Marine Pharmacology in 2019–2021: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(7), P. 309 - 309

Published: June 30, 2024

The current 2019-2021 marine pharmacology literature review provides a continuation of previous reviews covering the period 1998 to 2018.

Language: Английский

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Saved by seaweeds: phyconomic contributions in times of crises

Journal of Applied Phycology, Journal Year: 2020, Volume and Issue: 33(1), P. 443 - 458

Published: Nov. 7, 2020

Seaweeds (macroalgae) are, together with microalgae, main contributors to the Earth's production of organic matter and atmospheric oxygen as well fixation carbon dioxide. In addition, they contain a bounty fibres minerals, macro- micronutrients that can serve both technical medicinal purposes, be healthy nutritious food for humans animals. It is therefore natural seaweeds have had myriad interwoven relationships on evolutionary timescales in recent millennia centuries all way into Anthropocene. no wonder also entered served saviour humankind around globe many periods severe needs crises. Indeed, sometimes been last resort, it during times famine, warfare, outbreak diseases, nuclear accidents, or components securing fabric social stability. The present topical review presents testimony from history human interaction has, over again, 'saved by seaweeds'. remains historical fact extreme conditions, such shortage wars, turned 'needs must' created new opportunities their uses order mitigate disasters. Lessons learned this used reminders inspiration, guide how turn current inevitable, future crises, not least deal changing climates pressing challenges sustainable eating.

Language: Английский

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Exploitation of Marine Molecules to Manage Alzheimer’s Disease

Marine Drugs, Journal Year: 2021, Volume and Issue: 19(7), P. 373 - 373

Published: June 28, 2021

Neurodegenerative diseases are sociosanitary challenges of today, as a result increased average life expectancy, with Alzheimer’s disease being one the most prevalent. This pathology is characterized by brain impairment linked to neurodegenerative process culminating in cognitive decline and behavioral disorders. Though etiology this still unknown, it usually associated appearance senile plaques neurofibrillary tangles. The used prophylaxis relies on anticholinesterase drugs NMDA receptor antagonists, whose main action relieve symptoms not treat or prevent disease. Currently, scientific community gathering efforts disclose new natural compounds effective against other pathologies. Marine products have been shown be promising candidates, some proven exert high neuroprotection effect, constituting large reservoir potential nutraceutical agents. present article attempts describe processes extraction isolation bioactive derived from sponges, algae, marine bacteria, invertebrates, crustaceans, tunicates drug candidates AD, focus success pharmacological activity finding compounds.

Language: Английский

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Marine-Derived Leads as Anticancer Candidates by Disrupting Hypoxic Signaling through Hypoxia-Inducible Factors Inhibition

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(4), P. 143 - 143

Published: March 23, 2024

The inadequate vascularization seen in fast-growing solid tumors gives rise to hypoxic areas, fostering specific changes gene expression that bolster tumor cell survival and metastasis, ultimately leading unfavorable clinical prognoses across different cancer types. Hypoxia-inducible factors (HIF-1 HIF-2) emerge as druggable pivotal players orchestrating metastasis angiogenesis, thus positioning them prime targets for treatment. A range of HIF inhibitors, notably natural compounds originating from marine organisms, exhibit encouraging anticancer properties, underscoring their significance promising therapeutic options. Bioprospection the environment is now a well-settled approach discovery development agents might have medicinal chemistry developed into candidates. However, despite massive increase number products classified ‘anticancer leads,’ most which correspond general cytotoxic agents, only few been characterized regarding molecular mechanisms action. current review presents critical analysis inhibitors HIF-1 HIF-2 hypoxia-selective sourced organisms act new chemotherapeutic candidates or serve templates structurally similar derivatives with improved efficacy.

Language: Английский

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Neuroprotective Effect of Carotenoid-Rich Enteromorpha prolifera Extract via TrkB/Akt Pathway against Oxidative Stress in Hippocampal Neuronal Cells

Marine Drugs, Journal Year: 2020, Volume and Issue: 18(7), P. 372 - 372

Published: July 19, 2020

In this study, we found that E. prolifera extract (EAEP) exhibits neuroprotective effects in oxidative stress-induced neuronal cells. EAEP improved cell viability as well attenuated the formation of intracellular reactive oxygen species (ROS) and apoptotic bodies glutamate-treated hippocampal cells (HT-22). Furthermore, expression brain-derived neurotrophic factor (BDNF) antioxidant enzymes such heme oxygenase-1 (HO-1), NAD(P)H quinine oxidoreductase-1 (NQO-1), glutamate–cysteine ligase catalytic subunit (GCLC) via tropomyosin-related kinase receptor B/ protein B (TrkB/Akt) signaling pathway. contrast, pre-incubation K252a, a TrkB inhibitor, or MK-2206, an Akt-selective ameliorated These results suggest protects against apoptosis by upregulating BDNF activation TrkB/Akt conclusion, effect EAEP, which is rich carotenoid-derived compounds, may justify its application food supplement prevention treatment neurodegenerative disorders.

Language: Английский

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