Neuroprotective Effect of Carotenoid-Rich Enteromorpha prolifera Extract via TrkB/Akt Pathway against Oxidative Stress in Hippocampal Neuronal Cells DOI Creative Commons
Seung Yeon Baek, Mee Ree Kim

Marine Drugs, Journal Year: 2020, Volume and Issue: 18(7), P. 372 - 372

Published: July 19, 2020

In this study, we found that E. prolifera extract (EAEP) exhibits neuroprotective effects in oxidative stress-induced neuronal cells. EAEP improved cell viability as well attenuated the formation of intracellular reactive oxygen species (ROS) and apoptotic bodies glutamate-treated hippocampal cells (HT-22). Furthermore, expression brain-derived neurotrophic factor (BDNF) antioxidant enzymes such heme oxygenase-1 (HO-1), NAD(P)H quinine oxidoreductase-1 (NQO-1), glutamate–cysteine ligase catalytic subunit (GCLC) via tropomyosin-related kinase receptor B/ protein B (TrkB/Akt) signaling pathway. contrast, pre-incubation K252a, a TrkB inhibitor, or MK-2206, an Akt-selective ameliorated These results suggest protects against apoptosis by upregulating BDNF activation TrkB/Akt conclusion, effect EAEP, which is rich carotenoid-derived compounds, may justify its application food supplement prevention treatment neurodegenerative disorders.

Language: Английский

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety DOI Open Access
Md. Abdul Hannan, Md. Ataur Rahman, Abdullah Al Mamun Sohag

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(6), P. 1784 - 1784

Published: May 24, 2021

Mounting evidence support the potential benefits of functional foods or nutraceuticals for human health and diseases. Black cumin (Nigella sativa L.), a highly valued nutraceutical herb with wide array benefits, has attracted growing interest from health-conscious individuals, scientific community, pharmaceutical industries. The pleiotropic pharmacological effects black cumin, its main bioactive component thymoquinone (TQ), have been manifested by their ability to attenuate oxidative stress inflammation, promote immunity, cell survival, energy metabolism, which underlie diverse including protection against metabolic, cardiovascular, digestive, hepatic, renal, respiratory, reproductive, neurological disorders, cancer, so on. Furthermore, acts as an antidote, mitigating various toxicities drug-induced side effects. Despite significant advances in this miracle active components are still far clinical application. This review begins highlighting research trends revisiting phytochemical profiles. Subsequently, attributes TQ critically reviewed. We overview molecular pharmacology gain insight into underlying mechanism benefits. Issues related pharmacokinetic herb-drug interactions, drug delivery, safety also addressed. Identifying knowledge gaps, our current effort will direct future advance applications

Language: Английский

Citations

219

Marine Algae-Derived Bioactive Compounds: A New Wave of Nanodrugs? DOI Creative Commons
Farid Menaa, Udari Wijesinghe, Gobika Thiripuranathar

et al.

Marine Drugs, Journal Year: 2021, Volume and Issue: 19(9), P. 484 - 484

Published: Aug. 26, 2021

Marine algae are rich in bioactive nutraceuticals (e.g., carbohydrates, proteins, minerals, fatty acids, antioxidants, and pigments). Biotic plants, microorganisms) abiotic factors temperature, pH, salinity, light intensity) contribute to the production of primary secondary metabolites by algae. Easy, profitable, sustainable recovery methods include novel solid-liquid liquid-liquid extraction techniques supercritical, high pressure, microwave, ultrasound, enzymatic). The spectacular findings algal-mediated synthesis nanotheranostics has attracted further interest because availability microalgae-based natural therapeutic compounds cost-effective commercialization stable microalgal drugs. Algal extracts can serve as stabilizing/capping reducing agents for thermodynamically nanoparticles (NPs). Different types nanotherapeutics have been synthesized using physical, chemical, biological methods. a fascinating source lead theranostics compounds, development linked enhanced drug efficacy safety. Indeed, remarkable nanobiofactories, their pragmatic properties reside (i) ease handling; (ii) capacity absorb/accumulate inorganic metallic ions; (iii) cost-effectiveness; (iv) eco-friendly, rapid, healthier NPs. Preclinical clinical trials shall enable really define effective algal-based nanotherapies. This review aims provide an overview main algal that be extracted purified nanotheranostic purposes.

