Current and investigational medications for the treatment of sarcopenia

Metabolism, Journal Year: 2023, Volume and Issue: 149, P. 155597 - 155597

Published: June 21, 2023

Language: Английский

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Vitamin D Determinants, Status, and Antioxidant/Anti-inflammatory-Related Effects in Cardiovascular Risk and Disease: Not the Last Word in the Controversy

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 948 - 948

Published: April 18, 2023

Beyond its key role in calcium homeostasis, vitamin D has been found to significantly affect the cardiovascular (CV) system. In fact, low levels have associated with increased CV risk, as well morbidity and mortality. The majority of effects this molecule are related directly or indirectly antioxidative anti-inflammatory properties. Generally, insufficiency is considered for 25-hydroxyvitamin (25(OH)D) between 21–29 ng/mL (corresponding 52.5–72.5 nmol/L), deficiency 25(OH)D less than 20 (<50 extreme 10 (<25 nmol/L). However, definition an optimal status, defined by 25(OH)D, remains controversial many extra-bone conditions, including disease. review, confounding factors affecting measurement status will be discussed. particular, available evidence on mechanism relation risk disease through antioxidant effect reported, also facing aspect regarding debate minimum blood level required ensure health.

Language: Английский

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The efficacy of cholecalciferol in the comprehensive treatment of patients with autoimmune diabetes

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2025, Volume and Issue: 20(8), P. 565 - 572

Published: Jan. 4, 2025

Background. Vitamin D deficiency is a global issue negatively affecting the course of autoimmune diabetes, including classical type 1 diabetes mellitus (T1DM) and latent in adults (LADA). plays vital role immune response regulation, maintaining β-cell function pancreas, metabolic balance. The purpose study was to evaluate efficacy adding cholecalciferol at dose 20,000 IU (once weekly for 3 months) standard therapy improve status patients with T1DM LADA. Materials methods. A total 72 participated study: 36 They were divided into subgroups depending on treatment received: basic or vitamin supplementation. comprehensive evaluation carbohydrate metabolism indicators (fasting glycemia, HbA1c, HOMA-IR, insulin, C-peptide levels), activity (antibodies glutamic acid decarboxylase (antiGAD)), lipid profile conducted before after treatment. Results. addition significantly increased serum 25(OH)D levels, ensuring substantial improvement patients. In groups receiving supplemental cholecalciferol, there notable reduction fasting glucose HbА1с, antiGAD titers, indicating positive impact glycemic control decrease activity. Additionally, exhibited improvements metabolism, decreased levels cholesterol, low-density lipoprotein triglycerides, high-density cholesterol. Particularly significant an increase observed LADA, reflecting enhanced pancreas. This effect may be related as well anti-inflammatory properties D, which contribute maintenance β-cells their ability secrete insulin. confirms pleiotropic effects D: reducing inflammation, impro­ving insulin sensitivity, normalizing profiles, supporting function. Conclusions. findings highlight importance monitoring correcting particularly presence deficiency. above data could used optimize therapeutic approaches reduce risk complications this patient population.

Language: Английский

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Vitamin D Supplementation: Practical Advice in Different Clinical Settings

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 783 - 783

Published: Feb. 24, 2025

A global deficiency in vitamin D is now widely prevalent. Extensive scientific research has provided compelling evidence of the detrimental effects on skeletal system. Furthermore, supplementation not only helps prevent bone fractures but may also slow progression various conditions, such as diabetes, autoimmune disorders, and cardiovascular disease. Achieving optimal circulating levels can be challenging, particularly certain clinical scenarios. Moreover, effect varies depending factors body weight, pregnancy status, absorption capacity, metabolic rate, renal function. This review aims to explore which formulations are most effective specific contexts where reaching adequate straightforward.

Language: Английский

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Evaluation of the Relationship between Serum 25(OH) Vitamin D Levels and Cardiac Functions in Adolescent Athletes

Nigerian Journal of Clinical Practice, Journal Year: 2025, Volume and Issue: 28(4), P. 471 - 479

Published: April 1, 2025

Background: Vitamin D is a prohormone necessary for the optimal functioning of locomotor and circulatory systems in humans. As caveat, vitamin metabolism crucial maintaining musculoskeletal cardiovascular health overexercising people, like athletes. Our study intended to explore relationship between serum 25-hydroxy (25(OH) D) levels left ventricle/right ventricle (LV/RV) systolic diastolic function adolescent athletes using 2D Doppler studies. Methods: In our cross-sectional study, 100 were divided into two groups: insufficiency (25(OH)D<20 ng/mL) sufficiency (25(OH)D>20 with 30 males 20 females both groups. A detailed physical examination basic biochemical tests performed; 25(OH)D determined, an echocardiographic evaluation was performed. Results: We found that decreased associated impairment many indicators cardiac function, such as ventricular-right ventricular-interventricular septum peak velocity (Sm) Tei index, inflow early late ratio (E/A), annulus myocardial (E′), E/E′ ratio. Conclusions: To protect functions athletes, we suggest screening 25(OH) during certain periods, fall winter, supplementation if necessary.

Language: Английский

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Peculiarities of vitamin D metabolism in diabetic kidney disease

KIDNEYS, Journal Year: 2025, Volume and Issue: 13(4), P. 257 - 260

Published: Jan. 9, 2025

The analysis of literature revealed the peculiarities vitamin D metabolism in diabetic kidney damage, as well its role development renal, metabolic changes, including bone and mineral disorders. Vitamin D, due to influence on various physiological processes through receptors, plays a key regulation metabolism, functioning immune system control other extraskeletal effects. In patients with deficiency causes impaired hydroxylation formation an active metabolite (1,25(OH)2D3), which leads progression proteinuria fibrosis. mechanisms glucose interaction at level proximal tubules were analyzed, emphasizes need for further research develop therapeutic strategies correcting damage order improve their prognosis.

