have
been
manifested
by
their
ability
to
attenuate
oxidative
stress
inflammation,
promote
immunity,
cell
survival,
energy
metabolism,
which
underlie
diverse
including
protection
against
metabolic,
cardiovascular,
digestive,
hepatic,
renal,
respiratory,
reproductive,
neurological
disorders,
cancer,
so
on.
Furthermore,
acts
as
an
antidote,
mitigating
various
toxicities
drug-induced
side
effects.
Despite
significant
advances
in
this
miracle
active
components
are
still
far
clinical
application.
This
review
begins
highlighting
research
trends
revisiting
phytochemical
profiles.
Subsequently,
attributes
TQ
critically
reviewed.
We
overview
molecular
pharmacology
gain
insight
into
underlying
mechanism
benefits.
Issues
related
pharmacokinetic
herb-drug
interactions,
drug
delivery,
safety
also
addressed.
Identifying
knowledge
gaps,
our
current
effort
will
direct
future
advance
applications
Marine Drugs,
Journal Year:
2021,
Volume and Issue:
19(9), P. 484 - 484
Published: Aug. 26, 2021
Marine
algae
are
rich
in
bioactive
nutraceuticals
(e.g.,
carbohydrates,
proteins,
minerals,
fatty
acids,
antioxidants,
and
pigments).
Biotic
plants,
microorganisms)
abiotic
factors
temperature,
pH,
salinity,
light
intensity)
contribute
to
the
production
of
primary
secondary
metabolites
by
algae.
Easy,
profitable,
sustainable
recovery
methods
include
novel
solid-liquid
liquid-liquid
extraction
techniques
supercritical,
high
pressure,
microwave,
ultrasound,
enzymatic).
The
spectacular
findings
algal-mediated
synthesis
nanotheranostics
has
attracted
further
interest
because
availability
microalgae-based
natural
therapeutic
compounds
cost-effective
commercialization
stable
microalgal
drugs.
Algal
extracts
can
serve
as
stabilizing/capping
reducing
agents
for
thermodynamically
nanoparticles
(NPs).
Different
types
nanotherapeutics
have
been
synthesized
using
physical,
chemical,
biological
methods.
a
fascinating
source
lead
theranostics
compounds,
development
linked
enhanced
drug
efficacy
safety.
Indeed,
remarkable
nanobiofactories,
their
pragmatic
properties
reside
(i)
ease
handling;
(ii)
capacity
absorb/accumulate
inorganic
metallic
ions;
(iii)
cost-effectiveness;
(iv)
eco-friendly,
rapid,
healthier
NPs.
Preclinical
clinical
trials
shall
enable
really
define
effective
algal-based
nanotherapies.
This
review
aims
provide
an
overview
main
algal
that
be
extracted
purified
nanotheranostic
purposes.
Journal of Central Nervous System Disease,
Journal Year:
2021,
Volume and Issue:
13
Published: Jan. 1, 2021
Alzheimer’s
disease
(AD)
is
a
chronic
disabling
that
affects
the
central
nervous
system.
The
main
consequences
of
AD
include
decline
cognitive
functions
and
language
disorders.
One
causes
leading
to
decrease
neurotransmitter
acetylcholine
(ACh)
levels
in
brain,
part
due
higher
activity
acetylcholinesterase
(AChE),
enzyme
responsible
for
its
degradation.
Many
inhibitors
(AChEIs),
both
natural
synthetic,
have
been
developed
used
through
years
counteract
progression
disease.
first
such
drugs
approved
therapeutic
use
was
tacrine,
binds
reversible
bond
enzyme.
However,
tacrine
has
since
withdrawn
because
adverse
effects.
Currently,
donepezil
galantamine
are
very
promising
AChEIs
with
clinical
benefits.
Moreover,
rivastigmine
considered
pseudo-irreversible
compound
anti-AChE
action,
providing
similar
effects
at
level.
purpose
this
review
provide
an
overview
what
published
over
last
decade
on
effectiveness
AD,
analysing
most
relevant
issues
under
methodological
profiles
consequent
possible
welfare
whole
world.
Furthermore,
novel
approaches
also
discussed.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(17), P. 5327 - 5327
Published: Sept. 2, 2021
Natural
products
derived
from
plants,
as
well
their
bioactive
compounds,
have
been
extensively
studied
in
recent
years
for
therapeutic
potential
a
variety
of
neurodegenerative
diseases
(NDs),
including
Alzheimer’s
(AD),
Huntington’s
(HD),
and
Parkinson’s
(PD)
disease.
These
are
characterized
by
progressive
dysfunction
loss
neuronal
structure
function.
There
has
little
progress
designing
efficient
treatments,
despite
impressive
breakthroughs
our
understanding
NDs.
In
the
prevention
therapy
NDs,
use
natural
may
provide
great
opportunities;
however,
many
clinical
issues
emerged
regarding
use,
primarily
based
on
lack
scientific
support
or
proof
effectiveness
patient
safety.
Since
neurodegeneration
is
associated
with
myriad
pathological
processes,
targeting
multi-mechanisms
action
neuroprotection
approaches
that
include
preventing
cell
death
restoring
function
damaged
neurons
should
be
employed.
treatment
AD
PD,
neuroprotective
agents.
This
current
review
will
highlight
numerous
compounds
thatexert
effects
pathologies
Life,
Journal Year:
2023,
Volume and Issue:
13(3), P. 845 - 845
Published: March 21, 2023
Arthrospira
platensis
is
a
filamentous
cyanobacterium
of
the
class
Cyanophyceae
and
most
cultivated
photosynthetic
prokaryote.