Language: Английский

Citations

130

The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer’s Disease DOI Creative Commons
Immacolata Vecchio, Luca Sorrentino, Anna Maria Paoletti

et al.

Journal of Central Nervous System Disease, Journal Year: 2021, Volume and Issue: 13

Published: Jan. 1, 2021

Alzheimer’s disease (AD) is a chronic disabling that affects the central nervous system. The main consequences of AD include decline cognitive functions and language disorders. One causes leading to decrease neurotransmitter acetylcholine (ACh) levels in brain, part due higher activity acetylcholinesterase (AChE), enzyme responsible for its degradation. Many inhibitors (AChEIs), both natural synthetic, have been developed used through years counteract progression disease. first such drugs approved therapeutic use was tacrine, binds reversible bond enzyme. However, tacrine has since withdrawn because adverse effects. Currently, donepezil galantamine are very promising AChEIs with clinical benefits. Moreover, rivastigmine considered pseudo-irreversible compound anti-AChE action, providing similar effects at level. purpose this review provide an overview what published over last decade on effectiveness AD, analysing most relevant issues under methodological profiles consequent possible welfare whole world. Furthermore, novel approaches also discussed.

Language: Английский

Citations

113

Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges DOI Creative Commons
Md. Habibur Rahman, Johny Bajgai, Ailyn Fadriquela

et al.

Molecules, Journal Year: 2021, Volume and Issue: 26(17), P. 5327 - 5327

Published: Sept. 2, 2021

Natural products derived from plants, as well their bioactive compounds, have been extensively studied in recent years for therapeutic potential a variety of neurodegenerative diseases (NDs), including Alzheimer’s (AD), Huntington’s (HD), and Parkinson’s (PD) disease. These are characterized by progressive dysfunction loss neuronal structure function. There has little progress designing efficient treatments, despite impressive breakthroughs our understanding NDs. In the prevention therapy NDs, use natural may provide great opportunities; however, many clinical issues emerged regarding use, primarily based on lack scientific support or proof effectiveness patient safety. Since neurodegeneration is associated with myriad pathological processes, targeting multi-mechanisms action neuroprotection approaches that include preventing cell death restoring function damaged neurons should be employed. treatment AD PD, neuroprotective agents. This current review will highlight numerous compounds thatexert effects pathologies

Language: Английский

Citations

107

Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature DOI Creative Commons
Galia Gentscheva, Krastena Nikolova, Veselina Panayotova

et al.

Life, Journal Year: 2023, Volume and Issue: 13(3), P. 845 - 845

Published: March 21, 2023

Arthrospira platensis is a filamentous cyanobacterium of the class Cyanophyceae and most cultivated photosynthetic prokaryote. It used in pharmaceutical sector, medicine food industry. has rich micro- macro-element composition, containing proteins, lipids, carbohydrates, essential amino acids, polyunsaturated fatty minerals raw fibers. commonly ingredient products nutritional supplements. The wide range biologically active components determines its diverse pharmacological properties (antioxidant, antidiabetic, antimicrobial, antineoplastic, antitumor, anti-inflammatory, photoprotective, antiviral, etc.). This review summarizes research related to taxonomy, distribution chemical composition as well potential application industries. Attention drawn various medical applications an antidiabetic antiobesity agent, with hepatoprotective, antimicrobial antiviral effects regulatory on neurodegenerative diseases.

Language: Английский

Citations

48

Therapeutic Potential of Polyphenols and Other Micronutrients of Marine Origin DOI Creative Commons
Leonel Pereira, João Cotas

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(6), P. 323 - 323

Published: May 26, 2023

Polyphenols are compounds found in various plants and foods, known for their antioxidant anti-inflammatory properties. Recently, researchers have been exploring the therapeutic potential of marine polyphenols other minor nutrients that algae, fish crustaceans. These unique chemical structures exhibit diverse biological properties, including anti-inflammatory, antioxidant, antimicrobial antitumor action. Due to these being investigated as possible agents treatment a wide variety conditions, such cardiovascular disease, diabetes, neurodegenerative diseases cancer. This review focuses on applications human health, also, phenolic classes, extraction methods, purification techniques future compounds.

