Valuable pigments from microalgae: phycobiliproteins, primary carotenoids, and fucoxanthin

Photochemical & Photobiological Sciences, Journal Year: 2023, Volume and Issue: 22(8), P. 1733 - 1789

Published: April 10, 2023

Abstract Phycobiliproteins, carotenoids and fucoxanthin are photosynthetic pigments extracted from microalgae cyanobacteria with great potential biotechnological applications, as healthy food colorants cosmetics. Phycocyanin possesses a brilliant blue color, fluorescent properties making it useful reagent for immunological essays. The most important source of phycocyanin is the cyanobacterium Arthrospira platensis, however, recently, Rhodophyta Galdieria sulphuraria has also been identified such. main obstacle to commercialization represented by its chemical instability, strongly reducing shelf-life. Moreover, high level purity needed pharmaceutical applications requires several steps which increase both production time cost. Microalgae ( Chlorella , Dunaliella Nannochloropsis Scenedesmus ) produce light harvesting carotenoids, able manage oxidative stress, due their free radical scavenging properties, makes them suitable use natural antioxidants. Many studies focused on selection promising strains producing valuable extraction purification. Among produced marine microalgae, abundant, representing more than 10% total carotenoids. Despite abundance diversity only few species have studied commercial production, relevant being Phaeodactylum tricornutum . Due antioxidant activity, can bring various benefits prevention treatment lifestyle-related diseases. In this review, we update results achieved in extraction, purification, these pigments, motivating cultivation pigments. Graphical abstract

Language: Английский

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Carotenoids Composition of Green Algae Caulerpa racemosa and Their Antidiabetic, Anti-Obesity, Antioxidant, and Anti-Inflammatory Properties

Molecules, Journal Year: 2023, Volume and Issue: 28(7), P. 3267 - 3267

Published: April 6, 2023

Green alga Caulerpa racemosa is an underexploited species of macroalgae, even though it characterized by a green color that indicates abundance bioactive pigments, such as chlorophyll and possibly xanthophyll. Unlike chlorophyll, which has been well explored, the composition carotenoids C. its biological activities have not reported. Therefore, this study aims to look at carotenoid profile racemose determine their activities, include antidiabetic, anti-obesity, anti-oxidative, anti-inflammatory, cytotoxicity in vitro. The detected were all xanthophylls, included fucoxanthin, lutein, astaxanthin, canthaxanthin, zeaxanthin, β-carotene, β-cryptoxanthin based on orbitrap-mass spectrometry (MS) rapid ultra-high performance liquid chromatography (UHPLC) diode array detector. Of seven observed, should be highlighted β-carotene canthaxanthin two most dominant present racemosa. Interestingly, extract good activity inhibiting α-glucosidase, α-amylase, DPPH ABTS, TNF-α mTOR, upregulating AMPK, makes drug candidate or functional antidiabetic food, very promising anti-obesity anti-inflammatory. More interestingly, value shows level safety normal cells, potential for further development nutraceuticals pharmaceuticals.

Language: Английский

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Microalgae, Seaweeds and Aquatic Bacteria, Archaea, and Yeasts: Sources of Carotenoids with Potential Antioxidant and Anti-Inflammatory Health-Promoting Actions in the Sustainability Era

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(6), P. 340 - 340

Published: June 1, 2023

Carotenoids are a large group of health-promoting compounds used in many industrial sectors, such as foods, feeds, pharmaceuticals, cosmetics, nutraceuticals, and colorants. Considering the global population growth environmental challenges, it is essential to find new sustainable sources carotenoids beyond those obtained from agriculture. This review focuses on potential use marine archaea, bacteria, algae, yeast biological factories carotenoids. A wide variety carotenoids, including novel ones, were identified these organisms. The role organisms their actions have also been discussed. Marine great capacity synthesize which can be renewable manner without depleting natural resources. Thus, concluded that they represent key source could help Europe achieve its Green Deal Recovery Plan. Additionally, lack standards, clinical studies, toxicity analysis reduces traditional Therefore, further research processing organisms, biosynthetic pathways, extraction procedures, examination content needed increase carotenoid productivity, document safety, decrease costs for implementation.

Language: Английский

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Bioactive Molecules from Marine Diatoms and Their Value for the Nutraceutical Industry

Nutrients, Journal Year: 2023, Volume and Issue: 15(2), P. 464 - 464

Published: Jan. 16, 2023

The search for novel sources of nutrients is among the basic goals achievement sustainable progress. In this context, microalgae are relevant organisms, being rich in high-value compounds and able to grow open ponds or photobioreactors, thus enabling profitable exploitation aquatic resources. Microalgae, a huge taxon containing photosynthetic microorganisms living freshwater, as well brackish marine waters, typically unicellular eukaryotic, include green algae (Chlorophyceae), red (Rhodophyceae), brown (Phaeophyceae) diatoms (Bacillariophyceae). recent decades, have been considered most humans with respect other microalgae. This review focuses on studies exploring their bio-pharmacological activities when human disease prevention and/or treatment. addition, we extracts (or purified compounds) specific nutraceutical applications.