It
used
in
pharmaceutical
sector,
medicine
food
industry.
has
rich
micro-
macro-element
composition,
containing
proteins,
lipids,
carbohydrates,
essential
amino
acids,
polyunsaturated
fatty
minerals
raw
fibers.
commonly
ingredient
products
nutritional
supplements.
The
wide
range
biologically
active
components
determines
its
diverse
pharmacological
properties
(antioxidant,
antidiabetic,
antimicrobial,
antineoplastic,
antitumor,
anti-inflammatory,
photoprotective,
antiviral,
etc.).
This
review
summarizes
research
related
to
taxonomy,
distribution
chemical
composition
as
well
potential
application
industries.
Attention
drawn
various
medical
applications
an
antidiabetic
antiobesity
agent,
with
hepatoprotective,
antimicrobial
antiviral
effects
regulatory
on
neurodegenerative
diseases.
Marine Drugs,
Journal Year:
2023,
Volume and Issue:
21(6), P. 323 - 323
Published: May 26, 2023
Polyphenols
are
compounds
found
in
various
plants
and
foods,
known
for
their
antioxidant
anti-inflammatory
properties.
Recently,
researchers
have
been
exploring
the
therapeutic
potential
of
marine
polyphenols
other
minor
nutrients
that
algae,
fish
crustaceans.
These
unique
chemical
structures
exhibit
diverse
biological
properties,
including
anti-inflammatory,
antioxidant,
antimicrobial
antitumor
action.
Due
to
these
being
investigated
as
possible
agents
treatment
a
wide
variety
conditions,
such
cardiovascular
disease,
diabetes,
neurodegenerative
diseases
cancer.
This
review
focuses
on
applications
human
health,
also,
phenolic
classes,
extraction
methods,
purification
techniques
future
compounds.
Frontiers in Pharmacology,
Journal Year:
2021,
Volume and Issue:
12
Published: May 7, 2021
Bioactive
plant
derived
compounds
are
important
for
a
wide
range
of
therapeutic
applications,
and
some
display
promising
anticancer
properties.
Further
evidence
suggests
that
phytochemicals
modulate
autophagy
apoptosis,
the
two
crucial
cellular
pathways
involved
in
underlying
pathobiology
cancer
development
regulation.
Pharmacological
targeting
apoptosis
signaling
using
therefore
offers
strategy
is
complementary
to
conventional
chemotherapy.
In
this
review,
we
sought
highlight
molecular
basis
autophagic-apoptotic
pathway
understand
its
implication
cancer,
explore
fundamental
process
as
druggable
target.
We
also
aimed
present
recent
advances
address
limitations
faced
phytochemical-based
drugs.
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(8), P. 2704 - 2704
Published: Aug. 5, 2021
Nutrition
and
rehabilitation
are
crucial
in
post-stroke
recovery,
especially
the
elderly.
Since
stroke
is
leading
cause
of
long-term
disability,
there
a
need
to
promote
special,
individually
tailored
nutrition
strategies
targeting
older
patients
with
low
motor
ability.
Chronic
survivors
have
higher
risk
developing
nutrition-related
chronic
diseases,
such
as
sarcopenia,
anemia,
type
2
diabetes
mellitus
osteoporosis.
Moreover,
reduced
activity,
cognitive
impairment
depression
might
be
aggravated
by
poor
malnutrition
status.
Accumulated
data
suggest
that
nutritional
supplements
neuroprotective
diets
can
associated
better
effectiveness
well
brain
recovery.
Therefore,
this
review
focuses
on
preventive
improve
dietary
intake
change
patterns.
We
highlight
importance
diets,
problem
dysphagia
role
rehabilitation.
This
article
potential
may
an
impact
functional
recovery
during
after
new
approach
neuroplasticity
including
use
agents
from
marine
sources
fucoxanthin
tramiprosate
compounds
used
neuroprotectants
antioxidative
anti-inflammatory
properties
introduced.
Marine Drugs,
Journal Year:
2022,
Volume and Issue:
20(5), P. 279 - 279
Published: April 22, 2022
Fucoxanthin,
belonging
to
the
xanthophyll
class
of
carotenoids,
is
a
natural
antioxidant
pigment
marine
algae,
including
brown
macroalgae
and
diatoms.
It
represents
10%
total
carotenoids
in
nature.
The
plethora
scientific
evidence
supports
potential
benefits
nutraceutical
pharmaceutical
uses
fucoxanthin
for
boosting
human
health
disease
management.
Due
its
unique
chemical
structure
action
as
single
compound
with
multi-targets
effects,
it
has
attracted
mounting
attention
from
community,
resulting
an
escalated
number
publications
January
2017
February
2022.
Fucoxanthin
remained
most
popular
option
anti-cancer
anti-tumor
activity,
followed
by
protection
against
inflammatory,
oxidative
stress-related,
nervous
system,
obesity,
hepatic,
diabetic,
kidney,
cardiac,
skin,
respiratory
microbial
diseases,
variety
model
systems.
Despite
much
pharmacological
vitro
vivo
findings,
clinical
research
still
not
satisfactory,
because
only
one
study
on
obesity
management
was
reported
last
five
years.
Additionally,
pharmacokinetics,
safety,
toxicity,
functional
stability,
perspective
are
substantially
addressed.
Nevertheless,
derivatives
shown
be
safe,
non-toxic,
readily
available
upon
administration.
This
review
will
provide
insights
into
fucoxanthin,
underlying
diverse
molecular
mechanisms
benefits.
However,
requires
more
activity-oriented
translational
humans
before
can
used
multi-target
drug.