Language: Английский

Citations

44

Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway DOI Creative Commons
Md. Ataur Rahman, Md. Abdul Hannan, Raju Dash

et al.

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: May 7, 2021

Bioactive plant derived compounds are important for a wide range of therapeutic applications, and some display promising anticancer properties. Further evidence suggests that phytochemicals modulate autophagy apoptosis, the two crucial cellular pathways involved in underlying pathobiology cancer development regulation. Pharmacological targeting apoptosis signaling using therefore offers strategy is complementary to conventional chemotherapy. In this review, we sought highlight molecular basis autophagic-apoptotic pathway understand its implication cancer, explore fundamental process as druggable target. We also aimed present recent advances address limitations faced phytochemical-based drugs.

Language: Английский

Citations

105

Nutritional Supplements and Neuroprotective Diets and Their Potential Clinical Significance in Post-Stroke Rehabilitation DOI Open Access
Ewa Zielińska-Nowak, Natalia Cichoń, Joanna Saluk

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(8), P. 2704 - 2704

Published: Aug. 5, 2021

Nutrition and rehabilitation are crucial in post-stroke recovery, especially the elderly. Since stroke is leading cause of long-term disability, there a need to promote special, individually tailored nutrition strategies targeting older patients with low motor ability. Chronic survivors have higher risk developing nutrition-related chronic diseases, such as sarcopenia, anemia, type 2 diabetes mellitus osteoporosis. Moreover, reduced activity, cognitive impairment depression might be aggravated by poor malnutrition status. Accumulated data suggest that nutritional supplements neuroprotective diets can associated better effectiveness well brain recovery. Therefore, this review focuses on preventive improve dietary intake change patterns. We highlight importance diets, problem dysphagia role rehabilitation. This article potential may an impact functional recovery during after new approach neuroplasticity including use agents from marine sources fucoxanthin tramiprosate compounds used neuroprotectants antioxidative anti-inflammatory properties introduced.

Language: Английский

Citations

65

A Systematic Review on Marine Algae-Derived Fucoxanthin: An Update of Pharmacological Insights DOI Creative Commons
Md. Mohibbullah, Md. Nazmul Haque, Abdullah Al Mamun Sohag

et al.

Marine Drugs, Journal Year: 2022, Volume and Issue: 20(5), P. 279 - 279

Published: April 22, 2022

Fucoxanthin, belonging to the xanthophyll class of carotenoids, is a natural antioxidant pigment marine algae, including brown macroalgae and diatoms. It represents 10% total carotenoids in nature. The plethora scientific evidence supports potential benefits nutraceutical pharmaceutical uses fucoxanthin for boosting human health disease management. Due its unique chemical structure action as single compound with multi-targets effects, it has attracted mounting attention from community, resulting an escalated number publications January 2017 February 2022. Fucoxanthin remained most popular option anti-cancer anti-tumor activity, followed by protection against inflammatory, oxidative stress-related, nervous system, obesity, hepatic, diabetic, kidney, cardiac, skin, respiratory microbial diseases, variety model systems. Despite much pharmacological vitro vivo findings, clinical research still not satisfactory, because only one study on obesity management was reported last five years. Additionally, pharmacokinetics, safety, toxicity, functional stability, perspective are substantially addressed. Nevertheless, derivatives shown be safe, non-toxic, readily available upon administration. This review will provide insights into fucoxanthin, underlying diverse molecular mechanisms benefits. However, requires more activity-oriented translational humans before can used multi-target drug.

Language: Английский

Citations

60

Evolving therapeutic interventions for the management and treatment of Alzheimer’s disease DOI
Faizan Ahmad, Anik Karan, Rashi Sharma

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 95, P. 102229 - 102229

Published: Feb. 15, 2024

Language: Английский

Citations

16