Language: Английский

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Fucoxanthin Production of Microalgae under Different Culture Factors: A Systematic Review

Marine Drugs, Journal Year: 2022, Volume and Issue: 20(10), P. 592 - 592

Published: Sept. 22, 2022

Fucoxanthin is one of the light-harvesting pigments in brown microalgae, which increasingly gaining attention due to its numerous health-promoting properties. Currently, production microalgal fucoxanthin not yet feasible from an economic perspective. However, cultivation microalgae at favourable conditions holds great potential increase viability this source. Hence, study aimed review under different systematically. A literature search was performed using Web Science, Scopus and PubMed databases. total 188 articles were downloaded 28 selected for current by two independent authors. Microalgae appeared be a more reliable source compared macroalgae. Overall, consensus condition obtained proposed: light intensity ranging 10 100 µmol/m2/s could achieve higher content. optimal producing species-specific. The serves as antecedent offering insights into fucoxanthin-producing response culture factors via systematic analysis. With findings recommendations, feasibility commercially enhanced possibly practical sustainable production.

Language: Английский

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Fucoxanthin alleviated myocardial ischemia and reperfusion injury through inhibition of ferroptosis via the NRF2 signaling pathway

Food & Function, Journal Year: 2023, Volume and Issue: 14(22), P. 10052 - 10068

Published: Jan. 1, 2023

Background: Myocardial ischemia and reperfusion injury (MIRI) is a severe complication of revascularization therapy in patients with myocardial infarction. Therefore, there an urgent requirement to find more therapeutic solutions for MIRI. Recently, ferroptosis, which characterized by lipid peroxidation, was considered critical contributor Fucoxanthin (FX), natural antioxidant carotenoid, abundant brown seaweed, exerts protective effects under various pathological conditions. However, whether FX alleviates MIRI unclear. This study aims clarify the on Methods: Mice left anterior descending artery ligation were used as vivo models. Neonatal rat cardiomyocytes (NRCs) induced hypoxia vitro TTC-Evans blue staining performed validate infarction size. Transmission electron microscopy employed detect mitochondrial cardiomyocytes. In addition, 4 weeks after MIRI, echocardiography measure cardiac function; fluorescent probes western blots ferroptosis. Results: showed that reduced size ameliorated MIRI-induced myofibril loss mitochondrion shrinkage. Furthermore, improved LVEF LVFS inhibited hypertrophy fibrosis mice study, calcein AM/PI TUNEL cell death caused treatment. DCFH-DA MitoSOX indicated cellular reactive oxygen species (ROS). Moreover, C11-BODIPY 581/591 staining, ferro-orange MDA assay, Fe2+ 4-hydroxynonenal enzyme-linked immunosorbent blot results revealed ferroptosis vivo, inhibiting ROS release, well modulating hallmark FTH, TFRC, GPX4 expression. Additionally, eliminated NRF2 inhibitor brusatol, observed from blotting, indicating exerted cardio-protective through pathway. Conclusion: Our alleviated inhibition via signaling

Language: Английский

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Recent advances of natural pigments from algae

Food Production Processing and Nutrition, Journal Year: 2023, Volume and Issue: 5(1)

Published: Aug. 8, 2023

Abstract Pigment is an important food additive that plays a major role in the sensory impact of food. And natural sources, healthy and non-toxic edible pigments are receiving lot attention. Algae source pigments, contain chlorophyll, phycoerythrin, carotene, other pigments. Besides staining, pigment also has powerful physiological activities such as antioxidants, anti-inflammatory, anti-obesity, lipid-lowering. In this paper, three seaweed were reviewed, their main structural properties functions presented, filling gap review with object introduction. This provides research basis for development new health foods, direction use chlorophyll pharmaceutical industries. Graphical

Language: Английский

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Molecular Mechanisms of Fucoxanthin in Alleviating Lipid Deposition in Metabolic Associated Fatty Liver Disease

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(18), P. 10391 - 10405

Published: April 26, 2024

Metabolic-associated fatty liver disease (MAFLD) is witnessing a global surge; however, it still lacks effective pharmacological interventions. Fucoxanthin, natural bioactive metabolite derived from marine brown algae, exhibits promising functions, particularly in ameliorating metabolic disorders. However, the mechanisms underlying its therapeutic efficacy addressing MAFLD remain elusive. Our present findings indicated that fucoxanthin significantly alleviated palmitic acid (PA)-induced hepatic lipid deposition

Language: Английский

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Stability and biological activity enhancement of fucoxanthin through encapsulation in alginate/chitosan nanoparticles

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 263, P. 130264 - 130264

Published: Feb. 16, 2024

Language: Английский

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Management of ROS and Regulatory Cell Death in Myocardial Ischemia–Reperfusion Injury

Molecular Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: June 9, 2024

Language: Английский

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