Language: Английский

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Imunorregulação e suplementação oral da Vitamina D: uma revisão integrativa

Brazilian Journal of Health Review, Journal Year: 2025, Volume and Issue: 8(1), P. e76783 - e76783

Published: Jan. 14, 2025

A suplementação de vitamina D tem-se mostrado promissora na imunorregulação doenças pacientes imunocompetentes. Esta revisão literatura destinou-se a: analisar como a oral atua doenças; considerar relação entre e as variáveis: faixa etária, etnia, localização geográfica etc; citar principais evidências médicas estudos científicos sobre o tratamento da terapia suplementar D; identificar doses restrições importância para sistema imunológico; pesquisar com algumas enfermidades imunocompetentes; elaborar um e-book os conhecimentos levantados neste Artigo. Tratou-se estudo qualitativo, do tipo bibliográfico-analítico, uma integrativa, busca ativa referencial literário científico em imunocomprometidos. Nesse viés, presente comprovou ingestão adequada D.

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Shining light on knee osteoarthritis: an overview of vitamin D supplementation studies

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 22, 2025

Background The impact of knee osteoarthritis on individuals’ daily functioning is significant. In recent years, Vitamin D supplements cure has garnered attention from medical professionals and patients due to its simplicity portability. Several systematic reviews (SRs) meta-analyses (MAs) have examined the efficacy vitamin supplementation for osteoarthritis, yet there variability in their methodology quality. Objective To search, gather, analyze data characteristics quantitative results SR/MA with KOA treated supplementation, objectively evaluate supplements. Then, provides clinical evidence recommendations use supplementation. Methods Two individuals reviewed collected four databases until October 2023. AMSTAR-2, ROBIS, PRISMA 2020, GRADE tools were used methodological quality, bias risk, reporting strength all SR/MA. Additionally, we applied corrected covered area (CCA) method measure overlap randomized controlled trials (RCTs) cited among Results 3 SRs 6 MAs included analysis: studies low quality by very According high-risk low-risk. 2020 most showed deficiencies comprehensive literature search strategy, reasons exclusion, preprocessing meta-analysis, exploration heterogeneity, sensitivity analysis, publication bias, disclosure funding conflicts interest. Grading consisted 5 items moderate 14 10 Bias risk imprecision main factors downgrading. calculation RCT between using CCA a high degree overlap. Conclusion may show potential ameliorating symptoms KOA. indicates that can improve patients’ Total WOMAC scores synovial fluid volume joints. Nevertheless, generally current studies, future research should prioritize improving primary establish more robust scientific evidence. Systematic review registration protocol this overview was registered International Prospective Register Reviews (PROSPERO) ( https://www.crd.york.ac.uk/PROSPERO/ ) number CRD42024535841.

Language: Английский

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Perinatal Vitamin D Deficiency Enhances Brown Adipose Tissue Thermogenesis in Weanling Rats

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4534 - 4534

Published: May 9, 2025

Perinatal vitamin D (Vit. D) deficiency (VDD) disrupts the development of key tissues involved in metabolic regulation, including endocrine pancreas, white adipose tissue, and skeletal muscle. Brown tissue (BAT), essential for thermoregulation energy homeostasis, may also be affected, but impact perinatal VDD on BAT physiology remains unclear. In this study, forty female Wistar rats were fed either a standard AIN93G diet (1000 IU Vit. D3/kg; control group, CT) (n = 20) or modified lacking (VDD group) six weeks prior to conception throughout gestation lactation. Male offspring evaluated at weaning (PN21) adulthood (PN180) after status was normalized through diet. We found that reduced total lipid droplet area, increased oxygen consumption, upregulated thermogenic gene expression weaning. Correspondingly, exhibited greater cold tolerance enhanced recruitment upon exposure (4 °C). Notably, normalization by fully reversed these changes, indicating while transiently enhances activity during early life, it does not produce lasting effects into adulthood.

Language: Английский

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Minipuberty in Sons of Women with Low Vitamin D Status during Pregnancy

Nutrients, Journal Year: 2023, Volume and Issue: 15(22), P. 4729 - 4729

Published: Nov. 9, 2023

Minipuberty is a transient phase of reproductive axis activation during the first several months life, playing an important role in development organs boys. Low 25-hydroxyvitamin D levels pregnancy are associated with increased risk neonatal complications. An inadequate gestational vitamin status hypothesized to affect postnatal hypothalamic–pituitary–gonadal axis. The purpose our study was assess whether low determines course minipuberty included three groups male infants born women different statuses: sons deficiency (group 1), insufficiency 2), and offspring females normal 3 (the reference group)). Concentrations testosterone, androstenedione, dehydroepiandrosterone sulfate, estradiol, progesterone, 17-hydroxyprogesterone saliva, as well concentrations gonadotropins urine, were assayed monthly from 1 6, once every 2 second half year life. Additionally, at each visit, penile length testicular volume assessed. FSH, LH, volume, greater group than 3. In turn, characterized by higher FSH Peak LH testosterone observed earlier remaining groups. obtained results suggest that may have stimulatory impact on activity early genital organs, correlating severity hypovitaminosis D.

Language: Английский

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